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1.发明申请Indol-containing beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions 有权含吲哚的β-激动剂，其制备方法及其作为药物组合物的用途公开(公告)号：US20070105906A1
公开(公告)日：2007-05-10
申请号：US11550830
申请日：2006-10-19
申请人： Rainer Walter , Bradford Hamilton , Thomas Trieselmann , Matthew Netherton , Marco Santagostino , Ingo Konetzki
发明人： Rainer Walter , Bradford Hamilton , Thomas Trieselmann , Matthew Netherton , Marco Santagostino , Ingo Konetzki
IPC分类号： A61K31/4439 , A61K31/433 , A61K31/41 , A61K31/405 , C07D413/02 , C07D409/02 , C07D403/02
CPC分类号： C07D209/08 , C07D209/18 , C07D209/42 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 and R2 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的新的β-激动剂，其中基团R 1和R 2 2具有权利要求书和说明书中给出的含义，互变异构体， 其外消旋物，对映异构体，非对映异构体，溶剂合物，水合物，其混合物，其前药及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，制备这些化合物的方法及其作为药物组合物的用途。
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2.发明申请Beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions 审中-公开β-激动剂，其制备方法及其作为药物组合物的用途公开(公告)号：US20080103138A1
公开(公告)日：2008-05-01
申请号：US11960306
申请日：2007-12-19
申请人： Thomas Trieselmann , Rainer Walter , Matthew Netherton , Marco Santagostino , Bradford Hamilton
发明人： Thomas Trieselmann , Rainer Walter , Matthew Netherton , Marco Santagostino , Bradford Hamilton
IPC分类号： A61K31/5377 , C07D235/06 , A61K31/4184 , A61P3/04 , A61P3/10 , C07D413/12
CPC分类号： C07D235/02 , C07D235/06 , C07D235/26
摘要： The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 to R4 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的新的β-激动剂，其中基团R 1至R 4具有权利要求和说明书中给出的含义，互变异构体， 其外消旋物，对映异构体，非对映异构体，溶剂合物，水合物，其混合物，其前药及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，制备这些化合物的方法及其作为药物组合物的用途。
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3.发明申请Beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions 审中-公开β-激动剂，其制备方法及其作为药物组合物的用途公开(公告)号：US20070112033A1
公开(公告)日：2007-05-17
申请号：US11550827
申请日：2006-10-19
申请人： Thomas Trieselmann , Rainer Walter , Matthew Netherton , Marco Santagostino , Bradford Hamilton
发明人： Thomas Trieselmann , Rainer Walter , Matthew Netherton , Marco Santagostino , Bradford Hamilton
IPC分类号： C07D403/02 , A61K31/4439 , A61K31/4184
CPC分类号： C07D235/02 , C07D235/06 , C07D235/26
摘要： The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 to R4 have the meanings given in ths claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的新的β-激动剂，其中基团R 1至R 4具有权利要求和说明书中给出的含义，互变异构体， 其外消旋物，对映异构体，非对映异构体，溶剂合物，水合物，其混合物，其前药及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，制备这些化合物的方法及其作为药物组合物的用途。
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4.发明授权Indol-containing beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions 有权含吲哚的β-激动剂，其制备方法及其作为药物组合物的用途公开(公告)号：US07754756B2
公开(公告)日：2010-07-13
申请号：US11550830
申请日：2006-10-19
申请人： Rainer Walter , Bradford S. Hamilton , Thomas Trieselmann , Matthew R. Netherton , Marco Santagostino , Ingo Konetzki
发明人： Rainer Walter , Bradford S. Hamilton , Thomas Trieselmann , Matthew R. Netherton , Marco Santagostino , Ingo Konetzki
IPC分类号： A61K31/4045 , A61K31/404 , C07D209/24 , C07D209/18 , C07D413/02
CPC分类号： C07D209/08 , C07D209/18 , C07D209/42 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 and R2 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的新β-激动剂，其中基团R 1和R 2具有权利要求和说明书中给出的含义，互变异构体，外消旋体，对映异构体，非对映异构体，溶剂合物，水合物，其混合物，其前药 其盐，特别是其与无机或有机酸或碱的生理学上可接受的盐，制备这些化合物的方法及其作为药物组合物的用途。
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5.发明申请Novel Beta-Agonists, Process for Their Preparation and Their Use as Medicaments 审中-公开新型β-激动剂，其制备方法及其用作药物公开(公告)号：US20080300290A1
公开(公告)日：2008-12-04
申请号：US12091823
申请日：2006-10-27
申请人： Rainer Walter , Thomas Trieselmann , Matthew R. Netherton , Marco Santagostino , Bradford S. Hamilton
发明人： Rainer Walter , Thomas Trieselmann , Matthew R. Netherton , Marco Santagostino , Bradford S. Hamilton
IPC分类号： A61K31/4164 , C07D233/61 , A61P3/04 , A61P3/10
CPC分类号： C07D233/64
摘要： Compounds of general formula (I) which are selective beta-3-agonists and useful for the treatment of obesity and type II diabetes. Exemplary compounds are: [4-(1-{3-[2-(3-phenylsulphonylamino-phenyl)-2-hydroxy-ethylamino]-3-methyl-butyl}-1H-imidazol-4-yl)-phenyl]-acetic acid and methyl [4-(1-{3-[2-(3-phenylsulphonylamino-phenyl)-2-hydroxy-ethylamino]-3-methyl-butyl}-1H-imidazol-4-yl)-phenyl]-acetate.
摘要翻译： 作为选择性β-3-激动剂并可用于治疗肥胖和II型糖尿病的通式（I）的化合物。 示例性化合物是：[4-（1- {3- [2-（3-苯基磺酰基氨基 - 苯基）-2-羟基 - 乙基氨基] -3-甲基 - 丁基} -1H-咪唑-4-基） - 苯基] 乙酸和[4-（1- {3- [2-（3-苯基磺酰基氨基 - 苯基）-2-羟基 - 乙基氨基] -3-甲基 - 丁基} -1H-咪唑-4-基） - 苯基] 乙酸盐。
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6.发明申请Cyanothiophenes, their preparation and their use in pharmaceutical compositions 审中-公开氰噻吩，它们的制备及其在药物组合物中的应用公开(公告)号：US20060094764A1
公开(公告)日：2006-05-04
申请号：US11250018
申请日：2005-10-13
申请人： Ralf Anderskewitz , Gerd Morschhaeuser , Ruediger Streicher , Thomas Trieselmann , Rainer Walter
发明人： Ralf Anderskewitz , Gerd Morschhaeuser , Ruediger Streicher , Thomas Trieselmann , Rainer Walter
IPC分类号： A61K31/4436 , A61K31/381 , C07D333/38 , C07D409/02
CPC分类号： C07D333/38 , C07D409/12
摘要： The present invention relates to cyanothiophenes of general formula wherein the Rs are defined as in the claims, the tautomers, their stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly a glugacon receptor-antagonistic activity.
摘要翻译： 本发明涉及通式的氰基噻吩，其中Rs如权利要求中所定义，互变异构体，其立体异构体，其混合物及其盐具有有价值的药理学性质，特别是glugacon受体拮抗活性。
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公开(公告)号：US20050014810A1
公开(公告)日：2005-01-20
申请号：US10744830
申请日：2003-12-23
申请人： Ruediger Streicher , Juergen Mack , Rainer Walter , Ingo Konetzki , Thomas Trieselmann , Volkhard Austel
发明人： Ruediger Streicher , Juergen Mack , Rainer Walter , Ingo Konetzki , Thomas Trieselmann , Volkhard Austel
IPC分类号： A61K31/4184
CPC分类号： A61K31/4184
摘要： The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula
摘要翻译： 本发明涉及式I的取代的2-苯基苯并咪唑的用途，其中R 1，R 2，R 3，R 4，R 5和m具有权利要求书中给出的含义 ，用于制备用于治疗或预防涉及胰高血糖素受体的疾病的药物，以及新的式I化合物，其中R 1是式
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8.发明申请公开(公告)号：US20080269281A1
公开(公告)日：2008-10-30
申请号：US12091828
申请日：2006-10-27
IPC分类号： A61K31/437 , C07D471/04 , A61P3/10 , A61P3/04
CPC分类号： C07D471/04
摘要： Compounds of the formula which are selective beta-3-agonists and useful for the treatment of obesity and type II diabetes. Exemplary compounds are: ethyl 3-{3-[(R)-2-(3-benzenesulphonylamino-phenyl)-2-hydroxy-ethylamino]-3-methyl-butyl}-3H-imidazo[4,5-b]pyridine-5-carboxylate and 3-{3-[(R)-2-(3-benzenesulphonylamino-phenyl)-2-hydroxy-ethylamino]-3-methyl-butyl}-3H-imidazo[4,5-b]pyridine-5-carboxylic acid.
摘要翻译： 作为选择性β-3-激动剂并可用于治疗肥胖和II型糖尿病的式的化合物。 示例性化合物是：3- {3 - [（R）-2-（3-苯磺酰氨基 - 苯基）-2-羟基 - 乙基氨基] -3-甲基 - 丁基} -3H-咪唑并[4,5-b]吡啶 -5-羧酸乙酯和3- {3 - [（R）-2-（3-苯磺酰基氨基 - 苯基）-2-羟基 - 乙基氨基] -3-甲基 - 丁基} -3H-咪唑并[4,5-b]吡啶 -5-羧酸。
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公开(公告)号：US09651163B2
公开(公告)日：2017-05-16
申请号：US14129182
申请日：2012-05-08
申请人： Rainer Walter , Johannes Schmid , Juergen Graner , Matthias Schumacher , Andreas Burghardt , Ralph Engelberg , Jochen Rager
发明人： Rainer Walter , Johannes Schmid , Juergen Graner , Matthias Schumacher , Andreas Burghardt , Ralph Engelberg , Jochen Rager
CPC分类号： F16K31/0675 , F02M51/0614 , F02M63/0019 , F02M2200/8046 , F02M2200/9061 , Y10T137/0491 , Y10T137/5987
摘要： A single-piece component for a magnetic actuator, in particular for fuel injection, including an internal pole, a magnetic sleeve, and a non-magnetic separating sleeve, the internal pole, the magnetic sleeve and the separating sleeve being integrated into the single-piece component. A method for manufacturing a single-piece component for an magnetic actuator with the aid of a two-component powder injection molding method.
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公开(公告)号：US08372838B2
公开(公告)日：2013-02-12
申请号：US13031895
申请日：2011-02-22
申请人： Norbert Hauel , Angelo Ceci , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter , Dieter Wiedenmayer
发明人： Norbert Hauel , Angelo Ceci , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter , Dieter Wiedenmayer
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D405/12 , C07C237/24 , C07C2601/02 , C07D207/277 , C07D211/62 , C07D213/81 , C07D233/90 , C07D239/28 , C07D239/557 , C07D261/18 , C07D271/10 , C07D401/12
摘要： Compounds of the formula I wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and X are defined as described in the specification, which are bradykinin B1 antagonists, and their use as medicaments.
摘要翻译： 其中n，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11和X如说明书中所描述的缓激肽B1拮抗剂及其作为药物的用途的式I化合物 。
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