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1.发明授权Substituted benzene compounds as antiproliferative and cholesterol lowering action 失效取代苯化合物作为抗增殖和降胆固醇的作用公开(公告)号：US06284923B1
公开(公告)日：2001-09-04
申请号：US08917025
申请日：1997-08-22
IPC分类号： A61K3136
CPC分类号： C07C311/21
摘要： The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general Formula I:
摘要翻译： 本发明提供了与新型亲电芳族衍生物有关的化合物，组合物和方法及其作为药理学活性剂的用途。 该组合物特别用作治疗疾病状态，特别是癌症，牛皮癣，血管再狭窄，感染，动脉粥样硬化和高胆固醇血症中的药理作用，或作为用于开发此类药物的铅化合物。 组合物包括通式I的化合物：
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公开(公告)号：US06962929B2
公开(公告)日：2005-11-08
申请号：US10270259
申请日：2002-10-11
IPC分类号： C07D295/12 , A61K31/165 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/47 , A61K31/5375 , A61P35/00 , C07C309/73 , C07C311/21 , C07C313/04 , C07C313/06 , C07C323/49 , C07D209/08 , C07D213/76 , C07D231/56 , C07D295/135 , C07D317/66 , C07D319/18 , C07K14/00 , C07K14/47 , A61K31/38 , A61K31/34
CPC分类号： C07K14/47 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/47 , A61K31/5375 , C07C309/73 , C07C311/21 , C07C313/06 , C07C323/49 , C07D209/08 , C07D213/76 , C07D231/56 , C07D295/135 , C07D317/66 , C07D319/18 , Y02A50/411
摘要： The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, vascular restenosis, microbial infections, and psoriasis, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:
摘要翻译： 本发明提供了与新的五氟苯基磺酰胺衍生物和类似物有关的方法和组合物及其作为药理活性剂的用途。 该组合物特别用作治疗疾病状态，特别是癌症，血管再狭窄，微生物感染和牛皮癣的药理作用，或作为用于开发这种药物的铅化合物。 组合物包括通式I的化合物：
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公开(公告)号：US6121304A
公开(公告)日：2000-09-19
申请号：US227216
申请日：1999-01-06
IPC分类号： C07D295/12 , A61K31/00 , A61K31/18 , A61K31/275 , A61K31/335 , A61K31/357 , A61K31/36 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/06 , A61P3/08 , A61P9/00 , A61P9/10 , C07C309/73 , C07C311/21 , C07C311/29 , C07C323/36 , C07C323/49 , C07D209/08 , C07D213/72 , C07D213/75 , C07D231/56 , C07D317/66 , C07D319/14 , C07D319/18 , A01N43/38 , C07C303/00 , C07C307/00
CPC分类号： C07D319/18 , A61K31/18 , A61K31/275 , A61K31/357 , A61K31/404 , A61K31/416 , A61K31/44 , A61K31/5375 , C07C311/21 , C07C311/29 , C07C323/49 , C07D209/08 , C07D213/75 , C07D231/56 , C07D317/66
摘要： The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolernia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I: ##STR1##
摘要翻译： 本发明提供了与新的五氟苯基磺酰胺衍生物和类似物有关的方法和组合物及其作为药理活性剂的用途。 该组合物特别用作治疗疾病状态，特别是动脉粥样硬化和高胆固醇血症的药物剂，或作为用于开发此类药物的铅化合物。 组合物包括通式I的化合物：
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公开(公告)号：US5880151A
公开(公告)日：1999-03-09
申请号：US896827
申请日：1997-07-18
IPC分类号： C07D295/12 , A61K31/00 , A61K31/18 , A61K31/275 , A61K31/335 , A61K31/357 , A61K31/36 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/06 , A61P3/08 , A61P9/00 , A61P9/10 , C07C309/73 , C07C311/21 , C07C311/29 , C07C323/36 , C07C323/49 , C07D209/08 , C07D213/72 , C07D213/75 , C07D231/56 , C07D317/66 , C07D319/14 , C07D319/18 , A01N41/02 , C07C303/00 , C07D265/30
CPC分类号： C07D319/18 , A61K31/18 , A61K31/275 , A61K31/357 , A61K31/404 , A61K31/416 , A61K31/44 , A61K31/5375 , C07C311/21 , C07C311/29 , C07C323/49 , C07D209/08 , C07D213/75 , C07D231/56 , C07D317/66
摘要： The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I: ##STR1##
摘要翻译： 本发明提供了与新的五氟苯基磺酰胺衍生物和类似物有关的方法和组合物及其作为药理活性剂的用途。 该组合物特别用作治疗疾病状态，特别是动脉粥样硬化和高胆固醇血症中的药理学作用，或作为用于开发此类药物的铅化合物。 组合物包括通式I的化合物：
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公开(公告)号：US06388131B2
公开(公告)日：2002-05-14
申请号：US09872463
申请日：2001-05-31
IPC分类号： A61K3136
CPC分类号： C07C311/21
摘要： The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general Formula I:
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公开(公告)号：US06482860B1
公开(公告)日：2002-11-19
申请号：US08896280
申请日：1997-07-18
IPC分类号： A61K3118
CPC分类号： C07K14/47 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/47 , A61K31/5375 , C07C309/73 , C07C311/21 , C07C313/06 , C07C323/49 , C07D209/08 , C07D213/76 , C07D231/56 , C07D295/135 , C07D317/66 , C07D319/18 , Y02A50/411
摘要： The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, vascular restenosis, microbial infections, and psoriasis, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:
摘要翻译： 本发明提供了与新的五氟苯基磺酰胺衍生物和类似物有关的方法和组合物及其作为药理活性剂的用途。 该组合物特别用作治疗疾病状态，特别是癌症，血管再狭窄，微生物感染和牛皮癣的药理作用，或作为用于开发这种药物的铅化合物。 组合物包括通式I的化合物：
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公开(公告)号：US06316484B1
公开(公告)日：2001-11-13
申请号：US09633740
申请日：2000-08-07
IPC分类号： C07D40900
CPC分类号： C07D319/18 , A61K31/18 , A61K31/275 , A61K31/357 , A61K31/404 , A61K31/416 , A61K31/44 , A61K31/5375 , C07C311/21 , C07C311/29 , C07C323/49 , C07D209/08 , C07D213/75 , C07D231/56 , C07D317/66
摘要： The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:
摘要翻译： 本发明提供了与新的五氟苯基磺酰胺衍生物和类似物有关的方法和组合物及其作为药理活性剂的用途。 该组合物特别用作治疗疾病状态，特别是动脉粥样硬化和高胆固醇血症中的药理学作用，或作为用于开发此类药物的铅化合物。 组合物包括通式I的化合物：
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公开(公告)号：US07138418B2
公开(公告)日：2006-11-21
申请号：US09972743
申请日：2001-10-05
申请人： John Flygare , Julio C. Medina , Bei Shan , David L. Clark , Terry J. Rosen
发明人： John Flygare , Julio C. Medina , Bei Shan , David L. Clark , Terry J. Rosen
IPC分类号： C07D211/56 , A61K31/357 , C07C307/00
CPC分类号： C07D319/18 , A61K31/18 , A61K31/275 , A61K31/357 , A61K31/404 , A61K31/416 , A61K31/44 , A61K31/5375 , C07C311/21 , C07C311/29 , C07C323/49 , C07D209/08 , C07D213/75 , C07D231/56 , C07D317/66
摘要： The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:
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公开(公告)号：US20120251544A1
公开(公告)日：2012-10-04
申请号：US13494912
申请日：2012-06-12
申请人： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
发明人： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
IPC分类号： C07K16/40 , A61P7/00 , A61K39/395
CPC分类号： C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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公开(公告)号：US20120093818A1
公开(公告)日：2012-04-19
申请号：US13174423
申请日：2011-06-30
申请人： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
发明人： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
IPC分类号： A61K39/395 , C12P21/02 , A61P7/00 , C07K16/40
CPC分类号： C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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