公开(公告)号：US08941495B2

公开(公告)日：2015-01-27

申请号：US13493627

申请日：2012-06-11

申请人： Brian Wiese ,  David Christianson ,  Mark Shafer

发明人： Brian Wiese ,  David Christianson ,  Mark Shafer

IPC分类号： G08B13/14 ,  G08B13/08 ,  G08B13/16

CPC分类号： G08B13/08 ,  G08B13/1654

摘要： According to some example embodiments, systems, apparatus, methods, computer readable media, and computer program products are provided for implementing a wireless shelf pusher activity detection system. One example apparatus is a monitoring device for monitoring theft or sales activity associated with a product pusher device. The monitoring device may include a sensor configured to detect movement of a pusher member of the product pusher device, a wireless communications interface, and a processor. The processor may be configured to receive at least one sensor signal from the sensor indicating movement of the pusher member, determine a product movement activity type based on characteristics of the at least one sensor signal, and generate, for transmission via the wireless communications interface, a pusher activity message indicating the product movement activity type.

摘要翻译： 根据一些示例性实施例，提供了系统，装置，方法，计算机可读介质和计算机程序产品，用于实现无线货架推动器活动检测系统。 一个示例性装置是用于监视与产品推送装置相关联的盗窃或销售活动的监视装置。 监视装置可以包括被配置为检测产品推动装置的推动构件的移动的传感器，无线通信接口和处理器。 处理器可以被配置为从传感器接收至少一个传感器信号，指示推动器构件的移动，基于至少一个传感器信号的特性来确定产品运动活动类型，并且为了经由无线通信接口进行传输， 指示产品运动活动类型的推送器活动消息。

公开(公告)号：US06284544B1

公开(公告)日：2001-09-04

申请号：US09071351

申请日：1998-04-30

申请人： Richard B. Thompson ,  Daniel Elbaum ,  Vincent L. Feliccia ,  David Christianson ,  Marcia W. Patchan ,  Zhengfang Ge ,  Badri P. Maliwal

发明人： Richard B. Thompson ,  Daniel Elbaum ,  Vincent L. Feliccia ,  David Christianson ,  Marcia W. Patchan ,  Zhengfang Ge ,  Badri P. Maliwal

IPC分类号： G01N3320

CPC分类号： G01N33/542 ,  G01N21/6445 ,  G01N33/20 ,  G01N33/582 ,  G01N2333/988

摘要： Homogeneous fluorescence polarization (anisotropy) assays for detecting and quantifying metal ions in solution, based the metal-dependent binding of a fluorescent ligand to an unlabeled macromolecule, or the binding of a metal ion to a fluorescent labeled macromolecule. The metal-dependent binding of a fluorescent ligand to an unlabeled macromolecule (metallo-macromolecule) effects a measurable change in anisotropy as will the binding of metal ions to a fluorescent labeled macromolecule. Binding of the fluorescent ligand to the unlabeled macromolecule is metal dependent with the change in anisotropy being proportional to the concentration of bound metal ions. No binding of the fluorescent ligand to the macromolecule occurs in the absence of metal ions. Conversely, if the fluorescent label is first conjugated to a metallo-macromolecule and the metallo-macromolecule is subsequently stripped of its metal ion, it may then be used to transduce the binding of metal ions. Transduction is provided wherein the covalently bound fluorescent label exhibits changes in anisotropy proportional to the concentration of bound metal ions. In all methods, the change in anisotropy may be simply related to the metal ion concentration of the test solution.

摘要翻译： 基于荧光配体与未标记的大分子的金属依赖性结合，或金属离子与荧光标记的大分子的结合，用于检测和定量溶液中的金属离子的均匀荧光偏振（各向异性）测定。 荧光配体与未标记的大分子（金属 - 大分子）的金属依赖性结合对金属离子与荧光标记的大分子的结合将产生各向异性的可测量的变化。 荧光配体与未标记的大分子的结合是金属依赖性的，各向异性的变化与结合的金属离子的浓度成比例。 在不存在金属离子的情况下，不发生荧光配体与大分子的结合。 相反，如果荧光标记首先与金属 - 大分子缀合，并且金属 - 大分子随后被其金属离子剥离，则其可用于转导金属离子的结合。 提供转导，其中共价结合的荧光标记表现出与结合的金属离子浓度成比例的各向异性变化。 在各种方法中，各向异性的变化可能与测试溶液的金属离子浓度有关。

公开(公告)号：US6135845A

公开(公告)日：2000-10-24

申请号：US71931

申请日：1998-05-01

申请人： Randall Jon Klimpert ,  Ann Danielak Klimpert ,  David Christianson ,  Dieter Herbstler ,  Anne Pitrone

发明人： Randall Jon Klimpert ,  Ann Danielak Klimpert ,  David Christianson ,  Dieter Herbstler ,  Anne Pitrone

IPC分类号： A63H3/28

CPC分类号： A63H3/28 ,  A63H2200/00

摘要： A toy doll includes a body having an opening simulating a mouth and first and second electrical switches, each switch being disposed proximal to the simulated mouth and activatable by an object inserted at least partially into the mouth. A speaker is attached to the body. An electrical circuit including an integrated circuit chip is electrically connected with the switches and with the speaker. A base configured as a feeding tray is disposed externally of and is detachably connected with the body. The base has three external switches electrically connected with the circuit chip. The circuit chip has a plurality of memory registers, each register storing a separate signal corresponding to a separate audio message. The chip is configured to randomly select a prompt signal from the memory registers and to transmit the stored signal to the speaker. The prompt signal prompts the user to select a specified one of the switches. The chip is also configured to compare the selected switch with the specified switch. Further, the chip is configured to transmit a first message to the speaker when the specified switch is activated and a second message when a switch other than the specified switch is activated. The first message informs the user that the selection was correct and the second message informs the user that the selection was incorrect.

摘要翻译： 玩具娃娃包括具有模拟嘴部的开口的本体和第一和第二电开关，每个开关设置在模拟口附近，并且可由至少部分插入口中的物体激活。 扬声器附在身上。 包括集成电路芯片的电路与开关和扬声器电连接。 构造为进料盘的基座设置在主体的外部并与主体可拆卸地连接。 基座有三个外部开关与电路芯片电连接。 电路芯片具有多个存储器寄存器，每个寄存器存储对应于单独的音频消息的单独信号。 芯片被配置为从存储器寄存器中随机选择提示信号，并将存储的信号发送到扬声器。 提示信号提示用户选择一个指定的开关。 该芯片还配置为将所选择的开关与指定的开关进行比较。 此外，芯片被配置为当指定的开关被激活时向扬声器发送第一消息，并且当除了指定的开关之外的开关被激活时，发送第二消息。 第一条消息通知用户选择是正确的，第二条消息通知用户选择不正确。

公开(公告)号：US6102969A

公开(公告)日：2000-08-15

申请号：US310899

申请日：1999-05-12

申请人： David Christianson ,  Robert B. Doorenbos ,  Oren Etzioni ,  Chung Kwok ,  Gregory Lauckhart ,  Erik Selberg ,  Daniel S. Weld

发明人： David Christianson ,  Robert B. Doorenbos ,  Oren Etzioni ,  Chung Kwok ,  Gregory Lauckhart ,  Erik Selberg ,  Daniel S. Weld

IPC分类号： G06F13/00 ,  G06F17/30 ,  H04L29/06 ,  H04L29/08

CPC分类号： G06F17/30864 ,  H04L29/06 ,  H04L67/02 ,  H04L67/2814 ,  H04L67/2819 ,  H04L67/2823 ,  H04L69/329 ,  H04L67/16 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99935 ,  Y10S707/99944

摘要： This invention provides assistance to a user in accessing network attached information sources. In one aspect, the invention is a method for intelligently routing a user query to information sources relevant to that query, extracting relevant data fields from received responses, and intelligently presenting the extracted data in order of estimated relevance. The system of this invention implements one or more steps of the method in a centralized or distributed manner on one or more network attached computers. Further, this invention provides a novel language and implementation that facilitates easily written and maintained descriptions of information source query and response formats.

公开(公告)号：US07842491B2

公开(公告)日：2010-11-30

申请号：US10982956

申请日：2004-11-08

申请人： Richard B. Thompson ,  Daniel Elbaum ,  Vincent L. Feliccia ,  David Christianson ,  Marcia W. Patchan ,  Zhengfang Ge ,  Badri P. Maliwal

发明人： Richard B. Thompson ,  Daniel Elbaum ,  Vincent L. Feliccia ,  David Christianson ,  Marcia W. Patchan ,  Zhengfang Ge ,  Badri P. Maliwal

IPC分类号： C12Q1/34 ,  C12Q1/00 ,  G01N21/00 ,  G01N33/20

CPC分类号： G01N33/542 ,  C12N9/88 ,  G01N21/6445 ,  Y10S435/975

摘要： The invention relates to compositions and kits for homogeneous fluorescence polarization (anisotropy) assays for detecting and quantifying metal ions in solution. Metal-dependent binding of a fluorescent ligand to an unlabeled macromolecule effects a measurable change in anisotropy as will the binding of metal ions to a fluorescent labeled macromolecule. Binding of the fluorescent ligand to the unlabeled macromolecule is metal dependent with the change in anisotropy being proportional to the concentration of bound metal ions. Conversely, if the fluorescent label is first conjugated to a macromolecule and the macromolecule is subsequently stripped of metal ion, it may then be used to signal binding of metal ions. The covalently bound fluorescent label exhibits changes in anisotropy proportional to the concentration of bound metal ions. Kits comprise a fluorescent molecule and a macromolecule.

摘要翻译： 本发明涉及用于检测和定量溶液中的金属离子的均匀荧光偏振（各向异性）测定的组合物和试剂盒。 荧光配体与未标记的大分子的金属依赖性结合影响各向异性的可测量的变化，以及金属离子与荧光标记的大分子的结合。 荧光配体与未标记的大分子的结合是金属依赖性的，各向异性的变化与结合的金属离子的浓度成比例。 相反，如果荧光标记首先与大分子缀合并且随后大分子被金属离子剥离，则可以用它来信号结合金属离子。 共价结合的荧光标记表现出与结合金属离子浓度成比例的各向异性变化。 试剂盒包含荧光分子和大分子。

公开(公告)号：US20070042199A1

公开(公告)日：2007-02-22

申请号：US11429923

申请日：2006-05-08

申请人： Bret Chisholm ,  Philip Boudjouk ,  Johnson Thomas ,  David Christianson ,  Shane Stafslien

发明人： Bret Chisholm ,  Philip Boudjouk ,  Johnson Thomas ,  David Christianson ,  Shane Stafslien

IPC分类号： B32B27/00 ,  C08G77/04 ,  C08L83/04

CPC分类号： B63B59/04 ,  C08G77/385 ,  C09D5/1675 ,  C09D179/02 ,  C09D183/04 ,  C09D183/10 ,  C09D183/14 ,  Y10T428/31663 ,  C08L2666/44

摘要： Polyamine cross-linked polysiloxanes, such as functionalized polysiloxane cross-linked with a polyalkylenepolyamine are described herein. The polyamine cross-linked polysiloxanes may be used in an antifouling composition to prevent biological fouling in marine environments.

摘要翻译： 多胺交联聚硅氧烷，例如与聚亚烷基多胺交联的官能化聚硅氧烷。 多胺交联聚硅氧烷可用于防污组合物中以防止海洋环境中的生物污染。

公开(公告)号：US06475056B1

公开(公告)日：2002-11-05

申请号：US10083141

申请日：2002-02-27

申请人： James David Christianson

发明人： James David Christianson

IPC分类号： A63H3340

CPC分类号： A63H33/40

摘要： The invention discloses colorful wind indicator toys and kites having an improved disk structure for securing various rotatable wind collecting parts of the wind indicators and kites.. More specifically, it is proposed that a hub lock be used instead of a disk type structure to secure the vanes of the wind indicator toys, therein “locking” the projections of the vanes into the hub lock, preventing the vanes or similar structures from disengaging and flying away from the structure during high winds..

摘要翻译： 本发明公开了彩色风指示玩具和风筝，其具有改进的盘结构，用于固定风指示器和风筝的各种可旋转风收集部分。更具体地，提出使用轮毂锁而不是盘式结构来固定 风指示器玩具的叶片在其中将叶片的突起“锁定”到轮毂锁中，防止叶片或类似结构在高风期间脱离和离开结构。

公开(公告)号：US06723710B2

公开(公告)日：2004-04-20

申请号：US10053939

申请日：2002-01-23

申请人： David Christianson ,  Ricky Baggio ,  Daniel Elbaum

发明人： David Christianson ,  Ricky Baggio ,  Daniel Elbaum

IPC分类号： A61K3169

CPC分类号： A61K31/195 ,  A61K31/69 ,  C07F5/025

摘要： Compositions and methods for inhibiting arginase activity, including arginase activity in a mammal, are provided. Methods of making the compositions of the invention are also provided as are methods of using the compositions therapeutically. The compositions described herein are useful for alleviating or inhibiting a variety of arinase- and NO synthase-related disorders, including heart disease, gastrointestinal motility disorders, and penile erectile dysfunction in humans.

摘要翻译： 提供了抑制精氨酸酶活性的组合物和方法，包括哺乳动物中的精氨酸酶活性。 还提供了制备本发明组合物的方法，就是使用该组合物治疗的方法。 本文描述的组合物可用于缓解或抑制人类中的多种arinase-和NO合酶相关病症，包括心脏病，胃肠蠕动障碍和阴茎勃起功能障碍。

公开(公告)号：US06387890B1

公开(公告)日：2002-05-14

申请号：US09545737

申请日：2000-04-10

申请人： David Christianson ,  Ricky Baggio ,  Daniel Elbaum

发明人： David Christianson ,  Ricky Baggio ,  Daniel Elbaum

IPC分类号： A61K3169

CPC分类号： A61K31/195 ,  A61K31/69 ,  C07F5/025

摘要： Compositions and methods for inhibiting arginase activity, including arginase activity in a mammal, are provided. Methods of making the compositions of the invention are also provided as are methods of using the compositions therapeutically. The compositions described herein are useful for alleviating or inhibiting a variety of arinase- and NO synthase-related disorders, including heart diseae, gastrointestinal motility disorders, and penile erectile dysfunction in humans.

摘要翻译： 提供了抑制精氨酸酶活性的组合物和方法，包括哺乳动物中的精氨酸酶活性。 还提供了制备本发明组合物的方法，就是使用该组合物治疗的方法。 本文所述的组合物可用于减轻或抑制人类中的多种arinase-和NO合酶相关病症，包括心脏病，胃肠蠕动障碍和阴茎勃起功能障碍。

公开(公告)号：US6085186A

公开(公告)日：2000-07-04

申请号：US933782

申请日：1997-09-19

申请人： David Christianson ,  Robert B. Doorenbos ,  Oren Etzioni ,  Chung Kwok ,  Gregory Lauckhart ,  Erik Selberg ,  Daniel S. Weld

发明人： David Christianson ,  Robert B. Doorenbos ,  Oren Etzioni ,  Chung Kwok ,  Gregory Lauckhart ,  Erik Selberg ,  Daniel S. Weld

IPC分类号： G06F13/00 ,  G06F17/30 ,  H04L29/06 ,  H04L29/08

CPC分类号： G06F17/30864 ,  H04L29/06 ,  H04L67/02 ,  H04L67/2814 ,  H04L67/2819 ,  H04L67/2823 ,  H04L69/329 ,  H04L67/16 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99935 ,  Y10S707/99944

摘要： This invention provides assistance to a user in accessing network attached information sources. In one aspect, the invention is a method for intelligently routing a user query to information sources relevant to that query, extracting relevant data fields from received responses, and intelligently presenting the extracted data in order of estimated relevance. The system of this invention implements one or more steps of the method in a centralized or distributed manner on one or more network attached computers. Further, this invention provides a novel language and implementation that facilitates easily written and maintained descriptions of information source query and response formats.

摘要翻译： 本发明提供对用户访问网络附加信息源的帮助。 一方面，本发明是用于将用户查询智能地路由到与该查询相关的信息源的方法，从接收的响应中提取相关数据字段，并且以估计的相关性的顺序智能地呈现所提取的数据。 本发明的系统在一个或多个网络连接的计算机上以集中或分布的方式实现该方法的一个或多个步骤。 此外，本发明提供了一种新颖的语言和实现，其便于容易地编写和维护信息源查询和响应格式的描述。