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1.发明授权Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof 有权与冠状动脉事件和药物反应相关的遗传多态性，检测方法及其用途公开(公告)号：US08148070B2
公开(公告)日：2012-04-03
申请号：US12569475
申请日：2009-09-29
申请人： Olga Iakoubova , James J. Devlin , Carmen Tong , Charles Rowland
发明人： Olga Iakoubova , James J. Devlin , Carmen Tong , Charles Rowland
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N33/6893 , G01N2333/914 , G01N2500/04 , G01N2800/32 , G01N2800/324 , G01N2800/329 , Y10T436/143333
摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明提供了与冠心病（特别是心肌梗塞），动脉瘤/解剖和/或对药物治疗，特别是他汀类药物治疗的反应相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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2.发明申请Genetic polymorphisms associated with coronary events and drung response, methods of detection and uses thereof 有权与冠状动脉事件和肺部反应有关的遗传多态性，检测方法及其应用公开(公告)号：US20080241846A1
公开(公告)日：2008-10-02
申请号：US12077935
申请日：2008-03-21
申请人： Olga Iakoubova , James Devlin , Charles Rowland , Carmen Tong
发明人： Olga Iakoubova , James Devlin , Charles Rowland , Carmen Tong
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N33/6893 , G01N2333/914 , G01N2500/04 , G01N2800/32 , G01N2800/324 , G01N2800/329 , Y10T436/143333
摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明提供了与冠心病（特别是心肌梗塞），动脉瘤/解剖和/或对药物治疗，特别是他汀类药物治疗的反应相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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3.发明授权Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof 有权与冠状动脉事件和药物反应相关的遗传多态性，检测方法及其用途公开(公告)号：US07695916B2
公开(公告)日：2010-04-13
申请号：US12077935
申请日：2008-03-21
申请人： Olga Iakoubova , James Devlin , Charles Rowland , Carmen Tong
发明人： Olga Iakoubova , James Devlin , Charles Rowland , Carmen Tong
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N33/6893 , G01N2333/914 , G01N2500/04 , G01N2800/32 , G01N2800/324 , G01N2800/329 , Y10T436/143333
摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明提供了与冠心病（特别是心肌梗塞），动脉瘤/解剖和/或对药物治疗，特别是他汀类药物治疗的反应相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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4.发明申请Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof 有权与心肌梗死相关的遗传多态性，检测方法及其应用公开(公告)号：US20090118217A1
公开(公告)日：2009-05-07
申请号：US12287505
申请日：2008-10-08
申请人： Michele Cargill , James J. Devlin , Olga Iakoubova
发明人： Michele Cargill , James J. Devlin , Olga Iakoubova
IPC分类号： A61K31/7088 , C12Q1/68 , A61P9/10
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与心肌梗塞相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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5.发明申请Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof 审中-公开与心肌梗死相关的遗传多态性，检测方法及其应用公开(公告)号：US20080248476A1
公开(公告)日：2008-10-09
申请号：US11977366
申请日：2007-10-23
申请人： Michele Cargill , James J. Devlin , Olga Iakoubova , Dov Shiffman
发明人： Michele Cargill , James J. Devlin , Olga Iakoubova , Dov Shiffman
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与心肌梗塞相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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6.发明授权Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof 有权与心肌梗死相关的遗传多态性，检测方法及其用途公开(公告)号：US07781168B2
公开(公告)日：2010-08-24
申请号：US12287505
申请日：2008-10-08
申请人： Olga Iakoubova , James J. Devlin
发明人： Olga Iakoubova , James J. Devlin
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与心肌梗塞相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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7.发明授权公开(公告)号：US07482117B2
公开(公告)日：2009-01-27
申请号：US10741600
申请日：2003-12-22
申请人： Michele Cargill , James J. Devlin , Olga Iakoubova
发明人： Michele Cargill , James J. Devlin , Olga Iakoubova
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
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8.发明授权Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof 有权与心血管疾病和药物反应相关的遗传多态性，检测方法及其应用公开(公告)号：US07799530B2
公开(公告)日：2010-09-21
申请号：US11526137
申请日：2006-09-22
申请人： Olga Iakoubova , James Devlin
发明人： Olga Iakoubova , James Devlin
CPC分类号： C12Q1/6883 , A61K31/70 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual having a cardiovascular disorder to treatment of the disorder with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与心血管疾病特别是急性冠状动脉事件（例如心肌梗死和中风）相关的遗传多态性的发现，以及与具有心血管疾病的个体的反应性相关的遗传多态性与该疾病的治疗相关 他汀 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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9.发明申请Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof 审中-公开与心肌梗死相关的遗传多态性，检测方法及其应用公开(公告)号：US20070042382A1
公开(公告)日：2007-02-22
申请号：US10796307
申请日：2004-03-10
申请人： Michele Cargill , James Devlin , Olga Iakoubova , Dov Shiffman
发明人： Michele Cargill , James Devlin , Olga Iakoubova , Dov Shiffman
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与心肌梗塞相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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10.发明申请Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof 有权与心肌梗死相关的遗传多态性，检测方法及其应用公开(公告)号：US20050026169A1
公开(公告)日：2005-02-03
申请号：US10741600
申请日：2003-12-22
申请人： Michele Cargill , James Devlin , Olga Iakoubova
发明人： Michele Cargill , James Devlin , Olga Iakoubova
IPC分类号： A61B20060101 , C07H21/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N15/12 , C12P19/34 , G01N33/53 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译： 本发明基于与心肌梗塞相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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