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公开(公告)号：US5582973A
公开(公告)日：1996-12-10
申请号：US160547
申请日：1993-12-02
申请人： Ian T. Magrath , Bruce Shiramizu
发明人： Ian T. Magrath , Bruce Shiramizu
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q1/686 , C12Q1/6876 , C12Q2600/156
摘要： A sensitive method for identifying chromosomal breakpoints flanked by repeat sequences, through amplification by polymerase chain reaction, is described. The application of the method to the detection of Burkitt's lymphoma cells is demonstrated.
摘要翻译： 描述了通过聚合酶链式反应扩增鉴定侧重于重复序列的染色体断点的敏感方法。 证明了将该方法应用于伯基特淋巴瘤细胞的检测。
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2.发明授权公开(公告)号：US06537523B1
公开(公告)日：2003-03-25
申请号：US08975532
申请日：1997-11-20
IPC分类号： A61K4900
CPC分类号： C12Q1/703 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/5055 , Y10S435/81
摘要： The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
摘要翻译： 前癌和癌组织中克隆巨噬细胞的存在代表了由于HIV整合或其他遗传突变而发生巨噬细胞的克隆扩张的疾病的早期阶段。 克隆扩张的巨噬细胞诱导周围组织的增殖导致癌性肿瘤生长。 本发明提供用于诊断前癌和癌组织中巨噬细胞的HIV和非HIV相关克隆扩增的方法和试剂盒。 本发明还提供了治疗由克隆巨噬细胞扩增和周围组织的增殖诱导的癌症的方法。
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公开(公告)号：US5580715A
公开(公告)日：1996-12-03
申请号：US286745
申请日：1994-08-05
CPC分类号： C12Q1/703 , C12Q1/6886 , G01N33/5055 , C12Q2600/112 , C12Q2600/136 , Y10S435/81
摘要： The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
摘要翻译： 前癌和癌组织中克隆巨噬细胞的存在代表了由于HIV整合或其他遗传突变而发生巨噬细胞的克隆扩张的疾病的早期阶段。 克隆扩张的巨噬细胞诱导周围组织的增殖导致癌性肿瘤生长。 本发明提供用于诊断前癌和癌组织中巨噬细胞的HIV和非HIV相关克隆扩增的方法和试剂盒。 本发明还提供了治疗由克隆巨噬细胞扩增和周围组织的增殖诱导的癌症的方法。
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公开(公告)号：US5744122A
公开(公告)日：1998-04-28
申请号：US601865
申请日：1996-02-15
CPC分类号： C12Q1/703 , C12Q1/6886 , G01N33/5055 , C12Q2600/112 , C12Q2600/136 , Y10S435/81
摘要： The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
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5.发明授权Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement 失效具有克隆性巨噬细胞介导的细胞增殖性疾病的诊断和治疗
公开(公告)号：US5639600A
公开(公告)日：1997-06-17
申请号：US473040
申请日：1995-06-06
IPC分类号： G01N33/15 , A61K35/74 , A61P35/00 , C12N15/09 , C12Q1/68 , C12Q1/70 , G01N33/50 , C07K16/00 , C12P19/34
CPC分类号： C12Q1/703 , C12Q1/6886 , G01N33/5055 , C12Q2600/112 , C12Q2600/136 , Y10S435/81
摘要： The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue and other cell proliferative diseased tissue. The invention also provides methods for the treatment of cell proliferative diseases induced by clonal macrophage expansion and proliferation of surrounding tissue.
摘要翻译： 前癌和癌组织中克隆巨噬细胞的存在代表了由于HIV整合或其他遗传突变而发生巨噬细胞的克隆扩张的疾病的早期阶段。 克隆扩张的巨噬细胞诱导周围组织的增殖导致癌性肿瘤生长。 本发明提供用于诊断前癌和癌组织和其他细胞增殖性病变组织中巨噬细胞的HIV和非HIV相关克隆扩增的方法和试剂盒。 本发明还提供了治疗由克隆巨噬细胞扩增和周围组织增殖诱导的细胞增殖性疾病的方法。
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