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    Cryo sensitizing agents for the enhancement of cryotherapy
    2.
    发明授权
    Cryo sensitizing agents for the enhancement of cryotherapy 有权
    冷冻敏化剂用于加强冷冻治疗

    公开(公告)号：US09078636B2

    公开(公告)日：2015-07-14

    申请号：US13555221

    申请日：2012-07-23

    申请人： Claudia Lueckge ,  Ethel Rubin

    发明人： Claudia Lueckge ,  Ethel Rubin

    IPC分类号： A61B18/02 ,  A61B18/14

    CPC分类号： A61B18/02 ,  A61B18/148 ,  A61B2018/0293

    摘要： A method and device for treating tissue with temperature-sensitizing adjuvants to enhance the effects of ablation therapy. The method may comprise identifying tissue to receive ablation therapy, treating the tissue with a temperature-sensitizing agent, and activating an ablation therapy device proximate the treated tissue. The device may comprise a cryo-sensitizing adjuvant operable in association with a cryotherapy device, the cryo-sensitizing adjuvant enhancing the effectiveness of tissue destruction upon application of temperatures below 0° C.

    摘要翻译： 一种用温度敏化佐剂处理组织以增强消融治疗效果的方法和装置。 该方法可以包括识别组织以接受消融治疗，用温度敏化剂处理组织，以及激活靠近治疗组织的消融治疗装置。 该装置可以包括与冷冻治疗装置相关联的可操作的低温敏化佐剂，该低温敏化佐剂在施加低于0℃的温度时增强组织破坏的有效性。

    Cryosurgical linear ablation structure
    4.
    发明授权
    Cryosurgical linear ablation structure 失效
    冷冻线性消融结构

    公开(公告)号：US5899899A

    公开(公告)日：1999-05-04

    申请号：US893825

    申请日：1997-07-11

    申请人： Steven G. Arless ,  Fredric L. Milder ,  Kenneth A. Spector ,  Dan Wittenberger ,  Domenic N. Santoianni ,  Claudia Lueckge

    发明人： Steven G. Arless ,  Fredric L. Milder ,  Kenneth A. Spector ,  Dan Wittenberger ,  Domenic N. Santoianni ,  Claudia Lueckge

    IPC分类号： A61B17/00 ,  A61B18/00 ,  A61B18/02 ,  A61F7/02 ,  A61M25/00 ,  A61B17/36

    CPC分类号： A61B18/02 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00973 ,  A61B2018/00095 ,  A61B2018/0212 ,  A61F2007/0298 ,  A61M2025/0039 ,  A61M25/0029

    摘要： A cryogenic catheter includes a flexible member having an elongate, thermally-transmissive region and a cryogenic fluid path through the flexible member to the thermally-transmissive region. The thermally-transmissive region can be deformable from a linear configuration to an arcuate configuration and can include multiple thermally-transmissive elements having a first side exposed to the cryogenic fluid path and a second side exposed to points exterior to the flexible member. The thermally-transmissive elements can be rigid or flexible longitudinal strips. Alternatively, annular, cylindrical, or wedge-shaped metallic structures disposed in a spaced-apart relationship can define the thermally-transmissive region. In other embodiments the thermally-transmissive region is defined by a helical coil that is at least partially embedded in the flexible member. The helical coil can also define at least a portion of the cryogenic fluid path through the flexible member and include a gas expansion or boiling chamber.

    摘要翻译： 低温导管包括具有细长的热透射区域的柔性构件和通过柔性构件到达热传导区域的低温流体路径。 热传导区域可以从线性构造变形到弓形构造，并且可以包括具有暴露于低温流体路径的第一侧的多个热传递元件和暴露于柔性构件外部的点的第二侧。 透光元件可以是刚性或柔性的纵向条。 或者，以间隔开的关系设置的环形，圆柱形或楔形金属结构可以限定热传导区域。 在其它实施例中，热传导区域由至少部分地嵌入在柔性构件中的螺旋线圈限定。 螺旋线圈还可以限定通过柔性构件的低温流体路径的至少一部分，并且包括气体膨胀或沸腾室。

    DUAL INJECTION TUBE CRYOCATHETER AND METHOD FOR USING SAME
    6.
    发明申请
    DUAL INJECTION TUBE CRYOCATHETER AND METHOD FOR USING SAME 有权
    双注射管结晶器及其使用方法

    公开(公告)号：US20120029493A1

    公开(公告)日：2012-02-02

    申请号：US12844388

    申请日：2010-07-27

    申请人： Dan WITTENBERGER ,  Claudia LUECKGE ,  Miriam LANE

    发明人： Dan WITTENBERGER ,  Claudia LUECKGE ,  Miriam LANE

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00642 ,  A61B2018/0212 ,  A61B2090/064

    摘要： A medical device includes a catheter body having a first injection lumen, a second injection lumen, and an exhaust lumen, where the first injection lumen provides a fluid flow rate greater than a fluid flow rate provided by the second injection lumen; an expandable element coupled to the catheter body in fluid communication with the first and second injection lumens; a cryogenic fluid source in fluid communication with the first and second injection lumens; a valve in fluid communication with the first and second injection lumens to selectively allow fluid flow to at least one of the first and second injection lumens; a pressure sensor in fluid communication with an interior defined by the expandable element; and a controller in communication with the pressure sensor programmed to regulate fluid flow through the first injection lumen based at least in part on a signal from the pressure sensor.

    摘要翻译： 医疗装置包括具有第一注射腔，第二注射内腔和排气腔的导管主体，其中第一注射腔提供大于由第二注射腔提供的流体流速的流体流速; 耦合到所述导管主体的可扩张元件，其与所述第一和第二注射腔流体连通; 与所述第一和第二注射腔流体连通的低温流体源; 与所述第一和第二注射腔流体连通的阀，以选择性地允许流体流向所述第一和第二注射腔中的至少一个; 与由可膨胀元件限定的内部流体连通的压力传感器; 以及与所述压力传感器通信的控制器，其被编程为至少部分地基于来自所述压力传感器的信号来调节通过所述第一喷射腔的流体流动。

    Multi-Lumen Axial Cryogenic Connector
    7.
    发明申请
    Multi-Lumen Axial Cryogenic Connector 审中-公开
    多流明轴向低温连接器

    公开(公告)号：US20110225988A1

    公开(公告)日：2011-09-22

    申请号：US13050055

    申请日：2011-03-17

    申请人： John M. Baust ,  Claudia Lueckge ,  Roy Cheeks ,  Melissa K. Dobson ,  Anthony T. Robilotto

    发明人： John M. Baust ,  Claudia Lueckge ,  Roy Cheeks ,  Melissa K. Dobson ,  Anthony T. Robilotto

    IPC分类号： F17C13/00 ,  F16L39/00

    CPC分类号： F16L39/00 ,  A61B18/02 ,  A61B2018/00172 ,  F16L13/103 ,  F16L15/00 ,  F16L25/01 ,  F16L37/00 ,  F16L2201/44 ,  F17C7/02

    摘要： An embodiment of the invention is a cryo-connector, a connector that allows for the delivery and return of a cryogen in an axial configuration. In one embodiment, the connector is a tri-axial configuration allowing for the delivery and return of pressurized cryogen as well as the application of an independent vacuum in the third lumen. Various configurations, however, may accommodate any number of luminary spaces such that cryogen (or other fluids) and/or vacuum spaces may be created in a fashion complementary to the components that the connector will affix to and interconnect with. The connectors can be utilized with any low temperature, cryogenic device and at varying pressures.

    摘要翻译： 本发明的一个实施例是一种冷冻连接器，一种允许在轴向配置中输送和返回冷冻剂的连接器。 在一个实施例中，连接器是允许加压制冷剂的输送和返回以及在第三管腔中施加独立真空的三轴构造。 然而，各种配置可以容纳任何数量的发光空间，使得制冷剂（或其它流体）和/或真空空间可以以与连接器将固定到其上并与之相互连接的部件互补的方式产生。 连接器可以与任何低温，低温装置和变化的压力一起使用。

    Endovascular cryotreatment catheter
    8.
    发明授权
    Endovascular cryotreatment catheter 有权

    公开(公告)号：US06283959B1

    公开(公告)日：2001-09-04

    申请号：US09378972

    申请日：1999-08-23

    申请人： Jean Pierre Lalonde ,  Robert Martin ,  Claudia Lueckge ,  Leonilda Capuano ,  John W. Lehmann ,  Daniel Nahon

    发明人： Jean Pierre Lalonde ,  Robert Martin ,  Claudia Lueckge ,  Leonilda Capuano ,  John W. Lehmann ,  Daniel Nahon

    IPC分类号： A61B1818

    CPC分类号： A61B18/02 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

    摘要： A catheter is attached to an elongated catheter body adapted for endovascular insertion with a balloon assembly at its distal end. Coolant injected through the catheter body may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. A valve may regulate back pressure in the return passage to coordinate the flow of coolant into and out of the balloon so as to both inflate the balloon and achieve cryogenic cooling at the surface of the balloon. The coolant is biologically safe, and may be liquid carbon dioxide. Plural balloons may be provided adjacent the cooling segment, and one balloon may be shaped to treat the ostium of a vessel. Preferably, thermal conductivity of the balloon wall is enhanced by inclusion of thermally conductive material, such as metal, which may be introduced as a component of a composite elastomer material, or as a patterned metal layer that defines a pattern of thermally conductive treatment regions of the balloon surface. Patterns formed by printing, lithography or other means with copper, silver or other highly thermally conductive material enhance through-conduction characteristics of the wall so icing preferentially occurs to stimulate tissue destruction and vascular regeneration. Suitable patterns include spirals, dots, arrays of separated segments, or meandering curves which allow expansion of the balloon body without introducing delamination, localized stress cracking or separation of the balloon material. The conductive patterns may include patterns such as waffle-iron or other arrays of small lesions that are effective to treat the endovascular wall. When separate media are used for cooling and for balloon expansion, the cooling chamber may have a large diameter, and the balloon may form a thin shell or cuff. In that case, the balloon may be quickly inflated with a medium such as a saline to provide a quickly deployed and compliant contact structure of excellent conductivity.

    Dual injection tube cryocatheter and method for using same
    9.
    发明授权
    Dual injection tube cryocatheter and method for using same 有权

    公开(公告)号：US09931152B2

    公开(公告)日：2018-04-03

    申请号：US12844388

    申请日：2010-07-27

    申请人： Dan Wittenberger ,  Claudia Lueckge ,  Miriam Lane

    发明人： Dan Wittenberger ,  Claudia Lueckge ,  Miriam Lane

    IPC分类号： A61B18/02 ,  A61B18/00 ,  A61B90/00

    CPC分类号： A61B18/02 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00642 ,  A61B2018/0212 ,  A61B2090/064

    摘要： A medical device includes a catheter body having a first injection lumen, a second injection lumen, and an exhaust lumen, where the first injection lumen provides a fluid flow rate greater than a fluid flow rate provided by the second injection lumen; an expandable element coupled to the catheter body in fluid communication with the first and second injection lumens; a cryogenic fluid source in fluid communication with the first and second injection lumens; a valve in fluid communication with the first and second injection lumens to selectively allow fluid flow to at least one of the first and second injection lumens; a pressure sensor in fluid communication with an interior defined by the expandable element; and a controller in communication with the pressure sensor programmed to regulate fluid flow through the first injection lumen based at least in part on a signal from the pressure sensor.