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公开(公告)号：US08198034B2
公开(公告)日：2012-06-12
申请号：US12403531
申请日：2009-03-13
申请人： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
发明人： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
IPC分类号： G01N33/53
CPC分类号： C07K16/1282 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12Q1/37 , G01N33/5014 , G01N33/566 , G01N33/6854
摘要： The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
摘要翻译： 本说明书公开了SNAP-25组合物，制备α-SNAP-25抗体的方法，所述α-SNAP-25抗体结合来自SNAP-25裂解产物的BoNT / A切割位点剪切键的P1残基处的包含羧基末端的表位， SNAP-25抗体结合来自SNAP-25切割产物的BoNT / A切割位点剪切键的P1残基处的羧基末端的表位，检测BoNT / A活性的方法和检测中和α-BoNT的方法 / A抗体。
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2.发明申请公开(公告)号：US20120122128A1
公开(公告)日：2012-05-17
申请号：US12403531
申请日：2009-03-13
申请人： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
发明人： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
IPC分类号： G01N33/566
CPC分类号： C07K16/1282 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12Q1/37 , G01N33/5014 , G01N33/566 , G01N33/6854
摘要： The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
摘要翻译： 本说明书公开了SNAP-25组合物，制备α-SNAP-25抗体的方法，所述α-SNAP-25抗体结合来自SNAP-25裂解产物的BoNT / A切割位点剪切键的P1残基处的包含羧基末端的表位， SNAP-25抗体结合来自SNAP-25切割产物的BoNT / A切割位点剪切键的P1残基处的羧基末端的表位，检测BoNT / A活性的方法和检测中和α-BoNT的方法 / A抗体。
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3.发明申请公开(公告)号：US20130040368A1
公开(公告)日：2013-02-14
申请号：US13649923
申请日：2012-10-11
申请人： Ester Fernandez-Salas , Joanne Wang , Patton E. Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
发明人： Ester Fernandez-Salas , Joanne Wang , Patton E. Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
IPC分类号： C12N9/52
摘要： The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
摘要翻译： 本说明书公开了SNAP-25组合物，制备α-SNAP-25抗体的方法，所述α-SNAP-25抗体结合来自SNAP-25裂解产物的BoNT / A切割位点剪切键的P1残基处的包含羧基末端的表位， SNAP-25抗体结合来自SNAP-25切割产物的BoNT / A切割位点剪切键的P1残基处的羧基末端的表位，检测BoNT / A活性的方法和检测中和α-BoNT的方法 / A抗体。
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公开(公告)号：US09249216B2
公开(公告)日：2016-02-02
申请号：US13475553
申请日：2012-05-18
申请人： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Diane Hodges , Kei Roger Aoki
发明人： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Diane Hodges , Kei Roger Aoki
CPC分类号： C07K16/1282 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12Q1/37 , G01N33/5014 , G01N33/566 , G01N33/6854
摘要： The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
摘要翻译： 本说明书公开了SNAP-25组合物，制备α-SNAP-25抗体的方法，所述α-SNAP-25抗体结合来自SNAP-25裂解产物的BoNT / A切割位点剪切键的P1残基处的包含羧基末端的表位， SNAP-25抗体结合来自SNAP-25切割产物的BoNT / A切割位点剪切键的P1残基处的羧基末端的表位，检测BoNT / A活性的方法和检测中和α-BoNT的方法 / A抗体。
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公开(公告)号：US20120225436A1
公开(公告)日：2012-09-06
申请号：US13475553
申请日：2012-05-18
申请人： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Diane Hodges , Kei Roger Aoki
发明人： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Diane Hodges , Kei Roger Aoki
IPC分类号： G01N33/53
CPC分类号： C07K16/1282 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12Q1/37 , G01N33/5014 , G01N33/566 , G01N33/6854
摘要： The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
摘要翻译： 本说明书公开了SNAP-25组合物，制备α-SNAP-25抗体的方法，所述α-SNAP-25抗体结合来自SNAP-25裂解产物的BoNT / A切割位点剪切键的P1残基处的包含羧基末端的表位， SNAP-25抗体结合来自SNAP-25切割产物的BoNT / A切割位点剪切键的P1残基处的羧基末端的表位，检测BoNT / A活性的方法和检测中和α-BoNT的方法 / A抗体。
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公开(公告)号：US20100203559A1
公开(公告)日：2010-08-12
申请号：US12723474
申请日：2010-03-12
申请人： Fernandez-Salas Ester , Joanne Wang , Patton Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
发明人： Fernandez-Salas Ester , Joanne Wang , Patton Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
CPC分类号： C07K16/1282 , C07K2317/34 , C07K2317/77 , C12Q1/37 , G01N33/56911 , G01N2333/33 , G01N2333/705 , G01N2333/952
摘要： The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
摘要翻译： 本说明书公开了SNAP-25组合物，制备α-SNAP-25抗体的方法，所述α-SNAP-25抗体结合来自SNAP-25裂解产物的BoNT / A切割位点剪切键的P1残基处的包含羧基末端的表位， SNAP-25抗体结合来自SNAP-25切割产物的BoNT / A切割位点剪切键的P1残基处的羧基末端的表位，检测BoNT / A活性的方法和检测中和α-BoNT的方法 / A抗体。
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公开(公告)号：US08618261B2
公开(公告)日：2013-12-31
申请号：US12723474
申请日：2010-03-12
申请人： Fernandez-Salas Ester , Joanne Wang , Patton Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
发明人： Fernandez-Salas Ester , Joanne Wang , Patton Garay , Lina S. Wong , D. Dianne Hodges , Kei Roger Aoki
IPC分类号： C07K16/00
CPC分类号： C07K16/1282 , C07K2317/34 , C07K2317/77 , C12Q1/37 , G01N33/56911 , G01N2333/33 , G01N2333/705 , G01N2333/952
摘要： The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
摘要翻译： 本说明书公开了SNAP-25组合物，制备α-SNAP-25抗体的方法，所述α-SNAP-25抗体结合来自SNAP-25裂解产物的BoNT / A切割位点剪切键的P1残基处的包含羧基末端的表位， SNAP-25抗体结合包含来自SNAP-25切割产物的BoNT / A切割位点剪切键的P1残基处的羧基末端的表位，检测BoNT / A活性的方法和检测中和α-BoNT的方法 / A抗体。
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公开(公告)号：US20080003240A1
公开(公告)日：2008-01-03
申请号：US10598073
申请日：2005-02-23
CPC分类号： G01N33/56911 , G01N2333/50
摘要： Methods for detecting BoNT/A activity in a sample, methods for screening molecules able to compete with BoNT/A receptor binding, methods for reducing BoNT/A activity in a human and methods of marketing a neurotoxin capable of selectively binding to FGFR3 to a governmental or regional regulatory authority.
摘要翻译： 用于检测样品中BoNT / A活性的方法，用于筛选能够与BoNT / A受体结合竞争的分子的方法，用于降低人类中的BoNT / A活性的方法和将能够选择性结合FGFR3的神经毒素销售给政府的方法 或区域监管机构。
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公开(公告)号：US08257914B2
公开(公告)日：2012-09-04
申请号：US12545647
申请日：2009-08-21
CPC分类号： G01N33/56911 , G01N2333/50
摘要： Methods for detecting BoNT/A activity in a sample, methods for screening molecules able to compete with BoNT/A receptor binding, methods for reducing BoNT/A activity in a human and methods of marketing a neurotoxin capable of selectively binding to FGFR3 to a governmental or regional regulatory authority.
摘要翻译： 用于检测样品中BoNT / A活性的方法，用于筛选能够与BoNT / A受体结合竞争的分子的方法，用于降低人类中的BoNT / A活性的方法和将能够选择性结合FGFR3的神经毒素销售给政府的方法 或区域监管机构。
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10.发明申请公开(公告)号：US20120207733A1
公开(公告)日：2012-08-16
申请号：US13371796
申请日：2012-02-13
申请人： Birgitte P.S. Jacky , Patton E. Garay , Yanira Molina , Joseph Francis , Lance E. Steward , Sanjiv Ghanshani , Terrence J. Hunt , Kei Roger Aoki , Ester Fernandez-Salas
发明人： Birgitte P.S. Jacky , Patton E. Garay , Yanira Molina , Joseph Francis , Lance E. Steward , Sanjiv Ghanshani , Terrence J. Hunt , Kei Roger Aoki , Ester Fernandez-Salas
CPC分类号： A61K38/4893
摘要： The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer or a disease of hyperproliferation in a mammal using such TVEMP compositions.
摘要翻译： 本说明书公开了TVEMP，包含这种TVEMP的组合物和使用这种TVEMP组合物治疗哺乳动物的癌症或过度增生疾病的方法。
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