公开(公告)号：US20080103138A1

公开(公告)日：2008-05-01

申请号：US11960306

申请日：2007-12-19

Applicant: Thomas Trieselmann ,  Rainer Walter ,  Matthew Netherton ,  Marco Santagostino ,  Bradford Hamilton

Inventor： Thomas Trieselmann ,  Rainer Walter ,  Matthew Netherton ,  Marco Santagostino ,  Bradford Hamilton

IPC: A61K31/5377 ,  C07D235/06 ,  A61K31/4184 ,  A61P3/04 ,  A61P3/10 ,  C07D413/12

CPC classification number: C07D235/02 ,  C07D235/06 ,  C07D235/26

Abstract: The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 to R4 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.

Abstract translation: 本发明涉及通式（I）的新的β-激动剂，其中基团R 1至R 4具有权利要求和说明书中给出的含义，互变异构体， 其外消旋物，对映异构体，非对映异构体，溶剂合物，水合物，其混合物，其前药及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，制备这些化合物的方法及其作为药物组合物的用途。

公开(公告)号：US20070112033A1

公开(公告)日：2007-05-17

申请号：US11550827

申请日：2006-10-19

Applicant: Thomas Trieselmann ,  Rainer Walter ,  Matthew Netherton ,  Marco Santagostino ,  Bradford Hamilton

Inventor： Thomas Trieselmann ,  Rainer Walter ,  Matthew Netherton ,  Marco Santagostino ,  Bradford Hamilton

IPC: C07D403/02 ,  A61K31/4439 ,  A61K31/4184

CPC classification number: C07D235/02 ,  C07D235/06 ,  C07D235/26

Abstract: The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 to R4 have the meanings given in ths claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.

Abstract translation: 本发明涉及通式（I）的新的β-激动剂，其中基团R 1至R 4具有权利要求和说明书中给出的含义，互变异构体， 其外消旋物，对映异构体，非对映异构体，溶剂合物，水合物，其混合物，其前药及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，制备这些化合物的方法及其作为药物组合物的用途。

公开(公告)号：US20070105906A1

公开(公告)日：2007-05-10

申请号：US11550830

申请日：2006-10-19

Applicant: Rainer Walter ,  Bradford Hamilton ,  Thomas Trieselmann ,  Matthew Netherton ,  Marco Santagostino ,  Ingo Konetzki

Inventor： Rainer Walter ,  Bradford Hamilton ,  Thomas Trieselmann ,  Matthew Netherton ,  Marco Santagostino ,  Ingo Konetzki

IPC: A61K31/4439 ,  A61K31/433 ,  A61K31/41 ,  A61K31/405 ,  C07D413/02 ,  C07D409/02 ,  C07D403/02

CPC classification number: C07D209/08 ,  C07D209/18 ,  C07D209/42 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

Abstract: The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 and R2 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.

Abstract translation: 本发明涉及通式（I）的新的β-激动剂，其中基团R 1和R 2 2具有权利要求书和说明书中给出的含义，互变异构体， 其外消旋物，对映异构体，非对映异构体，溶剂合物，水合物，其混合物，其前药及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，制备这些化合物的方法及其作为药物组合物的用途。

公开(公告)号：US20050245526A1

公开(公告)日：2005-11-03

申请号：US11118295

申请日：2005-04-29

Applicant: Thomas Trieselmann ,  Bradford Hamilton

Inventor： Thomas Trieselmann ,  Bradford Hamilton

IPC: C07D233/36 ,  C07D233/54 ,  C07D233/68 ,  C07D233/90 ,  C07D235/06 ,  C07D237/32 ,  C07D249/06 ,  C07D249/08 ,  C07D401/04 ,  C07D403/10 ,  C07D409/04 ,  C07D413/04 ,  A61K31/498 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/425 ,  C07D43/02 ,  C07D49/14

CPC classification number: C07D249/08 ,  C07D233/36 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D235/06 ,  C07D237/32 ,  C07D249/06 ,  C07D401/04 ,  C07D403/10 ,  C07D409/04 ,  C07D413/04

Abstract: The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 to R7 have the meanings given in the claims and specification, the tautomers, the enantiomers, the diastereomers, the mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, processes for preparing these compounds and their use as pharmaceutical compositions.

Abstract translation: 本发明涉及通式（I）的新的β-激动剂，其中基团R 1至R 7具有权利要求和说明书中给出的含义，互变异构体， 对映异构体，非对映异构体，其混合物，其前药及其盐，特别是其与无机或有机酸或碱的生理学上可接受的盐，制备这些化合物的方法及其作为药物组合物的用途。

公开(公告)号：US20060173061A1

公开(公告)日：2006-08-03

申请号：US11276649

申请日：2006-03-09

Applicant: Thomas Trieselmann ,  Bradford Hamilton ,  Dirk Stenkamp ,  Stephan Mueller

Inventor： Thomas Trieselmann ,  Bradford Hamilton ,  Dirk Stenkamp ,  Stephan Mueller

IPC: A61K31/4178 ,  A61K31/4172

CPC classification number: C07D233/64 ,  C07D233/84 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12

Abstract: The present invention relates to new beta-agonists of general formula 1: wherein the groups R1 to R12 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these compounds and their use as pharmaceutical compositions.

Abstract translation: 本发明涉及通式1的新β-激动剂：其中R 1至R 12基团具有权利要求书和说明书中给出的含义，其异构体， 制备这些化合物的方法及其作为药物组合物的用途。