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    Antibodies specific for fullerenes
    1.
    发明授权
    Antibodies specific for fullerenes 失效
    富勒烯特异性抗体

    公开(公告)号：US06593137B1

    公开(公告)日：2003-07-15

    申请号：US09386658

    申请日：1999-08-31

    Applicant: Bernard F. Erlanger ,  Bi-Xing Chen

    Inventor： Bernard F. Erlanger ,  Bi-Xing Chen

    IPC: C12N520

    CPC classification number: B82Y30/00 ,  B82Y5/00 ,  C07K16/44 ,  G01N33/5308 ,  G01N2430/00 ,  Y10S530/807

    Abstract: This invention provides a hybridoma produced by the fusion of a mouse antibody-producing cell and a mouse myeloma which is designated 1-10F-8A and deposited with the ATCC under Accession Number PTA-279, said hybridoma producing a monoclonal antibody which binds to fullerene C60. This invention provides a mouse monoclonal antibody specific for a fullerene-C60 and produced by the mouse monoclonal antibody-producing hybridoma designated 1-10F-8A. The invention provides the amino acid and encoding nucleic acid sequences of the heavy and light chains of the 1-10F-8A monoclonal antibody. This invention also provides methods of determining a serum concentration of a fullerene in a subject and of purifying a fullerene from a sample.

    Abstract translation: 本发明提供了通过将小鼠抗体产生细胞与小鼠骨髓瘤融合而产生的杂交瘤，其被命名为1-10F-8A，并以保藏号PTA-279保藏在ATCC中，所述杂交瘤产生结合富勒烯的单克隆抗体 C60。 本发明提供了对富勒烯-C60特异性并由指定为1-10F-8A的产生小鼠单克隆抗体的杂交瘤产生的小鼠单克隆抗体。 本发明提供1-10F-8A单克隆抗体的重链和轻链的氨基酸和编码核酸序列。 本发明还提供了确定受试者中富勒烯的血清浓度并从样品中纯化富勒烯的方法。

    Vehicle theft indicating device
    2.
    发明授权
    Vehicle theft indicating device 失效
    车辆盗窃指示装置

    公开(公告)号：US06452488B1

    公开(公告)日：2002-09-17

    申请号：US09770264

    申请日：2001-01-26

    Applicant: Yuan Jing He ,  Bi-Xing Chen

    Inventor： Yuan Jing He ,  Bi-Xing Chen

    IPC: B60Q126

    CPC classification number: B60R25/104 ,  B60Q1/2611 ,  B60R25/1003

    Abstract: A vehicle theft indicating device for alerting the police and others that the vehicle is stolen. The vehicle theft indicating device includes a light-emitting support member being adapted to be securely attached to a top of a roof of a vehicle; and also includes a light-emitting assembly including a light socket member being securely attached to the light-emitting support member and being adapted to be connected to a power supply, and also including a light-emitting member being disposed in the light socket member, and further including a transmitter for activating the light-emitting member; and further includes a transparent cover being removably disposed over the light-emitting member and being securely attached to the light-emitting support member with fasteners.

    Abstract translation: 一种车辆盗窃指示装置，用于警告警察和其他人车辆被盗。 车辆盗窃指示装置包括适于牢固地附接到车辆顶部的发光支撑构件; 并且还包括发光组件，其包括牢固地附接到发光支撑构件并且适于连接到电源的灯座构件，并且还包括布置在灯座构件中的发光构件， 并且还包括用于激活所述发光构件的发射器; 并且还包括可移除地设置在所述发光构件上方并且用紧固件牢固地附接到所述发光支撑构件的透明盖。

    Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates
    4.
    发明授权
    Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates 失效
    通过使用针对探针标记和测定底物之间的反应产物的抗体来提高免疫测定程序的灵敏度

    公开(公告)号：US5925532A

    公开(公告)日：1999-07-20

    申请号：US898583

    申请日：1997-07-22

    Applicant: Bernard F. Erlanger ,  Bi-Xing Chen

    Inventor： Bernard F. Erlanger ,  Bi-Xing Chen

    IPC: C12Q1/70 ,  G01N33/53 ,  G01N33/537 ,  G01N33/542 ,  G01N33/543

    CPC classification number: G01N33/54306 ,  C12Q1/6804

    Abstract: The subject invention provides an antibody which specifically binds to the product of a reaction between a labeling substance and a substrate. The subject invention also provides a method of making an immunogen used to produce the antibody of the subject invention. The invention further provides methods of using the subject antibody for detecting an antigen of interest in a sample, for example, detecting a protein comprising an amino acid sequence of interest and detecting a nucleic acid molecule comprising a nucleic acid sequence of interest, detecting a polypeptide such as those expressed by infectious agents, fungi or parasites.

    Abstract translation: 本发明提供了与标记物质和底物之间的反应的产物特异性结合的抗体。 本发明还提供了制备用于产生本发明抗体的免疫原的方法。 本发明还提供使用本发明抗体检测样品中目的抗原的方法，例如检测包含感兴趣的氨基酸序列的蛋白质并检测包含感兴趣的核酸序列的核酸分子，检测多肽 例如由感染因子，真菌或寄生虫表达的那些。

    Endogenous taxol-like substance in human serum, monoclonal antibodies directed thereto and methods of assaying therefor
    7.
    发明授权
    Endogenous taxol-like substance in human serum, monoclonal antibodies directed thereto and methods of assaying therefor 失效
    人血清中的内源性紫杉醇样物质，针对其的单克隆抗体及其测定方法

    公开(公告)号：US5756301A

    公开(公告)日：1998-05-26

    申请号：US25557

    申请日：1993-03-03

    Applicant: Bernard F. Erlanger ,  Jyh-Gang Leu ,  Bi-Xing Chen

    Inventor： Bernard F. Erlanger ,  Jyh-Gang Leu ,  Bi-Xing Chen

    IPC: C07K16/16 ,  C07K16/42 ,  G01N33/53 ,  G01N33/574 ,  G01N33/92 ,  G01N33/567

    CPC classification number: C07K16/16 ,  C07K16/4208 ,  G01N33/5308 ,  G01N33/57415 ,  G01N33/57449 ,  G01N33/92

    Abstract: The present invention provides two monoclonal antibodies capable of binding to taxol and taxol-like substances which are produced by hybridomas designated 69E4A8E, having ATCC Accession No. HB11281 and 29B7B3C, having ATCC Accession No. HB11280. The present invention also provides a method for detecting the presence of taxol or a taxol-like substance in a sample, a method for screening for a ligand in a subject which is not being treated with taxol, an endogenous taxol-like substance in human serum detected by this screening method, a method of quantitatively determining the amount of taxol or taxol-like substance in a biological fluid sample and a kit for assaying for taxol or a taxol-like substance in a sample.

    Abstract translation: 本发明提供了能够结合紫杉醇和紫杉醇样物质的两种单克隆抗体，其由具有ATCC登录号HB11281和ATCCB2B3C的具有ATCC登录号HB11280的69E4A8E的杂交瘤产生。 本发明还提供了一种用于检测样品中紫杉醇或类紫杉醇样物质的存在的方法，用于筛选未用紫杉醇处理的受试者中的配体的方法，人血清中的内源性紫杉醇样物质 通过该筛选方法检测生物流体样品中紫杉醇或类紫杉醇样物质的量的定量方法和用于测定样品中紫杉醇或类紫杉醇样物质的试剂盒。

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