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![3-β-D-ribofuranosylthiazolo[4-5-d]pyrimidine nucleosides and uses thereof](/abs-image/US/2011/05/17/US07943759B2/abs.jpg.150x150.jpg)
1.发明授权3-β-D-ribofuranosylthiazolo[4-5-d]pyrimidine nucleosides and uses thereof 有权3-呋喃核糖基噻唑并[4,5-d]嘧啶核苷及其用途公开(公告)号：US07943759B2
公开(公告)日：2011-05-17
申请号：US12823747
申请日：2010-06-25
Applicant: Devron R. Averett , Stephen E. Webber , Joseph R. Lennox , Erik J. Rueden , David Louis Clark , Alan Xin Xiang
Inventor： Devron R. Averett , Stephen E. Webber , Joseph R. Lennox , Erik J. Rueden , David Louis Clark , Alan Xin Xiang
CPC classification number: C07H19/24
Abstract: The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
Abstract translation: 本发明涉及3-＆bgr-D-呋喃核糖基噻唑并[4,5-d]嘧啶核苷和含有具有免疫调节活性的化合物的药物组合物。 本发明还涉及通过施用有效量的这种化合物来治疗或预防使用这些化合物和组合物，以及本文所述的疾病和病症的治疗方法。
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公开(公告)号：US06482860B1
公开(公告)日：2002-11-19
申请号：US08896280
申请日：1997-07-18
Applicant: John A. Flygare , Julio Cesar Medina , Bei Shan , David Louis Clark , Terry J. Rosen
Inventor： John A. Flygare , Julio Cesar Medina , Bei Shan , David Louis Clark , Terry J. Rosen
IPC: A61K3118
CPC classification number: C07K14/47 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/47 , A61K31/5375 , C07C309/73 , C07C311/21 , C07C313/06 , C07C323/49 , C07D209/08 , C07D213/76 , C07D231/56 , C07D295/135 , C07D317/66 , C07D319/18 , Y02A50/411
Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, vascular restenosis, microbial infections, and psoriasis, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:
Abstract translation: 本发明提供了与新的五氟苯基磺酰胺衍生物和类似物有关的方法和组合物及其作为药理活性剂的用途。 该组合物特别用作治疗疾病状态，特别是癌症，血管再狭窄，微生物感染和牛皮癣的药理作用，或作为用于开发这种药物的铅化合物。 组合物包括通式I的化合物：
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公开(公告)号：US06316484B1
公开(公告)日：2001-11-13
申请号：US09633740
申请日：2000-08-07
Applicant: John A. Flygare , Julio Cesar Medina , Bei Shan , David Louis Clark , Terry J. Rosen
Inventor： John A. Flygare , Julio Cesar Medina , Bei Shan , David Louis Clark , Terry J. Rosen
IPC: C07D40900
CPC classification number: C07D319/18 , A61K31/18 , A61K31/275 , A61K31/357 , A61K31/404 , A61K31/416 , A61K31/44 , A61K31/5375 , C07C311/21 , C07C311/29 , C07C323/49 , C07D209/08 , C07D213/75 , C07D231/56 , C07D317/66
Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:
Abstract translation: 本发明提供了与新的五氟苯基磺酰胺衍生物和类似物有关的方法和组合物及其作为药理活性剂的用途。 该组合物特别用作治疗疾病状态，特别是动脉粥样硬化和高胆固醇血症中的药理学作用，或作为用于开发此类药物的铅化合物。 组合物包括通式I的化合物：
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![3-B-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF](/abs-image/US/2008/10/16/US20080255063A1/abs.jpg.150x150.jpg)
4.发明申请3-B-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF 有权3-B-D-RIBOFURAOSYLTHIAZOLO [4,5-d]嘧啶核苷及其用途公开(公告)号：US20080255063A1
公开(公告)日：2008-10-16
申请号：US12015821
申请日：2008-01-17
Applicant: Devron R. Averet , Stephen E. Webber , Joseph R. Lennox , Erik J. Rueden , David Louis Clark , Alan X. Xiang
Inventor： Devron R. Averet , Stephen E. Webber , Joseph R. Lennox , Erik J. Rueden , David Louis Clark , Alan X. Xiang
IPC: A61K31/7064 , A61P31/12
CPC classification number: C07H19/24
Abstract: The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
Abstract translation: 本发明涉及3-β-D-呋喃核糖基噻唑并[4,5-d]嘧啶核苷和含有具有免疫调节活性的化合物的药物组合物。 本发明还涉及通过施用有效量的这种化合物来治疗或预防使用这些化合物和组合物，以及本文所述的疾病和病症的治疗方法。
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5.发明授权Substituted benzene compounds as antiproliferative and cholesterol lowering action 失效取代苯化合物作为抗增殖和降胆固醇的作用公开(公告)号：US06284923B1
公开(公告)日：2001-09-04
申请号：US08917025
申请日：1997-08-22
Applicant: Julio Cesar Medina , David Louis Clark , John A. Flygare , Terry J. Rosen , Bei Shan
Inventor： Julio Cesar Medina , David Louis Clark , John A. Flygare , Terry J. Rosen , Bei Shan
IPC: A61K3136
CPC classification number: C07C311/21
Abstract: The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general Formula I:
Abstract translation: 本发明提供了与新型亲电芳族衍生物有关的化合物，组合物和方法及其作为药理学活性剂的用途。 该组合物特别用作治疗疾病状态，特别是癌症，牛皮癣，血管再狭窄，感染，动脉粥样硬化和高胆固醇血症中的药理作用，或作为用于开发此类药物的铅化合物。 组合物包括通式I的化合物：
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Patent Agency Ranking
公开(公告)号：US06962929B2
公开(公告)日：2005-11-08
申请号：US10270259
申请日：2002-10-11
Applicant: John A. Flygare , Julio Cesar Medina , Bei Shan , David Louis Clark , Terry J. Rosen
Inventor： John A. Flygare , Julio Cesar Medina , Bei Shan , David Louis Clark , Terry J. Rosen
IPC: C07D295/12 , A61K31/165 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/47 , A61K31/5375 , A61P35/00 , C07C309/73 , C07C311/21 , C07C313/04 , C07C313/06 , C07C323/49 , C07D209/08 , C07D213/76 , C07D231/56 , C07D295/135 , C07D317/66 , C07D319/18 , C07K14/00 , C07K14/47 , A61K31/38 , A61K31/34
CPC classification number: C07K14/47 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/47 , A61K31/5375 , C07C309/73 , C07C311/21 , C07C313/06 , C07C323/49 , C07D209/08 , C07D213/76 , C07D231/56 , C07D295/135 , C07D317/66 , C07D319/18 , Y02A50/411
Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, vascular restenosis, microbial infections, and psoriasis, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:
Abstract translation: 本发明提供了与新的五氟苯基磺酰胺衍生物和类似物有关的方法和组合物及其作为药理活性剂的用途。 该组合物特别用作治疗疾病状态，特别是癌症，血管再狭窄，微生物感染和牛皮癣的药理作用，或作为用于开发这种药物的铅化合物。 组合物包括通式I的化合物：
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公开(公告)号：US6121304A
公开(公告)日：2000-09-19
申请号：US227216
申请日：1999-01-06
Applicant: John A. Flygare , Julio Cesar Medina , Bei Shan , David Louis Clark , Terry J. Rosen
Inventor： John A. Flygare , Julio Cesar Medina , Bei Shan , David Louis Clark , Terry J. Rosen
IPC: C07D295/12 , A61K31/00 , A61K31/18 , A61K31/275 , A61K31/335 , A61K31/357 , A61K31/36 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/06 , A61P3/08 , A61P9/00 , A61P9/10 , C07C309/73 , C07C311/21 , C07C311/29 , C07C323/36 , C07C323/49 , C07D209/08 , C07D213/72 , C07D213/75 , C07D231/56 , C07D317/66 , C07D319/14 , C07D319/18 , A01N43/38 , C07C303/00 , C07C307/00
CPC classification number: C07D319/18 , A61K31/18 , A61K31/275 , A61K31/357 , A61K31/404 , A61K31/416 , A61K31/44 , A61K31/5375 , C07C311/21 , C07C311/29 , C07C323/49 , C07D209/08 , C07D213/75 , C07D231/56 , C07D317/66
Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolernia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I: ##STR1##
Abstract translation: 本发明提供了与新的五氟苯基磺酰胺衍生物和类似物有关的方法和组合物及其作为药理活性剂的用途。 该组合物特别用作治疗疾病状态，特别是动脉粥样硬化和高胆固醇血症的药物剂，或作为用于开发此类药物的铅化合物。 组合物包括通式I的化合物：
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公开(公告)号：US5880151A
公开(公告)日：1999-03-09
申请号：US896827
申请日：1997-07-18
Applicant: Julio Cesar Medina , David Louis Clark , John A. Flygare , Terry J. Rosen , Bei Shan
Inventor： Julio Cesar Medina , David Louis Clark , John A. Flygare , Terry J. Rosen , Bei Shan
IPC: C07D295/12 , A61K31/00 , A61K31/18 , A61K31/275 , A61K31/335 , A61K31/357 , A61K31/36 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/06 , A61P3/08 , A61P9/00 , A61P9/10 , C07C309/73 , C07C311/21 , C07C311/29 , C07C323/36 , C07C323/49 , C07D209/08 , C07D213/72 , C07D213/75 , C07D231/56 , C07D317/66 , C07D319/14 , C07D319/18 , A01N41/02 , C07C303/00 , C07D265/30
CPC classification number: C07D319/18 , A61K31/18 , A61K31/275 , A61K31/357 , A61K31/404 , A61K31/416 , A61K31/44 , A61K31/5375 , C07C311/21 , C07C311/29 , C07C323/49 , C07D209/08 , C07D213/75 , C07D231/56 , C07D317/66
Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I: ##STR1##
Abstract translation: 本发明提供了与新的五氟苯基磺酰胺衍生物和类似物有关的方法和组合物及其作为药理活性剂的用途。 该组合物特别用作治疗疾病状态，特别是动脉粥样硬化和高胆固醇血症中的药理学作用，或作为用于开发此类药物的铅化合物。 组合物包括通式I的化合物：
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![3-ß-D-RIBOFURANOSYLTHIAZOLO[4-5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF](/abs-image/US/2010/10/14/US20100261667A1/abs.jpg.150x150.jpg)
9.发明申请3-ß-D-RIBOFURANOSYLTHIAZOLO[4-5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF 有权3-D-RIBOFURANOSYLTHIAZOLO [4-5-d]嘧啶核苷及其用途公开(公告)号：US20100261667A1
公开(公告)日：2010-10-14
申请号：US12823747
申请日：2010-06-25
Applicant: Devron R. Averett , Stephen E. Webber , Joseph R. Lennox , Erik J. Rueden , David Louis Clark , Alan X. Xiang
Inventor： Devron R. Averett , Stephen E. Webber , Joseph R. Lennox , Erik J. Rueden , David Louis Clark , Alan X. Xiang
IPC: A61K31/7064 , C07H19/24 , A61P31/14 , A61P31/12
CPC classification number: C07H19/24
Abstract: The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
Abstract translation: 本发明涉及3-＆bgr-D-呋喃核糖基噻唑并[4,5-d]嘧啶核苷和含有具有免疫调节活性的化合物的药物组合物。 本发明还涉及通过施用有效量的这种化合物来治疗或预防使用这些化合物和组合物，以及本文所述的疾病和病症的治疗方法。
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![3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof](/abs-image/US/2008/01/22/US07321033B2/abs.jpg.150x150.jpg)
10.发明授权3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof 有权3-B-D-呋喃核糖基噻唑并[4,5-d]嘧啶核苷及其用途公开(公告)号：US07321033B2
公开(公告)日：2008-01-22
申请号：US10861430
申请日：2004-06-07
Applicant: Devron R. Averett , Stephen E. Webber , Joseph R. Lennox , Erik J. Rueden , David Louis Clark , Alan Xin Xiang
Inventor： Devron R. Averett , Stephen E. Webber , Joseph R. Lennox , Erik J. Rueden , David Louis Clark , Alan Xin Xiang
IPC: C07H19/00 , C07H19/044 , C07D239/00 , C07D239/70 , C07D471/00 , C07D487/00 , C07D491/00 , C07D239/02 , A01N43/90 , A61K31/519
CPC classification number: C07H19/24
Abstract: The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
Abstract translation: 本发明涉及含有具有免疫调节活性的化合物的3-β-D-呋喃核糖基噻唑并[4,5-d]哒嗪亚胺核苷和药物组合物。 本发明还涉及通过施用有效量的这种化合物来治疗或预防使用这些化合物和组合物，以及本文所述的疾病和病症的治疗方法。
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