公开(公告)号：US5155239A

公开(公告)日：1992-10-13

申请号：US731831

申请日：1991-07-16

申请人： Karl-Heinrich Schulte-Elte ,  Roger L. Snowden ,  Claudio Tarchini ,  Beatrice Baer ,  Christian Vial

发明人： Karl-Heinrich Schulte-Elte ,  Roger L. Snowden ,  Claudio Tarchini ,  Beatrice Baer ,  Christian Vial

IPC分类号： C07C33/14 ,  C07D307/74 ,  C07D307/79 ,  C07D307/92

CPC分类号： C07D307/79 ,  C07C33/14 ,  C07D307/74 ,  C07D307/92 ,  Y02P20/55

摘要： Process for the preparation of polycyclic ethers of formula ##STR1## wherein X represents --(CH.sub.2).sub.n --, index n stands for integer 0 or 1, symbol R.sup.4 designated a hydrogen atom or a methyl radical, R.sup.2 identical or different, represent each a hydrogen atom or a lower alkyl radical from C.sub.1 to C.sub.3 and R designates either a C.sub.1 to C.sub.6 linear or branched alkyl radical, or a substituted or unsubstituted alkenyl radical having 2 or 3 carbon atoms in the main chain, said alkenyl radical forming a ring such as indicated by the dotted line, which process comprises the cyclization by means of an acidic agent of an unsaturated compound:a) of formula ##STR2## having a double bond in one of the positions indicated by the dotted lines, and wherein index m defines an integer number equal to 1 or 2, symbol R.sup.3 stands for a hydrogen atom or a protecting group of the hydroxyl function bound to the oxygen atom and able to dissociate itself from the latter under the reaction conditions, the wavy line represents a C--C bond of cis or trans configuration and index n and symbols R, R.sup.2 and R.sup.4 are defined as above; orb) of formula ##STR3## wherein symbols R.sup.2, R.sup.3 and R.sup.4, index n and the wavy line are defined as above; orc) of formula ##STR4## wherein symbols R.sup.2, R.sup.3 and R.sup.4, index n and the wavy line are defined as above.Some of the compounds (I) are novel and can be used in the perfume industry.

摘要翻译： 用于制备式（IMA）的多环醚的方法，其中X表示 - （CH 2）n - ，指数n表示整数0或1，表示氢原子或甲基的符号R 4相同或不同，表示各a 氢原子或C1至C3的低级烷基，R表示C1至C6直链或支链烷基或主链中具有2或3个碳原子的取代或未取代的烯基，所述烯基形成环，例如 如虚线所示，该方法包括通过不饱和化合物的酸性试剂环化：a）在虚线表示的一个位置具有双键的式（IIa）（IIa），其中 指数m定义等于1或2的整数，符号R3表示氢原子或与氧原子结合的羟基官能团的保护基团，并且能够在反应条件下自身与后者分离，波浪线表示 是顺式或反式构型和指数n的C-C键，符号R，R 2和R 4如上定义; 或b）式（IIb）其中符号R2，R3和R4，指数n和波浪线如上定义; 或c）式（IIc）其中符号R2，R3和R4，指数n和波浪线如上定义。 一些化合物（I）是新颖的并且可以用于香料工业中。

公开(公告)号：US5155238A

公开(公告)日：1992-10-13

申请号：US731834

申请日：1991-07-16

申请人： Karl-Heinrich Schulte-Elte ,  Roger L. Snowden ,  Claudio Tarchini ,  Beatrice Baer ,  Christian Vial

发明人： Karl-Heinrich Schulte-Elte ,  Roger L. Snowden ,  Claudio Tarchini ,  Beatrice Baer ,  Christian Vial

IPC分类号： A61K8/49 ,  A61Q13/00 ,  C07C33/14 ,  C07D307/74 ,  C07D307/79 ,  C07D307/92 ,  C07D311/92 ,  C11B9/00

CPC分类号： C07D307/79 ,  C07C33/14 ,  C07D307/74 ,  C07D307/92 ,  Y02P20/55

摘要： Process for the preparation of polycyclic ethers of formula ##STR1## wherein X represents --(CH.sub.2).sub.n --, index n stands for integer 0 or 1, symbol R.sup.4 designates a hydrogen atom or a methyl radical, symbols R.sup.1 and R.sup.2, identical or different, represent each a hydrogen atom or a lower alkyl radical from C.sub.1 to C.sub.3 and R designates either a C.sub.1 to C.sub.6 linear or branched alkyl radical, or a substituted or unsubstituted alkenyl radical having 2 or 3 carbon atoms in the main chain, said alkenyl radical forming a ring such as indicated by the dotted line, which process comprises the cyclization by means of an acidic agent of an unsaturated compound:a) of formula ##STR2## having a double bond in one of the positions indicated by the dotted lines, and wherein index m defines an integer number equal to 1 or 2, symbol R.sup.3 stands for a hydrogen atom or a protecting group of the hydroxyl function bound to the oxygen atom and able to dissociate itself from the latter under the reaction conditions, the wavy line represents a C--C bond of cis or trans configuration and index n and symbols R, R.sup.2 and R.sup.4 are defined as above; orb) of formula ##STR3## wherein symbols R.sup.2, R.sup.3 and R.sup.4, index n and the wavy line are defined as above; orc) of formula ##STR4## wherein symbols, R.sup.2, R.sup.3 and R.sup.4, index n and the wavy line are defined as above.Some of the compounds (I) are novel and can be used in the perfume industry.

摘要翻译： 制备式（I）的多环醚的方法其中X表示 - （CH2）n-，索引n代表整数0或1，符号R4表示氢原子或甲基，符号R1和R2， 相同或不同，表示各自为C1至C3的氢原子或低级烷基，R表示C1至C6直链或支链烷基或在主链中具有2或3个碳原子的取代或未取代的烯基， 所述烯基形成如虚线所示的环，该方法包括通过不饱和化合物的酸性试剂环化：a）在指示的位置之一具有双键的式“IMAGE”（IIa） 并且其中索引m定义等于1或2的整数，符号R3表示氢原子或与氧原子结合的羟基官能团的保护基团，并且能够在反应下从自身离解自身 条件， 波浪线表示顺式或反式构型和指数n的C-C键，符号R，R2和R4如上定义; 或b）式（IIb）其中符号R2，R3和R4，指数n和波浪线如上定义; 或c）式（IIc）其中符号，R2，R3和R4，指数n和波浪线如上定义。 一些化合物（I）是新颖的并且可以用于香料工业中。

公开(公告)号：US4671798A

公开(公告)日：1987-06-09

申请号：US716078

申请日：1985-03-26

申请人： Claudio Tarchini

发明人： Claudio Tarchini

IPC分类号： C07C29/136 ,  A61K8/34 ,  A61Q13/00 ,  C07C27/00 ,  C07C29/143 ,  C07C35/36 ,  C07C45/00 ,  C07C45/69 ,  C07C45/72 ,  C07C49/603 ,  C07C49/637 ,  C07C67/00 ,  C11B9/00 ,  C11D3/50 ,  D06M13/02 ,  D06M13/144 ,  D06M13/152 ,  D06P3/80 ,  C07C35/22 ,  C11D9/00 ,  C11D17/00

CPC分类号： C11B9/0053 ,  C07C35/36 ,  C07C45/69 ,  C07C45/72 ,  C07C49/603 ,  C07C49/637

摘要： Bicyclic carbinol of formula ##STR1## or 1,2,3,4,4a,5,8,8a-octahydro-2,2,6,8-tetramethyl-1-naphthalenol possesses useful odorous properties and it can be used advantageously as perfuming ingredient. A two-step process for its synthesis is disclosed starting from 2-methylpenta-1,3-diene and 6,6-dimethyl-cyclohex-2-en-1-one.

摘要翻译： 具有式（I）或1,2,3,4,4a，5,8,8a-八氢-2,2,6,8-四甲基-1-萘酚的双环甲醇具有有用的气味性质，它可以是 有利地用作加香成分。 公开了从2-甲基戊-1,3-二烯和6,6-二甲基 - 环己-2-烯-1-酮开始合成的两步法。

公开(公告)号：US5077417A

公开(公告)日：1991-12-31

申请号：US539113

申请日：1990-06-15

申请人： Karl-Heinrich Schulte-Elte ,  Roger L. Snowden ,  Claudio Tarchini ,  Beatrice Baer ,  Christian Vial

发明人： Karl-Heinrich Schulte-Elte ,  Roger L. Snowden ,  Claudio Tarchini ,  Beatrice Baer ,  Christian Vial

IPC分类号： A61K8/49 ,  A61Q13/00 ,  C07C33/14 ,  C07D307/74 ,  C07D307/79 ,  C07D307/92 ,  C07D311/92 ,  C11B9/00

CPC分类号： C07D307/79 ,  C07C33/14 ,  C07D307/74 ,  C07D307/92 ,  Y02P20/55

摘要： Process for the preparation of polycyclic ethers of formula ##STR1## wherein X represents --(CH.sub.2).sub.n --, index n stands for integer 0 or 1, symbol R.sup.4 designates a hydrogen atom or a methyl radical, symbols R.sup.1 and R.sup.2, identical or different, represent each a hydrogen atom or a lower alkyl radical from C.sub.1 to C.sub.3 and R designates either a C.sub.1 to C.sub.6 linear or branched alkyl radical, or a substituted or unsubstituted alkylene radical having 2 or 3 carbon atoms in the main chain, said alkylene radical forming a ring such as indicated by the dotted line, which process comprises the cyclization by means of an acidic agent of an unsaturated compound:a) of formula ##STR2## having a double bond in one of the positions indicated by the dotted lines, and wherein index m defines an integer number equal to 1 or 2, symbol R.sup.3 stands for a hydrogen atom or a protecting group of the hydroxyl function bound to the oxygen atom and able to dissociate itself from the latter under the reaction conditions, the wavy line represents a C-C bond of cis or trans configuration and index n and symbols R, R.sup.2 and R.sup.4 are defined as above; orb) of formula ##STR3## wherein symbols R.sup.2, R.sup.3 and R.sup.4, index n and the wavy line are defined as above; orc) of formula ##STR4## wherein symbols R.sup.2, R.sup.3 and R.sup.4, index n and the wavy line are defined as above.Some of the compounds (I) are novel and can be used in the perfume industry.

摘要翻译： 制备式（I）的多环醚的方法其中X表示 - （CH2）n-，索引n代表整数0或1，符号R4表示氢原子或甲基，符号R1和R2， 相同或不同，表示氢原子或C1至C3的低级烷基，R表示C1至C6直链或支链烷基或主链中具有2或3个碳原子的取代或未取代的亚烷基， 所述亚烷基形成如虚线所示的环，该方法包括通过不饱和化合物的酸性试剂环化：a）在指示的位置之一具有双键的式“IMAGE”（IIa） 并且其中索引m定义等于1或2的整数，符号R3表示氢原子或与氧原子结合的羟基官能团的保护基团，并且能够在反应下从自身离解自身 条件，t 其波浪线表示顺式或反式构型和指数n的C-C键，符号R，R2和R4如上定义; 或b）式（IIb）其中符号R2，R3和R4，指数n和波浪线如上定义; 或c）式（IIc）其中符号R2，R3和R4，指数n和波浪线如上定义。 一些化合物（I）是新颖的并且可以用于香料工业中。