公开(公告)号：US20130152672A1

公开(公告)日：2013-06-20

申请号：US13721489

申请日：2012-12-20

Applicant: Colin Donald Cook

Inventor： Colin Donald Cook

IPC: F16K1/32 ,  G01M3/02

CPC classification number: G01N3/12 ,  F16K1/32 ,  F16K11/07 ,  G01M3/02

Abstract: The present disclosure is directed to systems and methods which provide a seal-less high temperature and pressure valve for use in many applications.

Abstract translation: 本公开涉及提供用于许多应用中的无密封的高温和高压阀的系统和方法。

公开(公告)号：US20080312206A1

公开(公告)日：2008-12-18

申请号：US12097652

申请日：2006-12-19

Applicant: Brian Aquila ,  Donald Cook ,  Leslie Dakin ,  Stephanos Ioannidis ,  Paul Lyne ,  David Scott ,  Xiaolan Zheng

Inventor： Brian Aquila ,  Donald Cook ,  Leslie Dakin ,  Stephanos Ioannidis ,  Paul Lyne ,  David Scott ,  Xiaolan Zheng

IPC: A61K31/427 ,  C07D277/46 ,  A61K31/426 ,  A61P35/00 ,  C07D417/02

CPC classification number: C07D277/46 ,  C07D417/12

Abstract: The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

Abstract translation: 本发明涉及具有CSF 1R激酶抑制活性的化学化合物或其药学上可接受的盐，其具有CSF 1R激酶抑制活性，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制备用于在温血动物如人中产生抗癌作用的药物中的用途。

公开(公告)号：US07400128B2

公开(公告)日：2008-07-15

申请号：US11221164

申请日：2005-09-07

Applicant: Donald Cook Richardson

Inventor： Donald Cook Richardson

IPC: G05F3/26 ,  G05F3/24

CPC classification number: G05F3/30

Abstract: A circuit and method for reducing the variation of a reference voltage as a function of resistivity ρ in a current-mode bandgap reference circuit generating a reference current that is applied to an output resistor to generate the reference voltage. According to the invention, a substantially constant current is generated and added to the reference current.

Abstract translation: 一种用于减小作为电流模式带隙基准电路中的电阻率rho的函数的参考电压的变化的电路和方法，该电路产生施加到输出电阻器以产生参考电压的参考电流。 根据本发明，产生基本恒定的电流并将其加到参考电流上。

公开(公告)号：US4446458A

公开(公告)日：1984-05-01

申请号：US302094

申请日：1981-09-14

Applicant: Donald Cook

Inventor： Donald Cook

IPC: G08B25/06 ,  G08B26/00 ,  H02J13/00 ,  H04B3/54 ,  H04Q9/00 ,  H04M11/04

CPC classification number: H02J13/0031 ,  G08B25/06 ,  G08B26/002 ,  H04B3/542 ,  H04B2203/5416 ,  H04B2203/5437 ,  H04B2203/5441 ,  H04B2203/545 ,  H04B2203/5458 ,  H04B2203/5483 ,  H04B2203/5491 ,  H04B2203/5495 ,  Y02B90/2692 ,  Y04S40/146

Abstract: A carrier current security monitoring and control system utilizes the alternating current power distribution system for residential, commercial, and industrial applications employs a synchronously gated, stable radio frequency carrier. A continuously supervised remote monitoring system comprising a central module and a plurality of remote modules, operating in a full duplex transmission mode for maximum reliability and integrity in a hostile transmission environment is provided.

Abstract translation: 载波电流安全监控系统利用交流电分配系统进行住宅，商业和工业应用，采用同步门控，稳定的射频载波。 提供了一种连续监督的远程监视系统，其包括以全双工传输模式操作的中央模块和多个远程模块，以在恶劣的传输环境中实现最大的可靠性和完整性。

公开(公告)号：US2772650A

公开(公告)日：1956-12-04

申请号：US52228055

申请日：1955-07-15

Applicant: DONALD COOK EDWARD

Inventor： DONALD COOK EDWARD

IPC: G01M15/02 ,  G01M15/06

CPC classification number: G01M15/02 ,  G01M15/06 ,  Y10S116/14

公开(公告)号：US2572110A

公开(公告)日：1951-10-23

申请号：US11519749

申请日：1949-09-12

Applicant: DONALD COOK

Inventor： DONALD COOK

IPC: A63F9/00

CPC classification number: A63F9/0093

公开(公告)号：US2051681A

公开(公告)日：1936-08-18

申请号：US16735

申请日：1935-01-02

Applicant: DONALD COOK JOHN WILLIAM

Inventor： DONALD COOK JOHN WILLIAM

IPC: A47F5/04

CPC classification number: A47F5/04

公开(公告)号：US07215185B2

公开(公告)日：2007-05-08

申请号：US11138946

申请日：2005-05-26

Applicant: Donald Cook Richardson

Inventor： Donald Cook Richardson

IPC: G05F1/10

CPC classification number: G05F1/465 ,  G11C16/06 ,  H03K3/0231 ,  H03K4/502 ,  H03K17/302 ,  H03K2005/00123

Abstract: A system for providing a threshold voltage (VT) includes a VT extractor that extracts the VT for a MOS transistor relative to a first voltage rail. An inversion circuit inverts the extracted VT (e.g., VT+VIN) relative to a reference voltage that is intermediate the first voltage rail and a second voltage rail and provides an output corresponding to the VT (e.g., VT+VIN) relative to the second voltage rail. The relative voltages at the voltage rails generally will depend on whether the VT is being extracted for a p-channel MOS transistor or an n-channel MOS transistor. The VT can be employed to generate a ramp voltage across a capacitor formed of another MOS transistor.

Abstract translation: 用于提供阈值电压（V SUB T）的系统包括提取MOS晶体管相对于第一电压的V SUB T提取器的V SUB提取器 电压轨。 反相电路相对于在第一电压轨之间的参考电压使提取的V SUB（例如，V SUB T + V IN IN）反相 和第二电压轨，并且相对于第二电压轨提供对应于V SUB（例如，V IN T + V IN IN IN）的输出 。 电压轨上的相对电压通常取决于是否为p沟道MOS晶体管或n沟道MOS晶体管提取V SUB。 可以采用V SUB来产生由另一MOS晶体管形成的电容器两端的斜坡电压。

公开(公告)号：US20130152669A1

公开(公告)日：2013-06-20

申请号：US13721436

申请日：2012-12-20

Applicant: Colin Donald Cook

Inventor： Colin Donald Cook

IPC: G01M3/02

CPC classification number: G01M3/02 ,  G01M3/04

Abstract: This disclosure relates generally to systems and methods for testing hoses, and also to a configuration for an intensifier for increasing the pressure and temperature of oil within the hoses to be tested.

Abstract translation: 本公开一般涉及用于测试软管的系统和方法，以及用于增加待测试软管内的油的压力和温度的增压器的配置。

公开(公告)号：US20090054411A1

公开(公告)日：2009-02-26

申请号：US12250314

申请日：2008-10-13

Applicant: Donald Cook ,  Leslie Dakin ,  David Del Valle ,  Thomas Gero ,  David Scott ,  Xiaolan Zheng

Inventor： Donald Cook ,  Leslie Dakin ,  David Del Valle ,  Thomas Gero ,  David Scott ,  Xiaolan Zheng

IPC: A61K31/496 ,  C07D401/04 ,  A61K31/5377 ,  A61P35/00 ,  A61K31/551 ,  C07D413/04

CPC classification number: C07D215/54 ,  C07D401/04

Abstract: The invention relates to chemical compounds of formula IA or IB: or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

Abstract translation: 本发明涉及具有CSF-1R激酶抑制活性的式IA或IB化学化合物或其药学上可接受的盐，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。