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15 条记录 (耗时 0.028 秒)

    Endogenous taxol-like substance in human serum, monoclonal antibodies directed thereto and methods of assaying therefor
    1.
    发明授权
    Endogenous taxol-like substance in human serum, monoclonal antibodies directed thereto and methods of assaying therefor 失效
    人血清中的内源性紫杉醇样物质，针对其的单克隆抗体及其测定方法

    公开(公告)号：US5756301A

    公开(公告)日：1998-05-26

    申请号：US25557

    申请日：1993-03-03

    申请人： Bernard F. Erlanger ,  Jyh-Gang Leu ,  Bi-Xing Chen

    发明人： Bernard F. Erlanger ,  Jyh-Gang Leu ,  Bi-Xing Chen

    IPC分类号： C07K16/16 ,  C07K16/42 ,  G01N33/53 ,  G01N33/574 ,  G01N33/92 ,  G01N33/567

    CPC分类号： C07K16/16 ,  C07K16/4208 ,  G01N33/5308 ,  G01N33/57415 ,  G01N33/57449 ,  G01N33/92

    摘要： The present invention provides two monoclonal antibodies capable of binding to taxol and taxol-like substances which are produced by hybridomas designated 69E4A8E, having ATCC Accession No. HB11281 and 29B7B3C, having ATCC Accession No. HB11280. The present invention also provides a method for detecting the presence of taxol or a taxol-like substance in a sample, a method for screening for a ligand in a subject which is not being treated with taxol, an endogenous taxol-like substance in human serum detected by this screening method, a method of quantitatively determining the amount of taxol or taxol-like substance in a biological fluid sample and a kit for assaying for taxol or a taxol-like substance in a sample.

    摘要翻译： 本发明提供了能够结合紫杉醇和紫杉醇样物质的两种单克隆抗体，其由具有ATCC登录号HB11281和ATCCB2B3C的具有ATCC登录号HB11280的69E4A8E的杂交瘤产生。 本发明还提供了一种用于检测样品中紫杉醇或类紫杉醇样物质的存在的方法，用于筛选未用紫杉醇处理的受试者中的配体的方法，人血清中的内源性紫杉醇样物质 通过该筛选方法检测生物流体样品中紫杉醇或类紫杉醇样物质的量的定量方法和用于测定样品中紫杉醇或类紫杉醇样物质的试剂盒。

    Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates
    3.
    发明授权
    Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates 失效
    通过使用针对探针标记和测定底物之间的反应产物的抗体来提高免疫测定程序的灵敏度

    公开(公告)号：US5925532A

    公开(公告)日：1999-07-20

    申请号：US898583

    申请日：1997-07-22

    申请人： Bernard F. Erlanger ,  Bi-Xing Chen

    发明人： Bernard F. Erlanger ,  Bi-Xing Chen

    IPC分类号： C12Q1/70 ,  G01N33/53 ,  G01N33/537 ,  G01N33/542 ,  G01N33/543

    CPC分类号： G01N33/54306 ,  C12Q1/6804

    摘要： The subject invention provides an antibody which specifically binds to the product of a reaction between a labeling substance and a substrate. The subject invention also provides a method of making an immunogen used to produce the antibody of the subject invention. The invention further provides methods of using the subject antibody for detecting an antigen of interest in a sample, for example, detecting a protein comprising an amino acid sequence of interest and detecting a nucleic acid molecule comprising a nucleic acid sequence of interest, detecting a polypeptide such as those expressed by infectious agents, fungi or parasites.

    摘要翻译： 本发明提供了与标记物质和底物之间的反应的产物特异性结合的抗体。 本发明还提供了制备用于产生本发明抗体的免疫原的方法。 本发明还提供使用本发明抗体检测样品中目的抗原的方法，例如检测包含感兴趣的氨基酸序列的蛋白质并检测包含感兴趣的核酸序列的核酸分子，检测多肽 例如由感染因子，真菌或寄生虫表达的那些。

    Antibodies specific for fullerenes
    5.
    发明授权
    Antibodies specific for fullerenes 失效
    富勒烯特异性抗体

    公开(公告)号：US06593137B1

    公开(公告)日：2003-07-15

    申请号：US09386658

    申请日：1999-08-31

    申请人： Bernard F. Erlanger ,  Bi-Xing Chen

    发明人： Bernard F. Erlanger ,  Bi-Xing Chen

    IPC分类号： C12N520

    CPC分类号： B82Y30/00 ,  B82Y5/00 ,  C07K16/44 ,  G01N33/5308 ,  G01N2430/00 ,  Y10S530/807

    摘要： This invention provides a hybridoma produced by the fusion of a mouse antibody-producing cell and a mouse myeloma which is designated 1-10F-8A and deposited with the ATCC under Accession Number PTA-279, said hybridoma producing a monoclonal antibody which binds to fullerene C60. This invention provides a mouse monoclonal antibody specific for a fullerene-C60 and produced by the mouse monoclonal antibody-producing hybridoma designated 1-10F-8A. The invention provides the amino acid and encoding nucleic acid sequences of the heavy and light chains of the 1-10F-8A monoclonal antibody. This invention also provides methods of determining a serum concentration of a fullerene in a subject and of purifying a fullerene from a sample.

    摘要翻译： 本发明提供了通过将小鼠抗体产生细胞与小鼠骨髓瘤融合而产生的杂交瘤，其被命名为1-10F-8A，并以保藏号PTA-279保藏在ATCC中，所述杂交瘤产生结合富勒烯的单克隆抗体 C60。 本发明提供了对富勒烯-C60特异性并由指定为1-10F-8A的产生小鼠单克隆抗体的杂交瘤产生的小鼠单克隆抗体。 本发明提供1-10F-8A单克隆抗体的重链和轻链的氨基酸和编码核酸序列。 本发明还提供了确定受试者中富勒烯的血清浓度并从样品中纯化富勒烯的方法。

    Methods relating to immunogenic dextran-protein conjugates
    7.
    发明授权
    Methods relating to immunogenic dextran-protein conjugates 失效
    与免疫原性葡聚糖 - 蛋白质共轭物相关的方法

    公开(公告)号：US06287568B1

    公开(公告)日：2001-09-11

    申请号：US09149997

    申请日：1998-09-09

    申请人： Denong Wang ,  Bernard F. Erlanger ,  Elvin A. Kabat

    发明人： Denong Wang ,  Bernard F. Erlanger ,  Elvin A. Kabat

    IPC分类号： A01N6500

    CPC分类号： A61K47/646 ,  A61K47/61 ,  Y10S424/804 ,  Y10S424/812

    摘要： This invention includes the conception of T-independent conjugate-vaccines and its application in the induction of antigen specific IgA response. We demonstrated that 1) &agr;(1,6)dextran can elicit a markedly enhanced IgA response in T-cell free mice (20-50 fold higher than in normal mice); 2)co-injection of the molecule with other antigens can enhance the IgA response to the co-antigen; and 3)a dextran-Gag conjugate can elicit the Gag-specific IgA. Thus, the invention identified &agr;(1,6)dextran as a carrier molecule for producing the T-independent conjugates and as an adjuvant for the enhancement of IgA production. The T-independent property of these conjugates makes it especially useful in vaccinations against HIV and other infectious and non-infectious diseases associated with T-cell deficiency.

    摘要翻译： 本发明包括T非依赖性缀合物疫苗的概念及其在诱导抗原特异性IgA应答中的应用。 我们证明1）α（1,6）葡聚糖可以在无T细胞的小鼠中引起显着增强的IgA反应（比正常小鼠高20-50倍）; 2）共注射分子与其他抗原可以增强对共抗原的IgA反应; 和3）葡聚糖-Gag缀合物可以引发Gag特异性IgA。 因此，本发明鉴定了α（1,6）葡聚糖作为产生T非依赖性缀合物的载体分子和用于增强IgA产生的佐剂。 这些缀合物的T独立性质使其特别适用于针对HIV和与T细胞缺乏相关的其他感染性和非感染性疾病的疫苗接种。

    Non-radioactive carbodiimide precursor to nucleic acid probes
    9.
    发明授权
    Non-radioactive carbodiimide precursor to nucleic acid probes 失效
    核酸探针的非放射性碳二亚胺前体

    公开(公告)号：US4895955A

    公开(公告)日：1990-01-23

    申请号：US199570

    申请日：1988-05-27

    申请人： John P. Ford ,  Charles W. Blewett ,  Michael D. Sublett ,  Bernard F. Erlanger ,  Alan F. Cook

    发明人： John P. Ford ,  Charles W. Blewett ,  Michael D. Sublett ,  Bernard F. Erlanger ,  Alan F. Cook

    IPC分类号： C07D495/04 ,  C07H21/00

    CPC分类号： C07D495/04 ,  C07H21/00 ,  Y02P20/55

    摘要： This invention relates to carbodiimide compounds of the formula:Z--L--W--N.dbd.C.dbd.N--R.sub.1wherein Z is a signalling moiety or a protecting group; L is a divalent linking group; W is an alkylene group having up to 24 carbon atoms which can be substituted or interrupted by a water solubility enhancing group or cleavable S--S group; and R.sub.1 is an alkyl group having up to 18 carbon atoms. These compounds are useful in the nonradioactive labelling of nucleic acid probes, and methods employing same.

    摘要翻译： 本发明涉及下式的碳二亚胺化合物：Z-L-W-N = C = N-R1其中Z是信号传导部分或保护基; L是二价连接基团; W是具有至多24个碳原子的亚烷基，其可以被水溶性增强基团或可切割的S-S基团取代或中断; 并且R 1是具有至多18个碳原子的烷基。 这些化合物可用于核酸探针的非放射性标记和使用其的方法。