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1.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH CORONARY EVENTS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF 有权与冠状动脉和药物反应相关的遗传多态性，检测方法及其用途公开(公告)号：US20100120040A1
公开(公告)日：2010-05-13
申请号：US12569475
申请日：2009-09-29
申请人： Olga IAKOUBOVA , James J. DEVLIN , Charles ROWLAND , Carmen TONG
发明人： Olga IAKOUBOVA , James J. DEVLIN , Charles ROWLAND , Carmen TONG
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N33/6893 , G01N2333/914 , G01N2500/04 , G01N2800/32 , G01N2800/324 , G01N2800/329 , Y10T436/143333
摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明提供了与冠心病（特别是心肌梗塞），动脉瘤/解剖和/或对药物治疗，特别是他汀类药物治疗的反应相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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公开(公告)号：US20190079070A1
公开(公告)日：2019-03-14
申请号：US15942188
申请日：2018-03-30
申请人： Dov Shiffman , Carmen Tong , James J. Devlin , Michael J. McPhaul
发明人： Dov Shiffman , Carmen Tong , James J. Devlin , Michael J. McPhaul
摘要： Methods are described for diagnosing or prognosing insulin resistance in diabetic and pre-diabetic patients, the method comprising determining the amount of insulin and C-peptide in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
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3.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH CORONARY EVENTS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF 审中-公开与冠状动脉和药物反应相关的遗传多态性，检测方法及其用途公开(公告)号：US20130058914A1
公开(公告)日：2013-03-07
申请号：US13407501
申请日：2012-02-28
申请人： Olga IAKOUBOVA , James DEVLIN , Charles ROWLAND , Carmen TONG
发明人： Olga IAKOUBOVA , James DEVLIN , Charles ROWLAND , Carmen TONG
IPC分类号： C12Q1/68 , A61K31/7088 , A61K38/02 , A61K39/395
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N33/6893 , G01N2333/914 , G01N2500/04 , G01N2800/32 , G01N2800/324 , G01N2800/329 , Y10T436/143333
摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明提供了与冠心病（特别是心肌梗塞），动脉瘤/解剖和/或对药物治疗，特别是他汀类药物治疗的反应相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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4.发明授权Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof 有权与冠状动脉事件和药物反应相关的遗传多态性，检测方法及其用途公开(公告)号：US08148070B2
公开(公告)日：2012-04-03
申请号：US12569475
申请日：2009-09-29
申请人： Olga Iakoubova , James J. Devlin , Carmen Tong , Charles Rowland
发明人： Olga Iakoubova , James J. Devlin , Carmen Tong , Charles Rowland
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N33/6893 , G01N2333/914 , G01N2500/04 , G01N2800/32 , G01N2800/324 , G01N2800/329 , Y10T436/143333
摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明提供了与冠心病（特别是心肌梗塞），动脉瘤/解剖和/或对药物治疗，特别是他汀类药物治疗的反应相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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5.发明申请Genetic polymorphisms associated with coronary events and drung response, methods of detection and uses thereof 有权与冠状动脉事件和肺部反应有关的遗传多态性，检测方法及其应用公开(公告)号：US20080241846A1
公开(公告)日：2008-10-02
申请号：US12077935
申请日：2008-03-21
申请人： Olga Iakoubova , James Devlin , Charles Rowland , Carmen Tong
发明人： Olga Iakoubova , James Devlin , Charles Rowland , Carmen Tong
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N33/6893 , G01N2333/914 , G01N2500/04 , G01N2800/32 , G01N2800/324 , G01N2800/329 , Y10T436/143333
摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明提供了与冠心病（特别是心肌梗塞），动脉瘤/解剖和/或对药物治疗，特别是他汀类药物治疗的反应相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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6.发明授权Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof 有权与冠状动脉事件和药物反应相关的遗传多态性，检测方法及其用途公开(公告)号：US07695916B2
公开(公告)日：2010-04-13
申请号：US12077935
申请日：2008-03-21
申请人： Olga Iakoubova , James Devlin , Charles Rowland , Carmen Tong
发明人： Olga Iakoubova , James Devlin , Charles Rowland , Carmen Tong
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N33/6893 , G01N2333/914 , G01N2500/04 , G01N2800/32 , G01N2800/324 , G01N2800/329 , Y10T436/143333
摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明提供了与冠心病（特别是心肌梗塞），动脉瘤/解剖和/或对药物治疗，特别是他汀类药物治疗的反应相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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