公开(公告)号：US20240102915A1

公开(公告)日：2024-03-28

申请号：US17766562

申请日：2020-10-06

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE (CNRS) ,  JUNIA

Inventor： Dominique COLLARD ,  Hiroyuki FUJITA ,  Stanislav KARSTEN ,  Mehmet Cagatay TARHAN

IPC: G01N15/14 ,  B01L3/00 ,  G01N15/10 ,  G01N33/487

CPC classification number: G01N15/1484 ,  B01L3/502761 ,  G01N15/1031 ,  G01N33/48728 ,  B01L2200/0663 ,  B01L2300/0645 ,  G01N2015/1006 ,  G01N2015/1495

Abstract: The invention relates to a measuring device (10) for measuring physical characteristics of cells. The device (10) comprises: a microfluidic chip (20) provided with a flow channel (22) for allowing cells to flow through; a manipulator (24) configured to apply deformation force to a cell in a continuous flow; and a sensor (26) configured to sense a physical characteristic of the cell. The manipulator (24) and the sensor (26) are configured to define a width (W2) of the flow channel (22) as a gap formed between them. The manipulator (24) is configured to apply the deformation force to the cell by compressing the cell against the sensor (26).

公开(公告)号：US20230002497A1

公开(公告)日：2023-01-05

申请号：US17638464

申请日：2020-09-03

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÈ ET DE LA RECHERCH MÉDICALE ,  Centre National de la Recherche Scientifque (CNRS) ,  Université de Lille ,  Institut Pasteur de Lille ,  Université de Montpellier ,  INSTITUT RÉGIONAL DU CANCER DE MONTPELLIER

Inventor： Philippe GOSSET ,  Muriel PICHAVANT ,  Pierre MARTINEAU ,  Myriam CHENTOUF ,  Bruno ROBERT ,  Mélina LE ROUX

IPC: C07K16/28 ,  A61P11/00

Abstract: Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality worldwide. Acute exacerbation of COPD (AE-COPD) in patients are mostly due to respiratory infection and are associated with an inexorable decline in lung function, enhanced oedema as well as airway and systemic inflammation. Previous results show that treatment with anti-IL-20Rb blocking antibodies increased the bacterial clearance in control mice infected by S. pneumoniae and protected CS-exposed mice from bacterial infection, by decreasing the bacterial burden and the inflammatory infiltrate. Therefore there is an interest for generating monoclonal antibodies specific for IL-20Rb with a neutralizing activity for their use in the treatment of AE-COPD. The present invention fulfills this need by providing antibodies having specificity for IL-20Rb.

公开(公告)号：US20210177814A1

公开(公告)日：2021-06-17

申请号：US17053817

申请日：2018-05-09

Applicant: INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université d'Aix Marseille ,  Centre National de la Recherche Scientifque (CNRS)

Inventor： Jessica PEREGO ,  Philippe PIERRE ,  Evelina GATTI

IPC: A61K31/44 ,  A61K31/40 ,  A61K31/155 ,  A61P31/14

Abstract: The present invention relates to the use of Guanabenz or derivates thereof for the treatment of type I IFN-dependent pathologies. The inventors investigate here how pharmacological interference with the eIF2α-P pathway can be beneficial for the treatment of immune pathological conditions. Using both mouse and human DCs, as well as B cells, they show that GBZ prevents endosomal toll-like-receptor 9 (TLR9) activation by CpG ODN or DNA-Immunoglobulin complexes, as well as TLR3, TLR7 and RIG-I like receptors (RLR, RIG-I or MDA5), by RNAs or small compounds. In vivo, GBZ treatment protects mice from CpG-dependent cytokine shock and decreases anti-nucleic acid auto-antibodies production in the TMPD-induced systemic lupus erythematosus model. The present invention thus relates to a method of treating a type I IFN-dependent pathology in a subject comprising administering the subject with Guanabenz or a derivative thereof.

公开(公告)号：US20230293490A1

公开(公告)日：2023-09-21

申请号：US18019219

申请日：2021-08-12

Applicant: University of Pittsburgh- Of the Commonwealth System of Higher Education ,  Sorbonne Université ,  Centre National de la Recherche Scientifque ,  INSERM(Institut National de la Sante et de la Recherche Medicale)

Inventor： Partha Roy ,  Lee McDermott ,  Abigail E. Allen ,  David Koes ,  David M. Gau ,  Paul G. Francoeur ,  Xavier Guillonneau

IPC: A61K31/4155 ,  A61P35/00

CPC classification number: A61K31/4155 ,  A61P35/00

Abstract: Disclosed are anti-angiogenic agents that target Pfn1:actin interaction. Also disclosed are compounds for treating ocular diseases or conditions. Further disclosed are compounds for treating cancer.

公开(公告)号：US20220074460A1

公开(公告)日：2022-03-10

申请号：US17428890

申请日：2020-02-11

Applicant: Thales ,  Centre national de la recherche scientifque ,  Universite De Franche-Comte

Inventor： Kevin JABOVISTE ,  Gaël CHEVALLIER ,  Emeline SADOULET-REBOUL ,  Nicolas PEYRET ,  Eric COLLARD ,  Charles ARNOULD

IPC: F16F7/104 ,  F16M13/02 ,  B64C1/00

Abstract: The invention relates to a device comprising a body and a set of vibration absorbers mounted on the body, each absorber being movable relative to the body between a first position and a second position, each absorber being capable of oscillating relative to the body between its first and second positions, a first natural frequency being defined for each absorber, at least one absorber having a first natural frequency different from the first natural frequency of another absorber.
Each absorber comprises at least one deformation part capable of deforming as the vibration absorber oscillates between its first position and its second position, the deformation part having at least two faces configured to rub against each other during the deformation of the deformation part.

公开(公告)号：US20220053791A1

公开(公告)日：2022-02-24

申请号：US17416269

申请日：2019-12-20

Applicant: Avril ,  Universite De Lorraine ,  Centre National De La Recherche Scientifque

Inventor： Olivier GALET ,  Romain KAPEL ,  Sara ALBE SLABI

IPC: A23J1/14 ,  B01D61/14 ,  B01D61/16 ,  A23L33/185 ,  C07K14/415

Abstract: A process for preparing a sunflower seed protein isolate and a protein isolate which is obtainable by such process. The process comprises the following steps: mixing a defatted seed meal with an aqueous NaCl solution at a basic pH; separating said solubilised protein solution from solids; diafiltering said solubilised protein solution through an ultrafiltration membrane system using an aqueous NaCl diafiltration NaCl solution and at least 2 diavolumes of said aqueous NaCl diafiltration solution, diafiltering said NaCl-diafiltered protein; concentrating said purified protein solution; and drying said purified protein concentrate to obtain a protein isolate.

公开(公告)号：US11427796B2

公开(公告)日：2022-08-30

申请号：US16335390

申请日：2017-09-19

Applicant: INRIA INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE (C.N.R.S) ,  UNIVERSITE NICE SOPHIA ANITPOLIS

Inventor： Olivier Bernard ,  Hubert Bonnefond ,  Antoine Sciandra ,  Éric Pruvost ,  Ghjuvan Grimaud

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/34 ,  C12N5/00 ,  C12M1/36 ,  C12N1/12 ,  C12M1/42

Abstract: The invention relates to a bioreactor comprising a tank (100) capable of being operated for a working period, said tank (100) being intended to receive a culture medium comprising a cellular culture of photosynthetic microorganisms, a light source (200) arranged to emit incident light having a chosen incoming light intensity (Iin) in the direction of the tank, a temperature probe (400) for measuring the temperature of said culture medium in the tank, and a temperature regulator (500) capable of raising and lowering the temperature of said culture medium in the tank, and further comprising a control (700) of the temperature regulator arranged to adjust the temperature of the culture medium to a low setpoint value (VCB) during a first period, and to adjust the temperature of the culture medium to a high setpoint value (VCH) during a second period, the succession of said first and second periods making it possible to induce a cellular stress in at least some of said photosynthetic microorganisms during the working period.

公开(公告)号：US20210277155A1

公开(公告)日：2021-09-09

申请号：US16330645

申请日：2017-09-07

Applicant: Total Research & Technology Feluy ,  Centre National de la Recherche Scientifque (CNRS)

Inventor： Alexandre Welle ,  Aurélien Vantomme ,  Jean-François Carpentier ,  Gilles Schnee ,  Olivier Miserque ,  Evgueni Kirillov

IPC: C08F10/06 ,  C08F2/02 ,  C08F4/659 ,  C08F4/6592

Abstract: The present invention relates to a new process for preparing a polypropylene using new bis(metallocene) compounds in catalyst compositions. The bis(metallocene) compounds of the invention are homo- or hetero bis(metallocene) molecules in which same or different metallocene moieties are connected by a phenylene bridge. The phenylene bridge is either para-substituted, meta-substituted or ortho-substituted by the two metallocene moieties

公开(公告)号：US20150139595A1

公开(公告)日：2015-05-21

申请号：US14383822

申请日：2013-03-05

Applicant: COMMISSARIAT A L 'ENERGIE ATOMIQUE ET AUX ENE ALT ,  UNIVERSIT LILLE 1 SCIENCES ET TECHNOLOGIES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE

Inventor： Emmanuel Hugonnot ,  Arnaud Mussot ,  Yves Quiquepois ,  Geraud Bouwmans ,  Laurent Bigot ,  Constance Valentin

IPC: G02B6/14

CPC classification number: G02B6/14 ,  B23K26/064 ,  B23K26/073 ,  B23K26/0734 ,  B23K26/21 ,  G02B6/03611 ,  G02B6/03622 ,  G02B27/09 ,  H01S3/06741 ,  H01S3/06745

Abstract: A device for converting transverse spatial profile of intensity of a light beam, using a microstructured optical fiber. Transverse dimensions of the fiber vary longitudinally and both its ends have opto-geometrical parameters such that at the wavelength of the beam the fiber has a fundamental mode having two different profile shapes at its two ends. Thus by introducing the beam with one of the profiles through one of the two ends, the beam emerges through the other end with the other profile, whose shape is different from that of the profile of the introduced beam.

Abstract translation: 使用微结构光纤转换光束强度的横向空间分布的装置。 纤维的横向尺寸纵向变化，并且其端部都具有光学几何参数，使得在光束的波长处，光纤具有在其两端具有两个不同轮廓形状的基本模式。 因此，通过将光束中的一个通过将两个端部中的一个引入到光束中，光束通过另一端与另一个轮廓一起出射，另一个轮廓的形状与引入的光束的轮廓的形状不同。

公开(公告)号：US20150017322A1

公开(公告)日：2015-01-15

申请号：US14378699

申请日：2013-02-27

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE ,  UNIVERSITE DE PICARDIE JULES VERNE

Inventor： Marine Reynaud ,  Mohamed Ati ,  Jean-Noel Choland ,  Jean-Marie Tarascon

IPC: H01M4/136 ,  H01M4/58 ,  H01M4/62 ,  H01M4/1397

CPC classification number: H01M4/136 ,  C01B17/96 ,  C01D5/02 ,  C01G49/009 ,  C01G49/14 ,  C01P2002/72 ,  C01P2002/88 ,  C01P2006/40 ,  H01M4/0404 ,  H01M4/0445 ,  H01M4/0471 ,  H01M4/049 ,  H01M4/1397 ,  H01M4/5825 ,  H01M4/622 ,  H01M4/625 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/054 ,  H01M2004/028

Abstract: The invention relates to an electrode material.Said material is characterized in that it contains, as positive electrode active material, at least one sulphate of iron in the +II oxidation state and of alkali metal corresponding to the formula (Na1−aLib)xFey(SO4), (I) in which the subscripts a, b, x, y and z are chosen so as to ensure the electroneutrality of the compound, with 0≦a≦1, 0≦b≦1, 1≦x≦3, 1≦y≦2, 1≦z≦3, and 2≦(2z−x)/y

Abstract translation: 本发明涉及电极材料。 所述材料的特征在于，其包含作为正极活性物质的至少一种+ II氧化态的铁硫酸盐和对应于式（Na1-aLib）xFey（SO4），（I）的碱金属，其中 选择下标a，b，x，y和z，以确保化合物的电中性与0和nlE; a＆nlE; 1,0＆amp; nlE; b＆nlE; 1，1＆nlE; x＆nlE; 3，1＆nlE; y＆nlE; 2,1＆ z和nlE; 3和2＆nlE;（2z-x）/ y <3，使得至少一部分铁处于+ II氧化态，排除化合物Li 2 Fe 2（SO 4）3。 特别是碱金属离子电池中的正极材料。