利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.045 秒)

    Anti-cancer compounds and methods of use thereof
    5.
    发明申请
    Anti-cancer compounds and methods of use thereof 审中-公开

    公开(公告)号：US20050209320A1

    公开(公告)日：2005-09-22

    申请号：US10963991

    申请日：2004-10-14

    申请人： Duane Miller ,  Mitchell Steiner ,  Karen Veverka ,  Christina Barrett ,  Seoungsoo Hong

    发明人： Duane Miller ,  Mitchell Steiner ,  Karen Veverka ,  Christina Barrett ,  Seoungsoo Hong

    IPC分类号： A61K20060101 ,  A61K31/165 ,  A61K31/277 ,  A61K31/325 ,  A61K39/395 ,  C07C235/24 ,  C07C255/60 ,  C07C271/24 ,  C07C309/87 ,  C07C317/40 ,  C07C323/60 ,  C07D207/448 ,  C07F9/09

    CPC分类号： C07D207/448 ,  C07C215/76 ,  C07C235/16 ,  C07C235/24 ,  C07C255/60 ,  C07C271/24 ,  C07C309/87 ,  C07C317/46 ,  C07C323/60 ,  C07D233/74

    摘要： The present invention relates to a novel class of anti-cancer compounds which selectively target androgen receptor (AR)-expressing cancer cells, such as prostate cancer cells and breast cancer cells. These agents comprise an androgen receptor (AR) binding moiety, which selectively targets the compounds to (AR)-expressing cancer cells, and a cytotoxic ablating moiety, such as a nitrogen mustard moiety. The inherent high density expression of the androgen receptor in certain cancers, such as prostate cancer and breast cancer, is thus used as a tool to selectively increase the intracellular concentration of cytotoxic compounds, such as alkylating agents, e.g. DNA alkylating agents, by selectively targeting the agents to the AR-expressing cancer cells. These agents, either alone or in a composition, are thus useful for treating, delaying the progression of, treating the recurrence of, suppressing, inhibiting or reducing the incidence of cancers characterized by the presence of AR-expressing cells, such as prostate cancer. Accordingly, the present invention provides a) methods of selectively killing an (AR)-expressing cancer cell; b) methods of inducing apoptosis in an (AR)-expressing cancer cell; c) methods of treating a cancer characterized by the presence of AR-expressing cells in a subject; d) methods of delaying the progression of a cancer characterized by the presence of AR-expressing cells in a subject; e) methods of treating the recurrence of a cancer characterized by the presence of AR-expressing cells in a subject; f) methods of suppressing, inhibiting or reducing the incidence of a cancer characterized by the presence of AR-expressing cells in a subject; and g) methods of treating metastasis of a cancer characterized by the presence of AR-expressing cells in a subject; by administering to the subject or by contacting the cancer cells with a compound comprising an androgen receptor ligand moiety and an alkylating moiety, such as the novel compounds described herein.