Production of aldehyde-treated allergen-containing substances
    5.
    发明授权
    Production of aldehyde-treated allergen-containing substances 失效
    生产含醛处理过敏原物质

    公开(公告)号:US4234569A

    公开(公告)日:1980-11-18

    申请号:US948409

    申请日:1978-10-04

    申请人: David G. Marsh

    发明人: David G. Marsh

    IPC分类号: A61K39/35 A61K39/36 C07G7/00

    CPC分类号: A61K39/35 Y10S514/889

    摘要: This invention relates to a method of production of formaldehyde, and lower saturated aliphatic dialdehyde-treated allergens suitable for the immunotherapy (desensitization) of individuals suffering from allergies of the immediate type in a plurality of steps wherein said formaldehyde and/or said dialdehyde is utilized alone or in combination for the modification of allergen-containing materials. These lower saturated aliphatic mono- and dialdehyde treated allergen-containing materials are useful in ameliorating the symptoms of allergic (atopic) people. Also, they are able to induce formation of blocking antibody in mammals which cross-reacts with the native allergen-containing materials. Reactions with formaldehyde are carried out in a non-phenolic environment in a plurality of steps. The reaction involving combinations of aldehydes can be carried out in a single step.

    摘要翻译: 本发明涉及一种生产甲醛的方法和适用于在多个步骤中患有立即型过敏症的个体的免疫治疗(脱敏)的低级饱和脂族二醛处理的变应原,其中所述甲醛和/或所述二醛被利用 单独或组合用于改变含过敏原的材料。 这些低饱和脂肪族单和二醛处理过的变应原材料可用于改善过敏(特应性)人的症状。 此外,它们能够诱导与天然变应原材料交叉反应的哺乳动物中形成阻断抗体。 与甲醛的反应在非酚类环境中以多个步骤进行。 涉及醛的组合的反应可以在一个步骤中进行。

    Formalinized allergen-containing substances and production thereof
    6.
    发明授权
    Formalinized allergen-containing substances and production thereof 失效
    含有含过敏原的物质及其生产

    公开(公告)号:US4226853A

    公开(公告)日:1980-10-07

    申请号:US550535

    申请日:1975-02-18

    申请人: David G. Marsh

    发明人: David G. Marsh

    IPC分类号: A61K39/35 A61K39/36 C07G7/00

    CPC分类号: A61K39/35 A61K39/36

    摘要: This invention relates to the production of formaldehyde treated allergens suitable for the immunotherapy (desensitization) of individuals suffering from allergies of the immediate type. These formalinized allergen-containing materials are also useful to induce formation of antibody in mammals which cross reacts with the native allergen-containing materials.

    摘要翻译: 本发明涉及适用于患有直接型过敏症的个体的免疫治疗(脱敏)的甲醛处理的过敏原的生产。 这些含福尔马昔酸过敏原的材料也可用于诱导与天然变应原材料交叉反应的哺乳动物中的抗体形成。