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公开(公告)号：US20120264127A1
公开(公告)日：2012-10-18
申请号：US13518135
申请日：2010-12-30
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , G01N33/57492 , G01N33/74 , G01N2333/71 , G01N2333/91205
摘要： The present invention provides compositions and methods for simultaneously detecting mutational status and gene copy number. In particular, the present invention provides simultaneous measurement of gene copy number and detection of the L858R and Exon 19 del mutations in a tissue sample.
摘要翻译： 本发明提供同时检测突变状态和基因拷贝数的组合物和方法。 特别地，本发明提供了基因拷贝数的同时测量以及组织样本中L858R和外显子19 del突变的检测。
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公开(公告)号：US20080313975A1
公开(公告)日：2008-12-25
申请号：US11819109
申请日：2007-06-25
申请人： David Del Valle
发明人： David Del Valle
IPC分类号： E04B7/20
CPC分类号： E04H1/1205
摘要： The gazebo structure is made of four aluminum columns that support a roof made of aluminum, stainless steal, and trans-lucid acrylic resistant to ultraviolet rays.
摘要翻译： 凉亭结构由四个铝立柱组成，支撑由铝制成的屋顶，不锈钢和耐紫外线的反渗透丙烯酸酯屋顶。
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公开(公告)号：US20090270450A1
公开(公告)日：2009-10-29
申请号：US12435856
申请日：2009-05-05
申请人： Leslie Dakin , Kevin Daly , David Del Valle , Thomas Gero , Claude Afona Ogoe , David Scott , Xiaolan Zheng
发明人： Leslie Dakin , Kevin Daly , David Del Valle , Thomas Gero , Claude Afona Ogoe , David Scott , Xiaolan Zheng
IPC分类号： A61K31/47 , C07D215/44
CPC分类号： C07D215/54 , C07D401/04
摘要： The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.
摘要翻译： 本发明涉及具有CSF-1R激酶抑制活性的式（I）化合物或其药学上可接受的盐，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。
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公开(公告)号：US4831748A
公开(公告)日：1989-05-23
申请号：US95965
申请日：1987-09-10
摘要： An apparatus for drying resinous material includes a reaction vessel and a pair of counter-rotating hollow shafts disposed in the vessel. Each of the shafts supports a plurality of blades for stirring the resinous material to be dried in the vessel. A flow of hot gas is continuously supplied through hollow shafts into the blades and released into a reaction vessel through a plurality of apertures in the blades when the blades are in contact with the resinous material.
摘要翻译： 用于干燥树脂材料的设备包括反应容器和设置在容器中的一对反向旋转中空轴。 每个轴支撑多个叶片，用于搅拌容器中待干燥的树脂材料。 当气流与树脂材料接触时，热气流通过空心轴连续供给到叶片中并通过叶片中的多个孔释放到反应容器中。
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公开(公告)号：US4750556A
公开(公告)日：1988-06-14
申请号：US924484
申请日：1986-10-29
CPC分类号： C08F2/18 , B01J19/0013 , B01J8/087 , C08F14/06 , B01J2208/0007 , B01J2208/00221 , B01J2219/0009
摘要： A reactor apparatus is provided with an outer jacket surrounding the reaction vessel. The jacket is formed by a plurality of baffles having triangular cross-section. At least some of the baffles are provided with adjustable deflectors. Heat exchanging fluid is admitted into the space between the jacket and the vessel outer wall. The triangular cross-section of the baffles and adjustable deflectors allow optimum regulation of reaction conditions, for example reaction temperature and in effect increase reactor productivity.
摘要翻译： 反应器装置设有围绕反应容器的外护套。 护套由具有三角形横截面的多个挡板形成。 至少一些隔板设置有可调偏转器。 热交换流体进入夹套和容器外壁之间的空间。 挡板和可调偏转器的三角形横截面允许最佳地调节反应条件，例如反应温度，并且实际上提高了反应器的生产率。
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6.发明申请4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS 审中-公开4-ANILINOQUINOLINE-3-CARBOXAMIDES作为CSF-1R激酶抑制剂公开(公告)号：US20090054411A1
公开(公告)日：2009-02-26
申请号：US12250314
申请日：2008-10-13
申请人： Donald Cook , Leslie Dakin , David Del Valle , Thomas Gero , David Scott , Xiaolan Zheng
发明人： Donald Cook , Leslie Dakin , David Del Valle , Thomas Gero , David Scott , Xiaolan Zheng
IPC分类号： A61K31/496 , C07D401/04 , A61K31/5377 , A61P35/00 , A61K31/551 , C07D413/04
CPC分类号： C07D215/54 , C07D401/04
摘要： The invention relates to chemical compounds of formula IA or IB: or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.
摘要翻译： 本发明涉及具有CSF-1R激酶抑制活性的式IA或IB化学化合物或其药学上可接受的盐，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。
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公开(公告)号：US20080315001A1
公开(公告)日：2008-12-25
申请号：US11819110
申请日：2007-06-25
申请人： David Del Valle
发明人： David Del Valle
IPC分类号： E05B5/02
CPC分类号： E01B5/02
摘要： A rail that requires minimum force to slide an object. It can be assemble by rail pieces until obtaining the desired length.
摘要翻译： 需要最小力量滑动物体的轨道。 它可以通过轨道件组装，直到获得所需的长度。
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公开(公告)号：US20080282460A1
公开(公告)日：2008-11-20
申请号：US11798787
申请日：2007-05-17
申请人： David Del Valle
发明人： David Del Valle
IPC分类号： E04H4/08
CPC分类号： E04H4/086
摘要： A moveable gazebo structure that slides over the pool to cover it. The gazebo is mounted on a platform that rolls on rails installed adjacent to the pool. The gazebo may slide from north to south and vice-versa or from east to west or vice-versa. This invention is motorized but it may be moved manually.
摘要翻译： 一个可移动的凉亭结构，滑过泳池以覆盖它。 凉亭安装在与泳池相邻的轨道上滚动的平台上。 凉亭可能从北向南，反之亦然或从东向西滑动，反之亦然。 本发明是机动化的，但是它可以手动移动。
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