公开(公告)号：US09968564B2

公开(公告)日：2018-05-15

申请号：US12479444

申请日：2009-06-05

申请人： Anilkumar Ganapati Gaonkar ,  Ahmad Akashe ,  Les Lawrence ,  Amado R. Lopez ,  Ronald L. Meibach ,  Dana Sebesta ,  James D. White ,  Yan Wang ,  Leslie G. West

发明人： Anilkumar Ganapati Gaonkar ,  Ahmad Akashe ,  Les Lawrence ,  Amado R. Lopez ,  Ronald L. Meibach ,  Dana Sebesta ,  James D. White ,  Yan Wang ,  Leslie G. West

IPC分类号： A61K31/00 ,  A61K31/015 ,  A23P10/30 ,  A23L33/105

CPC分类号： A61K31/00 ,  A23L33/105 ,  A23P10/30 ,  A61K31/015

摘要： Functional ingredients including an esterified component and microencapsulated in an enteric matrix to increase the microencapsulation efficiency and reduce undesired organoleptic properties of the microencapsulated material while providing a desired release rate and ester hydrolysis rate, the process including forming an emulsion in water and titrating the emulsion with a precipitating agent to produce a particulate precipitate.

公开(公告)号：US20100310666A1

公开(公告)日：2010-12-09

申请号：US12479444

申请日：2009-06-05

申请人： Anilkumar Ganapati Gaonkar ,  Ahmad Akashe ,  Les Lawrence ,  Amado R. Lopez ,  Ronald L. Meibach ,  Dana Sebesta ,  James D. White ,  Yan Wang ,  Leslie G. West

发明人： Anilkumar Ganapati Gaonkar ,  Ahmad Akashe ,  Les Lawrence ,  Amado R. Lopez ,  Ronald L. Meibach ,  Dana Sebesta ,  James D. White ,  Yan Wang ,  Leslie G. West

IPC分类号： A61K9/16 ,  A61K31/015

CPC分类号： A61K31/00 ,  A23L33/105 ,  A23P10/30 ,  A61K31/015

摘要： Functional ingredients including an esterified component and microencapsulated in an enteric matrix to increase the microencapsulation efficiency and reduce undesired organoleptic properties of the microencapsulated material while providing a desired release rate and ester hydrolysis rate, the process including forming an emulsion in water and titrating the emulsion with a precipitating agent to produce a particulate precipitate.

摘要翻译： 功能成分包括酯化组分并且微胶囊化在肠溶基质中以提高微囊化效率并降低微囊化材料的不希望的感官特性，同时提供所需的释放速率和酯水解速率，该方法包括在水中形成乳液并用 沉淀剂以产生颗粒沉淀物。

公开(公告)号：US08765030B2

公开(公告)日：2014-07-01

申请号：US13475645

申请日：2012-05-18

申请人： Ahmad Akashe ,  Anilkumar Ganapati Gaonkar ,  Les Lawrence ,  Amado R. Lopez ,  Ronald L. Meibach ,  Dana Sebesta ,  Yan Wang ,  James D. White

发明人： Ahmad Akashe ,  Anilkumar Ganapati Gaonkar ,  Les Lawrence ,  Amado R. Lopez ,  Ronald L. Meibach ,  Dana Sebesta ,  Yan Wang ,  James D. White

IPC分类号： A61K9/127

CPC分类号： A61K36/48 ,  A23P10/35 ,  A61K8/11 ,  A61K8/645 ,  A61K8/927 ,  A61K9/0095 ,  A61K9/5015 ,  A61K9/5052 ,  A61K9/5063 ,  A61K31/015 ,  A61K31/045 ,  A61K31/05 ,  A61K31/31 ,  A61K2800/412 ,  A61Q13/00 ,  A61K2300/00

摘要： Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix.

摘要翻译： 疏水性液体在基本上不含有机溶剂的环境中由肠溶基质微胶囊化，该方法包括在肠液中形成肠溶性物质和疏水性液体的乳液，用酸滴定乳液，以形成微胶囊化疏水液体的颗粒状沉淀物 肠溶矩阵

公开(公告)号：US20120273982A1

公开(公告)日：2012-11-01

申请号：US13475645

申请日：2012-05-18

申请人： Ahmad Akashe ,  Anilkumar Ganapati Gaonkar ,  Les Lawrence ,  Amado R. Lopez ,  Ronald L. Meibach ,  Dana Sebesta ,  Yan Wang ,  James D. White

发明人： Ahmad Akashe ,  Anilkumar Ganapati Gaonkar ,  Les Lawrence ,  Amado R. Lopez ,  Ronald L. Meibach ,  Dana Sebesta ,  Yan Wang ,  James D. White

IPC分类号： A61J3/02

CPC分类号： A61K36/48 ,  A23P10/35 ,  A61K8/11 ,  A61K8/645 ,  A61K8/927 ,  A61K9/0095 ,  A61K9/5015 ,  A61K9/5052 ,  A61K9/5063 ,  A61K31/015 ,  A61K31/045 ,  A61K31/05 ,  A61K31/31 ,  A61K2800/412 ,  A61Q13/00 ,  A61K2300/00

摘要： Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix.

摘要翻译： 疏水性液体在基本上不含有机溶剂的环境中由肠溶基质微胶囊化，该方法包括在肠液中形成肠溶性物质和疏水性液体的乳液，用酸滴定乳液，以形成微胶囊化疏水液体的颗粒状沉淀物 肠溶矩阵

公开(公告)号：US20100310726A1

公开(公告)日：2010-12-09

申请号：US12479454

申请日：2009-06-05

申请人： Ahmad Akashe ,  Anilkumar Ganapati Gaonkar ,  Les Lawrence ,  Amado R. Lopez ,  Ronald L. Meibach ,  Dana Sebesta ,  Yan Wang ,  James D. White

发明人： Ahmad Akashe ,  Anilkumar Ganapati Gaonkar ,  Les Lawrence ,  Amado R. Lopez ,  Ronald L. Meibach ,  Dana Sebesta ,  Yan Wang ,  James D. White

IPC分类号： A23L1/00 ,  B29B9/00

CPC分类号： A61K36/48 ,  A23P10/35 ,  A61K8/11 ,  A61K8/645 ,  A61K8/927 ,  A61K9/0095 ,  A61K9/5015 ,  A61K9/5052 ,  A61K9/5063 ,  A61K31/015 ,  A61K31/045 ,  A61K31/05 ,  A61K31/31 ,  A61K2800/412 ,  A61Q13/00 ,  A61K2300/00

摘要： Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix.

摘要翻译： 疏水性液体在基本上不含有机溶剂的环境中由肠溶基质微胶囊化，该方法包括在肠液中形成肠溶性物质和疏水性液体的乳液，用酸滴定乳液，以形成微胶囊化疏水液体的颗粒状沉淀物 肠溶矩阵

公开(公告)号：US08859003B2

公开(公告)日：2014-10-14

申请号：US12976614

申请日：2010-12-22

申请人： Ahmad Akashe ,  Anilkumar Ganapati Gaonkar ,  Les Lawrence ,  Amado R. Lopez ,  George W. Haas ,  Dana Sebesta ,  Yan Wang

发明人： Ahmad Akashe ,  Anilkumar Ganapati Gaonkar ,  Les Lawrence ,  Amado R. Lopez ,  George W. Haas ,  Dana Sebesta ,  Yan Wang

IPC分类号： A61K9/16 ,  A61K9/00 ,  A61K31/045 ,  A61K8/92 ,  A23L2/39 ,  A61K31/31 ,  A61Q13/00 ,  A61K31/015 ,  A61K31/05 ,  A23L1/22 ,  A61K8/11 ,  A61K9/50 ,  A61K8/64 ,  A23L2/52 ,  A23L1/00

CPC分类号： A61K9/0095 ,  A23L2/39 ,  A23L2/52 ,  A23L27/72 ,  A23P10/35 ,  A61K8/11 ,  A61K8/645 ,  A61K8/927 ,  A61K9/5015 ,  A61K9/5052 ,  A61K31/015 ,  A61K31/045 ,  A61K31/05 ,  A61K31/31 ,  A61K2800/412 ,  A61Q13/00 ,  A61K2300/00

摘要： Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents. The process includes forming an emulsion of the enteric material and hydrophobic liquid in water, titrating the emulsion with an acid to form a particulate precipitate and optionally coating the particulate with a combination of enteric material and plasticizer.

摘要翻译： 疏水液体在基本上不含有机溶剂的环境中被肠溶基质微胶囊化。 该方法包括在水中形成肠溶性物质和疏水性液体的乳液，用酸滴定乳液以形成颗粒沉淀物，并任选地用肠溶性物质和增塑剂的组合物包被颗粒。

公开(公告)号：US20110159103A1

公开(公告)日：2011-06-30

申请号：US12976614

申请日：2010-12-22

申请人： Ahmad Akashe ,  Anilkumar Ganapati Gaonkar ,  Les Lawrence ,  Amado R. Lopez ,  George W. Haas ,  Dana Sebesta ,  Yan Wang

发明人： Ahmad Akashe ,  Anilkumar Ganapati Gaonkar ,  Les Lawrence ,  Amado R. Lopez ,  George W. Haas ,  Dana Sebesta ,  Yan Wang

IPC分类号： A61K9/50 ,  A61K36/48 ,  A61K36/31 ,  A61K31/222 ,  A61K31/23 ,  A61J3/07

CPC分类号： A61K9/0095 ,  A23L2/39 ,  A23L2/52 ,  A23L27/72 ,  A23P10/35 ,  A61K8/11 ,  A61K8/645 ,  A61K8/927 ,  A61K9/5015 ,  A61K9/5052 ,  A61K31/015 ,  A61K31/045 ,  A61K31/05 ,  A61K31/31 ,  A61K2800/412 ,  A61Q13/00 ,  A61K2300/00

摘要： Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents. The process includes forming an emulsion of the enteric material and hydrophobic liquid in water, titrating the emulsion with an acid to form a particulate precipitate and optionally coating the particulate with a combination of enteric material and plasticizer.

摘要翻译： 疏水液体在基本上不含有机溶剂的环境中被肠溶基质微胶囊化。 该方法包括在水中形成肠溶性物质和疏水性液体的乳液，用酸滴定乳液以形成颗粒沉淀物，并任选地用肠溶性物质和增塑剂的组合物包被颗粒。

公开(公告)号：US11952603B2

公开(公告)日：2024-04-09

申请号：US16108930

申请日：2018-08-22

申请人： Kenneth S. Manning ,  Yan Wang ,  Dustin Nielsen ,  Ryan Ruf ,  Colin Crowley ,  Jon Restivo ,  Dana Spangenberg ,  Karla Anhalt ,  Mark Romich ,  Anisha Akula ,  Carmen Fritz

发明人： Kenneth S. Manning ,  Yan Wang ,  Dustin Nielsen ,  Ryan Ruf ,  Colin Crowley ,  Jon Restivo ,  Dana Spangenberg ,  Karla Anhalt ,  Mark Romich ,  Anisha Akula ,  Carmen Fritz

IPC分类号： C12N9/92 ,  A61K9/00 ,  A61K31/327 ,  A61K35/39 ,  A61K38/46 ,  C12N7/00 ,  C12N9/94

CPC分类号： C12N9/94 ,  A61K9/00 ,  A61K31/327 ,  A61K35/39 ,  A61K38/46 ,  C12N7/00 ,  C12N2750/10063 ,  C12N2750/14363 ,  C12N2770/32263 ,  A61K35/39 ,  A61K2300/00 ,  A61K38/46 ,  A61K2300/00 ,  A61K31/327 ,  A61K2300/00

摘要： A pancreatin preparation having reduced viral infectivity includes one or more pancreatin enzymes and peracetic acid (PAA). At least one pancreatin enzyme may be derived from an animal source such as a porcine pancreas gland. In a particular embodiment, the one or more pancreatin enzymes are selected from the group consisting of lipases, proteases, and amylases.

公开(公告)号：USD985153S1

公开(公告)日：2023-05-02

申请号：US29770167

申请日：2021-02-10

申请人： Yan Wang

设计人： Yan Wang

公开(公告)号：US11579086B2

公开(公告)日：2023-02-14

申请号：US17496262

申请日：2021-10-07

申请人： Yan Wang ,  Cory McCluskey

发明人： Yan Wang ,  Cory McCluskey

IPC分类号： C12Q1/686 ,  G01N21/64 ,  B01L9/00

摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.