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公开(公告)号：US20070265296A1
公开(公告)日：2007-11-15
申请号：US11785251
申请日：2007-04-16
申请人： James Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane Miller , Michael Mohler , Ramesh Narayanan , Zhongzhi Wu
发明人： James Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane Miller , Michael Mohler , Ramesh Narayanan , Zhongzhi Wu
IPC分类号： A61K31/167 , A61K31/136 , A61K31/192 , A61K31/445 , A61P19/00 , A61P19/10 , A61P3/00 , A61P35/00 , A61P37/00 , A61P5/00 , C07C211/54 , C07C233/11 , C07C63/00 , C07D211/00 , C07D221/12
CPC分类号： A61K31/138 , A61K31/40 , A61K31/445 , A61K31/55 , C07D221/12
摘要： The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.
摘要翻译： 本发明涉及新型选择性雌激素受体调节剂（SERM）。 SERM化合物可用于预防和/或治疗各种疾病和病症，包括预防和治疗诸如前列腺和乳腺癌，骨质疏松症，激素相关疾病，潮热或血管舒缩症状，神经系统疾病， 心血管疾病和肥胖。
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公开(公告)号：US08158828B2
公开(公告)日：2012-04-17
申请号：US11785251
申请日：2007-04-16
申请人： James T. Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane D. Miller , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
发明人： James T. Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane D. Miller , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
IPC分类号： C07C233/65 , A61K31/165
CPC分类号： A61K31/138 , A61K31/40 , A61K31/445 , A61K31/55 , C07D221/12
摘要： The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.
摘要翻译： 本发明涉及新型选择性雌激素受体调节剂（SERM）。 SERM化合物可用于预防和/或治疗各种疾病和病症，包括预防和治疗诸如前列腺和乳腺癌，骨质疏松症，激素相关疾病，潮热或血管舒缩症状，神经系统疾病， 心血管疾病和肥胖。
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公开(公告)号：US08637706B2
公开(公告)日：2014-01-28
申请号：US13362242
申请日：2012-01-31
申请人： James T. Dalton , Christina Barrett , Duane D. Miller , Seoung-Soo Hong , Yali He , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
发明人： James T. Dalton , Christina Barrett , Duane D. Miller , Seoung-Soo Hong , Yali He , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
IPC分类号： C07C233/65 , A61K31/165
CPC分类号： A61K31/138 , A61K31/40 , A61K31/445 , A61K31/55 , C07C233/60 , C07C233/65 , C07C233/75 , C07C233/84 , C07C235/38 , C07C235/56 , C07C235/66 , C07C251/48 , C07C255/57 , C07C311/29 , C07C2601/14 , C07D221/12 , C07D265/34 , Y02A50/402 , Y02A50/411 , Y02A50/414 , Y02A50/423
摘要： The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.
摘要翻译： 本发明涉及新型选择性雌激素受体调节剂（SERM）。 SERM化合物可用于预防和/或治疗各种疾病和病症，包括预防和治疗诸如前列腺和乳腺癌，骨质疏松症，激素相关疾病，潮热或血管舒缩症状，神经系统疾病， 心血管疾病和肥胖。
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公开(公告)号：US20090062341A1
公开(公告)日：2009-03-05
申请号：US11604884
申请日：2006-11-28
申请人： James T. Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane D. Miller , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
发明人： James T. Dalton , Christina Barrett , Yali He , Seoung-Soo Hong , Duane D. Miller , Michael L. Mohler , Ramesh Narayanan , Zhongzhi Wu
IPC分类号： A61K31/4545 , C07C233/64 , A61K31/166 , A61K31/445 , C07D401/02 , C07K14/72 , C07D211/60 , C07D213/81 , A61K31/44
CPC分类号： A61K31/138 , A61K31/40 , A61K31/445 , A61K31/55 , C07D221/12
摘要： The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.
摘要翻译： 本发明涉及新型选择性雌激素受体调节剂（SERM）。 SERM化合物可用于预防和/或治疗各种疾病和病症，包括预防和治疗诸如前列腺和乳腺癌，骨质疏松症，激素相关疾病，潮热或血管舒缩症状，神经系统疾病， 心血管疾病和肥胖。
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公开(公告)号：US09078888B2
公开(公告)日：2015-07-14
申请号：US12010225
申请日：2008-01-22
申请人： James T. Dalton , Duane D. Miller , Michael L. Mohler , Seoung-Soo Hong , Zhongzhi Wu , Devesh Srivastava
发明人： James T. Dalton , Duane D. Miller , Michael L. Mohler , Seoung-Soo Hong , Zhongzhi Wu , Devesh Srivastava
IPC分类号： A61K31/47 , A61K31/472 , C07D217/22 , C07D217/24
CPC分类号： A61K31/472 , C07D217/22 , C07D217/24 , Y02A50/463
摘要： The present invention relates to a novel class of nuclear receptor binding agents (NRBAs). The NRBAs are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, inflammatory diseases, oxidative stress related disorders such as Parkinson's and stroke, neurological disorders, ophthalamic disorders, cardiovascular disease, and obesity.
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公开(公告)号：US20090030036A1
公开(公告)日：2009-01-29
申请号：US12010225
申请日：2008-01-22
申请人： James T. Dalton , Duane D. Miller , Michael L. Mohler , Seoung-Soo Hong , Zhongzhi Wu , Devesh Srivastava
发明人： James T. Dalton , Duane D. Miller , Michael L. Mohler , Seoung-Soo Hong , Zhongzhi Wu , Devesh Srivastava
IPC分类号： A61K31/47 , C07D217/00 , A61P25/00 , A61P9/00
CPC分类号： A61K31/472 , C07D217/22 , C07D217/24 , Y02A50/463
摘要： The present invention relates to a novel class of nuclear receptor binding agents (NRBAs). The NRBAs are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, inflammatory diseases, oxidative stress related disorders such as Parkinson's and stroke, neurological disorders, ophthalamic disorders, cardiovascular disease, and obesity.
摘要翻译： 本发明涉及一类新的核受体结合剂（NRBAs）。 NRBAs适用于预防和/或治疗各种疾病和病症，包括预防和治疗前列腺癌和乳腺癌等癌症，骨质疏松症，激素相关疾病，炎性疾病，氧化应激相关疾病如帕金森病 和中风，神经障碍，眼科疾病，心血管疾病和肥胖。
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公开(公告)号：US20110263703A1
公开(公告)日：2011-10-27
申请号：US13153427
申请日：2011-06-05
申请人： James T. Dalton , David A. Dickason , Seoung-Soo Hong , Thomas G. Bird , Tai Ahn
发明人： James T. Dalton , David A. Dickason , Seoung-Soo Hong , Thomas G. Bird , Tai Ahn
IPC分类号： A61K31/277 , A61P5/00 , C07C255/51
CPC分类号： A61K31/277 , C07C253/30 , C07C255/60
摘要： The present invention relates to solid forms of (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide and process for producing the same.
摘要翻译： 本发明涉及（S）-N-（4-氰基-3-（三氟甲基）苯基）-3-（4-氰基苯氧基）-2-羟基-2-甲基丙酰胺的固体形式及其制备方法。
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公开(公告)号：US08563606B2
公开(公告)日：2013-10-22
申请号：US13153427
申请日：2011-06-05
申请人： James T. Dalton , David A. Dickason , Seoung-Soo Hong , Thomas G. Bird , Tai Ahn
发明人： James T. Dalton , David A. Dickason , Seoung-Soo Hong , Thomas G. Bird , Tai Ahn
IPC分类号： A61K31/277 , A61P5/00 , C07C255/51
CPC分类号： A61K31/277 , C07C253/30 , C07C255/60
摘要： The present invention relates to solid forms of (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide and process for producing the same.
摘要翻译： 本发明涉及（S）-N-（4-氰基-3-（三氟甲基）苯基）-3-（4-氰基苯氧基）-2-羟基-2-甲基丙酰胺的固体形式及其制备方法。
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公开(公告)号：US07968603B2
公开(公告)日：2011-06-28
申请号：US12228100
申请日：2008-09-29
申请人： James T. Dalton , David A. Dickason , Seoung-Soo Hong , Thomas G. Bird , Tai Ahn
发明人： James T. Dalton , David A. Dickason , Seoung-Soo Hong , Thomas G. Bird , Tai Ahn
IPC分类号： A61K31/165 , A61P5/26 , C07C237/14
CPC分类号： A61K31/277 , C07C253/30 , C07C255/60
摘要： The present invention relates to solid forms of (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide and process for producing the same.
摘要翻译： 本发明涉及（S）-N-（4-氰基-3-（三氟甲基）苯基）-3-（4-氰基苯氧基）-2-羟基-2-甲基丙酰胺的固体形式及其制备方法。
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公开(公告)号：US20100022641A1
公开(公告)日：2010-01-28
申请号：US12228100
申请日：2008-09-29
申请人： James T. Dalton , David A. Dickason , Seoung-Soo Hong , Thomas G. Bird , Tai Ahn
发明人： James T. Dalton , David A. Dickason , Seoung-Soo Hong , Thomas G. Bird , Tai Ahn
IPC分类号： A61K31/277 , C07C255/50 , A61P5/26
CPC分类号： A61K31/277 , C07C253/30 , C07C255/60
摘要： The present invention relates to solid forms of (S)—N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide and process for producing the same.
摘要翻译： 本发明涉及（S）-N-（4-氰基-3-（三氟甲基）苯基）-3-（4-氰基苯氧基）-2-羟基-2-甲基丙酰胺的固体形式及其制备方法。
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