公开(公告)号：US20090203940A1

公开(公告)日：2009-08-13

申请号：US11658746

申请日：2004-09-15

Applicant: Dong Yeon Kim ,  Jae G. Kim ,  Dae Jin Cho ,  Gong Y. Lee ,  Hong Y. Kim ,  Seok H. Woo

Inventor： Dong Yeon Kim ,  Jae G. Kim ,  Dae Jin Cho ,  Gong Y. Lee ,  Hong Y. Kim ,  Seok H. Woo

IPC: C07C213/06

CPC classification number: C07C213/06 ,  C07C213/00 ,  C07C217/58

Abstract: The present invention relates to a novel method for preparing an itopride-hydrochloride mediate of the formula 1, which is useful for digestive tract activator, and more particularly, the present invention provides with a method for preparing 4-[2-(dimethylamino)ethoxy]benzylamine of the formula 1, an itopride-hydrochloride mediate, whereby being capable of manufacturing in a high yield and lowering cost through a simple purification and a selective reaction, and the method is harmless and safe to human and environment due to not generating toxic gas. And specially, a super-high pressure hydrogenation and a reduction reaction using a metal catalyst are not carried out, therefore, it is very safe method, and also special manufacturing equipments are not needed.

Abstract translation: 本发明涉及一种制备式1的伊曲肽 - 盐酸盐介质的新方法，其可用于消化道活化剂，更具体地说，本发明提供了制备4- [2-（二甲基氨基）乙氧基 ]苄胺，盐酸伊必利德介导，其通过简单的纯化和选择性反应能够以高产率制造并降低成本，并且该方法由于不产生有毒物质而对人和环境无害和安全 加油站。 特别是使用金属催化剂进行超高压氢化和还原反应不能进行，因此是非常安全的方法，也不需要特殊的制造设备。

公开(公告)号：US09132126B2

公开(公告)日：2015-09-15

申请号：US13979743

申请日：2012-03-30

Applicant: Dong Yeon Kim ,  Dae Jin Cho ,  Gong Yeal Lee ,  Hong Youb Kim ,  Seok Hun Woo ,  Hae Un Lee ,  Sung Moo Kim ,  Choong Am Ahn ,  Seung Bin Yoon

Inventor： Dong Yeon Kim ,  Dae Jin Cho ,  Gong Yeal Lee ,  Hong Youb Kim ,  Seok Hun Woo ,  Hae Un Lee ,  Sung Moo Kim ,  Choong Am Ahn ,  Seung Bin Yoon

IPC: C07D261/14 ,  C07D261/18 ,  C07D413/06 ,  A61K31/496 ,  C07D261/08 ,  A61K31/42 ,  A61K31/454 ,  A61K45/06

CPC classification number: A61K31/496 ,  A61K31/42 ,  A61K31/454 ,  A61K45/06 ,  C07D261/08 ,  C07D261/18 ,  C07D413/06

Abstract: Disclosed are a phenyl-isoxazol derivative compound, which is useful as a treatment material for virus infection, especially, infection of an influenza virus, or its pharmaceutically acceptable derivative, a preparation method thereof, and an illness treatment pharmaceutical composition including the compound as an active ingredient.

Abstract translation: 公开了苯并异恶唑衍生物化合物，其可用作病毒感染的治疗材料，特别是感染流感病毒或其药学上可接受的衍生物，其制备方法和疾病治疗药物组合物，其包含该化合物作为 有效成分。

公开(公告)号：US07595323B2

公开(公告)日：2009-09-29

申请号：US10806834

申请日：2004-03-22

Applicant: Dong-Yeon Kim ,  Jae-Gun Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Woo-Chul Bae ,  Sun-Ahe Lee ,  Byoung-Cheol Han

Inventor： Dong-Yeon Kim ,  Jae-Gun Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Woo-Chul Bae ,  Sun-Ahe Lee ,  Byoung-Cheol Han

IPC: C07D239/28 ,  A61K31/505

CPC classification number: C07D401/04 ,  C07D401/12

Abstract: The present invention relates to an N-phenyl-2-pyrimidine-amine derivative showing a superior effect on lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer, or cervical cancer, etc. of warm-blooded animals and its salt. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various diseases, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.

Abstract translation: 本发明涉及对肺癌，胃癌，结肠癌，胰腺癌，肝癌，前列腺癌，乳腺癌，慢性或急性白血病，血液恶性肿瘤，脑病等有显着影响的N-苯基-2-嘧啶胺衍生物 ，膀胱癌，直肠癌或子宫颈癌等，其温血动物及其盐。 本发明还涉及一种制备该化合物的方法以及用于治疗上述各种疾病的药物组合物，其包含有效量的作为活性成分的化合物以及药学上可接受的惰性载体。

公开(公告)号：US20080096899A1

公开(公告)日：2008-04-24

申请号：US11813175

申请日：2005-09-07

Applicant: Dong-Yeon Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Sun-Ahe Lee ,  Byoung-Cheol Han

Inventor： Dong-Yeon Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Sun-Ahe Lee ,  Byoung-Cheol Han

IPC: A61K31/506 ,  A61P35/00 ,  A61K31/497 ,  C07D403/04 ,  C07D417/04

CPC classification number: C07D417/14 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention relates to a novel N-phenyl-2-pyrimidine-amine derivative represented by the above formula (1) and its salt showing a superior effect on cancer in warm-blooded animals, such as lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer, cervical cancer, lymphoma, etc. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various diseases, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.

Abstract translation: 本发明涉及由上述式（1）表示的新型N-苯基-2-嘧啶胺衍生物及其对温血动物（例如肺癌，胃癌，结肠癌）中对癌症的显着影响的盐 ，胰腺癌，肝癌，前列腺癌，乳腺癌，慢性或急性白血病，血液恶性肿瘤，脑病，膀胱癌，直肠癌，子宫颈癌，淋巴瘤等。本发明还涉及一种制备该化合物的方法， 用于治疗上述各种疾病的药物组合物，其包含有效量的作为活性成分的化合物以及药学上可接受的惰性载体。

公开(公告)号：US20140031364A1

公开(公告)日：2014-01-30

申请号：US13979743

申请日：2012-03-30

Applicant: Dong Yeon Kim ,  Dae Jin Cho ,  Gong Yeal Lee ,  Hong Youb Kim ,  Seok Hun Woo ,  Hae Un Lee ,  Sung Moo Kim ,  Choong Am Ahn ,  Seung Bin Yoon

Inventor： Dong Yeon Kim ,  Dae Jin Cho ,  Gong Yeal Lee ,  Hong Youb Kim ,  Seok Hun Woo ,  Hae Un Lee ,  Sung Moo Kim ,  Choong Am Ahn ,  Seung Bin Yoon

IPC: A61K31/496 ,  A61K31/454 ,  A61K45/06 ,  C07D413/06 ,  C07D261/18 ,  A61K31/42

CPC classification number: A61K31/496 ,  A61K31/42 ,  A61K31/454 ,  A61K45/06 ,  C07D261/08 ,  C07D261/18 ,  C07D413/06

Abstract: Disclosed are a phenyl-isoxazol derivative compound, which is useful as a treatment material for virus infection, especially, infection of an influenza virus, or its pharmaceutically acceptable derivative, a preparation method thereof, and an illness treatment pharmaceutical composition including the compound as an active ingredient.

Abstract translation: 公开了苯并异恶唑衍生物化合物，其可用作病毒感染的治疗材料，特别是感染流感病毒或其药学上可接受的衍生物，其制备方法和疾病治疗药物组合物，其包含该化合物作为 有效成分。

公开(公告)号：US07501424B2

公开(公告)日：2009-03-10

申请号：US11813175

申请日：2005-09-07

Applicant: Dong-Yeon Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Sun-Ahe Lee ,  Byoung-Cheol Han

Inventor： Dong-Yeon Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Sun-Ahe Lee ,  Byoung-Cheol Han

IPC: C07D239/28 ,  A61K31/505

CPC classification number: C07D417/14 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention relates to a novel N-phenyl-2-pyrimidine-amine derivative represented by the above formula (1) and its salt showing a superior effect on cancer in warm-blooded animals, such as lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer, cervical cancer, lymphoma, etc. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various diseases, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.

Abstract translation: 本发明涉及由上述式（1）表示的新型N-苯基-2-嘧啶胺衍生物及其对温血动物（例如肺癌，胃癌，结肠癌）中对癌症的显着影响的盐 ，胰腺癌，肝癌，前列腺癌，乳腺癌，慢性或急性白血病，血液恶性肿瘤，脑病，膀胱癌，直肠癌，子宫颈癌，淋巴瘤等。本发明还涉及一种制备该化合物的方法， 用于治疗上述各种疾病的药物组合物，其包含有效量的作为活性成分的化合物以及药学上可接受的惰性载体。