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1.发明授权公开(公告)号：US12064763B2
公开(公告)日：2024-08-20
申请号：US17770643
申请日：2020-10-21
发明人： Alex Dehgan , Paul Bunje , Hallie Holmes , David Baisch , Cifeng Fang , Gareth Fotouhi , Misa Winters , Sam Kelly , Brad Zamft
CPC分类号： B01L3/502715 , B01L3/5085 , B01L7/52 , G01N21/0332 , G01N21/253 , G01N33/53 , B01L2200/0684 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , G01N2035/00376
摘要： A cartridge for providing a target analyte for detection is described. One such exemplar cartridge includes a base portion including: (1) a receiving area disposed at or near a center region of the base portion; (2) multiple reaction wells disposed outside the center region or radially disposed at or near a perimeter of the base portion; and (3) multiple connecting tracks that substantially linearly extend from a region at or proximate to the receiving area to the multiple reaction wells and designed to convey a sample including the target analyte from the receiving area to the multiple reaction wells, each of which are configured to transform the sample to a detectable sample.
Systems and methods of reacting and detecting the sample including the target analyte are also described.-
2.发明申请公开(公告)号：US20220250064A1
公开(公告)日：2022-08-11
申请号：US17725583
申请日：2022-04-21
发明人： Alex Dehgan , Paul Bunje , Hallie Holmes , David Baisch , Cifeng Fang , Gareth Fotouhi , Misa Winters , Sam Kelly , Brad Zamft
摘要： A cartridge for providing a target analyte for detection is described. One such exemplar cartridge includes a base portion including: (1) a receiving area disposed at or near a center region of the base portion; (2) multiple reaction wells disposed outside the center region or radially disposed at or near a perimeter of the base portion; and (3) multiple connecting tracks that substantially linearly extend from a region at or proximate to the receiving area to the multiple reaction wells and designed to convey a sample including the target analyte from the receiving area to the multiple reaction wells, each of which are configured to transform the sample to a detectable sample.
Systems and methods of reacting and detecting the sample including the target analyte are also described.-
3.发明授权公开(公告)号：US11311883B2
公开(公告)日：2022-04-26
申请号：US16758445
申请日：2018-10-23
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/6844
摘要： Aniosotropic Ratchet Conveyor (“ARC”)-based biomolecule processing devices and related methods are described. The ARC-based biomolecule processing devices include (i) a substrate having an ARC track defined on or within the substrate and including a biomolecule receiving area, which is designed to receive biomolecule, and a reconstituting area, which is designed to contain dry reagents and is designed to receive a transport solution such that at the reconstituting area, dry reagents are reconstituted with transport solution; and (ii) a microheater area disposed at or near the biomolecule receiving area, fitted with a microheater, which is designed to heat biomolecule that is received through the biomolecule receiving area and designed to process heated biomolecule and dry reagents reconstituted with transport solution. The ARC track includes an arrangement of a plurality of hydrophilic rungs disposed on a hydrophobic region such that between consecutive hydrophobic rungs, a portion of the hydrophobic region is exposed.
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4.发明申请公开(公告)号：US20220250065A1
公开(公告)日：2022-08-11
申请号：US17725590
申请日：2022-04-21
发明人： Alex Dehgan , Paul Bunje , Hallie Holmes , David Baisch , Cifeng Fang , Gareth Fotouhi , Misa Winters , Sam Kelly , Brad Zamft
摘要： A cartridge for providing a target analyte for detection is described. One such exemplar cartridge includes a base portion including: (1) a receiving area disposed at or near a center region of the base portion; (2) multiple reaction wells disposed outside the center region or radially disposed at or near a perimeter of the base portion; and (3) multiple connecting tracks that substantially linearly extend from a region at or proximate to the receiving area to the multiple reaction wells and designed to convey a sample including the target analyte from the receiving area to the multiple reaction wells, each of which are configured to transform the sample to a detectable sample.
Systems and methods of reacting and detecting the sample including the target analyte are also described.-
5.发明公开公开(公告)号：US20240330761A1
公开(公告)日：2024-10-03
申请号：US18293376
申请日：2022-08-01
发明人： Samuel James Kelly , Chad Stephen Gallinat , Henrik Thomas Oftedahl Cox , Patrict Edward Charles COME , Paul BUNJE , Alex DEHGAN
IPC分类号： G06N20/00
CPC分类号： G06N20/00
摘要： A process for facilitating environmental conservation is described. The process includes: (i) creating a model for describing phenomena relevant to environmental conservation; (ii) training the model using machine-learning to produce a candidate model; (iii) determining whether the candidate model satisfies predetermined model statistics, and if not, repeating previous step until they are satisfied; (iv) deeming the candidate model as a deployable model if the predetermined model statistics are satisfied; (v) deploying the candidate model to permit an inference; (vi) determining whether the inference satisfies predefined inference criteria; (vii) deeming the deployable model as the final model if the predefined inference criteria are satisfied, and if not, modifying the deployable model until they are satisfied to produce the final model; (viii) implementing the final model on an AI adapter device remote to the user to draw an inference; and (ix) taking action using the AI adapter device to facilitate environmental conservation.
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6.发明公开公开(公告)号：US20230390779A1
公开(公告)日：2023-12-07
申请号：US18038995
申请日：2021-12-21
发明人： Alex DEHGAN , Paul BUNJE , Hallie HOLMES , David BAISCH , Cifeng FANG , Gareth FOTOUHI , Misa WINTERS
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/0689 , B01L2200/142 , B01L2300/041
摘要： Systems and methods relating thereto for detecting target analytes, using hand-held detection devices and compression mechanisms, are described. An exemplar hand-held detection device includes a cartridge inlet and a cartridge stage for securing cartridge containing the sample including the target-analyte. The device further comprises a compression assembly including a pressing surface. In an open state of the compression assembly, the pressing surface is released, displacing away from the cartridge stage, and thereby allowing a cartridge inlet to provide access to an unobstructed loading path for the cartridge to be secured on the cartridge stage. Upon receiving an external pressing force on the pressing surface, the compression assembly is designed to acquire a compressed state, in which the pressing surface displaces towards the cartridge stage and the compression assembly seals off the cartridge present inside the cartridge stage from an environment around the cartridge stage.
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7.发明申请公开(公告)号：US20220347682A1
公开(公告)日：2022-11-03
申请号：US17770643
申请日：2020-10-21
发明人： Alex Dehgan , Paul Bunje , Hallie Holmes , David Baisch , Cifeng Fang , Gareth Fotouhi , Misa Winters , Sam Kelly , Brad Zamft
IPC分类号： B01L3/00
摘要： A cartridge for providing a target analyte for detection is described. One such exemplar cartridge includes a base portion including: (1) a receiving area disposed at or near a center region of the base portion; (2) multiple reaction wells disposed outside the center region or radially disposed at or near a perimeter of the base portion; and (3) multiple connecting tracks that substantially linearly extend from a region at or proximate to the receiving area to the multiple reaction wells and designed to convey a sample including the target analyte from the receiving area to the multiple reaction wells, each of which are configured to transform the sample to a detectable sample. Systems and methods of reacting and detecting the sample including the target analyte are also described.
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8.发明申请公开(公告)号：US20200254459A1
公开(公告)日：2020-08-13
申请号：US16758445
申请日：2018-10-23
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/6844
摘要： Aniosotropic Ratchet Conveyor (“ARC”)-based biomolecule processing devices and related methods are described. The ARC-based biomolecule processing devices include (i) a substrate having an ARC track defined on or within the substrate and including a biomolecule receiving area, which is designed to receive biomolecule, and a reconstituting area, which is designed to contain dry reagents and is designed to receive a transport solution such that at the reconstituting area, dry reagents are reconstituted with transport solution; and (ii) a microheater area disposed at or near the biomolecule receiving area, fitted with a microheater, which is designed to heat biomolecule that is received through the biomolecule receiving area and designed to process heated biomolecule and dry reagents reconstituted with transport solution. The ARC track includes an arrangement of a plurality of hydrophilic rungs disposed on a hydrophobic region such that between consecutive hydrophobic rungs, a portion of the hydrophobic region is exposed.
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