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公开(公告)号：US08604004B2
公开(公告)日：2013-12-10
申请号：US12681052
申请日：2008-10-03
申请人： Daniel Kahne , Suzanne Walker Kahne , Masaatsu Adachi , Emma Doud , Shinichiro Fuse , Xiaonan Lin , Yi Zhang , Hirokazu Tsukamoto , Bohdan Ostash
发明人： Daniel Kahne , Suzanne Walker Kahne , Masaatsu Adachi , Emma Doud , Shinichiro Fuse , Xiaonan Lin , Yi Zhang , Hirokazu Tsukamoto , Bohdan Ostash
IPC分类号： A61K31/702 , A61K31/715 , A61K31/7016 , A61K31/7028 , C07H5/04 , C07H5/06
摘要： The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.
摘要翻译： 本发明通过向有需要的受试者施用本发明化合物来提供新颖的新霉素类似物及其药物组合物，合成方法和用于治疗感染的方法。 门霉素类似物可以合成，生物合成或半合成制备。 类似物在治疗或预防革兰氏阳性生物引起的感染中特别有用。 某些本发明化合物可具有更广泛的覆盖范围，其包括革兰氏阴性生物体。
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公开(公告)号：US20110136759A1
公开(公告)日：2011-06-09
申请号：US12681052
申请日：2008-10-03
申请人： Daniel Kahne , Suzanne Kahne Walker , Masaatsu Adachi , Emma Doud , Shinichiro Fuse , Xiaonan Lin , Yi Zhang , Hirokazu Tsukamoto , Bohdan Ostash
发明人： Daniel Kahne , Suzanne Kahne Walker , Masaatsu Adachi , Emma Doud , Shinichiro Fuse , Xiaonan Lin , Yi Zhang , Hirokazu Tsukamoto , Bohdan Ostash
IPC分类号： A61K31/7024 , C07H13/00 , C12P19/26 , A61P31/04
摘要： The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.
摘要翻译： 本发明通过向有需要的受试者施用本发明化合物来提供新颖的新霉素类似物及其药物组合物，合成方法和用于治疗感染的方法。 门霉素类似物可以合成，生物合成或半合成制备。 类似物在治疗或预防革兰氏阳性生物引起的感染中特别有用。 某些本发明化合物可具有更广泛的覆盖范围，其包括革兰氏阴性生物体。
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公开(公告)号：US5069760A
公开(公告)日：1991-12-03
申请号：US542094
申请日：1990-06-22
摘要： A chemical treating system includes a main row or line of equally spaced, equal length chemical treatment workstations for sequentially treating a workpiece such as the cylinder bore of an internal combustion engine cylinder. Additional longer chemical treatment workstations are located transversely of the main row of workstations so that larger workstations can be included in the chemical treatment system without increasing the total length of the main row of workstations. By locating the longer workstations transversely of the main row, equal distances between the main row of workstations can be maintained by using work transfer devices that move the workpieces longitudinally along the main row and transversely to the additional chemical treatment workstations in a sequential process. At the transversely located workstation, an airblower is provided to remove residual chemical treatment solution from the workpieces before they are returned to the main line of workstations. Where the workstation constitutes an electrolytic plating system for the workpiece surfaces, an electrically conductive conduit is included for conveying the plating solution so that the conduit may be utilized as an electrode during the plating operation.
摘要翻译： 一种化学处理系统包括主排或等距间隔的等长化学处理工作站，用于顺序地处理诸如内燃机气缸的气缸孔的工件。 额外的更长的化学处理工作站位于主排的工作台的横向，以便在化学处理系统中可以包含较大的工作站，而不会增加主排工作站的总长度。 通过在主排横向设置较长的工作站，可以通过使用沿着主排纵向移动工件并沿着连续过程横向移动到附加化学处理工作站的工件传送装置来维持主排工作台之间的相等距离。 在横向位置的工作站，提供一个吹气器，以便在工件返回工作站的主线路之前从工件上除去残留的化学处理溶液。 在工作站构成用于工件表面的电解电镀系统的地方，包括用于输送电镀溶液的导电导管，使得导电管可以在电镀操作期间用作电极。
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