公开(公告)号：US06293752B1

公开(公告)日：2001-09-25

申请号：US09266408

申请日：1999-03-09

申请人： Cynthia T. Clague ,  Frank D. Dorman ,  Robert C. Hamlen ,  Donald W. Hegeman, III ,  Timothy A. Miller ,  Joseph E. Poissant ,  Richard T. Stone ,  Michael P Sullivan

发明人： Cynthia T. Clague ,  Frank D. Dorman ,  Robert C. Hamlen ,  Donald W. Hegeman, III ,  Timothy A. Miller ,  Joseph E. Poissant ,  Richard T. Stone ,  Michael P Sullivan

IPC分类号： F01D102

CPC分类号： A61M39/10 ,  A61M1/101 ,  A61M2202/0413 ,  A61M2206/10 ,  F04D29/428 ,  Y10S415/90 ,  Y10T137/2104 ,  Y10T137/2109 ,  Y10T137/2115

摘要： A biological fluid transport device comprises a cutwater at the junction of at least two blood flow paths. The cutwater is substantially straight, substantially vertical, or both. At least one of the fluid paths may be tubular, and in some embodiments all of the fluid paths are tubular. The shear sensitive fluid may be, without limitation, blood, blood-based combinations, cell culture media, cell suspensions, proteins, and microcapsule suspensions. The device may be part of an extracorporeal circuit (e.g., blood during heart-lung bypass procedures or blood processing), but it need not be. Preferred embodiments of the device include, without limitation, kinetic pumps, mass transfer devices, filters, reservoirs, and heat exchangers.

摘要翻译： 生物流体输送装置包括在至少两个血流路径的交界处的切割水。 切割水基本上是直的，基本垂直的，或两者都是。 流体路径中的至少一个可以是管状的，并且在一些实施例中，所有流体路径都是管状的。 剪切敏感流体可以是但不限于血液，基于血液的组合，细胞培养基，细胞悬浮液，蛋白质和微胶囊悬浮液。 该装置可以是体外循环的一部分（例如在心肺旁路手术或血液处理期间的血液），但是不需要。 装置的优选实施例包括但不限于动力泵，传质装置，过滤器，储存器和热交换器。

公开(公告)号：US5561515A

公开(公告)日：1996-10-01

申请号：US319660

申请日：1994-10-07

申请人： Peter P. Hairston ,  Frank D. Dorman ,  Gilmore J. Sem ,  Jugal K. Agarwal

发明人： Peter P. Hairston ,  Frank D. Dorman ,  Gilmore J. Sem ,  Jugal K. Agarwal

IPC分类号： G01N15/02 ,  G01P5/22 ,  G01P5/26 ,  G01P5/18 ,  G01N21/00 ,  G01P5/00

CPC分类号： G01P5/22 ,  G01P5/26 ,  G01N2015/0238

摘要： An aerodynamic particle size measuring device includes a laser energy source and beam splitting, shaping and polarizing optics for forming two parallel, peripherally overlapping beams. The beams are caused to intersect a gas stream perpendicular to the direction of gas flow, thus to form a measuring volume at the intersection of the beams and flow. Single particles are carried through the measuring volume with the gas flow, each particle scattering and extinguishing light according to the beam profile, as predetermined by the degree of beam overlap and the Gaussian intensity distribution of each beam. A photodetector, responsive either to scattered light or light extinction, generates a time-dependent voltage profile that tends to replicate the intensity profile. The resulting electrical signal is processed to determine an amplitude, set a threshold for minimally acceptable amplitudes, and to derive two negative-going zero crossings for an unambiguous time/velocity determination. Logic circuitry employs the threshold in combination with the zero crossings to reject velocity readings based on single trigger or coincidence events.

摘要翻译： 空气动力学粒度测量装置包括激光能量源和分束，成形和偏振光学器件，用于形成两个平行的外围重叠的光束。 使梁与垂直于气流方向的气流相交，从而在梁和流的交叉处形成测量体积。 单个颗粒通过气流被传送通过测量体积，每个颗粒根据束轮廓散射和熄灭光，如通过束重叠度和每个光束的高斯强度分布所预定的。 响应于散射光或光消失的光电检测器产生倾向于复制强度分布的时间依赖电压分布。 对所得到的电信号进行处理以确定振幅，设置最小可接受振幅的阈值，并且为明确的时间/速度确定导出两个负向零交叉。 逻辑电路采用阈值与零交叉结合，以基于单个触发或重合事件来拒绝速度读数。

公开(公告)号：US4772263A

公开(公告)日：1988-09-20

申请号：US102778

申请日：1987-09-23

申请人： Frank D. Dorman ,  Henry Buchwald

发明人： Frank D. Dorman ,  Henry Buchwald

IPC分类号： A61M5/142 ,  A61M5/145 ,  A61M5/20 ,  A61M1/00

CPC分类号： A61M5/14276 ,  A61M2005/14264 ,  A61M5/1454 ,  Y10S128/12

摘要： An implantable infusion pump (20) for infusing drugs or other chemicals or solutions into the body. A flexible spring diaphragm (25) forms an outer back wall portion (26) of a housing (22) of the infusion pump (20). The spring diaphragm (25) applies substantially constant force over a range of displacement and communicating internal body pressure to the drug chamber (30) so as to maintain a substantially uniform pressure difference between the drug chamber (30) and the internal body pressure.

摘要翻译： 一种用于将药物或其它化学物质或溶液注入体内的可植入输液泵（20）。 柔性弹簧隔膜（25）形成输液泵（20）的壳体（22）的外后壁部分（26）。 弹簧隔膜（25）在一定范围内施加基本上恒定的力，并将内部体压连通到药物室（30），以便在药物室（30）和内部身体压力之间保持基本均匀的压力差。

公开(公告)号：US4657536A

公开(公告)日：1987-04-14

申请号：US245379

申请日：1981-03-19

申请人： Frank D. Dorman

发明人： Frank D. Dorman

IPC分类号： A61M25/00 ,  A61M31/00

CPC分类号： A61M25/0075 ,  A61M25/00 ,  A61M31/00 ,  Y10T137/7896

摘要： A catheter having a tip which is resistant to plugging by blood components or other body fluids when used as a long term implant within a living body. A check valve is incorporated in the tip that is exposed to the blood stream or other body fluids. The central bore within the catheter is closed at its downstream end. A cross bore or port is provided immediately upstream from the closed end. This cross bore is covered by a thin elastic sleeve to create a check valve. The pressure developed by injected infusate through the catheter opens the valve against the elastic force of the outer sleeve. Fluids cannot enter the catheter either by diffusion against the high velocity exit flow or by suction applied to the proximal end of the catheter.

摘要翻译： 一种具有尖端的导管，其当用作活体内的长期植入物时，能够抵抗由血液成分或其它体液堵塞。 止回阀结合在暴露于血流或其他体液的尖端中。 导管内的中心孔在其下游端封闭。 在封闭端的上游紧邻提供十字孔或端口。 该十字孔被薄的弹性套筒覆盖以形成止回阀。 通过导管注入的压力产生的压力抵抗外套筒的弹力打开阀门。 流体不能通过对高速出口流的扩散或通过施加到导管的近端的抽吸进入导管。

公开(公告)号：US4644943A

公开(公告)日：1987-02-24

申请号：US632851

申请日：1984-07-20

申请人： Roby C. Thompson ,  Arthur G. Erdman ,  Frank D. Dorman

发明人： Roby C. Thompson ,  Arthur G. Erdman ,  Frank D. Dorman

IPC分类号： A61B17/72 ,  A61B17/88 ,  A61F5/04

CPC分类号： A61B17/88 ,  A61B17/72

摘要： A bone fixation device for securing adjacent and separated bone portions, such as at a joint or at a relatively clean, unsplintered break, comprises a pair of telescoping members which are pinned into the respective bone portions, and have internal actuating members to permit the telescoping parts to be moved together to bring the two bone portions to bear against one another at a desired level of pressure. After the telescoping members have been adjusted the members are permanently left in place to fix and hold the joint or break in a predetermined relationship. The adjusting members also remain in place as pins within the bone, which are accessible through incisions in the skin if later adjustment is necessary. The entire device is embedded, and is not external. The process of inserting is relatively simple to follow and rigidly fixes a joint or break between two abutting bone portions without having external members.

摘要翻译： 用于固定相邻和分离的骨部分的骨固定装置，例如在关节处或相对干净的未断裂处，包括一对伸缩构件，其被固定到相应的骨部分中，并且具有内部致动构件以允许伸缩 待移动的部件一起以使两个骨部分以期望的压力水平彼此承载。 在伸缩构件已被调节之后，构件永久地保持在适当位置以固定和保持接合或以预定的关系断裂。 调节构件也保持在骨骼内的销，如果需要进行后期的调整，则可以通过皮肤中的切口进入。 整个设备是嵌入式的，不是外部的。 插入过程相对简单，并且刚性地固定两个邻接骨部之间的关节或断裂而不具有外部构件。

公开(公告)号：US5971023A

公开(公告)日：1999-10-26

申请号：US800904

申请日：1997-02-12

申请人： Cynthia T. Clague ,  Frank D. Dorman ,  Robert C. Hamlen ,  Donald W. Hegeman, III ,  Timothy A. Miller ,  Joseph E. Poissant ,  Richard T. Stone ,  Michael P. Sullivan

发明人： Cynthia T. Clague ,  Frank D. Dorman ,  Robert C. Hamlen ,  Donald W. Hegeman, III ,  Timothy A. Miller ,  Joseph E. Poissant ,  Richard T. Stone ,  Michael P. Sullivan

IPC分类号： A61M5/142 ,  A61M1/10 ,  A61M39/10 ,  F15C1/16

CPC分类号： A61M39/10 ,  F04D29/428 ,  A61M1/101 ,  A61M2202/0413 ,  A61M2206/10 ,  Y10S415/90 ,  Y10T137/2104 ,  Y10T137/2109 ,  Y10T137/2115

摘要： A biological fluid transport device comprises a cutwater at the junction of at least two blood flow paths. The cutwater is substantially straight, substantially vertical, or both. At least one of the fluid paths may be tubular, and in some embodiments all of the fluid paths are tubular. The shear sensitive fluid may be, without limitation, blood, blood-based combinations, cell culture media, cell suspensions, proteins, and microcapsule suspensions. The device may be part of an extracorporeal circuit (e.g., blood during heart-lung bypass procedures or blood processing), but it need not be. Preferred embodiments of the device include, without limitation, kinetic pumps, mass transfer devices, filters, reservoirs, and heat exchangers.

摘要翻译： 生物流体输送装置包括在至少两个血流路径的交界处的切割水。 切割水基本上是直的，基本垂直的，或两者都是。 流体路径中的至少一个可以是管状的，并且在一些实施例中，所有流体路径都是管状的。 剪切敏感流体可以是但不限于血液，基于血液的组合，细胞培养基，细胞悬浮液，蛋白质和微胶囊悬浮液。 该装置可以是体外循环的一部分（例如在心肺旁路手术或血液处理期间的血液），但是不需要。 装置的优选实施例包括但不限于动力泵，传质装置，过滤器，储存器和热交换器。

公开(公告)号：US5325728A

公开(公告)日：1994-07-05

申请号：US81032

申请日：1993-06-22

申请人： Douglas J. Zimmerman ,  Frank D. Dorman

发明人： Douglas J. Zimmerman ,  Frank D. Dorman

IPC分类号： A61B5/0265 ,  G01F1/58 ,  G01F1/60 ,  G01F1/00

CPC分类号： A61B5/0265 ,  G01F1/588 ,  G01F1/60

摘要： An electromagnetic flow meter for measuring the flow of blood through a conduit. Flow rate is measured by applying an electromagnetic field around the conduit, with the moving electrolytic blood inducing a current that is sensed by electrodes. The flow meter includes a substantially "E"-shaped magnetic core structure as well as an "E"-shaped hinged cover piece for defining a complete flux loop. In the circuitry, a floating ground arrangement is provided for enhancing the stability and sensitivity of the meter and to ensure appropriate patient isolation. A strong magnetic field, covering the sensing region and with little flux leakage, is alternately switched in polarity. The magnetic coil driver circuit employs an arrangement of switches for facilitating very fast polarity reversal. A two-level current source in the coil current driver greatly enhances the meter's efficiency and power dissipation characteristics. Extensive provisions, both electrical and mechanical, are made to reduce the effects of capacitive coupling, spurious induced currents, electromagnetic interference, and susceptibility to noise and external magnetic fields. A dual gated sample hold circuit samples the sensor signal during steady intervals. A second dual sample-and-hold averaging circuit minimizes the effects of base-line drift in the sense signal and low-frequency noise in the amplifier stage. The flow meter includes a two section error detection circuit which generates an error signal either when the flow signal exceeds power supply limits or when the rate of change of the flow signal exceeds a clinically reasonable rate.

摘要翻译： 一种电磁流量计，用于测量通过导管的血液流量。 通过在导管周围施加电磁场来测量流速，移动的电解血液感应由电极感测的电流。 流量计包括基本上“E”形的磁芯结构以及用于限定完整磁通回路的“E”型铰接盖件。 在电路中，提供浮动接地装置，以提高仪表的稳定性和灵敏度，并确保适当的患者隔离。 覆盖感测区域并且具有很小的磁通泄漏的强磁场交替切换极性。 电磁线圈驱动器电路采用了一种用于促进非常快速极性反转的开关装置。 线圈电流驱动器中的两级电流源大大提高了仪表的效率和功耗特性。 制造了电气和机械的大量规定，以减少电容耦合，杂散感应电流，电磁干扰以及对噪声和外部磁场的敏感性的影响。 双门控采样保持电路在稳定间隔期间对传感器信号进行采样。 第二个双采样和保持平均电路最大限度地减少了放大级中感测信号和低频噪声的基线漂移的影响。 流量计包括一个两部分误差检测电路，当电流信号超过电源限制或流量信号的变化率超过临床合理的速率时，产生误差信号。

公开(公告)号：US5120312A

公开(公告)日：1992-06-09

申请号：US511562

申请日：1990-04-20

申请人： Bruce D. Wigness ,  Frank D. Dorman

发明人： Bruce D. Wigness ,  Frank D. Dorman

IPC分类号： A61M25/00 ,  A61M37/00

CPC分类号： A61M25/0069 ,  A61M37/00

摘要： A method and apparatus for catheterization is provided. The method and apparatus are particularly suited for bone catheterization, i.e. access to an internal cavity of an animal, by means of a bone associated therewith. The preferred apparatus includes a tap arrangement and a cannula arrangement, provided in fluid flow communication with one another. The tap arrangement is constructed and arranged for anchoring within a bone, in fluid flow communication with the cavity. The cannula is preferably oriented for fluid flow access therewith, from a remote location. In preferred applications, the cannula arrangement is provided in communication with a medical access port and/or infusion pump arrangement. A preferred tool is described, for implanting the apparatus in a bone of the subject.

摘要翻译： 提供一种用于导管插入术的方法和装置。 所述方法和装置特别适用于通过与其相关联的骨进行骨导管插入，即进入动物的内腔。 优选的装置包括彼此流体连通地设置的抽头装置和插管装置。 龙头装置被构造和布置成用于锚固在骨骼内，与腔体流体连通。 套管优选地定位成用于从远处位置流体流动。 在优选的应用中，套管装置设置成与医疗进入口和/或输液泵装置连通。 描述了一种优选的工具，用于将装置植入受试者的骨骼中。

公开(公告)号：US5076097A

公开(公告)日：1991-12-31

申请号：US546004

申请日：1990-06-28

申请人： Fahimeh Zarrin ,  Stanley L. Kaufman ,  Frank D. Dorman

发明人： Fahimeh Zarrin ,  Stanley L. Kaufman ,  Frank D. Dorman

IPC分类号： G01N15/06 ,  G01N30/62

CPC分类号： G01N15/065 ,  G01N30/62

摘要： An apparatus and method for determining the concentration of macromolecules and colloids in a liquid sample is disclosed. The apparatus preferably includes an electrospray apparatus 16 for forming droplets from the sample. Liquid is removed from the droplets by drying in the electrospray apparatus 16, thereby forming an aerosol. The aerosol of a size greater than a predetermined size is then counted by a condensation nucleus counter 52. In this manner, the target macromolecules and colloids are counted. This apparatus is capable of detecting very small macromolecules and colloids of a wide range of materials in a liquid, for example, individual molecules having molecular weight as small as 10,000.

摘要翻译： 公开了一种用于确定液体样品中大分子和胶体浓度的装置和方法。 该装置优选地包括用于从样品形成液滴的电喷射装置16。 通过在电喷雾装置16中干燥从液滴中除去液体，从而形成气溶胶。 然后通过冷凝核计数器52计数尺寸大于预定尺寸的气溶胶。以这种方式计数目标大分子和胶体。 该装置能够检测液体中各种材料的非常小的大分子和胶体，例如分子量小至10,000的单个分子。

公开(公告)号：US4306553A

公开(公告)日：1981-12-22

申请号：US171091

申请日：1980-07-22

申请人： Frank D. Dorman ,  Thomas D. Rohde ,  Thomas G. Rublein

发明人： Frank D. Dorman ,  Thomas D. Rohde ,  Thomas G. Rublein

IPC分类号： A61K47/20 ,  F02M25/07 ,  A61M5/00

CPC分类号： A61K9/0019 ,  A61K47/20

摘要： A method of preventing the precipitation of hormone preparations within drug delivery systems that depend on the fluidity of the infusate for proper function. A non-toxic water soluble detergent is dissolved in the hormone solution prior to the introduction of the solution into the drug delivery system. The detergent is added in amount sufficient to prevent precipitation of the hormone during long-term storage in the drug delivery device. According to one form of usage, the hormone-detergent solution is charged to the pressurized drug storage chamber of an implanted infusion pump by injection through the patient's skin. As the solution is discharged from the delivery device by the constant pressure exerted upon the storage chamber, its low rate of flow is controlled by a restricted fluid passage. The solution is conveyed to an infusion site and diluted by the blood stream.

摘要翻译： 一种防止药物递送系统中激素制剂沉淀的方法，其依赖于输注物的流动性以适当的功能。 在将溶液引入药物递送系统之前，将无毒的水溶性洗涤剂溶解在激素溶液中。 加入的洗涤剂的量足以防止在药物递送装置中长期储存期间激素的沉淀。 根据使用的一种形式，通过注射通过患者皮肤将激素 - 洗涤剂溶液装入植入的输注泵的加压药物储存室。 当溶液通过施加在储存室上的恒定压力从输送装置排出时，其低流速由受限的流体通道控制。 将溶液输送到输注部位并用血液稀释。