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    Combination Therapy to Treat Hepatitis B Virus
    1.
    发明申请
    Combination Therapy to Treat Hepatitis B Virus 审中-公开
    联合治疗乙型肝炎病毒

    公开(公告)号：US20090247487A1

    公开(公告)日：2009-10-01

    申请号：US12483800

    申请日：2009-06-12

    申请人： Phillip A. Furman ,  George R. Painter, III ,  David W. Barry ,  Franck Rousseau

    发明人： Phillip A. Furman ,  George R. Painter, III ,  David W. Barry ,  Franck Rousseau

    IPC分类号： A61K31/675 ,  A61K31/506 ,  A61K31/52

    CPC分类号： A61K31/675 ,  A61K31/52 ,  A61K31/66 ,  A61K31/70 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention is directed to a method for treating hepatitis B virus infection in humans comprising administering a synergistically effective amount of agents having known anti-hepatitis B virus activity in combination or alternation. Specifically, the invention is directed to a method for treating hepatitis B virus infection comprising administering FTC in combination or alternation with penciclovir, famciclovir or Bis-POM-PMEA. Additionally, the invention is directed to a method for treating hepatitis B virus infection comprising administering L-FMAU in combination or alternation with DAPD, penciclovir or Bis-POM-PMEA. The invention is further directed to a method for treating hepatitis B virus infection comprising administering DAPD in combination or alternation with Bis-POM-PMEA.

    摘要翻译： 本发明涉及用于治疗人类乙型肝炎病毒感染的方法，其包括组合或替代地施用协同有效量的具有已知抗乙型肝炎病毒活性的药剂。 具体地，本发明涉及治疗乙型肝炎病毒感染的方法，其包括与喷昔洛韦，泛昔洛韦或双-POM-PMEA组合或交替施用FTC。 另外，本发明涉及一种治疗乙型肝炎病毒感染的方法，包括与DAPD，喷昔洛韦或双-POM-PMEA组合或交替施用L-FMAU。 本发明进一步涉及一种治疗乙型肝炎病毒感染的方法，其包括与双-POM-PMEA组合或交替施用DAPD。

    Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens
    4.
    发明授权
    Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens 有权
    用于指导治疗方案选择的系统，方法和计算机程序产品

    公开(公告)号：US06188988B1

    公开(公告)日：2001-02-13

    申请号：US09523532

    申请日：2000-03-10

    申请人： David W. Barry ,  Carolyn S. Underwood ,  Bruce J. McCreedy ,  David D. Hadden ,  Jason L. Lucas

    发明人： David W. Barry ,  Carolyn S. Underwood ,  Bruce J. McCreedy ,  David D. Hadden ,  Jason L. Lucas

    IPC分类号： G06F1760

    CPC分类号： G06F19/3456 ,  G06F19/00 ,  G06F19/325 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/20 ,  G16H10/60 ,  G16H15/00 ,  G16H50/20 ,  G16H50/70 ,  Y10S706/924

    摘要： Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen for a known disease such as HIV infection are disclosed. The method comprises (a) providing patient information to a computing device (the computer device comprising: a first knowledge base comprising a plurality of different therapeutic treatment regimens for the disease; a second knowledge base comprising a plurality of expert rules for selecting a therapeutic treatment regimen for the disease; and a third knowledge base comprising advisory information useful for the treatment of a patient with different constituents of the different therapeutic treatment regimens; and (b) generating in the computing device a listing (preferably a ranked listing) of therapeutic treatment regimens for the patient; and (c) generating in the computing device advisory information for one or more treatment regimens in the listing based on the patient information and the expert rules.

    摘要翻译： 公开了用于指导对已知疾病如HIV感染的治疗性治疗方案的选择的系统，方法和计算机程序产品。 该方法包括（a）向计算设备提供患者信息（该计算机设备包括：第一知识库，包括用于该疾病的多种不同的治疗方案;第二知识库，包括用于选择治疗性治疗的多个专家规则 以及第三知识库，其包括可用于治疗患有不同治疗方案的不同成分的患者的咨询信息;以及（b）在计算设备中产生治疗性治疗的列表（优选排列的列表） 并且（c）基于患者信息和专家规则，在计算设备中产生针对列表中的一种或多种治疗方案的咨询信息。

    Treatment of human viral infections
    5.
    发明授权
    Treatment of human viral infections 失效
    人类病毒感染的治疗

    公开(公告)号：US5086044A

    公开(公告)日：1992-02-04

    申请号：US510590

    申请日：1990-04-18

    申请人： Janet L. Rideout ,  David W. Barry ,  Sandra N. Lehrman ,  Martha H. St. Clair ,  Phillip A. Furman

    发明人： Janet L. Rideout ,  David W. Barry ,  Sandra N. Lehrman ,  Martha H. St. Clair ,  Phillip A. Furman

    IPC分类号： C07H19/06 ,  C07H19/16

    CPC分类号： C07H19/06 ,  C07H19/16 ,  Y10S514/934

    摘要： Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose. Additionally, there is disclosed the treatment of Kaposi's sarcoma with 3'-azido-3'-deoxythymidine (AZT) and the synergistic activity in the treatment of humans infected with HTLV-III of AZT and interferon as well as AZT and acyclovir.

    摘要翻译： 使用化合物3'-叠氮基-3'-脱氧胸苷或其药学上可接受的碱性盐来公开用艾滋病病毒携带或感染艾滋病病毒或具有抗艾滋病病毒抗体的艾滋病或人类的治疗。 还公开了3'-叠氮基-3'-脱氧胸苷的5'-单，二和三磷酸或其药学上可接受的碱性盐用于相同目的。 另外，公开了用3'-叠氮基-3'-脱氧胸苷（AZT）处理卡波西氏肉瘤的方法，以及AZT和干扰素以及AZT和阿昔洛韦感染HTLV-III的人的治疗中的协同作用。

    Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens
    8.
    发明授权
    Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens 有权
    用于指导治疗方案选择的系统，方法和计算机程序产品

    公开(公告)号：US6081786A

    公开(公告)日：2000-06-27

    申请号：US283702

    申请日：1999-04-01

    申请人： David W. Barry ,  Carolyn S. Underwood ,  Bruce J. McCreedy ,  David D. Hadden ,  Jason L. Lucas

    发明人： David W. Barry ,  Carolyn S. Underwood ,  Bruce J. McCreedy ,  David D. Hadden ,  Jason L. Lucas

    IPC分类号： G06F19/00 ,  G06Q50/22 ,  G06Q50/24 ,  G06F17/60

    CPC分类号： G06F19/345 ,  G06F19/3443 ,  G06F19/3456 ,  G06Q50/22 ,  G06Q50/24 ,  G06F19/322 ,  G06F19/325 ,  G06F19/3487 ,  G06F19/363 ,  Y10S706/924

    摘要： Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen for a known disease such as HIV infection are disclosed. The method comprises (a) providing patient information to a computing device (the computer device comprising: a first knowledge base comprising a plurality of different therapeutic treatment regimens for the disease; a second knowledge base comprising a plurality of expert rules for selecting a therapeutic treatment regimen for the disease; and a third knowledge base comprising advisory information useful for the treatment of a patient with different constituents of the different therapeutic treatment regimens; and (b) generating in the computing device a listing (preferably a ranked listing) of therapeutic treatment regimens for the patient; and (c) generating in the computing device advisory information for one or more treatment regimens in the listing based on the patient information and the expert rules.

    摘要翻译： 公开了用于指导对已知疾病如HIV感染的治疗性治疗方案的选择的系统，方法和计算机程序产品。 该方法包括（a）向计算设备提供患者信息（该计算机设备包括：第一知识库，包括用于该疾病的多种不同的治疗方案;第二知识库，包括用于选择治疗性治疗的多个专家规则 以及第三知识库，其包括可用于治疗患有不同治疗方案的不同成分的患者的咨询信息;以及（b）在计算设备中产生治疗性治疗的列表（优选排列的列表） 并且（c）基于患者信息和专家规则，在计算设备中产生针对列表中的一种或多种治疗方案的咨询信息。