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公开(公告)号:US20120157539A1
公开(公告)日:2012-06-21
申请号:US13362242
申请日:2012-01-31
申请人: James T. DALTON , Christina BARRETT , Duane D. MILLER , Seoung-Soo HONG , Yali HE , Michael L. MOHLER , Ramesh NARAYANAN , Zhongzhi WU
发明人: James T. DALTON , Christina BARRETT , Duane D. MILLER , Seoung-Soo HONG , Yali HE , Michael L. MOHLER , Ramesh NARAYANAN , Zhongzhi WU
IPC分类号: A61K31/165 , C07C237/40 , A61P19/10 , A61P9/00 , A61P3/06 , A61P15/00 , A61P25/28 , A61P17/00 , A61P35/00 , A61P29/00 , A61P35/02 , A61P9/10 , A61P31/12 , A61P13/12 , A61P3/10 , A61P19/08 , C07K14/705
CPC分类号: A61K31/138 , A61K31/40 , A61K31/445 , A61K31/55 , C07C233/60 , C07C233/65 , C07C233/75 , C07C233/84 , C07C235/38 , C07C235/56 , C07C235/66 , C07C251/48 , C07C255/57 , C07C311/29 , C07C2601/14 , C07D221/12 , C07D265/34 , Y02A50/402 , Y02A50/411 , Y02A50/414 , Y02A50/423
摘要: The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.
摘要翻译: 本发明涉及新型选择性雌激素受体调节剂(SERM)。 SERM化合物可用于预防和/或治疗各种疾病和病症,包括预防和治疗诸如前列腺和乳腺癌,骨质疏松症,激素相关疾病,潮热或血管舒缩症状,神经系统疾病, 心血管疾病和肥胖。
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公开(公告)号:US20070265296A1
公开(公告)日:2007-11-15
申请号:US11785251
申请日:2007-04-16
申请人: James Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane Miller , Michael Mohler , Ramesh Narayanan , Zhongzhi Wu
发明人: James Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane Miller , Michael Mohler , Ramesh Narayanan , Zhongzhi Wu
IPC分类号: A61K31/167 , A61K31/136 , A61K31/192 , A61K31/445 , A61P19/00 , A61P19/10 , A61P3/00 , A61P35/00 , A61P37/00 , A61P5/00 , C07C211/54 , C07C233/11 , C07C63/00 , C07D211/00 , C07D221/12
CPC分类号: A61K31/138 , A61K31/40 , A61K31/445 , A61K31/55 , C07D221/12
摘要: The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.
摘要翻译: 本发明涉及新型选择性雌激素受体调节剂(SERM)。 SERM化合物可用于预防和/或治疗各种疾病和病症,包括预防和治疗诸如前列腺和乳腺癌,骨质疏松症,激素相关疾病,潮热或血管舒缩症状,神经系统疾病, 心血管疾病和肥胖。
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公开(公告)号:US08637706B2
公开(公告)日:2014-01-28
申请号:US13362242
申请日:2012-01-31
申请人: James T. Dalton , Christina Barrett , Duane D. Miller , Seoung-Soo Hong , Yali He , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
发明人: James T. Dalton , Christina Barrett , Duane D. Miller , Seoung-Soo Hong , Yali He , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
IPC分类号: C07C233/65 , A61K31/165
CPC分类号: A61K31/138 , A61K31/40 , A61K31/445 , A61K31/55 , C07C233/60 , C07C233/65 , C07C233/75 , C07C233/84 , C07C235/38 , C07C235/56 , C07C235/66 , C07C251/48 , C07C255/57 , C07C311/29 , C07C2601/14 , C07D221/12 , C07D265/34 , Y02A50/402 , Y02A50/411 , Y02A50/414 , Y02A50/423
摘要: The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.
摘要翻译: 本发明涉及新型选择性雌激素受体调节剂(SERM)。 SERM化合物可用于预防和/或治疗各种疾病和病症,包括预防和治疗诸如前列腺和乳腺癌,骨质疏松症,激素相关疾病,潮热或血管舒缩症状,神经系统疾病, 心血管疾病和肥胖。
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公开(公告)号:US20090062341A1
公开(公告)日:2009-03-05
申请号:US11604884
申请日:2006-11-28
申请人: James T. Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane D. Miller , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
发明人: James T. Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane D. Miller , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
IPC分类号: A61K31/4545 , C07C233/64 , A61K31/166 , A61K31/445 , C07D401/02 , C07K14/72 , C07D211/60 , C07D213/81 , A61K31/44
CPC分类号: A61K31/138 , A61K31/40 , A61K31/445 , A61K31/55 , C07D221/12
摘要: The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.
摘要翻译: 本发明涉及新型选择性雌激素受体调节剂(SERM)。 SERM化合物可用于预防和/或治疗各种疾病和病症,包括预防和治疗诸如前列腺和乳腺癌,骨质疏松症,激素相关疾病,潮热或血管舒缩症状,神经系统疾病, 心血管疾病和肥胖。
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公开(公告)号:US5882203A
公开(公告)日:1999-03-16
申请号:US456031
申请日:1995-05-31
IPC分类号: G09B19/00
CPC分类号: G06F19/363
摘要: The present invention relates to a method of detecting depression and its severity. A series of statements formulated to detect the presence and severity of depression are presented to the subject in a multiple item visual analog format. The subject's answers are given a numerical value. The total score is then normatively ranked to determine the presence and severity of the depression.
摘要翻译: 本发明涉及一种检测抑郁症及其严重程度的方法。 为了检测抑郁症的存在和严重程度而制定的一系列陈述以多项视觉模拟形式呈现给主题。 主题的答案给出一个数值。 总分数然后被规范排列,以确定抑郁症的存在和严重程度。
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公开(公告)号:US08158828B2
公开(公告)日:2012-04-17
申请号:US11785251
申请日:2007-04-16
申请人: James T. Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane D. Miller , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
发明人: James T. Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane D. Miller , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
IPC分类号: C07C233/65 , A61K31/165
CPC分类号: A61K31/138 , A61K31/40 , A61K31/445 , A61K31/55 , C07D221/12
摘要: The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.
摘要翻译: 本发明涉及新型选择性雌激素受体调节剂(SERM)。 SERM化合物可用于预防和/或治疗各种疾病和病症,包括预防和治疗诸如前列腺和乳腺癌,骨质疏松症,激素相关疾病,潮热或血管舒缩症状,神经系统疾病, 心血管疾病和肥胖。
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公开(公告)号:US20050209320A1
公开(公告)日:2005-09-22
申请号:US10963991
申请日:2004-10-14
IPC分类号: A61K20060101 , A61K31/165 , A61K31/277 , A61K31/325 , A61K39/395 , C07C235/24 , C07C255/60 , C07C271/24 , C07C309/87 , C07C317/40 , C07C323/60 , C07D207/448 , C07F9/09
CPC分类号: C07D207/448 , C07C215/76 , C07C235/16 , C07C235/24 , C07C255/60 , C07C271/24 , C07C309/87 , C07C317/46 , C07C323/60 , C07D233/74
摘要: The present invention relates to a novel class of anti-cancer compounds which selectively target androgen receptor (AR)-expressing cancer cells, such as prostate cancer cells and breast cancer cells. These agents comprise an androgen receptor (AR) binding moiety, which selectively targets the compounds to (AR)-expressing cancer cells, and a cytotoxic ablating moiety, such as a nitrogen mustard moiety. The inherent high density expression of the androgen receptor in certain cancers, such as prostate cancer and breast cancer, is thus used as a tool to selectively increase the intracellular concentration of cytotoxic compounds, such as alkylating agents, e.g. DNA alkylating agents, by selectively targeting the agents to the AR-expressing cancer cells. These agents, either alone or in a composition, are thus useful for treating, delaying the progression of, treating the recurrence of, suppressing, inhibiting or reducing the incidence of cancers characterized by the presence of AR-expressing cells, such as prostate cancer. Accordingly, the present invention provides a) methods of selectively killing an (AR)-expressing cancer cell; b) methods of inducing apoptosis in an (AR)-expressing cancer cell; c) methods of treating a cancer characterized by the presence of AR-expressing cells in a subject; d) methods of delaying the progression of a cancer characterized by the presence of AR-expressing cells in a subject; e) methods of treating the recurrence of a cancer characterized by the presence of AR-expressing cells in a subject; f) methods of suppressing, inhibiting or reducing the incidence of a cancer characterized by the presence of AR-expressing cells in a subject; and g) methods of treating metastasis of a cancer characterized by the presence of AR-expressing cells in a subject; by administering to the subject or by contacting the cancer cells with a compound comprising an androgen receptor ligand moiety and an alkylating moiety, such as the novel compounds described herein.
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