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公开(公告)号：US07037266B2
公开(公告)日：2006-05-02
申请号：US10131256
申请日：2002-04-25
IPC分类号： A61B8/06
CPC分类号： A61N1/36528 , A61N1/36571
摘要： An ultrasound method and medical devices using same provide for various techniques of sampling blood flow velocity, e.g., at several sampling rates. To minimize the energy required for ultrasound monitoring, pulsed Doppler signal packages provided by a pulsed ultrasound circuit are switched in such a way that the repetition rate is the lowest possible and yet sufficiently high to be able to record the blood flow velocity within the heart. For example, an ultrasound circuit may be activated only within a part of the cardiac cycle designated as the Doppler Measurement Interval (DMI); the ultrasound circuit may be switched between an on state and an off state during the DMI; and/or the ultrasound circuit may also be switched on and off in different sampling modes: detection mode and measurement mode (e.g., using different sampling rates).
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2.发明授权Tricuspid flow synchronized cardiac electrotherapy system with blood flow measurement transducer and controlled pacing signals based on blood flow measurement 失效基于血液流量测量的血液流量测量传感器和控制PAC信号的TRICUSPID流量同步心脏电泳系统
公开(公告)号：US5243976A
公开(公告)日：1993-09-14
申请号：US674607
申请日：1991-03-25
CPC分类号： A61B8/06 , A61B8/12 , A61B8/445 , A61N1/36528 , A61N1/36571
摘要： A cardiac electrotherapy system has flow velocity measurement capability for measuring a velocity of blood flow at a region of a tricuspid valve of a heart. A pacing system is provided which outputs a pacing electrical signal to the heart. A control unit which is responsive to a measured flow velocity from the flow velocity measurement unit detects heart irregularities and controls electrical pacing signals to the heart. In detecting heart irregularities, peak flow velocity waveforms are detected and analyzed. The flow velocity measurement employs a Doppler ultrasonic transducer which is mounted on a cardiac pacing lead in spaced relation to a pacing electrode at a distal end of the lead. When the pacing lead is inserted in the heart, the pacing electrode is placed at an apex of the right ventricle and the piezoelectric Doppler transducer is positioned at or near the tricuspid valve. The flow velocity transducer is preferably formed as an annular piezo body having associated electrodes. An ultrasonic lens directs ultrasonic rays from the transducer and an ultrasonic wave inhibitor structure prevents transmission of ultrasonic waves in an undesired direction. With the cardiac electrotherapy system disclosed, improved and more reliable monitoring of cardiac activity is achieved and a corresponding improved pacing results.
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公开(公告)号：US5913879A
公开(公告)日：1999-06-22
申请号：US952201
申请日：1997-11-06
IPC分类号： A61B5/0295 , A61N1/365 , A61N1/368 , A61N1/36
CPC分类号： A61N1/36514 , A61N1/36571
摘要： An implantable detection and therapy device allow prediction of the vasovagal syncope for use in administering therapy to a subject, the therapy including pacing pulses or drug delivery, or a combination thereof. The detection and therapy device includes a sensor which obtains blood flow velocity data or blood pressure data either in the area of the tricuspid valve or in the superior vena cava. The data are utilized in a control unit to identify the occurrence of venous pooling, which is recognized by the occurrence of a sudden reduction of the peak values of blood flow velocity waves or blood pressure waves. If this sudden reduction of the blood flow velocity waves or blood pressure waves is preceded by a sudden increase in the sinus heartbeat rate, the reduction is identified as being caused by venous pooling. The sudden increase in sinus heartbeat rate is caused by the increased sympathetic activity preceding the vasovagal syncope. The administration of appropriate therapy is then triggered upon the identification of venous pooling.
摘要翻译： PCT No.PCT / EP96 / 01933 Sec。 371日期：1997年11月6日 102（e）日期1997年11月6日PCT提交1996年5月8日PCT公布。 公开号WO96 / 35476 日期1996年11月14日可植入检测和治疗装置允许预测用于对受试者施用治疗的血管迷走性晕厥，包括起搏脉冲或药物递送或其组合。 检测和治疗装置包括在三尖瓣区域或上腔静脉中获得血流速度数据或血压数据的传感器。 在控制单元中利用数据来识别由血流速度波或血压波的峰值的突然降低而发生的静脉汇集的发生。 如果血流速度波或血压波的这种突然减少之前是窦性心跳速率的突然增加，则减少被鉴定为由静脉汇集引起的。 窦性心跳率的突然增加是由于血管迷走性晕厥之前的交感神经活动增加引起的。 然后在鉴定静脉血液池时触发适当的治疗。
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公开(公告)号：US5785657A
公开(公告)日：1998-07-28
申请号：US669473
申请日：1996-11-04
CPC分类号： G01F1/708 , A61B5/027 , A61B8/06 , A61B8/12 , G01F1/7082 , G01F1/7086 , G01F1/712
摘要： A blood flow velocity measurement device is devised where there exist such entities within the fluid which are detectable when axially flowing (passing by) an appropriate detector of known and well defined dimensions mounted onto a catheter. The entities produced for instance by a generator, when flowing by the detector, induced a known single response, the response bearing direct correlation to the flow velocity, in the form of direct reciprocity to the velocity and direct proportion to the length of the sensitive length of the detector. Autocorrelation of the function obtained by the overlap and pile-up of successive events is calculated and from the characteristic points in the autocorrelation function the axial velocity is inferred. The measurement is best when the probing beam is perpendicular to the flow.
摘要翻译： PCT No.PCT / EP95 / 00134 Sec。 371日期：1996年11月4日 102（e）日期1996年11月4日PCT 1995年1月13日PCT PCT。 WO95 / 19138 PCT出版物 日期1995年7月20日设计了一种血流速度测量装置，其中在流体内存在这样的实体，其在轴向流动（通过）安装到导管上的已知且明确限定的尺寸的适当检测器时可检测。 由发生器产生的实体在被检测器流动时产生已知的单一响应，响应与流速直接相关，以与速度直接相互作用的形式直接与敏感长度的长度成正比 的检测器。 计算通过连续事件重叠和堆积获得的函数的自相关，并从自相关函数的特征点推断出轴向速度。 当探测光束垂直于流时，测量最好。
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公开(公告)号：US4706681A
公开(公告)日：1987-11-17
申请号：US744375
申请日：1985-06-13
申请人： Branko Breyer , Ivo Cikes , Bozidar Ferek-Petric
发明人： Branko Breyer , Ivo Cikes , Bozidar Ferek-Petric
CPC分类号： A61B8/0841 , A61B8/0833 , A61B8/12 , A61N1/0565 , A61B2090/3929
摘要： Cardiac ultrasonically marked leads produced by mounting one or more piezoelectric marker transducers into the leads and connecting the transducers by electrical conductors to appropriate electronic circuits which, upon reception of the scanner ultrasonic signals by the marker transducers, generate appropriate electrical signals which localize unambiguously the marker transducers in an ultrasonic echographic image, thereby permitting guiding of pacing leads and detection of their malfunctions.
摘要翻译： 通过将一个或多个压电标记换能器安装到引线中并通过电导体将换能器连接到适当的电子电路而产生的心脏超声波标记的引线，其在由标记换能器接收到扫描仪超声波信号时产生适当的电信号，其明确定位该标记 换能器在超声回波图像中，从而允许引导起搏引线并检测其故障。
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公开(公告)号：US5959612A
公开(公告)日：1999-09-28
申请号：US693139
申请日：1996-08-13
CPC分类号： G06F3/011 , G01S15/872 , G01S17/875 , G06F3/0213 , G06F3/023
摘要： A compact computer pointing device without moving parts detects the movement of objects, typically an operator's hand, in a detection area at a pre-selected height above the device. In an ultrasonic embodiment, the device includes two ultrasonic transmitter-receivers mounted at an appropriate position on the computer housing or keyboard. These transmitter-receivers use the Doppler effect to sense the vector velocity of objects moving in front of them. In an optical embodiment, the device consists of two optical emitters-receivers mounted at an appropriate position on the computer housing or keyboard. These emitter-receivers sense the vector velocity of objects moving in front of by cross-correlating the light reflected from the object with the incident light. In both the ultrasonic and the optical embodiment, the velocity vector thus determined is used to generate signals for corresponding movement of a pointer on the computer display. The device is particularly suited for compact computers in which space is limited.
摘要翻译： PCT No.PCT / EP95 / 00549 Sec。 371日期：1996年8月13日 102（e）日期1996年8月13日PCT提交1995年2月15日PCT公布。 公开号WO95 / 22097 日期1995年8月17日没有移动部件的紧凑型计算机指示装置通过设备上方的预选高度的检测区域检测物体（通常是操作者的手）的移动。 在超声波实施例中，该装置包括安装在计算机外壳或键盘上的适当位置的两个超声波发射器 - 接收器。 这些发射器 - 接收器使用多普勒效应来感测在其前方移动的物体的矢量速度。 在光学实施例中，该装置由安装在计算机外壳或键盘上的适当位置的两个光发射器 - 接收器组成。 这些发射器 - 接收器通过将从物体反射的光与入射光互相关联来感测在前方移动的物体的矢量速度。 在超声波和光学实施例中，如此确定的速度矢量用于产生用于指示器在计算机显示器上的相应移动的信号。 该设备特别适用于空间有限的小型计算机。
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公开(公告)号：US5840030A
公开(公告)日：1998-11-24
申请号：US666508
申请日：1996-06-21
申请人： Bozidar Ferek-Petric , Branko Breyer , Ivo Cikes
发明人： Bozidar Ferek-Petric , Branko Breyer , Ivo Cikes
CPC分类号： A61B8/12 , A61B18/1492 , A61B8/0833 , A61B2017/00106 , A61B2017/00154 , A61B2017/00243 , A61B2017/00703 , A61B2018/00101 , A61B2018/00351 , A61B2018/00577 , A61B2018/00666 , A61B2018/00708 , A61B2090/065 , A61B2090/3782 , A61B2090/3929 , A61B8/445
摘要： A method and system for therapy of cardiac arrythmias is provided which uses a directional electric field applied via ablation electrode for cardiac ablation together with an ultrasonic imaging system including an ultrasonic marking transducer mounted fixedly in the vicinity of the ablation electrode and having ultrasonic sensitivity characteristics either in the same direction as the ablation field or in some other direction determined by a certain defined angle relative to the direction of the ablation field.
摘要翻译： PCT No.PCT / EP94 / 04252 Sec。 371日期：1996年6月21日 102（e）日期1996年6月21日PCT 1994年12月21日PCT PCT。 WO95 / 17131 PCT出版物 日期：1995年6月29日提供了一种用于心脏心律失常治疗的方法和系统，其使用通过消融电极施加的用于心脏消融的定向电场，以及包括固定地安装在消融电极附近的超声波标记换能器的超声成像系统，以及 具有与消融场相同的方向或者相对于消融场的方向由一定的限定角确定的某个其它方向的超声波敏感特性。
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公开(公告)号：US5271408A
公开(公告)日：1993-12-21
申请号：US855658
申请日：1992-03-23
摘要： A device for measuring blood flow in the vicinity of a catheter implanted within the vascular vessel or the heart uses hydrodynamic principles. The device has two transducers mounted at the exterior surface of the catheter spaced from each other. One of the transducers has a protrusion in the form of a hydrofoil profile, and the other transducer presents a substantially flat surface at the exterior of the catheter. The transducer having the hydrofoil profile generates a signal due to the quasi-static pressure acting on the transducer as well as due to the drag force acting on the transducer caused by the blood flow. The other transducer generates a signal solely due to the quasi-static pressure. The transducers can either be connected with opposite polarity, or their respective signals can be subtracted in a differential amplifier, so that a signal proportional to the axial flow velocity is obtained.
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公开(公告)号：US09042983B2
公开(公告)日：2015-05-26
申请号：US11930583
申请日：2007-10-31
申请人： Can Cinbis , Bozidar Ferek-Petric , Branko Breyer
发明人： Can Cinbis , Bozidar Ferek-Petric , Branko Breyer
CPC分类号： A61N1/056 , A61B5/027 , A61N1/08 , A61N1/36514 , A61N1/36571 , A61N1/375
摘要： An implantable medical device lead having a flow measurement sensor mounted thereon is provided with a capsule mounted proximate to the sensor. The capsule is used to house electrical circuitry corresponding to the sensor in order to prevent impedance on conductors of the lead, which gradually decreases over chronic periods, from directly affecting signal transmission between the sensor and the electrical circuitry. The electrical circuitry includes a charge amplifier used for processing signals from the sensor. In some cases, the amplifier can be initially calibrated and periodically tuned so as to have consistent functioning with the sensor over chronic periods.
摘要翻译： 具有安装在其上的流量测量传感器的可植入医疗装置引线设置有靠近传感器安装的胶囊。 胶囊用于容纳对应于传感器的电路，以便防止在慢性期逐渐减少的导线的阻抗直接影响传感器和电路之间的信号传输。 电路包括用于处理来自传感器的信号的电荷放大器。 在某些情况下，可以对放大器进行初始校准并定期调谐，以便在慢性期间与传感器具有一致的功能。
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公开(公告)号：US20090112275A1
公开(公告)日：2009-04-30
申请号：US11930583
申请日：2007-10-31
申请人： Can Cinbis , Bozidar Ferek-Petric , Branko Breyer
发明人： Can Cinbis , Bozidar Ferek-Petric , Branko Breyer
IPC分类号： A61N1/37
CPC分类号： A61N1/056 , A61B5/027 , A61N1/08 , A61N1/36514 , A61N1/36571 , A61N1/375
摘要： An implantable medical device lead having a flow measurement sensor mounted thereon is provided with a capsule mounted proximate to the sensor. The capsule is used to house electrical circuitry corresponding to the sensor in order to prevent impedance on conductors of the lead, which gradually decreases over chronic periods, from directly affecting signal transmission between the sensor and the electrical circuitry. The electrical circuitry includes a charge amplifier used for processing signals from the sensor. In some cases, the amplifier can be initially calibrated and periodically tuned so as to have consistent functioning with the sensor over chronic periods.
摘要翻译： 具有安装在其上的流量测量传感器的可植入医疗装置引线设置有靠近传感器安装的胶囊。 胶囊用于容纳对应于传感器的电路，以便防止在慢性期逐渐减少的导线的阻抗直接影响传感器和电路之间的信号传输。 电路包括用于处理来自传感器的信号的电荷放大器。 在某些情况下，可以对放大器进行初始校准并定期调谐，以便在慢性期间与传感器具有一致的功能。
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