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公开(公告)号：US07641909B2
公开(公告)日：2010-01-05
申请号：US11506251
申请日：2006-08-18
申请人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
发明人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
IPC分类号： A61K39/00 , A61K39/13 , A61K39/295 , C12N15/63
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural protein genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
摘要翻译： 提供无毒和免疫原性的嵌合黄病毒。 构建嵌合病毒以在黄病毒的非结构蛋白中含有氨基酸突变。 含有病毒衰减突变非结构基因的嵌合病毒被用作插入第二种黄病毒毒株的结构蛋白基因的骨架。 这些嵌合病毒引起显着的免疫原性，但缺乏伴随的病毒性疾病的临床症状。 减毒的嵌合病毒作为免疫原或疫苗是有效的，并且可以在药物组合物中组合以赋予多种病原性黄病毒的同时免疫。
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公开(公告)号：US20100255030A1
公开(公告)日：2010-10-07
申请号：US12607746
申请日：2009-10-28
申请人： Richard M. Kinney , Claire Y.H. Kinney , Siritorn Butrapet , Duane J. Gubler , Natth Bhamarapravati
发明人： Richard M. Kinney , Claire Y.H. Kinney , Siritorn Butrapet , Duane J. Gubler , Natth Bhamarapravati
IPC分类号： A61K39/295 , C07H21/04 , A61K31/7088 , A61K39/12 , A61K39/29 , A61P31/12
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
摘要翻译： 提供无毒和免疫原性的嵌合黄病毒。 构建嵌合病毒以在黄病毒的非结构病毒蛋白中含有氨基酸突变。 含有病毒的衰减突变非结构基因的嵌合病毒被用作插入第二种黄病毒毒株的结构基因的主链。 这些嵌合病毒引起显着的免疫原性，但缺乏伴随的病毒性疾病的临床症状。 减毒的嵌合病毒作为免疫原或疫苗是有效的，并且可以在药物组合物中组合以赋予多种病原性黄病毒的同时免疫。
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公开(公告)号：US20120014981A1
公开(公告)日：2012-01-19
申请号：US13212845
申请日：2011-08-18
申请人： Richard M. Kinney , Claire Y.H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
发明人： Richard M. Kinney , Claire Y.H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
IPC分类号： A61K39/295 , A61P31/14 , A61K39/12
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
摘要翻译： 提供无毒和免疫原性的嵌合黄病毒。 构建嵌合病毒以在黄病毒的非结构病毒蛋白中含有氨基酸突变。 含有病毒的衰减突变非结构基因的嵌合病毒被用作插入第二种黄病毒毒株的结构基因的主链。 这些嵌合病毒引起显着的免疫原性，但缺乏伴随的病毒性疾病的临床症状。 减毒的嵌合病毒作为免疫原或疫苗是有效的，并且可以在药物组合物中组合以赋予多种病原性黄病毒的同时免疫。
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公开(公告)号：US08673316B2
公开(公告)日：2014-03-18
申请号：US13212845
申请日：2011-08-18
申请人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
发明人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
IPC分类号： A61K39/12 , A61K35/00 , A61K39/295 , C12N15/63
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
摘要翻译： 提供无毒和免疫原性的嵌合黄病毒。 构建嵌合病毒以在黄病毒的非结构病毒蛋白中含有氨基酸突变。 含有病毒的衰减突变非结构基因的嵌合病毒被用作插入第二种黄病毒毒株的结构基因的主链。 这些嵌合病毒引起显着的免疫原性，但缺乏伴随的病毒性疾病的临床症状。 减毒的嵌合病毒作为免疫原或疫苗是有效的，并且可以在药物组合物中组合以赋予多种病原性黄病毒的同时免疫。
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公开(公告)号：US08025887B2
公开(公告)日：2011-09-27
申请号：US12607746
申请日：2009-10-28
申请人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
发明人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
摘要翻译： 提供无毒和免疫原性的嵌合黄病毒。 构建嵌合病毒以在黄病毒的非结构病毒蛋白中含有氨基酸突变。 含有病毒的衰减突变非结构基因的嵌合病毒被用作插入第二种黄病毒毒株的结构基因的主链。 这些嵌合病毒引起显着的免疫原性，但缺乏伴随的病毒性疾病的临床症状。 减毒的嵌合病毒作为免疫原或疫苗是有效的，并且可以在药物组合物中组合以赋予多种病原性黄病毒的同时免疫。
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公开(公告)号：US20090010961A1
公开(公告)日：2009-01-08
申请号：US11506251
申请日：2006-08-18
申请人： Richard M. Kinney , Claire Y.H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
发明人： Richard M. Kinney , Claire Y.H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural protein genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
摘要翻译： 提供无毒和免疫原性的嵌合黄病毒。 构建嵌合病毒以在黄病毒的非结构蛋白中含有氨基酸突变。 含有病毒衰减突变非结构基因的嵌合病毒被用作插入第二种黄病毒毒株的结构蛋白基因的骨架。 这些嵌合病毒引起显着的免疫原性，但缺乏伴随的病毒性疾病的临床症状。 减毒的嵌合病毒作为免疫原或疫苗是有效的，并且可以在药物组合物中组合以赋予多种病原性黄病毒的同时免疫。
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公开(公告)号：US07094411B2
公开(公告)日：2006-08-22
申请号：US10204252
申请日：2001-02-16
申请人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
发明人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
IPC分类号： A61K39/12 , A61K35/00 , A61K39/295 , C07K14/18 , C12N15/63 , C12N15/11 , C12N15/14 , C12N15/09 , C12N15/10 , C07H21/02 , C07H21/04
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural protein genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
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公开(公告)号：US20060062803A1
公开(公告)日：2006-03-23
申请号：US10204252
申请日：2001-02-16
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural protein genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
摘要翻译： 提供无毒和免疫原性的嵌合黄病毒。 构建嵌合病毒以在黄病毒的非结构蛋白中含有氨基酸突变。 含有病毒衰减突变非结构基因的嵌合病毒被用作插入第二种黄病毒毒株的结构蛋白基因的骨架。 这些嵌合病毒引起显着的免疫原性，但缺乏伴随的病毒性疾病的临床症状。 减毒的嵌合病毒作为免疫原或疫苗是有效的，并且可以在药物组合物中组合以赋予多种病原性黄病毒的同时免疫。
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