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    Human protein kinase HOACF72
    1.
    发明授权
    Human protein kinase HOACF72 失效
    人类蛋白激酶HOACF72

    公开(公告)号：US6159716A

    公开(公告)日：2000-12-12

    申请号：US350484

    申请日：1999-07-09

    申请人： Caretha L. Creasy ,  George P. Livi ,  Damien J. Dunnington ,  Usman Shabon

    发明人： Caretha L. Creasy ,  George P. Livi ,  Damien J. Dunnington ,  Usman Shabon

    IPC分类号： G01N33/15 ,  A61K31/70 ,  A61K38/55 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P43/00 ,  C07K16/40 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/54 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12N9/00 ,  C12N21/06

    CPC分类号： C12N9/1205 ,  A61K48/00

    摘要： hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK1 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthris, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, and diagnostic assays for such conditions.

    摘要翻译： 公开了通过重组技术生产这种多肽的hYAK1多肽和多核苷酸和方法。 还公开了在设计用于治疗包括骨质疏松症的骨丢失的方案中使用hYAK1多肽和多核苷酸的方法; 炎性疾病如成人呼吸系统综合症（ARDS），类风湿性关节炎，骨关节炎，炎性肠病（IBD），牛皮癣，皮炎，哮喘，过敏; 感染如细菌，真菌，原生动物和病毒感染，特别是HIV-1或HIV-2引起的感染; HIV相关性恶病质和其他免疫缺陷病症; 败血性休克 疼痛; 伤害 癌症; 厌食症 贪食 帕金森病 心血管疾病包括再狭窄，动脉粥样硬化，急性心力衰竭，心肌梗塞; 低血压 高血压; 尿潴留 心绞痛; 溃疡 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征，以及此类病症的诊断测定。

    Human protein kinase HOACF72
    2.
    发明授权
    Human protein kinase HOACF72 失效
    人类蛋白激酶HOACF72

    公开(公告)号：US5972606A

    公开(公告)日：1999-10-26

    申请号：US802466

    申请日：1997-02-19

    申请人： Caretha L. Creasy ,  George P. Livi ,  Damien J. Dunnington ,  Usman Shabon

    发明人： Caretha L. Creasy ,  George P. Livi ,  Damien J. Dunnington ,  Usman Shabon

    IPC分类号： G01N33/15 ,  A61K31/70 ,  A61K38/55 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P43/00 ,  C07K16/40 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/54 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C07H21/04 ,  C12N5/00 ,  C12P21/06

    CPC分类号： C12N9/1205 ,  A61K48/00

    摘要： hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK1 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndromne (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, and diagnostic assays for such conditions.

    摘要翻译： 公开了通过重组技术生产这种多肽的hYAK1多肽和多核苷酸和方法。 还公开了在设计用于治疗骨丢失（包括骨质疏松症）的方案中使用hYAK1多肽和多核苷酸的方法; 炎性疾病如成人呼吸系统疾病综合征（ARDS），类风湿性关节炎，骨关节炎，炎性肠病（IBD），牛皮癣，皮炎，哮喘，过敏; 感染如细菌，真菌，原生动物和病毒感染，特别是HIV-1或HIV-2引起的感染; HIV相关性恶病质和其他免疫缺陷病症; 败血性休克 疼痛; 伤害 癌症; 厌食症 贪食 帕金森病 心血管疾病包括再狭窄，动脉粥样硬化，急性心力衰竭，心肌梗塞; 低血压 高血压; 尿潴留 心绞痛; 溃疡 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征，以及此类病症的诊断测定。

    GPR14 polypeptides
    5.
    发明授权
    GPR14 polypeptides 失效
    GPR14多肽

    公开(公告)号：US6133420A

    公开(公告)日：2000-10-17

    申请号：US58725

    申请日：1998-04-10

    申请人： Robert S. Ames, Jr. ,  Henry M. Sarau ,  James J. Foley ,  Usman Shabon ,  Derk Bergsma ,  Jonathan K. Chambers

    发明人： Robert S. Ames, Jr. ,  Henry M. Sarau ,  James J. Foley ,  Usman Shabon ,  Derk Bergsma ,  Jonathan K. Chambers

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/72

    CPC分类号： C07K14/705 ,  C07K14/723 ,  A61K38/00 ,  A61K48/00

    摘要： Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了人GPR14多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用人GPR14多肽和多核苷酸的方法; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。

    Cloning of a novel G-Protein coupled 7TM receptor
    6.
    发明授权
    Cloning of a novel G-Protein coupled 7TM receptor 失效
    克隆一种新的G蛋白偶联的7TM受体

    公开(公告)号：US5871967A

    公开(公告)日：1999-02-16

    申请号：US788539

    申请日：1997-01-24

    申请人： Usman Shabon ,  Derk J. Bergsma ,  Ganesh M. Sathe

    发明人： Usman Shabon ,  Derk J. Bergsma ,  Ganesh M. Sathe

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  C07K14/705 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/00 ,  C12Q1/68 ,  C12R1/91

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： HNHCI32 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNHCI32 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了HNHCI32多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HNHCI32多肽和多核苷酸的方法; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。

    Mouse CC-CKR5 receptor polypeptide
    7.
    发明授权
    Mouse CC-CKR5 receptor polypeptide 失效
    小鼠CC-CKR5受体多肽

    公开(公告)号：US06388055B1

    公开(公告)日：2002-05-14

    申请号：US08724984

    申请日：1996-10-03

    申请人： Derk J. Bergsma ,  Mary E. Brawner ,  Usman Shabon

    发明人： Derk J. Bergsma ,  Mary E. Brawner ,  Usman Shabon

    IPC分类号： C07K1400

    CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00

    摘要： Mouse CC-CKR5 polypeptides and DNA (RNA) encoding such mouse CC-CKR5 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such mouse CC-CKR5 in the development of gene knockout mice for use as a model for human immunodeficiency virus.

    摘要翻译： 公开了编码这种小鼠CC-CKR5的小鼠CC-CKR5多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了在基因敲除小鼠的开发中利用这种小鼠CC-CKR5用作人类免疫缺陷病毒模型的方法。

    Human neurotensin receptor type 2 and splice variants thereof
    8.
    发明授权
    Human neurotensin receptor type 2 and splice variants thereof 失效
    人类神经降压素受体2型及其剪接变体

    公开(公告)号：US6166182A

    公开(公告)日：2000-12-26

    申请号：US372498

    申请日：1999-08-11

    申请人： Derk Jon Bergsma ,  Usman Shabon

    发明人： Derk Jon Bergsma ,  Usman Shabon

    IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P25/18 ,  A61P31/04 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N5/00 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/68 ,  C07K14/00 ,  C07K5/00

    CPC分类号： C07K14/723 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

    摘要： Human neurotensin type 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing human neurotensin type 2 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了人神经降压素2型多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用人神经降压素2型多肽和多核苷酸的方法; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。

    Method of finding agonist and antagonist to human and rat GPR14
    9.
    发明授权
    Method of finding agonist and antagonist to human and rat GPR14 失效
    寻找人和大鼠GPR14的激动剂和拮抗剂的方法

    公开(公告)号：US6159700A

    公开(公告)日：2000-12-12

    申请号：US232857

    申请日：1999-01-15

    申请人： Nambi V Aiyar ,  Robert S Ames ,  Anne Romanic Arnold ,  Kamal Al-Barazanji ,  Derk J Bergsma ,  Jon Chambers ,  Stephen A Douglas ,  James J Foley ,  Bernard Gout ,  Nassirah Khandoudi ,  Henry M Sarau ,  Usman Shabon ,  Robert N Willette

    发明人： Nambi V Aiyar ,  Robert S Ames ,  Anne Romanic Arnold ,  Kamal Al-Barazanji ,  Derk J Bergsma ,  Jon Chambers ,  Stephen A Douglas ,  James J Foley ,  Bernard Gout ,  Nassirah Khandoudi ,  Henry M Sarau ,  Usman Shabon ,  Robert N Willette

    IPC分类号： G01N33/50 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  A61P43/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/68 ,  G01N33/566 ,  C12N5/06 ,  C12P21/00

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00 ,  C07K14/723

    摘要： Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of ischemic coronary artery disease (angina and myocardial infarction); atherosclerosis; metabolic diseases (e.g. diabetes); CHF/myocardial dysfunction; arrhythmias; restenosis; hypertension; hypotension; pulmonary disease (hypertension, COPD, asthma); fibrotic vasculopathies (diabetes, SLE, AS, Reynaud's); cerebrovascular events (e.g. hemnorrhagic and ischemic stroke); neurogenic inflammation/migraine; hematopoictic disorders; ARDS; cancer; autoimmune diseases (e.g. HIV-1 and -2 infection and AIDS); gastrointestinal and genitourinary disturbances (e.g. ulcers) endocrine disorders; fibroproliferative disorders (e.g. psoriasis); inflammatory disease (e.g. RA, Crohn's, IBS); benign prostatic hypertrophy; renal failure and glomerulopathies; disease states, both cardiovascular and non-cardiovascular, which are characterized by excessive vasoconstriction, myocardial dysfunction and/or aberrant fibroproliferative/inflammatory responses; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation, Parkinson's disease, and dyskinesias, infections such as bacterial, fungal, protozoan and viral infections; pain; eating disorders, such as obesity, anorexia, and bulimia; asthma; urinary retention; osteoporosis; allergies; Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了人GPR14多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗缺血性冠状动脉疾病（心绞痛和心肌梗死）的方案中使用人GPR14多肽和多核苷酸的方法; 动脉粥样硬化 代谢疾病（如糖尿病）; CHF /心肌功能障碍; 心律不齐 再狭窄; 高血压; 低血压 肺疾病（高血压，COPD，哮喘）; 纤维化血管病变（糖尿病，SLE，AS，Reynaud's）; 脑血管事件（如出血性和缺血性中风）; 神经源性炎症/偏头痛; 造血障碍; ARDS; 癌症; 自身免疫性疾病（如HIV-1和-2感染和艾滋病）; 胃肠道和泌尿生殖系统紊乱（例如溃疡）内分泌紊乱; 纤维增生性疾病（例如牛皮癣）; 炎性疾病（例如RA，克罗恩氏病，IBS）; 良性前列腺肥大; 肾衰竭和肾小球病; 疾病状态，心血管和非心血管疾病，其特征在于血管收缩过度，心肌功能障碍和/或异常纤维增生/炎症反应; 精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆，严重智力迟钝，帕金森病和运动障碍，细菌，真菌，原生动物和病毒感染等感染; 疼痛; 饮食失调，如肥胖，厌食和贪食症; 哮喘; 尿潴留 骨质疏松症 过敏 亨廷顿氏病或吉尔斯·德拉图雷特综合征等，以及这些病症的诊断测定。