公开(公告)号：US5846419A

公开(公告)日：1998-12-08

申请号：US891267

申请日：1997-07-10

申请人： Bernd Nederlof

发明人： Bernd Nederlof

IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/34 ,  B01D61/14 ,  B01D65/02 ,  C02F1/44 ,  B01D61/26 ,  B01D61/28

CPC分类号： A61M1/3455 ,  A61M1/1672 ,  A61M1/3465 ,  B01D61/142 ,  B01D65/02 ,  C02F1/444 ,  A61M2205/7554 ,  B01D2321/02 ,  B01D2321/04

摘要： A hemo(dia)filtration apparatus (10) is described comprising a dialyzer (12) and two sterile filters (38) and (60). The first chambers (42) and (64) of both sterile filters (38) and (60) may be switched at least intermittently during flow through, thereby flushing out membranes (40) and (62) of both sterile filters (38) and (60) and effectively preventing an accumulation of germs and pyrogens. This prevents an increase in the transmembrane pressure (TMP), which reduces the likelihood of a rupture, thereby ensuring sterility of the dialyzer fluid and improving the operating safety of the hemodiafiltration apparatus (10).

摘要翻译： 包括透析器（12）和两个无菌过滤器（38）和（60）的血液（直径）过滤装置（10）。 无菌过滤器（38）和（60）的第一室（42）和（64）可以在流过期间至少间歇地切换，由此冲洗无菌过滤器（38）和（36）的膜（40）和（62） （60），有效防止细菌和热原的积聚。 这防止跨膜压力（TMP）的增加，这降低了破裂的可能性，从而确保透析器流体的无菌性和改善血液透析滤器（10）的操作安全性。

公开(公告)号：US08557571B2

公开(公告)日：2013-10-15

申请号：US11794234

申请日：2005-12-22

申请人： Franz Kugelmann ,  Paul Hengster ,  Raimund Margreiter ,  Bernd Nederlof ,  Massimo Fini ,  Ciro Tetta ,  Thomas Wild ,  Micaela Yakubovich ,  Michael Paul ,  Marco Caronna

发明人： Franz Kugelmann ,  Paul Hengster ,  Raimund Margreiter ,  Bernd Nederlof ,  Massimo Fini ,  Ciro Tetta ,  Thomas Wild ,  Micaela Yakubovich ,  Michael Paul ,  Marco Caronna

IPC分类号： C12M1/12

CPC分类号： C12M23/24 ,  C12M23/28 ,  C12M25/10 ,  C12M27/10 ,  C12M27/14

摘要： A reactor has a reactor unit with a first chamber and a second chamber, with the first chamber being formed by the interior of a housing and the second chamber being formed by the interior of a plurality of hollow fibers arranged in the housing. The hollow fibers are arranged in the housing such that their density in at least one region of the first chamber does not exceed 10 fibers/mm2, based on the cross-sectional area of the first chamber. The reactor unit can include two casting compounds, in which a portion of the hollow fibers are embedded and between which another portion of the hollow fibers extends. The length of at least some or all of the hollow fibers is at least 0.5% greater than the distance of the casting compounds.

摘要翻译： 反应器具有具有第一室和第二室的反应器单元，第一室由壳体的内部形成，第二室由布置在壳体中的多个中空纤维的内部形成。 中空纤维布置在壳体中，使得它们在第一室的至少一个区域中的密度基于第一室的横截面面积不超过10个纤维/ mm 2。 反应器单元可以包括两种铸造化合物，其中中空纤维的一部分被嵌入并且中空纤维的另一部分延伸。 至少部分或全部中空纤维的长度比铸塑料的距离大至少0.5％。

公开(公告)号：US5660722A

公开(公告)日：1997-08-26

申请号：US501210

申请日：1995-07-11

申请人： Bernd Nederlof

发明人： Bernd Nederlof

IPC分类号： A61M1/14 ,  A61M1/34 ,  B01D61/32 ,  B01D61/58

CPC分类号： A61M1/3413 ,  A61M1/342 ,  A61M1/3427 ,  A61M1/3437 ,  A61M1/3465 ,  A61M2205/705 ,  A61M2205/7518

摘要： Described is a hemo(dia)filtration apparatus (10) with two blood filters (60) and (12) connected in series and a sterile filter (38) connected upstream thereof. The first chambers (64) and (14) and the second chambers (68) and (16) of both blood filters (60) and (12) are connected to one another, respectively, by connecting lines (72) and (74). A means (76) is arranged in one of the connecting lines (72) and (74), which generates a positive transmembrane pressure in the direction of the blood path in one of the blood filters (60, 12) and a negative transmembrane pressure in the direction of the blood path (80) in the other blood filter (12, 60). This eliminates a costly substituate line with additional devices arranged therein, since the dialyzer fluid is passed as a substituate solution through the membrane of the one blood filter directly into the blood. Furthermore, with the use of suitable devices it is possible to precisely determine and individually adjust the filtrate and substituate flows.

摘要翻译： 描述了具有串联连接的两个血液过滤器（60）和（12）的血液（dia）过滤装置（10）和连接在其上游的无菌过滤器（38）。 血液过滤器（60）和（12）的第一室（64）和第二室（14）和第二室（68）和（16）分别通过连接管线（72）和（74）彼此连接， 。 一个连接线（72）和（74）中的一个设置有一个装置（76），它们在一个血液过滤器（60,12）中的血液通路的方向上产生正的跨膜压力，而负跨膜压力 在另一个血液过滤器（12,60）中的血液路径（80）的方向上。 这消除了在其中布置有附加装置的昂贵的取代线，因为透析器流体作为取代溶液通过一个血液过滤器的膜直接进入血液。 此外，通过使用合适的装置，可以精确地确定和分别调节滤液和取代流。

公开(公告)号：US20080145926A1

公开(公告)日：2008-06-19

申请号：US11794234

申请日：2005-12-22

申请人： Franz Kugelmann ,  Paul Hengster ,  Raimund Margreiter ,  Bernd Nederlof ,  Massimo Fini ,  Ciro Tetta ,  Thomas Wild ,  Micaela Yakubovich ,  Michael Paul ,  Marco Caronna

发明人： Franz Kugelmann ,  Paul Hengster ,  Raimund Margreiter ,  Bernd Nederlof ,  Massimo Fini ,  Ciro Tetta ,  Thomas Wild ,  Micaela Yakubovich ,  Michael Paul ,  Marco Caronna

IPC分类号： C12M1/08

CPC分类号： C12M23/24 ,  C12M23/28 ,  C12M25/10 ,  C12M27/10 ,  C12M27/14

摘要： This invention relates to a reactor unit with a first chamber and a second chamber, wherein the first chamber is formed by the interior of a housing and wherein the second chamber is formed by the interior of a plurality of hollow fibers arranged in the housing. The hollow fibers are arranged in the housing such that their density in at least one region of the first chamber does not exceed 10 fibers/mm2, based on the cross-sectional area of the first chamber. In accordance with another aspect of the invention it is provided that in the reactor unit two casting compounds are arranged, in which a portion of the hollow fibers is embedded and between which another portion of the hollow fibers extends, wherein the length of at least some or all hollow fibers is at least 0.5% greater than the distance of the casting compounds.

摘要翻译： 本发明涉及具有第一室和第二室的反应器单元，其中第一室由壳体的内部形成，并且其中第二室由布置在壳体中的多个中空纤维的内部形成。 中空纤维布置在壳体中，使得它们在第一腔室的至少一个区域中的密度基于第一腔室的横截面面积不超过10根纤维/ mm 2。 根据本发明的另一方面，提供了在反应器单元中，布置两个铸造化合物，其中中空纤维的一部分被嵌入，并且在另一部分中空纤维之间延伸，其中至少一些中空纤维的长度 或所有中空纤维比铸造化合物的距离大至少0.5％。