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公开(公告)号：US20130014528A1
公开(公告)日：2013-01-17
申请号：US13560647
申请日：2012-07-27
申请人： Halina Stabacinskiene , Jeffrey J. Gronsky , Christine M. Thomas , Pushkarraj V. Deshmukh , Alan C. Robins , Paul E. Fischione
发明人： Halina Stabacinskiene , Jeffrey J. Gronsky , Christine M. Thomas , Pushkarraj V. Deshmukh , Alan C. Robins , Paul E. Fischione
IPC分类号： F25B49/00
CPC分类号： G01N23/20033 , B01L7/50 , G01N2223/612 , H01J37/20 , H01J37/26 , H01J2237/0216 , H01J2237/2001 , H01J2237/20207 , H01J2237/204
摘要： An improved cryogenic specimen holder for imaging and analysis facilitates imaging at very high tilt angles with a large field of view. A retractable specimen holder tip protects the specimen during transport. An optimized Dewar design is positioned at a fixed, tilted angle with respect to the axis of the holder, providing a means of continuously cooling the specimen irrespective of the high tilt angle and amount of liquid nitrogen present in the vessel. The Dewar neck design reduces entrapment of nitrogen gas bubbles and its shape prevents the spilling of liquid nitrogen at high tilt angles. The specimen holder has a retractable tip that completely encapsulates the specimen within a shielded environment internal to the specimen holder body. The cooling and specimen transfer mechanisms reduce thermal drift and the detrimental effects of vibrations generated by both the evaporation of liquid nitrogen present in the Dewar and other environmental effects.
摘要翻译： 用于成像和分析的改进的低温试样保持器便于在具有大视场的非常高的倾斜角下进行成像。 可伸缩的样品架头在运输过程中保护样品。 优化的杜瓦设计相对于保持器的轴线定位成固定的倾斜角度，提供连续冷却样品的手段，而不管存在于容器中的高的倾斜角和液氮量。 杜瓦瓶颈设计减少了氮气气泡的夹带，其形状可以防止液氮在高倾角下溢出。 样品架具有可收缩的尖端，其将样品完全包封在样品保持体内部的屏蔽环境内。 冷却和样品转移机制降低了热漂移和由杜瓦瓶中存在的液氮蒸发和其他环境影响产生的振动的不利影响。
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公开(公告)号：US08336405B2
公开(公告)日：2012-12-25
申请号：US12845486
申请日：2010-07-28
申请人： Halina Stabacinskiene , Jeffrey J. Gronsky , Christine M. Thomas , Pushkarraj V. Deshmukh , Alan C. Robins , Paul E. Fischione
发明人： Halina Stabacinskiene , Jeffrey J. Gronsky , Christine M. Thomas , Pushkarraj V. Deshmukh , Alan C. Robins , Paul E. Fischione
CPC分类号： G01N23/20033 , H01J37/20 , H01J37/26 , H01J2237/2001 , H01J2237/20207 , H01J2237/204
摘要： An improved cryogenic specimen holder for imaging and analysis facilitates imaging at very high tilt angles with a large field of view. A retractable specimen holder tip protects the specimen during transport. An optimized Dewar design is positioned at a fixed, tilted angle with respect to the axis of the holder, providing a means of continuously cooling the specimen irrespective of the high tilt angle and the amount of liquid nitrogen present in the vessel. The Dewar neck design reduces the entrapment of nitrogen gas bubbles and its shape prevents the spilling of liquid nitrogen at high tilt angles. The specimen holder has a retractable tip that completely encapsulates the specimen within a shielded environment internal to the specimen holder body. The cooling and specimen transfer mechanisms reduce thermal drift and the detrimental effects of vibrations generated by both the evaporation of liquid nitrogen present in the Dewar as well as other environmental effects.
摘要翻译： 用于成像和分析的改进的低温试样保持器便于在具有大视场的非常高的倾斜角下进行成像。 可伸缩的样品架头在运输过程中保护样品。 优化的杜瓦设计相对于保持器的轴线定位成固定的倾斜角度，提供连续冷却样品的手段，而不管存在于容器中的高倾斜角和液氮量。 杜瓦瓶颈设计减少了氮气气泡的夹带，其形状可以防止液氮在高倾角下溢出。 样品架具有可收缩的尖端，其将样品完全包封在样品保持体内部的屏蔽环境内。 冷却和样品转移机制减少了热漂移和杜瓦瓶中存在的液氮蒸发产生的振动的不利影响以及其他环境影响。
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公开(公告)号：US07003072B2
公开(公告)日：2006-02-21
申请号：US10498951
申请日：2002-12-18
IPC分类号： A61B6/00
CPC分类号： A61B6/12 , A61B6/4028 , G01S5/166
摘要： A method for localizing a target (e.g., a tumor) in an object (e.g. human tissue) by scanning the object with an X-ray beam. The X-ray beam is translated and simultaneously rotated during the scan, the translatory and rotational movements being connected in such a way that the shadow image of the target is kept on the surface of a detector during the scan. In this way it is possible to measure the translation d of that image during the scan. From the translation in combination with the translation D and the rotation during the scan, the height of the target 2 above the detector surface 10 may be calculated. In this way only one scan is needed.
摘要翻译： 通过用X射线束扫描物体来定位物体（例如人体组织）中的靶（例如肿瘤）的方法。 在扫描期间，X射线束被平移并且同时旋转，平移和旋转运动以这样的方式连接，使得在扫描期间靶的阴影图像保持在检测器的表面上。 以这种方式，可以在扫描期间测量该图像的平移d。 从平移D和扫描期间的旋转的平移中可以计算出探测器表面10上方的目标2的高度。 这样只需要一次扫描。
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公开(公告)号：US20120024086A1
公开(公告)日：2012-02-02
申请号：US12845486
申请日：2010-07-28
申请人： Halina Stabacinskiene , Jeffrey J. Gronsky , Christine M. Thomas , Pushkarraj V. Deshmukh , Alan C. Robins , Paul E. Fischione
发明人： Halina Stabacinskiene , Jeffrey J. Gronsky , Christine M. Thomas , Pushkarraj V. Deshmukh , Alan C. Robins , Paul E. Fischione
IPC分类号： B01L3/00
CPC分类号： G01N23/20033 , H01J37/20 , H01J37/26 , H01J2237/2001 , H01J2237/20207 , H01J2237/204
摘要： An improved cryogenic specimen holder for imaging and analysis facilitates imaging at very high tilt angles with a large field of view. A retractable specimen holder tip protects the specimen during transport. An optimized Dewar design is positioned at a fixed, tilted angle with respect to the axis of the holder, providing a means of continuously cooling the specimen irrespective of the high tilt angle and the amount of liquid nitrogen present in the vessel. The Dewar neck design reduces the entrapment of nitrogen gas bubbles and its shape prevents the spilling of liquid nitrogen at high tilt angles. The specimen holder has a retractable tip that completely encapsulates the specimen within a shielded environment internal to the specimen holder body. The cooling and specimen transfer mechanisms reduce thermal drift and the detrimental effects of vibrations generated by both the evaporation of liquid nitrogen present in the Dewar as well as other environmental effects.
摘要翻译： 用于成像和分析的改进的低温试样保持器便于在具有大视场的非常高的倾斜角下进行成像。 可伸缩的样品架头在运输过程中保护样品。 优化的杜瓦设计相对于保持器的轴线定位成固定的倾斜角度，提供连续冷却样品的手段，而不管存在于容器中的高倾斜角和液氮量。 杜瓦瓶颈设计减少了氮气气泡的夹带，其形状可以防止液氮在高倾角下溢出。 样品架具有可收缩的尖端，其将样品完全包封在样品保持体内部的屏蔽环境内。 冷却和样品转移机制减少了热漂移和杜瓦瓶中存在的液氮蒸发产生的振动的不利影响以及其他环境影响。
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公开(公告)号：US09010202B2
公开(公告)日：2015-04-21
申请号：US13560647
申请日：2012-07-27
申请人： Halina Stabacinskiene , Jeffrey J. Gronsky , Christine M. Thomas , Pushkarraj V. Deshmukh , Alan C. Robins , Paul E. Fischione
发明人： Halina Stabacinskiene , Jeffrey J. Gronsky , Christine M. Thomas , Pushkarraj V. Deshmukh , Alan C. Robins , Paul E. Fischione
CPC分类号： G01N23/20033 , B01L7/50 , G01N2223/612 , H01J37/20 , H01J37/26 , H01J2237/0216 , H01J2237/2001 , H01J2237/20207 , H01J2237/204
摘要： An improved cryogenic specimen holder for imaging and analysis facilitates imaging at very high tilt angles with a large field of view. A retractable specimen holder tip protects the specimen during transport. An optimized Dewar design is positioned at a fixed, tilted angle with respect to the axis of the holder, providing a means of continuously cooling the specimen irrespective of the high tilt angle and amount of liquid nitrogen present in the vessel. The Dewar neck design reduces entrapment of nitrogen gas bubbles and its shape prevents the spilling of liquid nitrogen at high tilt angles. The specimen holder has a retractable tip that completely encapsulates the specimen within a shielded environment internal to the specimen holder body. The cooling and specimen transfer mechanisms reduce thermal drift and the detrimental effects of vibrations generated by both the evaporation of liquid nitrogen present in the Dewar and other environmental effects.
摘要翻译： 用于成像和分析的改进的低温试样保持器便于在具有大视场的非常高的倾斜角下进行成像。 可伸缩的样品架头在运输过程中保护样品。 优化的杜瓦设计相对于保持器的轴线定位成固定的倾斜角度，提供连续冷却样品的手段，而不管存在于容器中的高的倾斜角和液氮量。 杜瓦瓶颈设计减少了氮气气泡的夹带，其形状可以防止液氮在高倾角下溢出。 样品架具有可收缩的尖端，其将样品完全包封在样品保持体内部的屏蔽环境内。 冷却和样品转移机制降低了热漂移和由杜瓦瓶中存在的液氮蒸发和其他环境影响产生的振动的不利影响。
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