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    Small molecule Bcl-Xl/Bcl-2 binding inhibitors
    4.
    发明授权
    Small molecule Bcl-Xl/Bcl-2 binding inhibitors 失效
    小分子Bcl-X1 / Bcl-2结合抑制剂

    公开(公告)号：US08309582B2

    公开(公告)日：2012-11-13

    申请号：US12652456

    申请日：2010-01-05

    申请人： Ching-Shih Chen ,  Chung-Wai Shiau

    发明人： Ching-Shih Chen ,  Chung-Wai Shiau

    IPC分类号： A01N43/40 ,  A01N43/78 ,  A01N43/80 ,  A61K31/44 ,  A61K31/425 ,  C07D277/00

    CPC分类号： C07D417/12 ,  C07D277/34 ,  C07D311/58 ,  C07D417/14

    摘要： Bcl-xL/Bcl-2 binding inhibitors useful in the treatment of unwanted proliferating cells, including cancers and precancers, in subjects in need of such treatment. Also provided are methods of treating a subject having unwanted proliferating cells comprising administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject in need of such treatment. Also provided are methods of preventing the proliferation of unwanted proliferating cells, such as cancers and precancers, in a subject comprising the step of administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject at risk of developing a condition characterized by unwanted proliferating cells.

    摘要翻译： Bcl-xL / Bcl-2结合抑制剂可用于治疗需要这种治疗的受试者中不需要的增殖细胞，包括癌症和预处理剂。 还提供了治疗具有不想要的增殖细胞的受试者的方法，包括向需要这种治疗的受试者施用治疗有效量的本文所述的Bcl-xL / Bcl-2结合抑制剂。 还提供了防止不想要的增殖细胞如癌症和预处理剂在受试者中增殖的方法，包括将治疗有效量的本文所述的Bcl-xL / Bcl-2结合抑制剂施用于患有风险的受试者的步骤 发展以不想要的增殖细胞为特征的病症。

    SMALL MOLECULE BCL-X1/BCL-2 BINDING INHIBITORS
    9.
    发明申请
    SMALL MOLECULE BCL-X1/BCL-2 BINDING INHIBITORS 失效
    小分子BCL-X1 / BCL-2结合抑制剂

    公开(公告)号：US20100168184A1

    公开(公告)日：2010-07-01

    申请号：US12652456

    申请日：2010-01-05

    申请人： Ching-Shih Chen ,  Chung-Wai Shiau

    发明人： Ching-Shih Chen ,  Chung-Wai Shiau

    IPC分类号： A61K31/352 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/426 ,  A61P35/00

    CPC分类号： C07D417/12 ,  C07D277/34 ,  C07D311/58 ,  C07D417/14

    摘要： Bcl-xL/Bcl-2 binding inhibitors useful in the treatment of unwanted proliferating cells, including cancers and precancers, in subjects in need of such treatment. Also provided are methods of treating a subject having unwanted proliferating cells comprising administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject in need of such treatment. Also provided are methods of preventing the proliferation of unwanted proliferating cells, such as cancers and precancers, in a subject comprising the step of administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject at risk of developing a condition characterized by unwanted proliferating cells.

    摘要翻译： Bcl-xL / Bcl-2结合抑制剂可用于治疗需要这种治疗的受试者中不需要的增殖细胞，包括癌症和预处理剂。 还提供了治疗具有不想要的增殖细胞的受试者的方法，包括向需要这种治疗的受试者施用治疗有效量的本文所述的Bcl-xL / Bcl-2结合抑制剂。 还提供了防止不想要的增殖细胞如癌症和预处理剂在受试者中增殖的方法，包括将治疗有效量的本文所述的Bcl-xL / Bcl-2结合抑制剂施用于患有风险的受试者的步骤 发展以不想要的增殖细胞为特征的病症。