公开(公告)号：US20060182808A1

公开(公告)日：2006-08-17

申请号：US10553211

申请日：2004-04-28

申请人： Wridzer Bakker ,  Robert Geertman ,  Marianne Reedijk ,  Jozef Baltussen ,  Gerrald Bargeman ,  Cornelis Van Lare

发明人： Wridzer Bakker ,  Robert Geertman ,  Marianne Reedijk ,  Jozef Baltussen ,  Gerrald Bargeman ,  Cornelis Van Lare

IPC分类号： A61K31/57 ,  A61K9/14

CPC分类号： B01D9/0063 ,  A61K9/14 ,  A61K9/1688 ,  A61K31/57 ,  B01D9/005 ,  C01D3/24 ,  C07J1/00 ,  C07J7/0005 ,  C07J7/0045

摘要： The present invention relates to a antisolvent solidification process wherein a liquid medium comprising at least one organic or inorganic compound which is to be solidified is forced through a membrane into one or more antisolvents, or wherein one or more antisolvents are forced through a membrane into a liquid medium comprising at least one organic or inorganic compound which is to be solidified, yielding a composition comprising solid particles comprising said organic and/or inorganic compound(s).

摘要翻译： 本发明涉及一种抗溶剂固化方法，其中包含至少一种待固化的有机或无机化合物的液体介质被迫通过膜进入一种或多种抗溶剂，或其中一种或多种抗溶剂被迫通过膜进入 包含至少一种待固化的有机或无机化合物的液体介质，产生包含所述有机和/或无机化合物的固体颗粒的组合物。

公开(公告)号：US20080056981A1

公开(公告)日：2008-03-06

申请号：US11666000

申请日：2005-10-18

申请人： Gerrald Bargeman ,  Rene Demmer ,  Boris Kuzmanovic ,  Cornelis Van Lare ,  Mateo Mayer ,  Maarten Schutyser ,  Jan Westerink

发明人： Gerrald Bargeman ,  Rene Demmer ,  Boris Kuzmanovic ,  Cornelis Van Lare ,  Mateo Mayer ,  Maarten Schutyser ,  Jan Westerink

IPC分类号： C01D3/06

CPC分类号： C01D3/14 ,  C01D3/16 ,  C01D5/00 ,  C01D7/00 ,  C02F1/44 ,  C02F1/442 ,  C02F1/52 ,  C02F1/66 ,  C02F9/00 ,  C02F2001/5218 ,  C02F2101/10 ,  C02F2101/16 ,  C02F2103/08 ,  Y02A20/131

摘要： The invention pertains to a method for at least partially removing soluble divalent anions from an aqueous divalent anion-containing brine solution comprising a crystal growth inhibitor (CGI) for the divalent anion, the method comprising the process steps: obtaining a sodium chloride concentration between 100 g/L and saturation in the presence or absence of a CGI for sodium chloride or a sodium chloride concentration above saturation in the presence of a CGI for sodium chloride, and acidifying the solution to a pH below 11.5; subjecting the solution to a membrane filtration step thereby separating the brine solution into a brine stream being supersaturated for the divalent anion (concentrate), and a brine stream being undersaturated for the divalent anion (permeate); subjecting the supersaturated brine stream comprising the crystal growth inhibitor for the divalent anion to a crystallization process, removing crystallized divalent anion; and optionally, recycling the overflow of the crystallizer to the brine solution for subjecting it again to the membrane filtration step.

摘要翻译： 本发明涉及从含二价阴离子的含水二价阴离子盐水溶液中至少部分除去可溶性二价阴离子的方法，该方法包括二价阴离子的结晶生长抑制剂（CGI），该方法包括以下步骤：获得100 在存在或不存在用于氯化钠的CGI或在氯化钠的CGI存在下高于饱和的氯化钠浓度的情况下的饱和度，并将溶液酸化至低于11.5的pH; 使溶液进行膜过滤步骤，从而将盐水溶液分离成用于二价阴离子（浓缩物）过饱和的盐水流，并且对于二价阴离子（渗透物）不饱和的盐水流; 将包含结晶生长抑制剂的过饱和盐水流作为二价阴离子进行结晶处理，除去结晶二价阴离子; 并且可选地，将结晶器的溢流器再循环到盐水溶液中，以再次使其进行膜过滤步骤。

公开(公告)号：US20070231398A1

公开(公告)日：2007-10-04

申请号：US11579675

申请日：2005-04-21

申请人： Cornelis Van Lare ,  Jozef Baltussen ,  Marianne Reedijk ,  Boen O

发明人： Cornelis Van Lare ,  Jozef Baltussen ,  Marianne Reedijk ,  Boen O

IPC分类号： B01F3/00

CPC分类号： B01J2/003 ,  A61K9/1688 ,  A61K9/5192 ,  B01F3/08 ,  B01F2215/0032 ,  B01J2/06 ,  B01J13/06

摘要： The invention relates to a process for the controlled production of particles comprising the steps of producing an emulsion comprising one or more compounds to be solidified in its dispersed phase, and dosing a suitable antisolvent to said emulsion, forcing the one or more compounds to solidify. Optionally, the solidified compound(s) is/are encapsulated or coated.

摘要翻译： 本发明涉及一种用于控制生产颗粒的方法，包括以下步骤：生产包含一种或多种在其分散相中固化的化合物的乳液，以及向所述乳液中加入合适的抗溶剂，迫使一种或多种化合物固化。 任选地，固化的化合物被包封或涂覆。

公开(公告)号：US20060051420A1

公开(公告)日：2006-03-09

申请号：US10535009

申请日：2003-11-13

申请人： Pieter De Haan ,  Cornelis Van Lare

发明人： Pieter De Haan ,  Cornelis Van Lare

IPC分类号： A61K9/24 ,  A61K31/57

CPC分类号： A61K9/2826 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/2886 ,  A61K31/569 ,  A61K31/57

摘要： The present invention relates to a stabilized pharmaceutical tablet comprising an amount of from 0.1 to 10% by weight of tibolone provided with a coating, such as a film coating, a sugar coating, a sugar film coating or a “wrap” coating. The invention further relates to the use of a coating for stabilizing a pharmaceutical tablet comprising tibolone. Preferably, the coating is a sugar coating or a sugar film coating. Preferably, the sugar comprises sucrose. These tablets were shown to have a lower amount of OM38, i.e. an isomerization degradation product of tibolone, after storage as compared to uncoated tibolone tablets.

摘要翻译： 本发明涉及稳定的药物片剂，其包含0.1至10重量％的提供有涂层的替勃龙，例如膜包衣，糖衣，糖膜包衣或“包裹”包衣。 本发明还涉及用于稳定包含替勃龙的药物片剂的包衣的用途。 优选地，涂层是糖衣或糖膜涂层。 优选地，糖包括蔗糖。 与未涂布的替勃龙片相比，这些片剂在储存后显示具有较低量的OM38，即替勃龙的异构化降解产物。