公开(公告)号：US06653626B2

公开(公告)日：2003-11-25

申请号：US10155364

申请日：2002-05-23

申请人： Steven M. Fischer ,  Darrell L. Gourley ,  Patricia H. Cormia ,  James L. Bertsch

发明人： Steven M. Fischer ,  Darrell L. Gourley ,  Patricia H. Cormia ,  James L. Bertsch

IPC分类号： H01J4926

CPC分类号： G01N30/7253 ,  H01J27/24 ,  H01J49/0431 ,  H01J49/145 ,  H01J49/162

摘要： An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.

公开(公告)号：US20030075680A1

公开(公告)日：2003-04-24

申请号：US10265943

申请日：2002-10-07

发明人： James A. Apffel JR. ,  Mark H. Werlich ,  James L. Bertsch ,  Paul C. Goodley ,  Kent D. Henry

IPC分类号： H01J049/04

CPC分类号： H01J49/145 ,  G01N30/7253 ,  H01J49/0431 ,  H01J49/165 ,  H01J49/168

摘要： A method and apparatus are disclosed wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.

公开(公告)号：US5289003A

公开(公告)日：1994-02-22

申请号：US890194

申请日：1992-05-29

申请人： Steven M. Musser

发明人： Steven M. Musser

IPC分类号： G01N30/60 ,  G01N30/72 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

CPC分类号： G01N30/7253 ,  H01J49/04 ,  G01N2030/6013

摘要： A thermospray probe assembly which allows for easy replacement or exchange the central capillary tube without requiring replacement of the entire probe assembly when the capillary tube becomes degraded and/or clogged. The replaceable capillary tube is secured at a tip end to a tip of the outer tubular member of the probe assembly by a set screw. The other end of the replaceable capillary tube is sealingly secured by a compression fitting in an adapter connected to the outer tubular member.

摘要翻译： 一种热喷涂探针组件，其允许容易地更换或更换中央毛细管，而不需要在毛细管变质和/或堵塞时更换整个探针组件。 可替换毛细管通过固定螺钉固定在探针组件的外管状构件的尖端处。 可替换毛细管的另一端通过压缩配件密封地固定在连接到外管状构件的适配器中。

公开(公告)号：US5235186A

公开(公告)日：1993-08-10

申请号：US826922

申请日：1992-01-24

申请人： Russell H. Robins

发明人： Russell H. Robins

IPC分类号： G01N30/72 ,  H01J49/04

CPC分类号： G01N30/7266 ,  H01J49/165 ,  G01N30/7253

摘要： A probe adapter for converting a thermospray equipped LC/MS analyzer to an electrospray equipped LC/MS analyzer. The probe adapter includes structure defining an elongated and hollow first chamber opened at one end to atmosphere and closed at the other end by a first partition. Additional structure is provided defining a hole through the first partition and an elongated and hollow probe shaft is connected to and extends from the first partition on a side thereof remote from the opened end. A central axis of the probe shaft is coaxial with a central axis of the first hole. A second partition is provided in the first chamber and is spaced from the first partition and defines a second chamber therebetween. Adjusting structure is provided for selectively adjusting the spacing between the two partitions. A second hole is provided in the second partition and is coaxially aligned with the first hole. An elongated and hollow drift tube is mounted inside the probe shaft, an inlet end of the drift tube extending through the first hole in the first partition and terminating in the second chamber. An outlet end of the drift tube extends a finite distance beyond an end of the probe shaft remote from the first partition. The relative spacing between the first and second partitions determines a spacing between the inlet end of the drift tube and the second hole.

摘要翻译： 用于将配有热喷射的液相色谱/质谱分析仪转换成电喷射LC / MS分析仪的探头适配器。 探针适配器包括限定在一端到大气开放的细长空心的第一腔室的结构，并在另一端由第一隔板封闭。 提供了限定穿过第一隔板的孔的附加结构，并且细长且中空的探针轴在远离开口端的一侧连接到第一隔板并从其延伸。 探头轴的中心轴与第一孔的中心轴线同轴。 第二分隔件设置在第一室中并且与第一隔板间隔开并且在它们之间限定第二室。 提供调整结构以选择性地调节两个分隔件之间的间距。 第二孔设置在第二隔壁中并与第一孔同轴对准。 一个细长且中空的漂移管安装在探针轴内，漂移管的入口端延伸穿过第一隔板中的第一孔并终止在第二腔室中。 漂移管的出口端延伸超过远离第一分区的探针轴的端部的有限距离。 第一和第二分隔件之间的相对间隔确定漂移管的入口端和第二孔之间的间隔。

公开(公告)号：US5103093A

公开(公告)日：1992-04-07

申请号：US343363

申请日：1989-04-26

申请人： Minoru Sakairi ,  Hideki Kambara

发明人： Minoru Sakairi ,  Hideki Kambara

IPC分类号： G01N27/62 ,  G01N30/30 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

CPC分类号： H01J49/0468 ,  G01N30/7246 ,  G01N30/7253 ,  G01N30/7266 ,  G01N30/7293 ,  H01J49/0445 ,  G01N2030/3038

摘要： A mass spectrometer which comprises an ion source for ionizing a sample and a mass analyzing region for introducing the thus formed ions into a vacuum and mass analyzing the ions, the ion source being provided with a spray ion source comprising a heatable capillary working at least under the atmospheric pressure, the center axis of the capillary being aligned along the center of an aperture for withdrawing the ions and the tip end of the capillary being positioned close to the aperture ionizes a sample from a liquid chromatograph by both atmospheric pressure ionization mode and a thermospray ionization mode and mass analyze the ions, thereby obtaining more exact analytical information on the sample.

摘要翻译： 一种质谱仪，其包括用于离子化样品的离子源和用于将如此形成的离子引入真空并质量分析离子的质量分析区域，所述离子源设置有喷射离子源，所述喷雾离子源包括至少在下面工作的可加热毛细管 大气压力，毛细管的中心轴线沿着用于取出离子的孔的中心对准，并且靠近孔的位置的毛细管的末端将气相色谱仪的样品从大气压电离模式和 热离子电离模式和质量分析离子，从而获得更准确的样品分析信息。

公开(公告)号：US5030826A

公开(公告)日：1991-07-09

申请号：US487671

申请日：1990-03-01

申请人： Stuart C. Hansen

发明人： Stuart C. Hansen

IPC分类号： G01N27/62 ,  G01N30/38 ,  G01N30/72 ,  H01J49/04

CPC分类号： H01J49/049 ,  G01N30/7246 ,  G01N30/7253 ,  H01J49/0445 ,  G01N30/38 ,  G01N30/726 ,  G01N30/7293

摘要： An apparatus for providing an ion vapor to be analyzed. A vaporizer probe, with a capillary tube extending into a vapor port of an ion source, has a release end which ejects a spray of vapor into a spray region of the ion source. Molecules of interest within the vapor may be ions pre-formed in solution or may be ionized by chemical ionization or plasma discharge ionization. A minor portion of the vapor is extracted from the spray chamber for mass analysis. The major portion is coaxially redirected from the spray chamber for return to the same port which receives the capillary tube of the vapor probe. A return tube is vacuum sealed to the port and is in fluid communication with a roughing pump which draws the ion vapor from the spray region through the ion source and the port for coaxial vapor backflow with the capillary tube. The ion source has a split-block structure for ease of both manufacture and routine maintenance.

公开(公告)号：US09008496B2

公开(公告)日：2015-04-14

申请号：US13788393

申请日：2013-03-07

申请人： Shimadzu Corporation

发明人： Tomohito Nakano

IPC分类号： F24H1/10 ,  F24H3/00 ,  G01N30/72

CPC分类号： F24H3/002 ,  G01N30/7246 ,  G01N30/7253 ,  G01N30/7266

摘要： A probe including a liquid sample channel through which a liquid sample flows in a specified direction; a nebulizer gas channel through which a nebulizer gas flows in a specified direction, formed at the outer circumference of the liquid sample channel so as to have a round annular outer circumference and be coaxial with the liquid sample channel; a heating gas channel for injecting an assist gas in a specified direction, wherein a heating gas injection port is formed around the outlet end of the nebulizer gas channel so as to have a round annular outer circumference and be coaxial with the nebulizer gas channel; and a heating element which is arranged inside the heating gas channel and heats the assist gas for injecting through the heating gas injection port.

摘要翻译： 包括液体样品通道的探针，液体样品通过所述液体样品通道沿指定方向流动; 喷雾器气体通道，雾化器气体沿着指定方向流动，形成在液体样品通道的外周，以具有圆形环形外圆周并与液体样品通道同轴; 用于沿指定方向喷射辅助气体的加热气体通道，其中在雾化器气体通道的出口端周围形成加热气体注入口，以具有圆形环形外圆周并与喷雾器气体通道同轴; 以及加热元件，其设置在加热气体通道内部，并且通过加热气体注入口加热用于注入的辅助气体。

公开(公告)号：US20080089809A1

公开(公告)日：2008-04-17

申请号：US11667992

申请日：2005-11-11

申请人： Joachim Gerstel ,  Jorg Radtke

发明人： Joachim Gerstel ,  Jorg Radtke

IPC分类号： G01N30/02 ,  B01L11/00 ,  G01N30/72 ,  G01N30/84 ,  G01N1/28

CPC分类号： G01N30/7253 ,  G01N30/30 ,  G01N30/34 ,  G01N2030/3007 ,  G01N2030/3076 ,  G01N2030/342

摘要： An assembly for determining material properties and/or material concentrations of components of a sample, containing: a chromatographic separating column with a liquid mobile solvent; means for controlling the temperature inside the separating column between room temperature and 250° C.; means for creating a pressure level which is greater than ambient pressure inside the separating column; and a detector with a sample volume adapted to insert the components of the sample, is characterized in that the mobile solvent contains water to a large extent; means are provided for expanding the mobile solvent from the increased pressure level inside the separating column to the ambient pressure and for producing a phase change of the mobile solvent from the liquid to gaseous state; and means are provided for transferring the gaseous mobile solvent containing the components of the sample into the sample volume of the detector.

摘要翻译： 用于确定样品组分的材料性质和/或材料浓度的组件，其包含：具有液体移动溶剂的色谱分离柱; 用于在室温至250℃之间控制分离塔内的温度的装置; 用于在分离塔内产生大于环境压力的压力水平的装置; 并且具有适于插入样品组分的样品体积的检测器，其特征在于，所述移动溶剂在很大程度上含有水; 提供了用于将流动溶剂从分离塔内的增加的压力水平扩展到环境压力并且用于产生流动溶剂从液体到气态的相变的装置; 并且提供用于将含有样品组分的气态流动性溶剂转移到检测器的样品体积中的装置。

公开(公告)号：US20040046118A1

公开(公告)日：2004-03-11

申请号：US10640138

申请日：2003-08-13

发明人： James A. Apffel JR. ,  Mark H. Werlich ,  James L. Bertsch ,  Paul C. Goodley ,  Kent D. Henry

IPC分类号： H01J049/04

CPC分类号： H01J49/145 ,  G01N30/7253 ,  H01J49/0431 ,  H01J49/165 ,  H01J49/168

摘要： A method and apparatus are disclosed wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.

摘要翻译： 公开了一种方法和装置，其中将多个电场和蒸发的分析物的正交喷雾构型组合，以提高分析物检测和质量分析的效率。 本发明在API电喷雾和APCI操作模式中提供降低的噪声和增加的信号灵敏度。

公开(公告)号：US20010042829A1

公开(公告)日：2001-11-22

申请号：US09910222

申请日：2001-07-19

发明人： James A. Apffel ,  Mark H. Werlich ,  James L. Bertsch ,  Paul C. Goodley

IPC分类号： H01J049/00 ,  B01D059/44

CPC分类号： H01J49/145 ,  G01N30/7253 ,  H01J49/0431 ,  H01J49/165 ,  H01J49/168

摘要： A method and apparatus are disclosed wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both APT electrospray and APCI operating modes.

摘要翻译： 公开了一种方法和装置，其中将多个电场和蒸发的分析物的正交喷雾构型组合，以提高分析物检测和质量分析的效率。 本发明在APT电喷雾和APCI操作模式中提供降低的噪声和增加的信号灵敏度。