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1.发明授权Method of preventing coccidiosis with 3,5-dinitroaniline derivatives and veterinary compositions containing such derivatives 失效用3,5-二硝基苯胺衍生物预防球虫病的方法和含有这些衍生物的兽用组合物
公开(公告)号：US3976786A
公开(公告)日：1976-08-24
申请号：US598534
申请日：1975-07-23
Applicant: Brian William Sharp , Dennis Warburton , Raymond Barry Williams , Kenneth Robert Harry Wooldridge
Inventor： Brian William Sharp , Dennis Warburton , Raymond Barry Williams , Kenneth Robert Harry Wooldridge
IPC: A61K31/165
CPC classification number: A61K31/165
Abstract: Compounds of the formula: ##SPC1##Wherein R.sup.1 represents hydrogen, methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl or sec-butyl, R.sup.2 represents hydrogen or alkyl of 1 through 4 carbon atoms or cycloalkyl of 3 or 4 carbon atoms, and R.sup.3 represents hydrogen, methyl or ethyl, all of which are novel except for three compounds, have been found to be of use in the prevention of coccidiosis in chickens.
Abstract translation: 下式的化合物：
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Patent Agency Ranking
公开(公告)号：US5840724A
公开(公告)日：1998-11-24
申请号：US881888
申请日：1997-06-24
Applicant: Garry Fenton , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Keith Alfred James Stuttle , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher
Inventor： Garry Fenton , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Keith Alfred James Stuttle , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher
IPC: C07C43/225 , C07C45/00 , C07C45/29 , C07C45/71 , C07C47/575 , C07C49/84 , C07C59/58 , C07C59/60 , C07C59/62 , C07C65/21 , C07C65/24 , C07C65/26 , C07C65/42 , C07C69/76 , C07C69/92 , C07C205/59 , C07C217/88 , C07C235/56 , C07C255/60 , C07C275/34 , C07C311/29 , C07C311/46 , C07C317/40 , C07C323/42 , C07C327/48 , C07D213/50 , C07D213/75 , C07D213/89 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/02 , C07D275/03 , C07D409/12 , C07D213/02 , A61K31/44
CPC classification number: C07C43/225 , C07C205/59 , C07C217/88 , C07C235/56 , C07C255/60 , C07C275/34 , C07C311/29 , C07C311/46 , C07C317/40 , C07C323/42 , C07C327/48 , C07C45/004 , C07C45/292 , C07C45/71 , C07C47/575 , C07C49/84 , C07C59/58 , C07C59/60 , C07C59/62 , C07C65/21 , C07C65/24 , C07C65/26 , C07C65/42 , C07C69/76 , C07C69/92 , C07D213/50 , C07D213/75 , C07D213/89 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D409/12 , C07C2101/08 , C07C2101/14 , C07C2102/42
Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.
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3.发明授权Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group 失效含有通过含脂肪族或含杂原子的连接基与芳基或杂芳基连接的苯基的化合物公开(公告)号：US06255326B1
公开(公告)日：2001-07-03
申请号：US09239075
申请日：1999-01-27
Applicant: Michael John Ashton , David Charles Cook , Garry Fenton , Susan Jacqueline Hills , Ian Michael McFarlane , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher , Nigel Vicker
Inventor： Michael John Ashton , David Charles Cook , Garry Fenton , Susan Jacqueline Hills , Ian Michael McFarlane , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher , Nigel Vicker
IPC: C07D21172
CPC classification number: C07C43/225 , C07C45/004 , C07C45/292 , C07C45/71 , C07C47/575 , C07C49/84 , C07C59/58 , C07C59/60 , C07C59/62 , C07C65/21 , C07C65/24 , C07C65/26 , C07C65/42 , C07C69/76 , C07C69/92 , C07C205/59 , C07C217/88 , C07C235/56 , C07C255/57 , C07C255/60 , C07C275/34 , C07C311/29 , C07C311/46 , C07C317/40 , C07C323/42 , C07C327/48 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D213/50 , C07D213/75 , C07D213/89 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D409/12
Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.
Abstract translation: 本发明涉及通过各种连接与芳基部分连接的用于抑制肿瘤坏死因子的苯基化合物的药物用途。 本发明还涉及含有这些化合物的化合物及其制备方法和药物组合物。 此外，本发明涉及化合物抑制环AMP磷酸二酯酶的药物用途。
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4.发明授权Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group 有权含有通过含脂肪族或含杂原子的连接基与芳基或杂芳基连接的苯基的化合物
公开(公告)号：US6096768A
公开(公告)日：2000-08-01
申请号：US301877
申请日：1999-04-29
Applicant: Michael John Ashton , David Charles Cook , Garry Fenton , Susan Jacqueline Hills , Ian Michael McFarlane , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher , Nigel Vicker
Inventor： Michael John Ashton , David Charles Cook , Garry Fenton , Susan Jacqueline Hills , Ian Michael McFarlane , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher , Nigel Vicker
IPC: C07C65/21 , C07C65/24 , C07C65/26 , C07C65/42 , C07C69/76 , C07C69/92 , C07C235/56 , C07C255/60 , C07C311/46 , C07C323/42 , C07D213/75 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/02 , C07D275/03 , A61K31/435 , A61K31/165 , A61K31/44 , A61K31/4523 , C07D211/72
CPC classification number: C07D213/75 , C07C235/56 , C07C255/60 , C07C311/46 , C07C323/42 , C07C65/21 , C07C65/24 , C07C65/26 , C07C65/42 , C07C69/76 , C07C69/92 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07C2101/08 , C07C2101/14 , C07C2102/42
Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.
Abstract translation: 本发明涉及通过各种连接与芳基部分连接的用于抑制肿瘤坏死因子的苯基化合物的药物用途。 本发明还涉及含有这些化合物的化合物及其制备方法和药物组合物。 此外，本发明涉及化合物抑制环AMP磷酸二酯酶的药物用途。
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公开(公告)号：US5935978A
公开(公告)日：1999-08-10
申请号：US98178
申请日：1993-07-28
Applicant: Garry Fenton , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher , Michael John Ashton , David Charles Cook , Susan Jacqueline Hills , Ian Michael McFarlane , Nigel Vicker
Inventor： Garry Fenton , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher , Michael John Ashton , David Charles Cook , Susan Jacqueline Hills , Ian Michael McFarlane , Nigel Vicker
IPC: C07C43/225 , C07C45/00 , C07C45/29 , C07C45/71 , C07C47/575 , C07C49/84 , C07C59/58 , C07C59/60 , C07C59/62 , C07C65/21 , C07C65/24 , C07C65/42 , C07C69/76 , C07C69/92 , C07C205/59 , C07C217/88 , C07C235/56 , C07C255/57 , C07C255/60 , C07C275/34 , C07C311/29 , C07C311/46 , C07C317/40 , C07C323/42 , C07C327/48 , C07D213/50 , C07D213/75 , C07D213/89 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/02 , C07D275/03 , C07D409/12 , A61K31/44
CPC classification number: C07D213/75 , C07C205/59 , C07C217/88 , C07C235/56 , C07C255/57 , C07C255/60 , C07C275/34 , C07C311/29 , C07C311/46 , C07C317/40 , C07C323/42 , C07C327/48 , C07C43/225 , C07C45/004 , C07C45/292 , C07C45/71 , C07C47/575 , C07C49/84 , C07C59/58 , C07C59/60 , C07C59/62 , C07C65/21 , C07C65/24 , C07C65/42 , C07C69/76 , C07C69/92 , C07D213/50 , C07D213/89 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D409/12 , C07C2101/08 , C07C2101/14 , C07C2102/42
Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.
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6.发明授权Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group 失效含有通过含脂肪族或含杂原子的连接基与芳基或杂芳基连接的苯基的化合物
公开(公告)号：US5679696A
公开(公告)日：1997-10-21
申请号：US484805
申请日：1995-06-07
Applicant: Garry Fenton , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Keith Alfred James Stuttle , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher
Inventor： Garry Fenton , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Keith Alfred James Stuttle , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher
IPC: C07C65/21 , C07C65/24 , C07C65/26 , C07C65/42 , C07C69/76 , C07C69/92 , C07C235/56 , C07C255/60 , C07C311/46 , C07C323/42 , C07D213/75 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/02 , C07D275/03 , A61K31/44 , C07D213/02
CPC classification number: C07D213/75 , C07C235/56 , C07C255/60 , C07C311/46 , C07C323/42 , C07C65/21 , C07C65/24 , C07C65/26 , C07C65/42 , C07C69/76 , C07C69/92 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07C2101/08 , C07C2101/14 , C07C2102/42
Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.
Abstract translation: 本发明涉及通过各种连接与芳基部分连接的用于抑制肿瘤坏死因子的苯基化合物的药物用途。 本发明还涉及含有这些化合物的化合物及其制备方法和药物组合物。 此外，本发明涉及化合物抑制环AMP磷酸二酯酶的药物用途。
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