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    Method of detecting depression
    5.
    发明授权
    Method of detecting depression 失效
    检测抑郁症的方法

    公开(公告)号：US5882203A

    公开(公告)日：1999-03-16

    申请号：US456031

    申请日：1995-05-31

    申请人： Elsa I. Correa ,  Christina Barrett Barrick

    发明人： Elsa I. Correa ,  Christina Barrett Barrick

    IPC分类号： G09B19/00

    CPC分类号： G06F19/363

    摘要： The present invention relates to a method of detecting depression and its severity. A series of statements formulated to detect the presence and severity of depression are presented to the subject in a multiple item visual analog format. The subject's answers are given a numerical value. The total score is then normatively ranked to determine the presence and severity of the depression.

    摘要翻译： 本发明涉及一种检测抑郁症及其严重程度的方法。 为了检测抑郁症的存在和严重程度而制定的一系列陈述以多项视觉模拟形式呈现给主题。 主题的答案给出一个数值。 总分数然后被规范排列，以确定抑郁症的存在和严重程度。

    Anti-cancer compounds and methods of use thereof
    7.
    发明申请
    Anti-cancer compounds and methods of use thereof 审中-公开

    公开(公告)号：US20050209320A1

    公开(公告)日：2005-09-22

    申请号：US10963991

    申请日：2004-10-14

    申请人： Duane Miller ,  Mitchell Steiner ,  Karen Veverka ,  Christina Barrett ,  Seoungsoo Hong

    发明人： Duane Miller ,  Mitchell Steiner ,  Karen Veverka ,  Christina Barrett ,  Seoungsoo Hong

    IPC分类号： A61K20060101 ,  A61K31/165 ,  A61K31/277 ,  A61K31/325 ,  A61K39/395 ,  C07C235/24 ,  C07C255/60 ,  C07C271/24 ,  C07C309/87 ,  C07C317/40 ,  C07C323/60 ,  C07D207/448 ,  C07F9/09

    CPC分类号： C07D207/448 ,  C07C215/76 ,  C07C235/16 ,  C07C235/24 ,  C07C255/60 ,  C07C271/24 ,  C07C309/87 ,  C07C317/46 ,  C07C323/60 ,  C07D233/74

    摘要： The present invention relates to a novel class of anti-cancer compounds which selectively target androgen receptor (AR)-expressing cancer cells, such as prostate cancer cells and breast cancer cells. These agents comprise an androgen receptor (AR) binding moiety, which selectively targets the compounds to (AR)-expressing cancer cells, and a cytotoxic ablating moiety, such as a nitrogen mustard moiety. The inherent high density expression of the androgen receptor in certain cancers, such as prostate cancer and breast cancer, is thus used as a tool to selectively increase the intracellular concentration of cytotoxic compounds, such as alkylating agents, e.g. DNA alkylating agents, by selectively targeting the agents to the AR-expressing cancer cells. These agents, either alone or in a composition, are thus useful for treating, delaying the progression of, treating the recurrence of, suppressing, inhibiting or reducing the incidence of cancers characterized by the presence of AR-expressing cells, such as prostate cancer. Accordingly, the present invention provides a) methods of selectively killing an (AR)-expressing cancer cell; b) methods of inducing apoptosis in an (AR)-expressing cancer cell; c) methods of treating a cancer characterized by the presence of AR-expressing cells in a subject; d) methods of delaying the progression of a cancer characterized by the presence of AR-expressing cells in a subject; e) methods of treating the recurrence of a cancer characterized by the presence of AR-expressing cells in a subject; f) methods of suppressing, inhibiting or reducing the incidence of a cancer characterized by the presence of AR-expressing cells in a subject; and g) methods of treating metastasis of a cancer characterized by the presence of AR-expressing cells in a subject; by administering to the subject or by contacting the cancer cells with a compound comprising an androgen receptor ligand moiety and an alkylating moiety, such as the novel compounds described herein.