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公开(公告)号：US20060138049A1
公开(公告)日：2006-06-29
申请号：US10561110
申请日：2003-06-19
申请人： Sung-Teh Kim , Kunihiko Yamanaka , Naritomi Maeda , Katsunori Masaoka , Kayoko Segawa , Chieko Yamamoto
发明人： Sung-Teh Kim , Kunihiko Yamanaka , Naritomi Maeda , Katsunori Masaoka , Kayoko Segawa , Chieko Yamamoto
IPC分类号： B01D61/32
摘要： A novel single needle hemodiafiltration apparatus and a novel single needle hemodiafiltration method for purifying blood with excellent removal performance via extracorporeal circulation with a single needle type are provided. The single needle hemodiafiltration apparatus includes a blood supply system for supplying blood, a dialysis fluid supply system for supplying a dialysis fluid and a system for controlling a movement of a fluid between the two supply systems, and a filtration/back-filtration liquid supply unit provided in the dialysis fluid supply system is controlled in conjunction with a blood pump provided in the blood supply system so that blood is removed from the body synchronously with the filtration and returned to the body synchronously with the back-filtration, thereby enabling extracorporeal circulation with the single needle. At a time of filtration, substances are removed by diffusion and ultrafiltration. At a time of recirculation in the blood circuit, substances are removed by diffusion. A high removal efficiency that cannot be achieved by the conventional single needle blood dialysis can be achieved by appropriately selecting the stroke volume per cycle, the number and order of the filtration/back-filtration/blank phases and the blood flow rate in each phase.
摘要翻译： 提供了一种新颖的单针血液透析滤过装置和一种新型单针血液透析滤过法，用于通过单针型体外循环净化血液，具有优异的去除性能。 单针血液透析过滤装置包括用于供应血液的血液供给系统，用于供应透析液的透析液供给系统和用于控制两个供应系统之间的流体运动的系统，以及过滤/反向过滤液体供应单元 提供在透析液供给系统中的血液泵与血液供给系统中设置的血液泵一起被控制，使得与过滤体同步地从体内除去血液，并与背部滤液同步返回到身体，由此能够进行体外循环 单针。 在过滤时，通过扩散和超滤除去物质。 在血液循环中的再循环时，通过扩散除去物质。 通过适当选择每个循环的行程体积，过滤/反过滤/空白相的数量和顺序以及各相中的血液流量，可以实现常规单针血液透析无法实现的高去除效率。
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公开(公告)号：US20080251433A1
公开(公告)日：2008-10-16
申请号：US11887051
申请日：2006-03-31
CPC分类号： A61M1/16 , A61M1/1609 , A61M1/3612 , A61M1/365 , A61M2205/3331 , A61M2205/50 , A61M2205/7554 , B01D61/32 , B01D65/02 , B01D2321/04
摘要： Provided is a hemodialyzer in which deterioration in membrane performance of a hollow fiber with time can be grasped accurately during dialysis and the performance can be recovered quickly and positively. The hemodialyzer, constituted by connecting an artery side blood circuit (2) having a blood pump (7) to the artery side of a dialyzer (1), connecting a vein side blood circuit (3) to the vein side of the dialyzer (1), and connecting a dialysate supply line (4) and a dialysate discharge line (5), respectively, to the side face of the dialyzer (1), is provided with a detector (15) for determining the pressure in the blood circuit, and a detector (16) for determining the pressure in the dialysate line, in which transmembrane pressure is calculated based on the determined pressures, and reverse filtering is performed by the dialyzer (1) when the transmembrane pressure exceeds a predetermined level. Reverse filtering is performed by flushing operation and clogging of pores of the dialyzing membrane in the dialyzer (1) is eliminated thus recovering performance of the dialyzer (1).
摘要翻译： 本发明提供一种血液透析器，其中可以在透析期间精确地掌握中空纤维的膜性能劣化，并且可以快速，准确地恢复性能。 将具有血泵（7）的动脉侧血液回路（2）与透析器（1）的动脉侧连接的血液透析器，将静脉侧血液回路（3）连接到透析器（1）的静脉侧 ）和将透析液供给管线（4）和透析液排出管线（5）分别连接到透析器（1）的侧面，设置有用于确定血液回路中的压力的检测器（15） 以及检测器（16），用于确定透析液线中的压力，其中基于所确定的压力计算跨膜压力，并且当跨膜压力超过预定水平时，由透析器（1）进行反向过滤。 通过冲洗操作进行反向过滤，消除透析器（1）中透析膜孔的堵塞，从而恢复透析器（1）的性能。
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公开(公告)号：US07780848B2
公开(公告)日：2010-08-24
申请号：US10561110
申请日：2004-06-18
申请人： Sung-Teh Kim , Kunihiko Yamanaka , Naritomi Maeda , Katsunori Masaoka , Kayoko Segawa , Chieko Yamamoto
发明人： Sung-Teh Kim , Kunihiko Yamanaka , Naritomi Maeda , Katsunori Masaoka , Kayoko Segawa , Chieko Yamamoto
IPC分类号： A61M1/30
摘要： A single needle hemodiafiltration apparatus is provided. The single needle hemodiafiltration apparatus includes circuits for blood supply from a patient and blood return to a patient, a dialysis fluid supply system for supplying a dialysis fluid, and a system for controlling the blood flow and dialysis fluid flow in a separation device which is equipped to perform filtration and back-filtration operations. A controller is provided that controls, in a series of coordinated operations, the flow of blood from the patient into the separation device, the flow of filtration fluid and back filtration fluid, and the return of blood to the patient.
摘要翻译： 提供单针血液透析过滤装置。 单针血液透析过滤装置包括用于患者的血液供给和血液回到患者的回路，用于供应透析液的透析液供给系统，以及用于控制分离装置中的血流量和透析液流量的系统， 进行过滤和反过滤操作。 提供了一种控制器，其在一系列协调操作中控制从患者到分离装置的血液流，过滤流体和背部过滤流体的流动以及血液返回到患者。
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4.发明授权Hemodialyzer capable of intermittent repetition of infusion and water removal operation 有权血液透析器能够间歇性重复输液和除水手术公开(公告)号：US07914681B2
公开(公告)日：2011-03-29
申请号：US11597804
申请日：2004-05-28
IPC分类号： A61M1/34
CPC分类号： A61M1/342 , A61M1/3427
摘要： According to the present invention, there is provided a hemodiafiltration apparatus capable of easily and efficiently removing medium to large molecule solutes at a low cost. Provided is a hemodialysis apparatus which uses a hemodialyzer accommodating a hollow yarn membrane in hemodiafiltration to cause a dialysis fluid to flow from a dialysis fluid circuit side to a blood circuit side by forceful back-filtration via the hemodialyzer, and to cause a fluid in the blood circuit to reflux to a dialysis fluid circuit side by filtration via the hemodialyzer, the hemodialysis apparatus being characterized in that a flux operation of the fluid from the dialysis fluid side to the blood circuit side by the back-filtration, and a reflux operation of the fluid from the blood circuit side to the dialysis fluid circuit side by the filtration are repeated intermittently and for at least a plurality of times.
摘要翻译： 根据本发明，提供一种能够以低成本容易且高效地除去大分子溶质的血液透析过滤装置。 本发明提供一种血液透析装置，其在血液透析过滤中使用容纳中空丝膜的血液透析器，使透析液从透析液回路侧流经血液回路侧，经由血液透析器进行强力反向过滤， 血液循环通过血液透析器过滤回流到透析液回路侧，所述血液透析装置的特征在于，通过背过滤从所述透析液侧向所述血液回路侧的流体的通量运转，以及回流操作 通过过滤从血液回路侧到透析液回路侧的液体间歇地重复进行至少多次。
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公开(公告)号：US20100312162A1
公开(公告)日：2010-12-09
申请号：US12734697
申请日：2008-11-18
CPC分类号： A61M1/3643 , A61M1/3465 , A61M1/3644 , A61M1/3649 , A61M1/365
摘要： Provided is a hemodialysis apparatus which can fundamentally solve a problem in that air is trapped in a mesh disposed in a vein side chamber during priming. A hemodialysis apparatus includes control means that conducts, in the stated order: (A) a process in which a blood pump reversely rotates at the same speed as a reverse filtration speed made by third fluid feeding means, and a dialysate flows in a flow passage extending from a connection portion between a hemodialyzer and an artery side blood line to a vein side chamber through the joint portion in a loop formed by connecting the artery side blood line and the vein side blood line, to thereby prime the flow passage and the hemodialyzer, and (B) a process in which a reverse rotation speed of the blood pump is made lower than the reverse filtration speed made by the third fluid feeding means, and the dialysate of a flow rate corresponding to a speed obtained by subtracting the reverse rotation speed of the blood pump from the reverse filtration speed made by the third fluid feeding means flows in a flow passage extending from a connection portion between the hemodialyzer and the vein side blood line to the vein side chamber, which is a remaining flow passage of the loop, to thereby prime the flow passage and the hemodialyzer.
摘要翻译： 提供一种血液透析装置，其可以从根本上解决在启动期间空气被捕获在设置在静脉侧室中的网中的问题。 血液透析装置包括按照以下顺序进行的控制装置：（A）血泵以与第三流体供给装置的反过滤速度相同的速度反转的过程，并且透析液在流路 从血液透析器和动脉侧血液管线之间的连接部分通过连接动脉侧血液管线和静脉侧血液线形成的环路中的关节部分延伸到静脉侧腔室，从而使流路和血液透析器 ，和（B）使血液泵的反转速度低于由第三流体供给装置产生的反向过滤速度的过程，以及与通过减去反向旋转获得的速度相对应的流量的过程 由第三流体供给装置制成的反向过滤速度的血液泵的速度从在血液透析器和静脉侧之间的连接部分延伸的流路中流动 e血管线到静脉侧室，其是环的剩余流通道，从而引导流路和血液透析器。
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6.发明申请Hemodialyzer Capable Of Intermittent Repetition Of Infusion And Water Removal Operation 有权血液透析器能够间歇性重复输液和除水手术公开(公告)号：US20090159515A1
公开(公告)日：2009-06-25
申请号：US11597804
申请日：2004-05-28
IPC分类号： B01D61/32
CPC分类号： A61M1/342 , A61M1/3427
摘要： According to the present invention, there is provided a hemodiafiltration apparatus capable of easily and efficiently removing medium to large molecule solutes at a low cost. Provided is a hemodialysis apparatus which uses a hemodialyzer accommodating a hollow yarn membrane in hemodiafiltration to cause a dialysis fluid to flow from a dialysis fluid circuit side to a blood circuit side by forceful back-filtration via the hemodialyzer, and to cause a fluid in the blood circuit to reflux to a dialysis fluid circuit side by filtration via the hemodialyzer, the hemodialysis apparatus being characterized in that a flux operation of the fluid from the dialysis fluid side to the blood circuit side by the back-filtration, and a reflux operation of the fluid from the blood circuit side to the dialysis fluid circuit side by the filtration are repeated intermittently and for at least a plurality of times.
摘要翻译： 根据本发明，提供一种能够以低成本容易且高效地除去大分子溶质的血液透析过滤装置。 本发明提供一种血液透析装置，其在血液透析过滤中使用容纳中空丝膜的血液透析器，使透析液从透析液回路侧流经血液回路侧，经由血液透析器进行强力反向过滤， 血液循环通过血液透析器过滤回流到透析液回路侧，所述血液透析装置的特征在于，通过背过滤从所述透析液侧向所述血液回路侧的流体的通量运转，以及回流操作 通过过滤从血液回路侧到透析液回路侧的液体间歇地重复进行至少多次。
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7.发明授权Dialysis coupler assembly with joint members and hemodialysis system using same 有权透析耦合器组件与联合成员和血液透析系统使用相同公开(公告)号：US06971680B2
公开(公告)日：2005-12-06
申请号：US10378680
申请日：2003-03-05
申请人： Yoshihiko Nakanishi , Kunihiko Yamanaka , Hiromu Miura , Katsunori Masaoka , Takaaki Matsuo , Masahiro Taoka , Sung-Teh Kim
发明人： Yoshihiko Nakanishi , Kunihiko Yamanaka , Hiromu Miura , Katsunori Masaoka , Takaaki Matsuo , Masahiro Taoka , Sung-Teh Kim
IPC分类号： A61M1/16 , A61M39/10 , B01D61/30 , F16L37/252 , F16L25/00
CPC分类号： B01D61/30 , A61M1/16 , A61M39/1011 , F16L37/252
摘要： The present invention provides a dialysis coupler assembly comprising a pair of rubber-like elastic tubular couplers, and a pair of joint members for joining the couplers together. Each of the couplers includes an inner channel 14 allowing a connector associated with a medical device to be fitted therein, and a smooth surface 15, 16 perpendicular to the longitudinal axis of the coupler. The couplers are adapted to be joined together through the joint members in such manner that the smooth surfaces are in liquid-tight contact with one another. Each of the joint members is adapted to be attached slidably and rotatably onto corresponding one of the couplers, the joint members having first and second engagement portions, respectively. The first and second engagement portions are disposed opposed to one another and adapted to cooperatively engage the joint members with one another so as to allow the smooth surfaces to be brought into liquid-tight contact with one another.
摘要翻译： 本发明提供了一种透析耦合器组件，其包括一对橡胶状弹性管状耦合器和用于将耦合器连接在一起的一对接头构件。 每个耦合器包括允许与医疗装置相关联的连接器安装在其中的内部通道14以及垂直于耦合器的纵向轴线的平滑表面15,16。 联接器适于通过接合构件以使得光滑表面彼此液密接触的方式接合在一起。 每个联接构件适于被可滑动地和可旋转地附接到相应的一个联接器中，接头构件分别具有第一和第二接合部分。 第一和第二接合部分彼此相对布置并且适于彼此配合地接合接合构件，以便允许光滑表面彼此液密接触。
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公开(公告)号：US20070262013A1
公开(公告)日：2007-11-15
申请号：US11667529
申请日：2005-02-18
IPC分类号： C02F1/44
CPC分类号： A61M1/342 , A61M1/3434 , A61M1/3437 , A61M2205/33
摘要： An automatic reinfusing system which involves no contamination or medical errors or any other operational problems and allows easy and simple operation, without imposing any burden on the medical worker. The automatic reinfusing system includes a hemodialysis circuit, wherein a solution replenishing line has a replenishing solution supply source and an opening and closing arrangement for opening and closing the solution replenishing line, a dialysate supply line and a dialysate discharge line for perfusing to the dialyzer, with a solution feeding arrangement being respectively provided for the dialysate supply line and the dialysate discharge line. At least one filtering and reverse-filtering third solution feeding arrangement capable of normal and reverse rotation and allowing flow rate control serves to perform filtering and reverse filtering on one of the dialysate supply line and the dialysate discharge line in parallel with the solution feeding arrangement. A water-slowing and solution-discharging arrangement, with the blood-feeding means and the filtering and reverse-filtering third solution feeding arrangement are caused to communicate with each other by an interlocking control for controlling, in an interlocked manner, the blood feeding arrangement, the solution feeding arrangement, the opening and closing arrangement for opening and closing the solution replenishing line, and the opening and closing arrangement between the artery connection end the solution replenishing line branching part.
摘要翻译： 一种自动回灌系统，不涉及污染或医疗错误或任何其他操作问题，并且允许简单和简单的操作，而不会对医务人员造成任何负担。 自动回灌系统包括血液透析回路，其中溶液补充线具有补充溶液供应源和用于打开和关闭溶液补充生产线的开启和关闭装置，透析液供应管线和用于灌注到透析器的透析液排出管线， 分别为透析液供给管线和透析液排出管线提供溶液供给装置。 至少一个能够进行正常和反向旋转并允许流量控制的滤波和反向滤波的第三溶液馈送装置用于与溶液馈送装置并行地对透析液供应管线和透析液排放管线之一进行滤波和反向过滤。 通过采血装置和过滤和反向过滤第三溶液供给装置的减水和溶液排出装置通过互锁控制相互连通，以互锁的方式控制供血装置 溶液供给装置，用于打开和关闭溶液补充管线的打开和关闭装置，以及动脉连接端部溶液补充线分支部分之间的打开和关闭装置。
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公开(公告)号：US07842001B2
公开(公告)日：2010-11-30
申请号：US11794639
申请日：2006-01-06
申请人： Katsunori Masaoka , Takashi Doi , Kaoru Kushiyama
发明人： Katsunori Masaoka , Takashi Doi , Kaoru Kushiyama
CPC分类号： A61M1/3643 , A61M1/3644 , A61M1/3647
摘要： An automatic priming method in which an arterial-side chamber is maintained in a normal position during priming, as in a case of dialysis treatment, and in which forward and backward rotations of a blood pump are employed, and a speed of rotation, in particular, backward rotation, is adjusted to be low, so that air or the like is reliably prevented from entering a dialyzer. The priming method for use in a blood purification circuit in which priming is conducted by supplying physiological saline into a circulation circuit formed by connecting an arterial blood circuit with a venous blood circuit includes filling the venous blood circuit with a priming solution (physiological saline), discharging the priming solution for cleaning the arterial blood circuit, conducting a treatment in a direction opposite to the overflow step, which may be followed by a forward direction re-circulation step, and re-circulating in a forward direction.
摘要翻译： 一种自动起动方法，其中如在渗透处理的情况下，动脉侧腔室在启动期间保持在正常位置，并且其中采用血泵的向前和向后旋转，并且特别是旋转速度 ，向后旋转被调节为低，使得可靠地防止空气等进入透析器。 用于通过将生理盐水供给到通过将动脉血回路与静脉血液回路连接而形成的循环回路进行灌注的血液净化回路中的引发方法包括用引发液（生理盐水）填充静脉血回路， 排出用于清洁动脉血回路的引发溶液，以与溢流步骤相反的方向进行治疗，随后可以是正向再循环步骤，并且向前方向重新循环。
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公开(公告)号：US20100042036A1
公开(公告)日：2010-02-18
申请号：US11794639
申请日：2006-01-06
申请人： Katsunori Masaoka , Takashi Doi , Kaoru Kushiyama
发明人： Katsunori Masaoka , Takashi Doi , Kaoru Kushiyama
IPC分类号： A61M1/14
CPC分类号： A61M1/3643 , A61M1/3644 , A61M1/3647
摘要： The present invention provides an automatic priming method by which priming is conducted while keeping, in the automatic priming, an arterial-side chamber in a normal position as in a case of dialysis treatment, and in which forward and backward rotations of a blood pump are employed, and a speed of rotation, in particular, backward rotation is adjusted to be low so that air or the like is reliably prevented from entering a dialyzer. The priming method is characterized by including, in a blood purification circuit in which priming is conducted by supplying physiological saline into a circulation circuit formed by connecting an arterial blood circuit (L1) with a venous blood circuit (L2), (1) an early injection step of filling the venous blood circuit with a priming solution (physiological saline), (2) an overflow step of discharging the priming solution for cleaning the arterial blood circuit, (3) a reverse direction re-circulation step of conducting a treatment in a direction opposite to the overflow step, which may be followed by a forward direction re-circulation step, and (4) a forward direction re-circulation step.
摘要翻译： 本发明提供了一种自动起动方法，其中在自动起动中，如在透析治疗的情况下一样，将动脉侧腔保持在正常位置，并且其中血泵的向前和向后旋转是 并且将旋转速度，特别是反转速度调节为低，使得可靠地防止空气等进入透析器。 起动方法的特征在于，在通过将生理盐水供给到通过将动脉血液回路（L1）与静脉血液回路（L2）连接而形成的循环回路进行灌注的血液净化回路中，（1） 注射步骤，用灌注溶液（生理盐水）填充静脉血回路;（2）排出用于清洗动脉血回路的引发溶液的溢流步骤，（3）进行治疗的反向再循环步骤 与溢流步骤相反的方向，其可以是正向再循环步骤，以及（4）正向再循环步骤。
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