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公开(公告)号：US20100310666A1
公开(公告)日：2010-12-09
申请号：US12479444
申请日：2009-06-05
申请人： Anilkumar Ganapati Gaonkar , Ahmad Akashe , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , James D. White , Yan Wang , Leslie G. West
发明人： Anilkumar Ganapati Gaonkar , Ahmad Akashe , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , James D. White , Yan Wang , Leslie G. West
IPC分类号： A61K9/16 , A61K31/015
CPC分类号： A61K31/00 , A23L33/105 , A23P10/30 , A61K31/015
摘要： Functional ingredients including an esterified component and microencapsulated in an enteric matrix to increase the microencapsulation efficiency and reduce undesired organoleptic properties of the microencapsulated material while providing a desired release rate and ester hydrolysis rate, the process including forming an emulsion in water and titrating the emulsion with a precipitating agent to produce a particulate precipitate.
摘要翻译： 功能成分包括酯化组分并且微胶囊化在肠溶基质中以提高微囊化效率并降低微囊化材料的不希望的感官特性，同时提供所需的释放速率和酯水解速率，该方法包括在水中形成乳液并用 沉淀剂以产生颗粒沉淀物。
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公开(公告)号：US08765030B2
公开(公告)日：2014-07-01
申请号：US13475645
申请日：2012-05-18
申请人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , Yan Wang , James D. White
发明人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , Yan Wang , James D. White
IPC分类号： A61K9/127
CPC分类号： A61K36/48 , A23P10/35 , A61K8/11 , A61K8/645 , A61K8/927 , A61K9/0095 , A61K9/5015 , A61K9/5052 , A61K9/5063 , A61K31/015 , A61K31/045 , A61K31/05 , A61K31/31 , A61K2800/412 , A61Q13/00 , A61K2300/00
摘要： Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix.
摘要翻译： 疏水性液体在基本上不含有机溶剂的环境中由肠溶基质微胶囊化，该方法包括在肠液中形成肠溶性物质和疏水性液体的乳液，用酸滴定乳液，以形成微胶囊化疏水液体的颗粒状沉淀物 肠溶矩阵
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公开(公告)号：US20110159103A1
公开(公告)日：2011-06-30
申请号：US12976614
申请日：2010-12-22
申请人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , George W. Haas , Dana Sebesta , Yan Wang
发明人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , George W. Haas , Dana Sebesta , Yan Wang
CPC分类号： A61K9/0095 , A23L2/39 , A23L2/52 , A23L27/72 , A23P10/35 , A61K8/11 , A61K8/645 , A61K8/927 , A61K9/5015 , A61K9/5052 , A61K31/015 , A61K31/045 , A61K31/05 , A61K31/31 , A61K2800/412 , A61Q13/00 , A61K2300/00
摘要： Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents. The process includes forming an emulsion of the enteric material and hydrophobic liquid in water, titrating the emulsion with an acid to form a particulate precipitate and optionally coating the particulate with a combination of enteric material and plasticizer.
摘要翻译： 疏水液体在基本上不含有机溶剂的环境中被肠溶基质微胶囊化。 该方法包括在水中形成肠溶性物质和疏水性液体的乳液，用酸滴定乳液以形成颗粒沉淀物，并任选地用肠溶性物质和增塑剂的组合物包被颗粒。
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公开(公告)号：US09968564B2
公开(公告)日：2018-05-15
申请号：US12479444
申请日：2009-06-05
申请人： Anilkumar Ganapati Gaonkar , Ahmad Akashe , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , James D. White , Yan Wang , Leslie G. West
发明人： Anilkumar Ganapati Gaonkar , Ahmad Akashe , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , James D. White , Yan Wang , Leslie G. West
IPC分类号： A61K31/00 , A61K31/015 , A23P10/30 , A23L33/105
CPC分类号： A61K31/00 , A23L33/105 , A23P10/30 , A61K31/015
摘要： Functional ingredients including an esterified component and microencapsulated in an enteric matrix to increase the microencapsulation efficiency and reduce undesired organoleptic properties of the microencapsulated material while providing a desired release rate and ester hydrolysis rate, the process including forming an emulsion in water and titrating the emulsion with a precipitating agent to produce a particulate precipitate.
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公开(公告)号：US08859003B2
公开(公告)日：2014-10-14
申请号：US12976614
申请日：2010-12-22
申请人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , George W. Haas , Dana Sebesta , Yan Wang
发明人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , George W. Haas , Dana Sebesta , Yan Wang
IPC分类号： A61K9/16 , A61K9/00 , A61K31/045 , A61K8/92 , A23L2/39 , A61K31/31 , A61Q13/00 , A61K31/015 , A61K31/05 , A23L1/22 , A61K8/11 , A61K9/50 , A61K8/64 , A23L2/52 , A23L1/00
CPC分类号： A61K9/0095 , A23L2/39 , A23L2/52 , A23L27/72 , A23P10/35 , A61K8/11 , A61K8/645 , A61K8/927 , A61K9/5015 , A61K9/5052 , A61K31/015 , A61K31/045 , A61K31/05 , A61K31/31 , A61K2800/412 , A61Q13/00 , A61K2300/00
摘要： Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents. The process includes forming an emulsion of the enteric material and hydrophobic liquid in water, titrating the emulsion with an acid to form a particulate precipitate and optionally coating the particulate with a combination of enteric material and plasticizer.
摘要翻译： 疏水液体在基本上不含有机溶剂的环境中被肠溶基质微胶囊化。 该方法包括在水中形成肠溶性物质和疏水性液体的乳液，用酸滴定乳液以形成颗粒沉淀物，并任选地用肠溶性物质和增塑剂的组合物包被颗粒。
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公开(公告)号：US20120273982A1
公开(公告)日：2012-11-01
申请号：US13475645
申请日：2012-05-18
申请人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , Yan Wang , James D. White
发明人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , Yan Wang , James D. White
IPC分类号： A61J3/02
CPC分类号： A61K36/48 , A23P10/35 , A61K8/11 , A61K8/645 , A61K8/927 , A61K9/0095 , A61K9/5015 , A61K9/5052 , A61K9/5063 , A61K31/015 , A61K31/045 , A61K31/05 , A61K31/31 , A61K2800/412 , A61Q13/00 , A61K2300/00
摘要： Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix.
摘要翻译： 疏水性液体在基本上不含有机溶剂的环境中由肠溶基质微胶囊化，该方法包括在肠液中形成肠溶性物质和疏水性液体的乳液，用酸滴定乳液，以形成微胶囊化疏水液体的颗粒状沉淀物 肠溶矩阵
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公开(公告)号：US20100310726A1
公开(公告)日：2010-12-09
申请号：US12479454
申请日：2009-06-05
申请人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , Yan Wang , James D. White
发明人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , Yan Wang , James D. White
CPC分类号： A61K36/48 , A23P10/35 , A61K8/11 , A61K8/645 , A61K8/927 , A61K9/0095 , A61K9/5015 , A61K9/5052 , A61K9/5063 , A61K31/015 , A61K31/045 , A61K31/05 , A61K31/31 , A61K2800/412 , A61Q13/00 , A61K2300/00
摘要： Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix.
摘要翻译： 疏水性液体在基本上不含有机溶剂的环境中由肠溶基质微胶囊化，该方法包括在肠液中形成肠溶性物质和疏水性液体的乳液，用酸滴定乳液，以形成微胶囊化疏水液体的颗粒状沉淀物 肠溶矩阵
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