公开(公告)号：US5681474A

公开(公告)日：1997-10-28

申请号：US522616

申请日：1995-09-01

申请人： Joachim Gunther ,  Bernhard Krause ,  Gernot Mader ,  Wolfgang Sittig ,  Klaus Itter ,  Klaus-Jurgen Simon

发明人： Joachim Gunther ,  Bernhard Krause ,  Gernot Mader ,  Wolfgang Sittig ,  Klaus Itter ,  Klaus-Jurgen Simon

IPC分类号： G01N30/52 ,  B01D15/08 ,  G01N30/56 ,  G01N30/60

CPC分类号： B01D15/22 ,  G01N30/6021 ,  G01N2030/522 ,  G01N2030/565

摘要： This invention relates to a low-pressure chromatography column 1 having a diameter of more than 30 cm, and essentially consisting of a vertical cylinder 13 having a base plate 12, a lower sintered disk 3 arranged above the base plate 12, an upper sintered disk 16 fastened to the underside of a lid designed as a mobile plunger 4, and having at least three controllable elements 5 for raising or lowering the plunger 4, which are connected to the plunger 4, equipped with sensors 6 electrically connected to a control unit 10 for determining the vertical position and horizontal placement of the plunger 4. With the aid of an optical observation device (e.g., endoscope), the plunger/gel material can be adjusted exactly over the entire positioning range of the plunger. The advantages of the invention include simple and rapid production of the packing and purer products than could be obtained without such packing. The low-pressure chromatography column according to the invention is particularly suitable for purifying insulin and precursors of insulin thereof.

摘要翻译： 本发明涉及一种直径大于30cm的低压色谱柱1，其基本上由具有底板12的垂直圆柱体13，布置在底板12上方的下烧结盘3，上部烧结盘 16固定在设计成可移动柱塞4的盖的下侧，并且具有至少三个用于升高或降低柱塞4的可控元件5，该可控元件5连接到柱塞4，柱塞4配备有电连接到控制单元10的传感器6 用于确定柱塞4的垂直位置和水平放置。借助于光学观察装置（例如内窥镜），可以在柱塞的整个定位范围内精确地调节柱塞/凝胶材料。 本发明的优点包括简单快速地生产包装和更纯净的产品，而不需要这种包装。 根据本发明的低压色谱柱特别适用于纯化胰岛素及其胰岛素前体。

公开(公告)号：US07137794B2

公开(公告)日：2006-11-21

申请号：US10469745

申请日：2002-10-14

申请人： Johannes Pfetzer ,  Bernhard Krause

发明人： Johannes Pfetzer ,  Bernhard Krause

IPC分类号： F04B17/00

CPC分类号： F04D29/086 ,  F04D29/426 ,  F04D29/628 ,  F05D2260/33

摘要： A fluid pump, in particular a water pump, has a pump housing (11) that surrounds a pump wheel and a motor housing, connected to the pump housing, in which an electric motor (21) driving the pump wheel is received along with a stator (22) and rotor. For the sake of sealing off the pump from the escape of fluid and sealing off the motor housing from the penetration of fluid, with only one seal, and with assembly of the fluid pump without additional connecting elements, the pump housing (11) has a lower housing part (12) with an annular rib (14) protruding radially outward, and an upper housing part (13) slipped onto the lower housing part (12). Between the free annular face end of the upper housing part (13) and the annular rib (14), there is a sealing ring (15). The motor housing is embodied as a housing pot (26), which with a gripping edge (28) fits over the annular rib (14), sealing ring (15), and part of the upper housing part (13), and is locked to the upper housing part (13), producing an axial clamping force (FIG. 3).

摘要翻译： 流体泵，特别是水泵，具有围绕泵轮的泵壳体（11）和连接到泵壳体的马达壳体，驱动泵轮的电动马达（21）以及泵壳体 定子（22）和转子。 为了将泵从流体的逸出密封，并且密封马达外壳免受流体的渗透，只有一个密封，并且在没有附加连接元件的情况下组装流体泵，泵壳体（11）具有 下壳体部分（12）具有径向向外突出的环形肋（14）和滑动到下壳体部分（12）上的上壳体部分（13）。 在上部壳体部分（13）的自由环形端部与环形肋（14）之间存在密封环（15）。 马达壳体被实施为壳体（26），其中夹紧边缘（28）装配在环形肋（14），密封环（15）和上部壳体部分（13）的一部分上并被锁定 到上壳体部分（13），产生轴向夹紧力（图3）。

公开(公告)号：US5684475A

公开(公告)日：1997-11-04

申请号：US639957

申请日：1996-04-29

申请人： Bernhard Krause ,  Martin Pozybill

发明人： Bernhard Krause ,  Martin Pozybill

IPC分类号： G08G1/01 ,  G08G1/065

CPC分类号： G08G1/065 ,  G08G1/0104

摘要： In a method for recognizing disruptions in road traffic within a road sector that is to be monitored at respective measurement cross-sections at the beginning and at the end of the sector, the number and the speed of the vehicles passing through the measurement cross-sections are continuously acquired as measured data, which are collected and compiled cyclically during finite measurement intervals to provide average values of the traffic flow and the speed, and are then evaluated. Each measurement cross-section thereby encompasses all lanes of traffic that can be used in one direction of travel. In order to recognize disruptions in road traffic, independent of the traffic condition and with the smallest possible loss in time and low investment in data processing, a prognosis value of the traffic flow for the vehicles passing through the end of the road sector is calculated cyclically from the average values determined for the beginning of the road sector, taking into consideration the length of the road sector and an assumption about the driving behavior of the detected vehicles. Describable uncertainties arising in determining the prognosis value are taken into consideration by fuzzy modeling. The prognosis value is compared with the average value of the traffic flow at the end of the road sector determined from the measured data acquired at the measurement cross-section at the end of the road sector and the respective difference in traffic flow is determined cyclically. A cycle-spanning summation of the values of the difference in traffic flow is carried out and the number of the additional vehicles remaining in the road sector to be monitored is continuously determined.

摘要翻译： 在通过测量横截面的车辆的数量和速度的方法中，识别在扇区的开始和结束处的相应测量横截面处将被监视的道路部门内的道路交通中断的方法， 作为测量数据连续获取，它们在有限测量间隔期间循环收集和编译，以提供交通流量和速度的平均值，然后进行评估。 每个测量横截面因此包括可以在一个行进方向上使用的所有行车通道。 为了识别道路交通中断，独立于交通状况，尽可能小的时间损失和数据处理投资低，通过道路行车道终点的车辆的交通流预测值周期性地计算 从道路部门开始时确定的平均值，考虑到道路部门的长度和对所检测到的车辆的驾驶行为的假设。 通过模糊建模考虑了确定预后价值的可能的不确定性。 将预测值与在路段末端的测量横截面处获取的测量数据确定的道路段末端的交通流量的平均值进行比较，并且周期性地确定业务流量的相应差异。 执行交通流量差异的值的周期跨度求和，并且连续确定待监视的道路区域中剩余的附加车辆的数量。