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公开(公告)号：US20180067078A1
公开(公告)日：2018-03-08
申请号：US15713684
申请日：2017-09-24
IPC分类号： G01N27/62
CPC分类号： G01N27/622
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.
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公开(公告)号：US20190285583A1
公开(公告)日：2019-09-19
申请号：US16430309
申请日：2019-06-03
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method. In addition, automation of the direct spray needle can be achieved by setting up array of the spray needles that are loaded in a manner that rotates and/or moves to the next spray needle in the ESI source region.
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3.发明申请公开(公告)号：US20120228490A1
公开(公告)日：2012-09-13
申请号：US13419425
申请日：2012-03-13
IPC分类号： H01J49/26
CPC分类号： G01N27/622 , G01N27/624 , H01J49/067 , H01J49/165
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.
摘要翻译： 本发明中描述的IMS装置和方法涉及将离子检测器设置在漂移管的最高电位并将电离源设置在接地或接地电位。 该方法允许显着简单的样品引入，而不受前端样品传送的高电位（电压）的限制。 本发明还描述了将样品直接引入离子迁移率漂移管中。 本发明还描述了通过电喷雾离子化方法使用单个注射器进行样品引入。
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公开(公告)号：US10309928B2
公开(公告)日：2019-06-04
申请号：US15713684
申请日：2017-09-24
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.
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公开(公告)号：US09719963B2
公开(公告)日：2017-08-01
申请号：US14537863
申请日：2014-11-10
IPC分类号： G01N27/62
CPC分类号： G01N27/622
摘要： An ion mobility spectrometry method wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. Ion mobility spectrometer operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.
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公开(公告)号：US08884221B2
公开(公告)日：2014-11-11
申请号：US13475993
申请日：2012-05-20
CPC分类号： G01N27/622
摘要： An ion mobility spectrometer wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. An ion mobility spectrometer and operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.
摘要翻译： 离子迁移谱仪，其中离子沿着漂移轴线分离，同时在基本上不是在漂移轴线的方向上也不与漂移轴线相反的方向提供漂移气流。 离子迁移谱仪和操作方法在漂移管和/或分段漂移管中使用横向气流用于预分离。
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公开(公告)号：US20140367567A1
公开(公告)日：2014-12-18
申请号：US14338250
申请日：2014-07-22
CPC分类号： H01J49/009 , G01N27/622 , G01N30/7206 , G01N30/7233 , H01J49/0027 , H01J49/0031 , H01J49/004
摘要： The present invention relates to a parallel IMS and MS measurement method where a sample flow is split and delivered to an IMS and a MS in parallel. A parallel acquisition MS/IMS method is used to supplement LC-MS and or MS data by using a synchronized MS/IMS acquisition.
摘要翻译： 本发明涉及一种并行的IMS和MS测量方法，其中采样流被并行地分离并传送到IMS和MS。 并行采集MS / IMS方法用于通过使用同步的MS / IMS采集来补充LC-MS和/或MS数据。
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公开(公告)号：US08785848B2
公开(公告)日：2014-07-22
申请号：US13792043
申请日：2013-03-09
IPC分类号： H01J49/26
CPC分类号： H01J49/009 , G01N27/622 , G01N30/7206 , G01N30/7233 , H01J49/0027 , H01J49/0031 , H01J49/004
摘要： The present invention relates to a parallel IMS and MS measurement method where a sample flow is split and delivered to an IMS and a MS in parallel. A parallel acquisition MS/IMS method is used to supplement LC-MS and or MS data by using a synchronized MS/IMS acquisition.
摘要翻译： 本发明涉及一种并行的IMS和MS测量方法，其中采样流被并行地分离并传送到IMS和MS。 并行采集MS / IMS方法用于通过使用同步的MS / IMS采集来补充LC-MS和/或MS数据。
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公开(公告)号：US20120228491A1
公开(公告)日：2012-09-13
申请号：US13475993
申请日：2012-05-20
IPC分类号： H01J49/26
CPC分类号： G01N27/622
摘要： An ion mobility spectrometer wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. An ion mobility spectrometer and operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.
摘要翻译： 离子迁移谱仪，其中离子沿着漂移轴线分离，同时在基本上不是在漂移轴线的方向上也不与漂移轴线相反的方向提供漂移气流。 离子迁移谱仪和操作方法在漂移管和/或分段漂移管中使用横向气流用于预分离。
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公开(公告)号：US08492709B2
公开(公告)日：2013-07-23
申请号：US13544811
申请日：2012-07-09
CPC分类号： G01N27/622
摘要： The present invention describes a method and apparatus for separating chemical and/or biological samples based on selective ion-molecular interactions in the gas phase. A chemical modifier is added to the drift gas that interacts selectively with a targeted molecule in at least one component of the sample in a drift tube. The component may be impurities and/or interferences in the sample whereby the chemical modifier enhances sample resolution by shifting the components drift times. In addition, reagents can be added to the sample prior to, during, or after ionization to form a complex with selected components in the sample. In addition, one or more internal and/or external standard can also be added to the sample as a calibration for the measurement.
摘要翻译： 本发明描述了一种基于气相中选择性离子 - 分子相互作用分离化学和/或生物样品的方法和装置。 添加到漂移气体中的化学改性剂，其与漂移管中样品的至少一个组分中的目标分子选择性相互作用。 该组分可以是样品中的杂质和/或干扰物，由此化学改性剂通过移动组分漂移时间来提高样品分辨率。 此外，可以在电离之前，期间或之后将试剂加入到样品中以与样品中所选组分形成复合物。 此外，还可以将一个或多个内部和/或外部标准作为测量的校准添加到样品中。
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