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公开(公告)号：US08425474B2
公开(公告)日：2013-04-23
申请号：US12187781
申请日：2008-08-07
CPC分类号： A61M31/00 , A61M35/003 , A61M2210/1067
摘要： A pharmaceutical dispenser including a tube having an open end and a space filled with a composition, and an applicator including a first end removably coupled to the open end of the tube and a longitudinal portion with at least one aperture is described. The dispenser can also include a removable cover extending longitudinally and having a bore surrounding the longitudinal portion of the applicator. The composition may be an anal medication. A single dosage unit of the composition is usually contained in the tube, and the tube, applicator, and cover are disposable after use. Methods of using the dispenser include squeezing the tube, allowing the composition to exit the aperture of the applicator, and applying the composition to a target area.
摘要翻译： 一种药剂分配器，其包括具有开口端的管和填充有组合物的空间，以及涂抹器，其包括可移除地联接到管的开口端的第一端和具有至少一个孔的纵向部分。 分配器还可以包括纵向延伸的可移除盖，并且具有围绕施加器的纵向部分的孔。 组合物可以是肛门药物。 组合物的单个剂量单位通常包含在管中，并且管，涂敷器和盖子在使用后是一次性的。 使用分配器的方法包括挤压管，允许组合物离开施用器的孔，并将组合物施加到目标区域。
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公开(公告)号：US06743417B2
公开(公告)日：2004-06-01
申请号：US10127963
申请日：2002-04-22
IPC分类号： A61K600
CPC分类号： A61Q3/00 , A61K8/42 , A61K8/676 , A61K8/678 , A61K8/97 , A61K31/375 , A61K31/385 , A61K31/7024 , A61K36/87 , A61K38/063 , A61K2300/00
摘要： A method of treating onychomycosis is described which includes administration of a topical formulation containing an effective amount of urea and an antioxidant to an infected area around a nail of a patient.
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公开(公告)号：US20090048579A1
公开(公告)日：2009-02-19
申请号：US12187781
申请日：2008-08-07
IPC分类号： A61M31/00 , A61B19/02 , A61K31/167 , A61K31/565 , A61P1/00
CPC分类号： A61M31/00 , A61M35/003 , A61M2210/1067
摘要： A pharmaceutical dispenser including a tube having an open end and a space filled with a composition, and an applicator including a first end removably coupled to the open end of the tube and a longitudinal portion with at least one aperture is described. The dispenser can also include a removable cover extending longitudinally and having a bore surrounding the longitudinal portion of the applicator. The composition may be an anal medication. A single dosage unit of the composition is usually contained in the tube, and the tube, applicator, and cover are disposable after use. Methods of using the dispenser include squeezing the tube, allowing the composition to exit the aperture of the applicator, and applying the composition to a target area.
摘要翻译： 一种药剂分配器，其包括具有开口端的管和填充有组合物的空间，以及涂抹器，其包括可移除地联接到管的开口端的第一端和具有至少一个孔的纵向部分。 分配器还可以包括纵向延伸的可移除盖，并且具有围绕施加器的纵向部分的孔。 组合物可以是肛门药物。 组合物的单个剂量单位通常包含在管中，并且管，涂敷器和盖子在使用后是一次性的。 使用分配器的方法包括挤压管，允许组合物离开施用器的孔，并将组合物施加到目标区域。
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4.发明授权Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use 有权含有抗微生物剂和尿素用于治疗皮肤病的组合物及其使用方法公开(公告)号：US07074832B2
公开(公告)日：2006-07-11
申请号：US10365321
申请日：2003-02-11
CPC分类号： A61Q17/005 , A61K8/466 , A61Q5/00 , A61Q9/00 , A61Q19/00 , A61Q19/02 , Y10S514/859
摘要： Topical compositions which include urea and an antimicrobial agent, particularly sulfacetamide or metronidazole, are described. Sulfacetamide compositions further including sulfur are also described. Methods for treating dermatological disorders using the compositions are also described.
摘要翻译： 描述了包括尿素和抗微生物剂，特别是磺胺乙酰胺或甲硝唑的局部组合物。 还描述了进一步包含硫的硫代乙酰胺组合物。 还描述了使用该组合物治疗皮肤病的方法。
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公开(公告)号：US20050002979A1
公开(公告)日：2005-01-06
申请号：US10900279
申请日：2004-07-28
CPC分类号： A61K45/06 , A61K31/17 , A61K2300/00
摘要： Described is a novel approach for treating actinic keratosis which involves the use of urea in a dermatological composition. The urea composition can be included in pre-treatment, treatment and post-treatment steps. Also described are novel topical compositions for the treatment step containing a combination of urea and a pharmaceutical agent for treating actinic keratosis, such as a caustic agent, 5-fluorouracil or a photosensitizing agent.
摘要翻译： 描述了一种治疗光化性角化病的新方法，其涉及在皮肤病学组合物中使用尿素。 尿素组合物可以包括在预处理，处理和后处理步骤中。 还描述了用于治疗步骤的新型局部组合物，其含有尿素和用于治疗光化性角化病的药物的组合，例如苛性剂，5-氟尿嘧啶或光敏剂。
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公开(公告)号：US06827943B2
公开(公告)日：2004-12-07
申请号：US10328368
申请日：2002-12-23
IPC分类号： A61K600
CPC分类号： A61Q19/00 , A61K8/19 , A61K8/27 , A61K8/42 , A61K31/17 , A61K31/28 , A61K31/30 , A61K31/32 , Y10S514/844 , A61K2300/00
摘要： Described are dermatological compositions for treating, protecting and re-epitheliazing cutaneous wounds and damaged skin, such compositions including about 21 to about 40% urea and trace amounts of zinc, copper and manganese in the form of their respective pharmaceutically acceptable salts.
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7.发明授权Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use 有权用于治疗皮肤病的碳酰胺过氧化物组合物及其使用方法公开(公告)号：US06573301B1
公开(公告)日：2003-06-03
申请号：US10128674
申请日：2002-04-23
IPC分类号： A61K3117
CPC分类号： A61K31/17 , A61K31/075 , A61K2300/00
摘要： Topical compositions which include urea and carbamide peroxide are described. Compositions having a pH in the acidic range, particularly in the range of about 2.5 to about 9 are also described. Methods for treating dermatological disorders using the composition are also described.
摘要翻译： 描述了包括尿素和过氧化脲的局部组合物。 还描述了具有在酸性范围内，特别是约2.5至约9范围内的pH的组合物。 还描述了使用该组合物治疗皮肤病的方法。
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公开(公告)号：US06281239B1
公开(公告)日：2001-08-28
申请号：US09547841
申请日：2000-04-12
申请人： Daniel Glassman
发明人： Daniel Glassman
IPC分类号： A61K314174
CPC分类号： A61K8/361 , A61K8/02 , A61K8/31 , A61K8/34 , A61K8/342 , A61K8/375 , A61K8/42 , A61K8/494 , A61K8/73 , A61K8/92 , A61K9/06 , A61K31/4174 , A61K2800/88 , A61Q3/00
摘要： A method of treating onychomycosis is described which includes administration to an infected area around a nail of a patient a tissue softening composition containing urea and an antifungal composition in one or separate compositions, concurrently or non-concurrently. Also described is a kit which contains the unit dosage forms, a protective gel and appropriate dressings for ready application.
摘要翻译： 描述了一种治疗甲真菌病的方法，其包括向患者的指甲周围的感染区域施用同时或非同时在一个或多个组合物中含有尿素和抗真菌组合物的组织软化组合物。 还描述了一种试剂盒，其包含单位剂型，保护性凝胶和适当的敷料以备即用。
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公开(公告)号：US5899878A
公开(公告)日：1999-05-04
申请号：US103849
申请日：1998-06-24
申请人： Daniel Glassman
发明人： Daniel Glassman
CPC分类号： A61M3/0279 , A61M2210/0618 , A61M3/0258 , Y10S604/902
摘要： There is disclosed a nasal irrigation system having an applicator or irrigating member through which a pressurized stream of irrigating fluid is passed through to the nasal passage. The applicator or irrigating member includes a tubular member, adapted for receiving a pressurized stream of fluid from a fluid source, having a bore extending therethrough. The tubular member is formed of a first portion and a second portion offset at an angle from each other. One portion of the tubular member includes an opening extending into the bore. The covering and uncovering of the opening by the user allows for the user to control the pressure of the fluid stream through the irrigating member, such that the fluid stream is directed to the nose and nasal passages when desired. A fitting is attached to an end of the tubular member for further comfort for contacting the nose. A method for using the irrigating member and the system including this irrigating member is also disclosed.
摘要翻译： 公开了一种具有施用器或冲洗构件的鼻灌溉系统，通过该施用器或冲洗构件将加压流的冲洗流体通过鼻通道。 施用器或冲洗构件包括管状构件，其适于从流体源接收加压的流体流，其具有延伸穿过其中的孔。 管状构件由彼此成角度偏移的第一部分和第二部分形成。 管状构件的一部分包括延伸到孔中的开口。 使用者的开口的覆盖和露出允许使用者控制通过冲洗构件的流体流的压力，使得当需要时流体流被引导到鼻部和鼻部通道。 配件连接到管状构件的端部以进一步舒适地接触鼻子。 还公开了一种使用冲洗构件的方法和包括该冲洗构件的系统。
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公开(公告)号：US06986896B2
公开(公告)日：2006-01-17
申请号：US10370666
申请日：2003-02-20
CPC分类号： A61K8/42 , A61K9/0014 , A61K31/17 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/36 , A61Q3/00 , Y10S514/922
摘要： Methods of treating fungal conditions and onychomycosis are described which include administration of a safe and effective amount of urea in a topical formulation to an affected area on the skin or around a nail of a patient in need of treatment.
摘要翻译： 描述了治疗真菌病症和甲真菌病的方法，其包括将局部制剂中安全有效量的尿素施用于皮肤上的受影响区域或需要治疗的患者的指甲周围。
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