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公开(公告)号：US09878018B2
公开(公告)日：2018-01-30
申请号：US15103599
申请日：2014-12-11
CPC分类号： A61K38/39 , A61K9/0019 , A61K9/1658 , A61K9/70 , A61K47/60 , A61K47/64 , A61K47/6927 , A61K47/6929 , C07K14/78 , C07K2319/21
摘要： The present invention relates to an injectable preparation comprising particles or fibrils with length less than 10 μm and at least one pharmaceutically acceptable vehicle or excipient. The particles or fibrils comprise proteins or peptides inducing adhesion and activation of the platelets, or even aggregation thereof. The preparation is useful for treating hemorrhages.
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2.发明申请Collagen-Based Injectable Preparations Capable of Controlling Bleeding and/or of Substituting for Platelets in the Case of Haemorrhagic Syndromes 有权在出血性综合征的情况下，能够控制出血和/或替代血小板的胶原基注射剂公开(公告)号：US20160310577A1
公开(公告)日：2016-10-27
申请号：US15103599
申请日：2014-12-11
CPC分类号： A61K38/39 , A61K9/0019 , A61K9/1658 , A61K9/70 , A61K47/60 , A61K47/64 , A61K47/6927 , A61K47/6929 , C07K14/78 , C07K2319/21
摘要： The present invention relates to an injectable preparation comprising particles or fibrils with length less than 10 μm and at least one pharmaceutically acceptable vehicle or excipient. The particles or fibrils comprise proteins or peptides inducing adhesion and activation of the platelets, or even aggregation thereof. The preparation is useful for treating haemorrhages.
摘要翻译： 本发明涉及包含长度小于10μm的颗粒或原纤维和至少一种药学上可接受的载体或赋形剂的可注射制剂。 颗粒或原纤维包含诱导血小板粘附和活化的蛋白质或肽，或甚至其聚集。 该制剂可用于治疗出血。
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3.发明申请RECOMBINANT PROTEINS HAVING HAEMOSTATIC ACTIVITY AND CAPABLE OF INDUCING PLATELET AGGREGATION 有权具有HAEMOSTATIC活性的重组蛋白和能诱导平板聚集的重组蛋白公开(公告)号：US20110207669A1
公开(公告)日：2011-08-25
申请号：US13120838
申请日：2009-09-22
IPC分类号： A61K38/16 , C07K14/00 , C07H21/00 , C07K16/44 , C12N15/63 , C12N1/00 , C12N5/10 , A61P7/02 , A61P7/04 , A61K8/64 , A61Q19/00
CPC分类号： C07K14/001 , A61K38/00 , C07K14/78
摘要： Disclosed herein are recombinant proteins capable of inducing platelet aggregation and uses thereof.
摘要翻译： 本文公开了能够诱导血小板聚集的重组蛋白及其用途。
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4.发明授权Recombinant proteins having haemostatic activity and capable of inducing platelet aggregation 有权具有止血活性并能诱导血小板聚集的重组蛋白公开(公告)号：US08557774B2
公开(公告)日：2013-10-15
申请号：US13120838
申请日：2009-09-22
IPC分类号： A61K38/00
CPC分类号： C07K14/001 , A61K38/00 , C07K14/78
摘要： Disclosed herein are recombinant proteins capable of inducing platelet aggregation and uses thereof.
摘要翻译： 本文公开了能够诱导血小板聚集的重组蛋白及其用途。
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公开(公告)号：US20120003683A1
公开(公告)日：2012-01-05
申请号：US13254912
申请日：2010-03-08
CPC分类号： G01N33/68 , G01N33/5026
摘要： Methods of characterizing the extent to which a biological sample preserved at a very low temperature has been exposed to stress using indicator cells is provided.
摘要翻译： 提供了表征在非常低的温度下保存的生物样品的程度已经使用指示剂细胞暴露于应力的方法。
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