-
公开(公告)号：US20180067078A1
公开(公告)日：2018-03-08
申请号：US15713684
申请日：2017-09-24
IPC分类号： G01N27/62
CPC分类号： G01N27/622
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.
-
公开(公告)号：US09719963B2
公开(公告)日：2017-08-01
申请号：US14537863
申请日：2014-11-10
IPC分类号： G01N27/62
CPC分类号： G01N27/622
摘要： An ion mobility spectrometry method wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. Ion mobility spectrometer operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.
-
公开(公告)号：US08492709B2
公开(公告)日：2013-07-23
申请号：US13544811
申请日：2012-07-09
CPC分类号： G01N27/622
摘要： The present invention describes a method and apparatus for separating chemical and/or biological samples based on selective ion-molecular interactions in the gas phase. A chemical modifier is added to the drift gas that interacts selectively with a targeted molecule in at least one component of the sample in a drift tube. The component may be impurities and/or interferences in the sample whereby the chemical modifier enhances sample resolution by shifting the components drift times. In addition, reagents can be added to the sample prior to, during, or after ionization to form a complex with selected components in the sample. In addition, one or more internal and/or external standard can also be added to the sample as a calibration for the measurement.
摘要翻译： 本发明描述了一种基于气相中选择性离子 - 分子相互作用分离化学和/或生物样品的方法和装置。 添加到漂移气体中的化学改性剂，其与漂移管中样品的至少一个组分中的目标分子选择性相互作用。 该组分可以是样品中的杂质和/或干扰物，由此化学改性剂通过移动组分漂移时间来提高样品分辨率。 此外，可以在电离之前，期间或之后将试剂加入到样品中以与样品中所选组分形成复合物。 此外，还可以将一个或多个内部和/或外部标准作为测量的校准添加到样品中。
-
公开(公告)号：US20120273667A1
公开(公告)日：2012-11-01
申请号：US13544811
申请日：2012-07-09
CPC分类号： G01N27/622
摘要： The present invention describes a method and apparatus for separating chemical and/or biological samples based on selective ion-molecular interactions in the gas phase. A chemical modifier is added to the drift gas that interacts selectively with a targeted molecule in at least one component of the sample in a drift tube. The component may be impurities and/or interferences in the sample whereby the chemical modifier enhances sample resolution by shifting the components drift times. In addition, reagents can be added to the sample prior to, during, or after ionization to form a complex with selected components in the sample. In addition, one or more internal and/or external standard can also be added to the sample as a calibration for the measurement.
摘要翻译： 本发明描述了一种基于气相中选择性离子 - 分子相互作用分离化学和/或生物样品的方法和装置。 添加到漂移气体中的化学改性剂，其与漂移管中样品的至少一个组分中的目标分子选择性相互作用。 该组分可以是样品中的杂质和/或干扰物，由此化学改性剂通过移动组分漂移时间来提高样品分辨率。 此外，可以在电离之前，期间或之后将试剂加入到样品中以与样品中所选组分形成复合物。 此外，还可以将一个或多个内部和/或外部标准作为测量的校准添加到样品中。
-
公开(公告)号：US20100108877A1
公开(公告)日：2010-05-06
申请号：US12610306
申请日：2009-10-31
申请人： Ching Wu , Clinton Alawn Krueger
发明人： Ching Wu , Clinton Alawn Krueger
IPC分类号： H01J49/02
CPC分类号： G01N27/622
摘要： The present invention describes separating components in a sample in an ion mobility based spectrometer using at least one matching property of the components other than the molecular properties in conventional ion mobility measurements in noble drift gases to enhance separation and resolution of the sample. Separation based on the matching property is realized by altering the drift media of the IMS. Besides altering drift media, energy level of ions and/or drift media are also controlled during the separation process. This invention describes an ion mobility apparatus wherein an energy source is added to the IMS that provides additional energy to the ions and/or drift media and tuning methods that involve selecting drift media and optimizing the energy level in order to achieve optimal performance.
摘要翻译： 本发明描述了使用离子迁移率光谱仪中的样品中的组分，其使用除贵族漂移气体中的常规离子迁移率测量中的分子特性以外的组分的至少一个匹配性质以增强样品的分离和分离。 通过改变IMS的漂移介质来实现基于匹配特性的分离。 除了改变漂移介质之外，还可以在分离过程中控制离子和/或漂移介质的能级。 本发明描述了一种离子迁移率装置，其中向IMS提供能量源，其为离子和/或漂移介质提供额外的能量以及涉及选择漂移介质并优化能级以便实现最佳性能的调谐方法。
-
公开(公告)号：US08884221B2
公开(公告)日：2014-11-11
申请号：US13475993
申请日：2012-05-20
CPC分类号： G01N27/622
摘要： An ion mobility spectrometer wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. An ion mobility spectrometer and operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.
摘要翻译： 离子迁移谱仪，其中离子沿着漂移轴线分离，同时在基本上不是在漂移轴线的方向上也不与漂移轴线相反的方向提供漂移气流。 离子迁移谱仪和操作方法在漂移管和/或分段漂移管中使用横向气流用于预分离。
-
公开(公告)号：US08618476B2
公开(公告)日：2013-12-31
申请号：US13293317
申请日：2011-11-10
申请人： Ching Wu , Clinton Alawn Krueger
发明人： Ching Wu , Clinton Alawn Krueger
CPC分类号： G01N27/622
摘要： The present invention describes separating components in a sample in an ion mobility based spectrometer using at least one matching property of the components other than the molecular properties in conventional ion mobility measurements in noble drift gases to enhance separation and resolution of the sample. Separation based on the matching property is realized by altering the drift media of the IMS. Besides altering drift media, energy level of ions and/or drift media are also controlled during the separation process. This invention describes an ion mobility apparatus wherein an energy source is added to the IMS that provides additional energy to the ions and/or drift media and tuning methods that involve selecting drift media and optimizing the energy level in order to achieve optimal performance.
摘要翻译： 本发明描述了使用离子迁移率光谱仪中的样品中的组分，其使用除贵族漂移气体中的常规离子迁移率测量中的分子特性以外的组分的至少一个匹配性质以增强样品的分离和分离。 通过改变IMS的漂移介质来实现基于匹配特性的分离。 除了改变漂移介质之外，还可以在分离过程中控制离子和/或漂移介质的能级。 本发明描述了一种离子迁移率装置，其中向IMS提供能量源，其为离子和/或漂移介质提供额外的能量以及涉及选择漂移介质并优化能级以便实现最佳性能的调谐方法。
-
公开(公告)号：US08217338B2
公开(公告)日：2012-07-10
申请号：US12577062
申请日：2009-10-09
CPC分类号： G01N27/622
摘要： The present invention describes a method and apparatus for separating chemical and/or biological samples based on selective ion-molecular interactions in the gas phase. A chemical modifier is added to the drift gas that interacts selectively with a targeted molecule in at least one component of the sample in a drift tube. The component may be impurities and/or interferences in the sample whereby the chemical modifier enhances sample resolution by shifting the components drift times. In addition, reagents can be added to the sample prior to, during, or after ionization to form a complex with selected components in the sample. In addition, one or more internal and/or external standard can also be added to the sample as a calibration for the measurement.
摘要翻译： 本发明描述了一种基于气相中选择性离子 - 分子相互作用分离化学和/或生物样品的方法和装置。 添加到漂移气体中的化学改性剂，其与漂移管中样品的至少一个组分中的目标分子选择性相互作用。 该组分可以是样品中的杂质和/或干扰物，由此化学改性剂通过移动组分漂移时间来提高样品分辨率。 此外，可以在电离之前，期间或之后将试剂加入到样品中以与样品中所选组分形成复合物。 此外，还可以将一个或多个内部和/或外部标准作为测量的校准添加到样品中。
-
公开(公告)号：US20120049057A1
公开(公告)日：2012-03-01
申请号：US13293317
申请日：2011-11-10
申请人： Ching Wu , Clinton Alawn Krueger
发明人： Ching Wu , Clinton Alawn Krueger
IPC分类号： H01J49/26
CPC分类号： G01N27/622
摘要： The present invention describes separating components in a sample in an ion mobility based spectrometer using at least one matching property of the components other than the molecular properties in conventional ion mobility measurements in noble drift gases to enhance separation and resolution of the sample. Separation based on the matching property is realized by altering the drift media of the IMS. Besides altering drift media, energy level of ions and/or drift media are also controlled during the separation process. This invention describes an ion mobility apparatus wherein an energy source is added to the IMS that provides additional energy to the ions and/or drift media and tuning methods that involve selecting drift media and optimizing the energy level in order to achieve optimal performance.
摘要翻译： 本发明描述了使用离子迁移率光谱仪中的样品中的组分，其使用除贵族漂移气体中的常规离子迁移率测量中的分子特性以外的组分的至少一个匹配性质以增强样品的分离和分离。 通过改变IMS的漂移介质来实现基于匹配特性的分离。 除了改变漂移介质之外，还可以在分离过程中控制离子和/或漂移介质的能级。 本发明描述了一种离子迁移率装置，其中向IMS提供能量源，其为离子和/或漂移介质提供额外的能量以及涉及选择漂移介质并优化能级以便实现最佳性能的调谐方法。
-
公开(公告)号：US08063361B2
公开(公告)日：2011-11-22
申请号：US12610306
申请日：2009-10-31
申请人： Ching Wu , Clinton Alawn Krueger
发明人： Ching Wu , Clinton Alawn Krueger
CPC分类号： G01N27/622
摘要： The present invention describes separating components in a sample in an ion mobility based spectrometer using at least one matching property of the components other than the molecular properties in conventional ion mobility measurements in noble drift gases to enhance separation and resolution of the sample. Separation based on the matching property is realized by altering the drift media of the IMS. Besides altering drift media, energy level of ions and/or drift media are also controlled during the separation process. This invention describes an ion mobility apparatus wherein an energy source is added to the IMS that provides additional energy to the ions and/or drift media and tuning methods that involve selecting drift media and optimizing the energy level in order to achieve optimal performance.
摘要翻译： 本发明描述了使用离子迁移率光谱仪中的样品中的组分，其使用除贵族漂移气体中的常规离子迁移率测量中的分子特性以外的组分的至少一个匹配性质以增强样品的分离和分离。 通过改变IMS的漂移介质来实现基于匹配特性的分离。 除了改变漂移介质之外，还可以在分离过程中控制离子和/或漂移介质的能级。 本发明描述了一种离子迁移率装置，其中向IMS提供能量源，其为离子和/或漂移介质提供额外的能量以及涉及选择漂移介质并优化能级以便实现最佳性能的调谐方法。
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.013 秒)
