公开(公告)号：US6159716A

公开(公告)日：2000-12-12

申请号：US350484

申请日：1999-07-09

申请人： Caretha L. Creasy ,  George P. Livi ,  Damien J. Dunnington ,  Usman Shabon

发明人： Caretha L. Creasy ,  George P. Livi ,  Damien J. Dunnington ,  Usman Shabon

IPC分类号： G01N33/15 ,  A61K31/70 ,  A61K38/55 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P43/00 ,  C07K16/40 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/54 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12N9/00 ,  C12N21/06

CPC分类号： C12N9/1205 ,  A61K48/00

摘要： hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK1 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthris, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, and diagnostic assays for such conditions.

摘要翻译： 公开了通过重组技术生产这种多肽的hYAK1多肽和多核苷酸和方法。 还公开了在设计用于治疗包括骨质疏松症的骨丢失的方案中使用hYAK1多肽和多核苷酸的方法; 炎性疾病如成人呼吸系统综合症（ARDS），类风湿性关节炎，骨关节炎，炎性肠病（IBD），牛皮癣，皮炎，哮喘，过敏; 感染如细菌，真菌，原生动物和病毒感染，特别是HIV-1或HIV-2引起的感染; HIV相关性恶病质和其他免疫缺陷病症; 败血性休克 疼痛; 伤害 癌症; 厌食症 贪食 帕金森病 心血管疾病包括再狭窄，动脉粥样硬化，急性心力衰竭，心肌梗塞; 低血压 高血压; 尿潴留 心绞痛; 溃疡 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征，以及此类病症的诊断测定。

公开(公告)号：US6165766A

公开(公告)日：2000-12-26

申请号：US359257

申请日：1999-07-22

申请人： Caretha L. Creasy ,  Wei Xie

发明人： Caretha L. Creasy ,  Wei Xie

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P37/00 ,  C07K16/40 ,  C12N5/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/54 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/573 ,  G01N33/68

CPC分类号： C12N9/1205 ,  A61K38/00

摘要： hYAK3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK3 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers including testicular cancer; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome., among others, and diagnostic assays for such conditions.

摘要翻译： 公开了通过重组技术制备这种多肽的hYAK3多肽和多核苷酸和方法。 还公开了在设计用于治疗包括骨质疏松症的骨丢失的方案中使用hYAK3多肽和多核苷酸的方法; 炎症性疾病如成人呼吸系统综合症（ARDS），类风湿性关节炎，骨关节炎，炎性肠病（IBD），牛皮癣，皮炎，哮喘，过敏; 感染如细菌，真菌，原生动物和病毒感染，特别是HIV-1或HIV-2引起的感染; HIV相关性恶病质和其他免疫缺陷病症; 败血性休克 疼痛; 伤害 癌症包括睾丸癌; 厌食症 贪食 帕金森病 心血管疾病包括再狭窄，动脉粥样硬化，急性心力衰竭，心肌梗塞; 低血压 高血压; 尿潴留 心绞痛; 溃疡 良性前列腺肥大; 精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或吉尔斯·德拉·图雷特综合征，以及这些病症的诊断测定。

公开(公告)号：US5972606A

公开(公告)日：1999-10-26

申请号：US802466

申请日：1997-02-19

申请人： Caretha L. Creasy ,  George P. Livi ,  Damien J. Dunnington ,  Usman Shabon

发明人： Caretha L. Creasy ,  George P. Livi ,  Damien J. Dunnington ,  Usman Shabon

IPC分类号： G01N33/15 ,  A61K31/70 ,  A61K38/55 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P43/00 ,  C07K16/40 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/54 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C07H21/04 ,  C12N5/00 ,  C12P21/06

CPC分类号： C12N9/1205 ,  A61K48/00

摘要： hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK1 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndromne (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, and diagnostic assays for such conditions.

摘要翻译： 公开了通过重组技术生产这种多肽的hYAK1多肽和多核苷酸和方法。 还公开了在设计用于治疗骨丢失（包括骨质疏松症）的方案中使用hYAK1多肽和多核苷酸的方法; 炎性疾病如成人呼吸系统疾病综合征（ARDS），类风湿性关节炎，骨关节炎，炎性肠病（IBD），牛皮癣，皮炎，哮喘，过敏; 感染如细菌，真菌，原生动物和病毒感染，特别是HIV-1或HIV-2引起的感染; HIV相关性恶病质和其他免疫缺陷病症; 败血性休克 疼痛; 伤害 癌症; 厌食症 贪食 帕金森病 心血管疾病包括再狭窄，动脉粥样硬化，急性心力衰竭，心肌梗塞; 低血压 高血压; 尿潴留 心绞痛; 溃疡 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征，以及此类病症的诊断测定。

公开(公告)号：US5965420A

公开(公告)日：1999-10-12

申请号：US835170

申请日：1997-04-07

申请人： Caretha L. Creasy ,  Wei Xie

发明人： Caretha L. Creasy ,  Wei Xie

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P37/00 ,  C07K16/40 ,  C12N5/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/54 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/573 ,  G01N33/68 ,  C07H21/04

CPC分类号： C12N9/1205 ,  A61K38/00

摘要： hYAK3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK3 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers including testicular cancer; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome., among others, and diagnostic assays for such conditions.

摘要翻译： 公开了通过重组技术制备这种多肽的hYAK3多肽和多核苷酸和方法。 还公开了在设计用于治疗包括骨质疏松症的骨丢失的方案中使用hYAK3多肽和多核苷酸的方法; 炎症性疾病如成人呼吸系统综合症（ARDS），类风湿性关节炎，骨关节炎，炎性肠病（IBD），牛皮癣，皮炎，哮喘，过敏; 感染如细菌，真菌原生动物和病毒感染，特别是HIV-1或HIV-2引起的感染; HIV相关性恶病质和其他免疫缺陷病症; 败血性休克 疼痛; 伤害 癌症包括睾丸癌; 厌食症 贪食 帕金森病 心血管疾病包括再狭窄，动脉粥样硬化，急性心力衰竭，心肌梗塞; 低血压 高血压; 尿潴留 心绞痛; 溃疡 良性前列腺肥大; 精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或吉尔斯·德拉·图雷特综合征，以及这些病症的诊断测定。