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公开(公告)号：US08603813B2
公开(公告)日：2013-12-10
申请号：US13339268
申请日：2011-12-28
CPC分类号： C12N5/0618 , C12N5/0693 , G01N33/5014
摘要： The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
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2.发明授权Cells useful for immuno-based botulinum toxin serotype A activity assays 有权可用于基于免疫的肉毒杆菌毒素血清型A活性测定的细胞公开(公告)号：US08507271B2
公开(公告)日：2013-08-13
申请号：US13339106
申请日：2011-12-28
CPC分类号： C12N5/0618 , C12N5/0693 , G01N33/5014
摘要： The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
摘要翻译： 本说明书公开了对BoNT / A中毒敏感的克隆细胞系，产生这种克隆细胞系的方法，以及使用这种克隆细胞系检测肉毒杆菌毒素血清型A活性的方法。
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公开(公告)号：US08455247B2
公开(公告)日：2013-06-04
申请号：US13339079
申请日：2011-12-28
CPC分类号： C12N5/0618 , C12N5/0693 , G01N33/5014
摘要： The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
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公开(公告)号：US20120214231A1
公开(公告)日：2012-08-23
申请号：US13339268
申请日：2011-12-28
IPC分类号： C12N5/10
CPC分类号： C12N5/0618 , C12N5/0693 , G01N33/5014
摘要： The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
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公开(公告)号：US20120208272A1
公开(公告)日：2012-08-16
申请号：US13339237
申请日：2011-12-28
IPC分类号： C12N5/10
CPC分类号： C12N5/0618 , C12N5/0693 , G01N33/5014
摘要： The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
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公开(公告)号：US20120156775A1
公开(公告)日：2012-06-21
申请号：US13339225
申请日：2011-12-28
IPC分类号： C12N5/071 , C12N5/0793 , C12N5/09
CPC分类号： C12N5/0618 , C12N5/0693 , G01N33/5014
摘要： The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
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公开(公告)号：US20120149103A1
公开(公告)日：2012-06-14
申请号：US13339056
申请日：2011-12-28
IPC分类号： C12N5/07
摘要： The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
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8.发明申请公开(公告)号：US20120122128A1
公开(公告)日：2012-05-17
申请号：US12403531
申请日：2009-03-13
申请人： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
发明人： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
IPC分类号： G01N33/566
CPC分类号： C07K16/1282 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12Q1/37 , G01N33/5014 , G01N33/566 , G01N33/6854
摘要： The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
摘要翻译： 本说明书公开了SNAP-25组合物，制备α-SNAP-25抗体的方法，所述α-SNAP-25抗体结合来自SNAP-25裂解产物的BoNT / A切割位点剪切键的P1残基处的包含羧基末端的表位， SNAP-25抗体结合来自SNAP-25切割产物的BoNT / A切割位点剪切键的P1残基处的羧基末端的表位，检测BoNT / A活性的方法和检测中和α-BoNT的方法 / A抗体。
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公开(公告)号：US09625447B2
公开(公告)日：2017-04-18
申请号：US13339248
申请日：2011-12-28
CPC分类号： C12N5/0618 , C12N5/0693 , G01N33/5014
摘要： The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
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公开(公告)号：US08663982B2
公开(公告)日：2014-03-04
申请号：US13339232
申请日：2011-12-28
IPC分类号： C12N15/85
CPC分类号： C12N5/0618 , C12N5/0693 , G01N33/5014
摘要： The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
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