公开(公告)号：US09101313B2

公开(公告)日：2015-08-11

申请号：US13601844

申请日：2012-08-31

Applicant: Daniel Levin ,  Lena Westervall ,  Gustav Markkula ,  Peter Kronberg ,  Trent Victor

Inventor： Daniel Levin ,  Lena Westervall ,  Gustav Markkula ,  Peter Kronberg ,  Trent Victor

IPC: A61B5/18 ,  G08B21/06 ,  B60W40/09 ,  B60W40/08

CPC classification number: A61B5/18 ,  B60W40/09 ,  B60W2040/0872 ,  B60W2540/10 ,  B60W2540/18 ,  B60W2550/308 ,  G08B21/06

Abstract: System for improving a performance estimation of an operator of a vehicle, comprising a first module implementing a first method for estimating a performance state of vehicle operation, a second module implementing a second method for estimating at least one of a physiological and behavioral state of the operator, a device for sharing an estimated state between one of the first and the second module and the other one of the first and the second module, wherein the implemented estimation method of one of the first and the second module is adjusted based on the state of the other one of the first and the second module, thereby improving the estimation of at least one of the performance state of vehicle operation and the physiological and/or behavioral state of the operator.

Abstract translation: 用于改善车辆操作者的性能估计的系统，包括实现用于估计车辆操作的性能状态的第一方法的第一模块，实现用于估计车辆操作的生理和行为状态中的至少一个的第二方法的第二模块 操作者，用于在第一和第二模块之一和第一和第二模块中的一个模块之间共享估计状态的装置，其中基于状态来调整第一模块和第二模块之一的所实现的估计方法 的第一模块和第二模块中的另一个模块，从而改进对车辆操作的性能状态和操作者的生理和/或行为状态中的至少一个的估计。

公开(公告)号：US08965037B2

公开(公告)日：2015-02-24

申请号：US13601789

申请日：2012-08-31

Applicant: Daniel Levin ,  Gustav Markkula

Inventor： Daniel Levin ,  Gustav Markkula

IPC: G06T7/00 ,  B60W50/14 ,  B60K28/06 ,  A61B3/113 ,  A61B5/18 ,  G06F3/01

CPC classification number: B60K28/066 ,  A61B3/113 ,  A61B5/18 ,  G06F3/013 ,  G06K9/00604 ,  G06K9/00845

Abstract: The present invention relates to a method for determining a vehicle operator's visual input of an object in the operator's surroundings, which method comprises receiving an object position signal indicative of the position of at least one object, receiving an operator motion input signal indicative of operator physiological data comprising information relating to body motion of the operator, estimating an operator eye-gaze direction, and determining a visual input quality value representative of level of visual input of the at least one object received by the operator, based on the object position signal and the estimated operator eye-gaze direction.

Abstract translation: 本发明涉及一种用于确定车辆操作员在操作员周围环境中的物体的视觉输入的方法，该方法包括：接收表示至少一个物体的位置的物体位置信号，接收指示操作者生理学的操作者运动输入信号 数据，其包括与操作者的身体运动有关的信息，估计操作者的眼睛注视方向，以及基于对象位置信号确定代表操作者接收的至少一个对象的视觉输入的水平的视觉输入质量值，以及 估计操作者眼睛注视方向。

公开(公告)号：US08916545B2

公开(公告)日：2014-12-23

申请号：US13566731

申请日：2012-08-03

Applicant: Thomas Chen ,  Daniel Levin ,  Satish Pupalli

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: A61K47/48 ,  C07D207/26 ,  C07D487/04 ,  A61N5/10 ,  A61K45/06 ,  A61K31/415 ,  C07D231/12

CPC classification number: C07C33/14 ,  A61K9/0043 ,  A61K31/045 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/495 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61N5/10 ,  C07B59/00 ,  C07B2200/05 ,  C07C2601/16 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Abstract translation: 本发明提供单萜或倍半萜衍生物，例如芳香醇衍生物。 例如，紫苏醇衍生物可以是芳族醇氨基甲酸酯。 紫苏醇衍生物可以是与治疗剂如化学治疗剂缀合的紫苏醇。 本发明还提供了治疗诸如癌症的疾病的方法，其包括向患者递送治疗有效量的单萜（或倍半萜烯）衍生物的步骤。 给药途径可以变化，并且可以包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

公开(公告)号：US20130331422A1

公开(公告)日：2013-12-12

申请号：US13993910

申请日：2011-12-16

Applicant: Thomas Chen ,  Daniel Levin ,  Satish Puppali ,  Daniel Anthony Dickman

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali ,  Daniel Anthony Dickman

IPC: A61K31/045 ,  A61K31/4015 ,  A61K31/4188 ,  A61K45/06 ,  A61K31/415

CPC classification number: A61K31/045 ,  A61K31/05 ,  A61K31/165 ,  A61K31/325 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K45/06 ,  A61K47/54 ,  A61K47/55 ,  A61N5/10 ,  C07B2200/07 ,  C07C271/22 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K2300/00

Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Abstract translation: 本发明提供了治疗诸如癌症的疾病的方法，包括向患者施用治疗有效量的单萜烯或倍半萜烯（或其衍生物）的异构体或类似物，例如异环戊醇。 本发明还提供了治疗疾病的方法，其包括向患者施用治疗有效量的单萜或倍半萜的异构体或类似物的衍生物，例如异哌环醇氨基甲酸酯的步骤。 衍生物可以是与治疗剂如化学治疗剂缀合的异环戊醇。 给药途径可以变化，包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

公开(公告)号：US08524944B2

公开(公告)日：2013-09-03

申请号：US12988026

申请日：2009-04-15

Applicant: Daniel Levin ,  James Luchi

Inventor： Daniel Levin ,  James Luchi

IPC: C07C59/01

CPC classification number: C07D307/04

Abstract: The present invention is directed to a process for the preparation of the saponification products of lactones, preferably three- to eight-membered lactones. The present invention is also directed to a process for the preparation of compounds having general formula (I): wherein M is selected from the group consisting of cationic species, preferably metal cations (even more preferably Na), from a compound having the formula (II): comprising reacting a compound having formula (II) with a suitable hydroxide salt (M-OH) (III) such as, preferably, sodium hydroxide, in an aqueous medium. The reaction preferably utilizes a continuous process method for the substantial consumption of reagent and continuous, semi-continuous, and/or batch-wise processing for final consumption of reagent.

Abstract translation: 本发明涉及制备内酯，优选三至八元内酯的皂化产物的方法。 本发明还涉及制备具有通式（I）的化合物的方法：其中M选自具有式（I）的化合物的阳离子种类，优选金属阳离子（甚至更优选Na） II）：包括在水性介质中使具有式（II）的化合物与合适的氢氧化物盐（M-OH）（III），例如优选氢氧化钠反应。 该反应优选利用连续的方法来大量消耗试剂和连续，半连续和/或分批处理以最终消耗试剂。

公开(公告)号：US20110245494A1

公开(公告)日：2011-10-06

申请号：US13056843

申请日：2009-07-29

Applicant: Catherine Tachdjian ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Qing Chen ,  Peter Leeming ,  Tayyab Rashid ,  Daniel Levin

Inventor： Catherine Tachdjian ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Qing Chen ,  Peter Leeming ,  Tayyab Rashid ,  Daniel Levin

IPC: C07D285/16 ,  C07C255/60 ,  C07C381/00 ,  C07C237/44 ,  C07C229/40 ,  C07C231/06 ,  C07C231/02 ,  C07C253/30 ,  C07C255/58

CPC classification number: C07D285/16 ,  C01B21/096 ,  C07C231/02 ,  C07C231/14 ,  C07C235/20 ,  C07C237/44 ,  C07C253/30 ,  C07C255/54 ,  C07C255/57 ,  C07C255/59 ,  C07C303/40 ,  C07C307/10

Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.

Abstract translation: 本发明包括用于制备具有结构式（I）的化合物的方法/方法和中间体：其中X是烷基，取代的烷基，烯基，取代的烯基，杂烷基，取代的杂烷基，杂烯基或取代的杂烯基。

公开(公告)号：US07804413B2

公开(公告)日：2010-09-28

申请号：US11851706

申请日：2007-09-07

Applicant: Wolfgang Birk ,  Mattias Erik Brannstrom ,  Daniel Levin ,  Andreas Eidehall

Inventor： Wolfgang Birk ,  Mattias Erik Brannstrom ,  Daniel Levin ,  Andreas Eidehall

IPC: G08B23/00

CPC classification number: B60K28/02 ,  B60W40/09 ,  B60W2540/22

Abstract: An object awareness determination system includes an external object sensor system to sense objects and generate input data relating to the objects external to a host vehicle, wherein the input data includes an object position (x, y), an object velocity |({dot over (x)}, {dot over (y)})| and an object direction of movement (({dot over (x)}, {dot over (y)})/|({dot over (x)}, {dot over (y)})|) associated with each object in said detecting range. Additionally, the system includes a controller for determining awareness of the user to an object that recently entered the detecting range of the external object sensor system, and a method for determining awareness of the object.

Abstract translation: 对象感知判定系统包括：外部物体传感器系统，用于感测对象并产生与主车辆外部的对象相关的输入数据，其中所述输入数据包括物体位置（x，y），物体速度|（{dot over （x）}，{dot over（y）}）| 和与每个对象相关联的（{dot over（x）}，{dot over（y）}）/ |（{dot over（x）}，{dot over（y）}） 表示检测范围。 此外，该系统包括用于确定用户对最近进入外部对象传感器系统的检测范围的对象的意识的控制器，以及用于确定对象的意识的方法。

公开(公告)号：US06644703B1

公开(公告)日：2003-11-11

申请号：US10070263

申请日：2002-02-25

Applicant: Daniel Levin ,  Yuval Yassour

Inventor： Daniel Levin ,  Yuval Yassour

IPC: A47J4500

CPC classification number: B25J15/0616 ,  Y10T279/11

Abstract: A self-adaptive vacuum grip apparatus includes a vacuum source (51), a vacuum reservoir (54) fluidically connected to the vacuum source; a contact surface (56), and a plurality of conduits (55); where a conduit has an inlet (2) positioned on the contact surface and an outlet (3) fluidically connected to the vacuum reservoir. The conduit is provided with a plurality of fins (4, 5) mounted on the internal wall thereof arranged in two arrays substantially opposite each other. Each of the fins of the arrays, excluding the fin nearest to the inlet and the fin nearest to the outlet of the conduit, is positioned substantially opposite one of a plurality of cavities wherein opposing fin arrays are arranged asymmetrically. When fluid flows through the conduit, a plurality of vortices (6, 7) are formed within the cavities which exist at least temporarily during the flow, thus forming an aerodynamic blockage allowing a central core-flow, thus forming an aerodynamic blockage allowing a central core-flow, between the vortices and the tips of the fins suppressing the flow in a one-dimensional manner to limit the mass flow rate and maintain a substantial pressure drop withing the conduit.

Abstract translation: 一种自适应真空夹持装置包括真空源（51），与真空源流体连接的真空容器（54） 接触表面（56）和多个导管（55）; 其中导管具有定位在接触表面上的入口（2）和流体连接到真空容器的出口（3）。 导管设置有安装在基本上彼此相对的两个阵列的内壁上的多个翅片（4,5）。 阵列的每个散热片（不包括最接近入口的翅片和最靠近导管出口的翅片）被定位成与多个空腔中的一个基本上相对，其中相对的翅片阵列被不对称地布置。 当流体流过管道时，在空腔内形成多个涡流（6,7），其在流动期间至少暂时存在，从而形成允许中心芯流动的空气动力学阻塞，从而形成允许中心的空气动力学阻塞 涡流之间的涡流和翅片的尖端以一维方式抑制流动以限制质量流率并且保持与管道相当的压降。

公开(公告)号：US06523572B1

公开(公告)日：2003-02-25

申请号：US10070264

申请日：2002-02-25

Applicant: Daniel Levin ,  Yuvai Yassour

Inventor： Daniel Levin ,  Yuvai Yassour

IPC: F15D102

CPC classification number: F15D1/0005

Abstract: An injection system used to generate an acrodynamically induced force, with accordance to the present invention, serving as an air-cushion non-contact supporting system. The system comprises a high pressure manifold (101), connected by high pressure pipe (103), to a high pressure source (102). A SASO-conduit (1), whose inlet (2) is connected to the high pressure manifold, and the outlet (3) is located on the injection-surface (104), of the injection system.

Abstract translation: 根据本发明，用于产生侵蚀力的喷射系统用作气垫非接触支撑系统。 该系统包括由高压管道（103）连接到高压源（102）的高压歧管（101）。 SASO管道（1），其入口（2）连接到高压歧管，并且出口（3）位于注射系统的注射表面（104）上。

公开(公告)号：US06414165B1

公开(公告)日：2002-07-02

申请号：US09673377

申请日：2000-10-16

Applicant: Daniel Levin ,  Jonathan Guy ,  Nicholas Greeves

Inventor： Daniel Levin ,  Jonathan Guy ,  Nicholas Greeves

IPC: C07D30704

CPC classification number: C07D307/32 ,  C07C61/35 ,  C07D307/77

Abstract: A process for the preparation of cis-6,6-dimethyl-3-oxa-bicyclo[3.1.0]hexan-2-one which comprises either: 1) reacting a sulphonic ester of &bgr;,&bgr;-dimethyl-&ggr;-(hydroxymethyl)-&ggr;-butyrolactone with a compound of formula M(C1-6 alkoxide)y, in a suitable solvent; or 2) reacting a C1-4 alkyl ester of 4,5-epoxy-3,3-dimethylpentanoic acid with M(C1-6 alkoxide)y, in a suitable solvent; wherein M is a suitable cation and y fulfills valency requirements.

Abstract translation: 制备顺式-6,6-二甲基-3-氧杂双环[3.1.0]己-2-酮的方法，其包括：1）使β，β-二甲基-γ-（羟甲基 ） - γ-丁内酯与式M（C 1-6烷氧基）y的化合物在合适的溶剂中反应; 或2）使4,5-环氧-3,3-二甲基戊酸的C 1-4烷基酯与M（C 1-6烷氧基）y在合适的溶剂中反应; 其中M是合适的阳离子，y满足价态要求。