公开(公告)号：US20110136759A1

公开(公告)日：2011-06-09

申请号：US12681052

申请日：2008-10-03

申请人： Daniel Kahne ,  Suzanne Kahne Walker ,  Masaatsu Adachi ,  Emma Doud ,  Shinichiro Fuse ,  Xiaonan Lin ,  Yi Zhang ,  Hirokazu Tsukamoto ,  Bohdan Ostash

发明人： Daniel Kahne ,  Suzanne Kahne Walker ,  Masaatsu Adachi ,  Emma Doud ,  Shinichiro Fuse ,  Xiaonan Lin ,  Yi Zhang ,  Hirokazu Tsukamoto ,  Bohdan Ostash

IPC分类号： A61K31/7024 ,  C07H13/00 ,  C12P19/26 ,  A61P31/04

CPC分类号： C07H15/10 ,  C07H11/04

摘要： The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.

摘要翻译： 本发明通过向有需要的受试者施用本发明化合物来提供新颖的新霉素类似物及其药物组合物，合成方法和用于治疗感染的方法。 门霉素类似物可以合成，生物合成或半合成制备。 类似物在治疗或预防革兰氏阳性生物引起的感染中特别有用。 某些本发明化合物可具有更广泛的覆盖范围，其包括革兰氏阴性生物体。

公开(公告)号：US08604004B2

公开(公告)日：2013-12-10

申请号：US12681052

申请日：2008-10-03

申请人： Daniel Kahne ,  Suzanne Walker Kahne ,  Masaatsu Adachi ,  Emma Doud ,  Shinichiro Fuse ,  Xiaonan Lin ,  Yi Zhang ,  Hirokazu Tsukamoto ,  Bohdan Ostash

发明人： Daniel Kahne ,  Suzanne Walker Kahne ,  Masaatsu Adachi ,  Emma Doud ,  Shinichiro Fuse ,  Xiaonan Lin ,  Yi Zhang ,  Hirokazu Tsukamoto ,  Bohdan Ostash

IPC分类号： A61K31/702 ,  A61K31/715 ,  A61K31/7016 ,  A61K31/7028 ,  C07H5/04 ,  C07H5/06

CPC分类号： C07H15/10 ,  C07H11/04

摘要： The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.

摘要翻译： 本发明通过向有需要的受试者施用本发明化合物来提供新颖的新霉素类似物及其药物组合物，合成方法和用于治疗感染的方法。 门霉素类似物可以合成，生物合成或半合成制备。 类似物在治疗或预防革兰氏阳性生物引起的感染中特别有用。 某些本发明化合物可具有更广泛的覆盖范围，其包括革兰氏阴性生物体。