公开(公告)号：US20110136759A1

公开(公告)日：2011-06-09

申请号：US12681052

申请日：2008-10-03

申请人： Daniel Kahne ,  Suzanne Kahne Walker ,  Masaatsu Adachi ,  Emma Doud ,  Shinichiro Fuse ,  Xiaonan Lin ,  Yi Zhang ,  Hirokazu Tsukamoto ,  Bohdan Ostash

发明人： Daniel Kahne ,  Suzanne Kahne Walker ,  Masaatsu Adachi ,  Emma Doud ,  Shinichiro Fuse ,  Xiaonan Lin ,  Yi Zhang ,  Hirokazu Tsukamoto ,  Bohdan Ostash

IPC分类号： A61K31/7024 ,  C07H13/00 ,  C12P19/26 ,  A61P31/04

CPC分类号： C07H15/10 ,  C07H11/04

摘要： The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.

摘要翻译： 本发明通过向有需要的受试者施用本发明化合物来提供新颖的新霉素类似物及其药物组合物，合成方法和用于治疗感染的方法。 门霉素类似物可以合成，生物合成或半合成制备。 类似物在治疗或预防革兰氏阳性生物引起的感染中特别有用。 某些本发明化合物可具有更广泛的覆盖范围，其包括革兰氏阴性生物体。

公开(公告)号：US20100290987A1

公开(公告)日：2010-11-18

申请号：US12664559

申请日：2008-06-13

申请人： Benjamin Gross ,  Suzanne Kahne Walker ,  Jonathan Swoboda

发明人： Benjamin Gross ,  Suzanne Kahne Walker ,  Jonathan Swoboda

IPC分类号： A61K51/08 ,  C07K2/00 ,  C12N9/00 ,  C07K7/06 ,  G01N33/50 ,  A61K38/02 ,  A61K38/08 ,  A61K38/43 ,  C12N5/071 ,  A61P25/28 ,  A61P3/10

CPC分类号： C12Q1/37 ,  C07K7/06 ,  C07K2319/50 ,  C07K2319/60 ,  C12N9/12 ,  C12Q1/34 ,  G01N2333/924 ,  G01N2440/38 ,  G01N2500/02

摘要： The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for identifying therapeutic compounds to treat glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention is also useful for identifying therapeutic compounds to treat de-glycosylation-associated disorders such as ischemic damage and traumatic injury. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins and also relates in part to compounds to treat glycosylation-associated diseases and disorders.

摘要翻译： 本发明涉及调节蛋白质糖基化的方法和产品。 本发明可用于鉴定用于治疗糖基化相关疾病如神经变性，糖尿病，包括糖尿病并发症如胰岛素抵抗，肾病，微血管损伤和内皮功能障碍的治疗化合物。 本发明也可用于鉴定治疗化合物以治疗去糖基化相关疾病如缺血性损伤和创伤性损伤。 本发明还部分涉及可用于鉴定和测试用于调节蛋白质糖基化的候选化合物的测定法，并且还部分涉及用于治疗糖基化相关疾病和病症的化合物。