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    Apparatus for blood dialysis and filtration
    2.
    发明申请
    Apparatus for blood dialysis and filtration 失效
    用于血液透析和过滤的装置

    公开(公告)号：US20060138049A1

    公开(公告)日：2006-06-29

    申请号：US10561110

    申请日：2003-06-19

    申请人： Sung-Teh Kim ,  Kunihiko Yamanaka ,  Naritomi Maeda ,  Katsunori Masaoka ,  Kayoko Segawa ,  Chieko Yamamoto

    发明人： Sung-Teh Kim ,  Kunihiko Yamanaka ,  Naritomi Maeda ,  Katsunori Masaoka ,  Kayoko Segawa ,  Chieko Yamamoto

    IPC分类号： B01D61/32

    CPC分类号： A61M1/30 ,  A61M1/304 ,  A61M1/307

    摘要： A novel single needle hemodiafiltration apparatus and a novel single needle hemodiafiltration method for purifying blood with excellent removal performance via extracorporeal circulation with a single needle type are provided. The single needle hemodiafiltration apparatus includes a blood supply system for supplying blood, a dialysis fluid supply system for supplying a dialysis fluid and a system for controlling a movement of a fluid between the two supply systems, and a filtration/back-filtration liquid supply unit provided in the dialysis fluid supply system is controlled in conjunction with a blood pump provided in the blood supply system so that blood is removed from the body synchronously with the filtration and returned to the body synchronously with the back-filtration, thereby enabling extracorporeal circulation with the single needle. At a time of filtration, substances are removed by diffusion and ultrafiltration. At a time of recirculation in the blood circuit, substances are removed by diffusion. A high removal efficiency that cannot be achieved by the conventional single needle blood dialysis can be achieved by appropriately selecting the stroke volume per cycle, the number and order of the filtration/back-filtration/blank phases and the blood flow rate in each phase.

    摘要翻译： 提供了一种新颖的单针血液透析滤过装置和一种新型单针血液透析滤过法，用于通过单针型体外循环净化血液，具有优异的去除性能。 单针血液透析过滤装置包括用于供应血液的血液供给系统，用于供应透析液的透析液供给系统和用于控制两个供应系统之间的流体运动的系统，以及过滤/反向过滤液体供应单元 提供在透析液供给系统中的血液泵与血液供给系统中设置的血液泵一起被控制，使得与过滤体同步地从体内除去血液，并与背部滤液同步返回到身体，由此能够进行体外循环 单针。 在过滤时，通过扩散和超滤除去物质。 在血液循环中的再循环时，通过扩散除去物质。 通过适当选择每个循环的行程体积，过滤/反过滤/空白相的数量和顺序以及各相中的血液流量，可以实现常规单针血液透析无法实现的高去除效率。

    BLOOD DIALYSIS APPARATUS
    4.
    发明申请
    BLOOD DIALYSIS APPARATUS 审中-公开
    血液透析仪

    公开(公告)号：US20100312162A1

    公开(公告)日：2010-12-09

    申请号：US12734697

    申请日：2008-11-18

    申请人： Katsunori Masaoka ,  Kazuo Maehara ,  Shingo Chiba ,  Sung-Teh Kim ,  Chieko Yamamoto

    发明人： Katsunori Masaoka ,  Kazuo Maehara ,  Shingo Chiba ,  Sung-Teh Kim ,  Chieko Yamamoto

    IPC分类号： A61M1/16 ,  A61M1/14

    CPC分类号： A61M1/3643 ,  A61M1/3465 ,  A61M1/3644 ,  A61M1/3649 ,  A61M1/365

    摘要： Provided is a hemodialysis apparatus which can fundamentally solve a problem in that air is trapped in a mesh disposed in a vein side chamber during priming. A hemodialysis apparatus includes control means that conducts, in the stated order: (A) a process in which a blood pump reversely rotates at the same speed as a reverse filtration speed made by third fluid feeding means, and a dialysate flows in a flow passage extending from a connection portion between a hemodialyzer and an artery side blood line to a vein side chamber through the joint portion in a loop formed by connecting the artery side blood line and the vein side blood line, to thereby prime the flow passage and the hemodialyzer, and (B) a process in which a reverse rotation speed of the blood pump is made lower than the reverse filtration speed made by the third fluid feeding means, and the dialysate of a flow rate corresponding to a speed obtained by subtracting the reverse rotation speed of the blood pump from the reverse filtration speed made by the third fluid feeding means flows in a flow passage extending from a connection portion between the hemodialyzer and the vein side blood line to the vein side chamber, which is a remaining flow passage of the loop, to thereby prime the flow passage and the hemodialyzer.

    摘要翻译： 提供一种血液透析装置，其可以从根本上解决在启动期间空气被捕获在设置在静脉侧室中的网中的问题。 血液透析装置包括按照以下顺序进行的控制装置：（A）血泵以与第三流体供给装置的反过滤速度相同的速度反转的过程，并且透析液在流路 从血液透析器和动脉侧血液管线之间的连接部分通过连接动脉侧血液管线和静脉侧血液线形成的环路中的关节部分延伸到静脉侧腔室，从而使流路和血液透析器 ，和（B）使血液泵的反转速度低于由第三流体供给装置产生的反向过滤速度的过程，以及与通过减去反向旋转获得的速度相对应的流量的过程 由第三流体供给装置制成的反向过滤速度的血液泵的速度从在血液透析器和静脉侧之间的连接部分延伸的流路中流动 e血管线到静脉侧室，其是环的剩余流通道，从而引导流路和血液透析器。

    Hemodialyzer
    7.
    发明申请
    Hemodialyzer 审中-公开
    血液透析

    公开(公告)号：US20080251433A1

    公开(公告)日：2008-10-16

    申请号：US11887051

    申请日：2006-03-31

    申请人： Sung-Teh Kim ,  Chieko Yamamoto ,  Kayoko Segawa ,  Kunihiko Yamanaka ,  Katsunori Masaoka

    发明人： Sung-Teh Kim ,  Chieko Yamamoto ,  Kayoko Segawa ,  Kunihiko Yamanaka ,  Katsunori Masaoka

    IPC分类号： A61M1/16 ,  B01D61/28 ,  B01D61/32

    CPC分类号： A61M1/16 ,  A61M1/1609 ,  A61M1/3612 ,  A61M1/365 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/7554 ,  B01D61/32 ,  B01D65/02 ,  B01D2321/04

    摘要： Provided is a hemodialyzer in which deterioration in membrane performance of a hollow fiber with time can be grasped accurately during dialysis and the performance can be recovered quickly and positively. The hemodialyzer, constituted by connecting an artery side blood circuit (2) having a blood pump (7) to the artery side of a dialyzer (1), connecting a vein side blood circuit (3) to the vein side of the dialyzer (1), and connecting a dialysate supply line (4) and a dialysate discharge line (5), respectively, to the side face of the dialyzer (1), is provided with a detector (15) for determining the pressure in the blood circuit, and a detector (16) for determining the pressure in the dialysate line, in which transmembrane pressure is calculated based on the determined pressures, and reverse filtering is performed by the dialyzer (1) when the transmembrane pressure exceeds a predetermined level. Reverse filtering is performed by flushing operation and clogging of pores of the dialyzing membrane in the dialyzer (1) is eliminated thus recovering performance of the dialyzer (1).

    摘要翻译： 本发明提供一种血液透析器，其中可以在透析期间精确地掌握中空纤维的膜性能劣化，并且可以快速，准确地恢复性能。 将具有血泵（7）的动脉侧血液回路（2）与透析器（1）的动脉侧连接的血液透析器，将静脉侧血液回路（3）连接到透析器（1）的静脉侧 ）和将透析液供给管线（4）和透析液排出管线（5）分别连接到透析器（1）的侧面，设置有用于确定血液回路中的压力的​​检测器（15） 以及检测器（16），用于确定透析液线中的压力，其中基于所确定的压力计算跨膜压力，并且当跨膜压力超过预定水平时，由透析器（1）进行反向过滤。 通过冲洗操作进行反向过滤，消除透析器（1）中透析膜孔的堵塞，从而恢复透析器（1）的性能。

    Process for producing an asymmetric porous film
    10.
    发明授权
    Process for producing an asymmetric porous film 有权
    不对称多孔膜的制造方法

    公开(公告)号：US07441666B2

    公开(公告)日：2008-10-28

    申请号：US10475265

    申请日：2002-04-18

    申请人： Sung-Teh Kim ,  Chieko Yamamoto ,  Toshinori Koizumi ,  Masatoshi Saitoh ,  Shunji Maniwa

    发明人： Sung-Teh Kim ,  Chieko Yamamoto ,  Toshinori Koizumi ,  Masatoshi Saitoh ,  Shunji Maniwa

    IPC分类号： B01D29/00 ,  B01D71/68 ,  B01D71/26 ,  B01D71/28

    CPC分类号： B01D67/0088 ,  B01D63/021 ,  B01D67/0011 ,  B01D67/0093 ,  B01D69/02 ,  B01D69/08 ,  B01D69/12 ,  B01D71/68 ,  B01D71/80 ,  B01D2323/30 ,  B01D2325/022 ,  B01D2325/14

    摘要： It is intended to provide asymmetric porous films which are usable in blood dialysis, plasma separation, etc. and particularly excellent in the performance of selectively separating (fractionating) plasma protein, show little endogenous coagulation, complement or quinine activily and have an extremely high biocompatibility. Porous films made mainly of a synthetic polymer and having an asymmetric structure wherein, in the sectional structure, a dense layer substantially not charged at least on the outermost surface is provided in the side on which a liquid to be treated is loaded and at least part of the film other than the outermost surface is negatively charged. In the above films, the dense layer non-charged at least on the outermost surface serves as a size barrier while the part of the film other than the outermost surface serves as a charge barrier.

    摘要翻译： 旨在提供可用于血液透析，血浆分离等的不对称多孔膜，并且特别优选选择性分离（分级）血浆蛋白，活性地显示出少量内源性凝血，补体或奎宁，并且具有极高的生物相容性 。 主要由合成聚合物制成并具有不对称结构的多孔薄膜，其中在截面结构中，至少在最外表面上基本上未被充填的致密层设置在其上装载待处理液体的一侧，并且至少部分 的最外表面以外的膜是带负电荷的。 在上述膜中，至少在最外表面上未充电的致密层用作尺寸屏障，而除最外表面之外的膜的部分用作电荷屏障。