METHOD OF FORMING AN AEROSOL FOR INHALATION DELIVERY
    2.
    发明申请
    METHOD OF FORMING AN AEROSOL FOR INHALATION DELIVERY 审中-公开
    形成用于吸入输送的气溶胶的方法

    公开(公告)号:US20110240013A1

    公开(公告)日:2011-10-06

    申请号:US13078606

    申请日:2011-04-01

    IPC分类号: A61M11/00

    摘要: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming a vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

    摘要翻译: 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说,本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面,提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底,从而形成蒸气; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面,提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)加热涂覆有包含药物的组合物的基底以形成蒸气,其中所述涂覆的组合物为小于10μ厚的膜的形式; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面,提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气,其中蒸气的质量大于0.1mg; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶。

    Method of forming an aerosol for inhalation delivery
    3.
    发明授权
    Method of forming an aerosol for inhalation delivery 有权
    形成用于吸入输送的气溶胶的方法

    公开(公告)号:US07537009B2

    公开(公告)日:2009-05-26

    申请号:US10146088

    申请日:2002-05-13

    IPC分类号: A61L9/04

    摘要: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

    摘要翻译: 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说,本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面,提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底,从而形成蒸气; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面,提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)加热涂覆有包含药物的组合物以形成蒸气的基底,其中涂覆的组合物为小于10微米的膜的形式; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面,提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气,其中蒸气的质量大于0.1mg; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶。

    Multimedia apparatus for driving powered surgical instruments
    4.
    发明授权
    Multimedia apparatus for driving powered surgical instruments 失效
    用于驱动动力手术器械的多媒体设备

    公开(公告)号:US4770654A

    公开(公告)日:1988-09-13

    申请号:US82967

    申请日:1987-08-05

    IPC分类号: A61F9/007 A61M1/00 A61B17/20

    摘要: There is disclosed herein a system for providing control of multiple functions needed to perform eye surgery. A microprocessor based system controls a vacuum generation system using venturis and linear valves and a pneumatic system for driving vitrectomy probes and pneumatic scissors in either a variable frequency, multicut mode or a proportional cut mode where the cutting pressure is proportional to the position of a foot operated position sensor. The frequency of the vitrectomy probe cutting action can also be controlled and the level of vacuum can be controlled from a foot operated position sensor which can also be used to turn on or off a fragmentation device. The footswitch can also be used to turn irrigation fluid on or off, and the flow rate can be controlled from a control on the front panel. By making a certain foot motion in any certain aspiration modes, reflux of the aspiration line can be controlled. The vacuum level is continuously monitored over all aspiration conditions and adjusted to stay as close as possible to the desired vacuum level. A cassette proximity sensing system senses the presence of a cassette, and aids the user in drawing in and latching the cassette. The vacuum integrity of the cassette is automatically checked by the microprocessor each time one is drawn into the machine. The microprocessor also monitors the cassette for fullness and initiates a transfer to empty one bottle of the cassette into another bottle for storage when the first bottle becomes full. A back-up system checks the accuracy of cassette liquid level sensing apparatus by double checking for liquid in the line leading to the vacuum generation system. If water is detected, a fluid transfer from one bottle of the cassette to the other is initiated.

    摘要翻译: 这里公开了一种用于提供执行眼睛手术所需的多个功能的控制的系统。 基于微处理器的系统使用Venturis和线性阀控制真空生成系统,以及用于以可变频率,多模式或比例切割模式驱动玻璃体切割探针和气动剪刀的气动系统,其中切割压力与脚的位置成比例 操作位置传感器。 也可以控制玻璃体切割探针切割动作的频率,并且可以从脚踏操作位置传感器控制真空度,该脚踏操作位置传感器也可用于打开或关闭碎片装置。 脚踏开关还可用于打开或关闭冲洗液,并可通过前面板上的控制来控制流量。 通过在任何一定的吸气模式中进行一定的脚运动,可以控制抽吸管线的回流。 在所有抽吸条件下连续监测真空水平,并将其调节至尽可能接近所需的真空水平。 盒式接近感测系统感测盒的存在,并且帮助用户拉入和锁定盒。 每次将微机吸入机器时,盒子的真空完整性由微处理器自动检查。 微处理器还监控盒子的充满度,并开始传送,以便在第一瓶满满时将一个盒子的一个瓶子清空到另一个瓶子中以进行存储。 备用系统通过双重检查通向真空产生系统的管线中的液体来检查盒式液位感测装置的精度。 如果检测到水,则开始从盒的一个瓶到另一个瓶的液体转移。

    Surgical cassette proximity sensing and latching apparatus
    5.
    发明授权
    Surgical cassette proximity sensing and latching apparatus 失效
    手术盒接近感应和闭锁装置

    公开(公告)号:US4758220A

    公开(公告)日:1988-07-19

    申请号:US780613

    申请日:1985-09-26

    摘要: There is disclosed herein a system for providing control of multiple functions needed to perform eye surgery. A microprocessor based system controls a vacuum generation system using venturis and linear valves and a pneumatic system for driving vitrectomy probes and pneumatic scissors in either a variable frequency, multicut mode or a proportional cut mode where the cutting pressure is proportional to the position of a foot operated position sensor. The frequency of the vitrectomy probe cutting action can also be controlled and the level of vacuum can be controlled from a foot operated position sensor which can also be used to turn on or off a fragmentation device. The footswitch can also be used to turn irrigation fluid on or off, and the flow rate can be controlled from a control on the front panel. By making a certain foot motion in any certain aspiration modes, reflux of the aspiration line can be controlled. The vacuum level is continuously monitored over all aspiration conditions and adjusted to stay as close as possible to the desired vacuum level. A cassette proximity sensing system senses the presence of a cassette, and aids the user in drawing in and latching the cassette. The vacuum integrity of the cassette is automatically checked by the microprocessor each time one is drawn into the machine. The microprocessor also monitors the cassette for fullness an initiates a transfer to empty one bottle of the cassette into another bottle for storage when the first bottle becomes full. A back-up system checks the accuracy of cassette liquid level sensing apparatus by double checking for liquid in the line leading to the vacuum generation system. If water is detected, a fluid transfer from one bottle of the cassette to the other is initiated.

    摘要翻译: 这里公开了一种用于提供执行眼睛手术所需的多个功能的控制的系统。 基于微处理器的系统使用Venturis和线性阀控制真空生成系统,以及用于以可变频率,多模式或比例切割模式驱动玻璃体切割探针和气动剪刀的气动系统,其中切割压力与脚的位置成比例 操作位置传感器。 也可以控制玻璃体切割探针切割动作的频率,并且可以从脚踏操作位置传感器控制真空度,该脚踏操作位置传感器也可用于打开或关闭碎片装置。 脚踏开关还可用于打开或关闭冲洗液,并可通过前面板上的控制来控制流量。 通过在任何一定的吸气模式中进行一定的脚运动,可以控制抽吸管线的回流。 在所有抽吸条件下连续监测真空水平,并将其调节至尽可能接近所需的真空水平。 盒式接近感测系统感测盒的存在,并且帮助用户拉入和锁定盒。 每次将微机吸入机器时,盒子的真空完整性由微处理器自动检查。 微处理器还监控盒子的充满度,当第一瓶满满时,启动传送以将一个盒子的一个瓶子清空到另一个瓶子中以进行存储。 备用系统通过双重检查通向真空产生系统的管线中的液体来检查盒式液位感测装置的精度。 如果检测到水,则开始从盒的一个瓶到另一个瓶的液体转移。

    Method of forming an aerosol for inhalation delivery
    6.
    发明授权
    Method of forming an aerosol for inhalation delivery 有权
    形成用于吸入输送的气溶胶的方法

    公开(公告)号:US08074644B2

    公开(公告)日:2011-12-13

    申请号:US12471070

    申请日:2009-05-22

    IPC分类号: A61L9/04

    摘要: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

    摘要翻译: 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说,本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面,提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底,从而形成蒸气; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面,提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)加热涂覆有包含药物的组合物的基底以形成蒸气,其中所述涂覆的组合物为小于10μ厚的膜的形式; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面,提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气,其中蒸气的质量大于0.1mg; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶。

    Method Of Forming An Aerosol For Inhalation Delivery
    8.
    发明申请
    Method Of Forming An Aerosol For Inhalation Delivery 有权
    形成用于吸入输送的气雾剂的方法

    公开(公告)号:US20090229600A1

    公开(公告)日:2009-09-17

    申请号:US12471070

    申请日:2009-05-22

    IPC分类号: A61M11/00

    摘要: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy

    摘要翻译: 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说,本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面,提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底,从而形成蒸气; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面,提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)加热涂覆有包含药物的组合物的基底以形成蒸气,其中涂覆的组合物为小于10μm厚的膜的形式; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面,提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤:(a)加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气,其中蒸气的质量大于0.1mg; 和(b)允许蒸汽冷却,从而形成用于吸入治疗的气溶胶

    Surgical cassette proximity sensing and latching apparatus

    公开(公告)号:US4790816A

    公开(公告)日:1988-12-13

    申请号:US892347

    申请日:1986-07-31

    IPC分类号: A61B17/00 A61F9/007 A61M1/00

    摘要: There is disclosed herein a system for providing control of multiple functions needed to perform eye surgery. A microprocessor based system controls a vacuum generation system using venturis and linear valves and a pneumatic system for driving vitrectomy probes and pneumatic scissors in either a variable frequency, multicut mode or a proportional cut mode where the cutting pressure is proportional to the position of a foot operated position sensor. The frequency of the vitrectomy probe cutting action can also be controlled and the level of vacuum can be controlled from a foot operated position sensor which can also be used to turn on or off a fragmentation device. The footswitch can also be used to turn irrigation fluid on or off, and the flow rate can be controlled from a control on the front panel. By making a certain foot motion in any certain aspiration modes, reflux of the aspiration line can be controlled. The vacuum level is continuously monitored over all aspiration conditions and adjusted to stay as close as possible to the desired vacuum level. A cassette proximity sensing system senses the presence of a cassette, and aids the user in drawing in and latching the cassette. The vacuum integrity of the cassette is automatically checked by the microprocessor each time one is drawn into the machine. The microprocessor also monitors the cassette for fullness an initiates a transfer to empty one bottle of the cassette into another bottle for storage when the first bottle becomes full. A back-up system checks the accuracy of cassette liquid level sensing apparatus by double checking for liquid in the line leading to the vacuum generation system. If water is detected, a fluid transfer from one bottle of the cassette to the other is initiated.

    Variable pneumatic output means for use with ophthalmic micro-surgical
instruments
    10.
    发明授权
    Variable pneumatic output means for use with ophthalmic micro-surgical instruments 失效
    可变气动输出装置,用于眼科微手术器械

    公开(公告)号:US4622503A

    公开(公告)日:1986-11-11

    申请号:US781393

    申请日:1985-09-26

    IPC分类号: G05D16/20 G05D15/00

    CPC分类号: G05D16/202

    摘要: A variable pneumatic output device for use with ophthmalic micro-surgical instruments including a reversible servo motor which operates in response to instructions from an electronic control circuit. The rotatable drive shaft of the servo motor is operatively connected to the adjustable level control of a precision pressure regulator which operates between a fully open level and a fully closed level. The pressure regulator is operatively connected between a pressurized air source and the pneumatically driven micro-surgical instrument and according to the instructions of the electronic control circuitry, the servo motor, through the connecting drive to the regulator, adjusts the level of pneumatic output to the surgical instrument.

    摘要翻译: 一种可变气动输出装置,其用于包括可逆伺服电动机的光学微外科手术器械,其可响应于来自电子控制电路的指令而工作。 伺服电动机的可旋转驱动轴可操作地连接到精密压力调节器的可调节水平控制器,其在完全开启水平和完全关闭水平之间运行。 压力调节器可操作地连接在加压空气源和气动驱动的微外科手术器械之间,并且根据电子控制电路的指令,伺服电机通过连接到调节器的驱动器来调节气动输出的水平 手术器械。