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    TAU IMAGING PROBE
    1.
    发明申请
    TAU IMAGING PROBE 有权
    TAU成像探索

    公开(公告)号：US20160008494A1

    公开(公告)日：2016-01-14

    申请号：US14860823

    申请日：2015-09-22

    Applicant: CLINO LTD.

    Inventor： Yukitsuka KUDO ,  Shozo FURUMOTO ,  Nobuyuki OKAMURA

    IPC: A61K51/04

    CPC classification number: C07D215/12 ,  A61K9/0019 ,  A61K9/08 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07B59/002 ,  C07B2200/05 ,  C07D215/14 ,  C07D215/20 ,  C07D215/233 ,  C07D215/26 ,  C07D215/38 ,  C07D215/40 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14 ,  C07D498/04 ,  G01N33/6893 ,  G01N2800/2821

    Abstract: An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity.According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.

    Abstract translation: 本发明的目的是提供一种用于成像结构蛋白的探针，其可用于诊断构象疾病，特别是具有诸如tau蛋白的脑内积累的基本症状的疾病（tau蛋白病），例如 ， 阿尔茨海默氏病。 本发明的另一个目的是提供一种对tau高度特异性并且能够令人满意的感光度的tau成像的化合物，并且还具有高的脑转换，低或未被认可的寻骨性质和低或未被认可的毒性。 根据本发明，通过提供式I化合物（其中A，R 1，R 2，R 3，R 4，R 5，R 6，R a和R b如本说明书中所定义）或其药学上可接受的 盐或其溶剂化物。

    MAGNESIUM ALLOY THAT EXHIBITS SUPERELASTIC EFFECT AND/OR SHAPE-MEMORY EFFECT
    3.
    发明申请
    MAGNESIUM ALLOY THAT EXHIBITS SUPERELASTIC EFFECT AND/OR SHAPE-MEMORY EFFECT 审中-公开

    公开(公告)号：US20180291483A1

    公开(公告)日：2018-10-11

    申请号：US15767439

    申请日：2016-10-13

    Applicant: TOHOKU UNIVERSITY ,  CLINO LTD.

    Inventor： Daisuke Ando ,  Yuji Suto ,  Yukiko Ogawa ,  Junichi Koike

    IPC: C22C23/06 ,  C22F1/06

    Abstract: An object of the present invention is to provide a Mg alloy that exhibits a superelastic effect and a shape memory effect, and is excellent in cold workability. The Mg alloy is prepared so as to have a composition in which Sc is contained in a content of more than 13 at % and 30 at % or less, and the balance is Mg and inevitable impurities. In addition, the alloy may contain, in addition to the above-described composition, at least one or more additive elements selected from Li, Al, Zn, Y, Ag, In, Sn and Bi, in a total content of 0.001 at % or more and 9 at % or less in relation to the amount of the whole alloy defined to be 100 at %.

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